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Start Over Descriptor "POTENT ANTITUMOR-ACTIVITY" Publisher wiley
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1. Synthesis of a C-Iminoribofuranoside Analog of the Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitor FK866

Author

Somi Reddy Majjigapu, Annabelle Gillig, Bernard Sordat, and Pierre Vogel

Subjects
Target, Stereochemistry, Hematologic Malignancies, Pyridine nucleotides, Nicotinamide phosphoribosyltransferase, Pyridine-Nucleotides, Visfatin, C-imino, Human Leukemia-Cells, Colorectal-Cancer, Biochemistry, Catalysis, Inorganic Chemistry, chemistry.chemical_compound, Drug Discovery, Hydroxymethyl, Physical and Theoretical Chemistry, Inhibitors, Organic Chemistry, Nad Biosynthesis Inhibitor, Chs 828, Anticancer drug, In vitro, Fk866, chemistry, In-Vitro, Ribofuranoside analogs, Potent Antitumor-Activity
Abstract

FK866 (also named APO866 or WK175) is a potent NAMPT inhibitor being evaluated (Phase II) as a potential anticancer drug. The preparation of the C-iminoribofuranoside analog (2E)-N-[4-(1-benzoylpiperidin-4-yl)butyl]-3-{3-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl]phenyl}prop-2-enamide ((-)-1) is reported.

Published
2012
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