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Your search keyword '"Pérez-Millan, Agnès"' showing total 11 results
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11 results on '"Pérez-Millan, Agnès"'

1. Probabilistic computer‐aided diagnosis of Alzheimer’s disease and frontotemporal dementia based on MRI and biochemical markers

Author

Pérez‐Millan, Agnès, primary, Thirion, Bertrand, additional, Borrego‐Écija, Sergi, additional, Contador, José, additional, Juncà‐Parella, Jordi, additional, Bosch, Beatriz, additional, Falgàs, Neus, additional, Antonell, Anna, additional, Ruiz‐García, Raquel, additional, Naranjo, Laura, additional, Balasa, Mircea, additional, Lladó, Albert, additional, Sanchez‐Valle, Raquel, additional, and Sala‐Llonch, Roser, additional

Published
2023
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2. Exploring the relationship between MRI changes and cognitive/neuropsychiatric complaints in a cohort of long COVID‐19 patients: A cross‐sectional and longitudinal study

Author

Pérez‐Millan, Agnès, primary, Guillén, Núria, additional, Falgàs, Neus, additional, Botí, María Ángeles, additional, Tort‐Merino, Adrià, additional, Lledó‐Ibáñez, Gema María, additional, Ruiz‐García, Raquel, additional, Naranjo, Laura, additional, Rami, Lorena, additional, Balasa, Mircea, additional, Lladó, Albert, additional, Sala‐Llonch, Roser, additional, and Sanchez‐Valle, Raquel, additional

Published
2023
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3. Cognitive symptoms associated with COVID‐19: neuropsychological and biochemical characterization

Author

Guillén, Núria, primary, Pérez‐Millan, Agnès, additional, Martínez, Neus Falgàs, additional, Botí, María Ángeles, additional, Tort‐Merino, Adrià, additional, Lledó‐Ibáñez, Gema María, additional, Ruiz‐García, Raquel, additional, Naranjo, Laura, additional, Rami, Lorena, additional, Sala‐Llonch, Roser, additional, Balasa, Mircea, additional, Lladó, Albert, additional, and Sanchez‐Valle, Raquel, additional

Published
2023
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4. Plasma Neurofilament Light Chain predicts neuroimaging alterations and functional decline in frontotemporal dementia

Author

Borrego‐Écija, Sergi, primary, Juncà‐Parella, Jordi, additional, Ruiz‐García, Raquel, additional, Sarto, Jordi, additional, Martínez, Neus Falgàs, additional, Esteller, Diana, additional, Guillén, Núria, additional, Fernandez‐Villullas, Guadalupe, additional, González, Yolanda, additional, Pérez‐Millan, Agnès, additional, Tort‐Merino, Adrià, additional, Bosch, Beatriz, additional, Fort‐Aznar, Laura, additional, Antonell, Anna, additional, Naranjo, Laura, additional, Lladó, Albert, additional, Balasa, Mircea, additional, and Sanchez‐Valle, Raquel, additional

Published
2023
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5. Galectin‐3 is upregulated in frontotemporal dementia patients with subtype specificity

Author

Borrego–Écija, Sergi, primary, Pérez‐Millan, Agnès, additional, Antonell, Anna, additional, Fort‐Aznar, Laura, additional, Kaya‐Tilki, Elif, additional, León‐Halcón, Alberto, additional, Lladó, Albert, additional, Molina‐Porcel, Laura, additional, Balasa, Mircea, additional, Juncà‐Parella, Jordi, additional, Vitorica, Javier, additional, Luis Venero, Jose, additional, Deierborg, Tomas, additional, Boza‐Serrano, Antonio, additional, and Sánchez‐Valle, Raquel, additional

Published
2023
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6. Galectin-3 is upregulated in frontotemporal dementia patients with subtype specificity

Author

Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular, Instituto de Salud Carlos III, Generalitat de Catalunya, Ministerio de Ciencia e Innovación (MICIN). España, European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER), Borrego Écija, Sergi, Pérez Millan, Agnès, Antonell, Anna, Fort Aznar, Laura, Kaya Tilki, Elif, León Halcón, Alberto, Vitorica Ferrández, Francisco Javier, Venero Recio, José Luis, Boza Serrano, Antonio, Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular, Instituto de Salud Carlos III, Generalitat de Catalunya, Ministerio de Ciencia e Innovación (MICIN). España, European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER), Borrego Écija, Sergi, Pérez Millan, Agnès, Antonell, Anna, Fort Aznar, Laura, Kaya Tilki, Elif, León Halcón, Alberto, Vitorica Ferrández, Francisco Javier, Venero Recio, José Luis, and Boza Serrano, Antonio

Abstract

INTRODUCTION Neuroinflammation is a major contributor to the progression of frontotemporal dementia (FTD). Galectin-3 (Gal-3), a microglial activation regulator, holds promise as a therapeutic target and potential biomarker. Our study aimed to investigate Gal-3 levels in patients with FTD and assess its diagnostic potential. METHODS We examined Gal-3 levels in brain, serum, and cerebrospinal fluid (CSF) samples of patients with FTD and controls. Multiple linear regressions between Gal-3 levels and other FTD markers were explored. RESULTS Gal-3 levels were increased significantly in patients with FTD, mainly across brain tissue and CSF, compared to controls. Remarkably, Gal-3 levels were higher in cases with tau pathology than TAR-DNA Binding Protein 43 (TDP-43) pathology. Only MAPT mutation carriers displayed increased Gal-3 levels in CSF samples, which correlated with total tau and 14-3-3. DISCUSSION Our findings underscore the potential of Gal-3 as a diagnostic marker for FTD, particularly in MAPT cases, and highlights the relation of Gal-3 with neuronal injury markers.

Published
2023

7. Classifying Alzheimer's disease and frontotemporal dementia using machine learning with cross‐sectional and longitudinal magnetic resonance imaging data

Author

Pérez‐Millan, Agnès, primary, Contador, José, additional, Juncà‐Parella, Jordi, additional, Bosch, Beatriz, additional, Borrell, Laia, additional, Tort‐Merino, Adrià, additional, Falgàs, Neus, additional, Borrego‐Écija, Sergi, additional, Bargalló, Nuria, additional, Rami, Lorena, additional, Balasa, Mircea, additional, Lladó, Albert, additional, Sánchez‐Valle, Raquel, additional, and Sala‐Llonch, Roser, additional

Published
2023
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8. TheAPOE4effect: structural brain differences in Alzheimer's disease according to the age at symptom onset

Author

Forno, Gonzalo, primary, Contador, Jose, additional, Pérez‐Millan, Agnès, additional, Guillen, Nuria, additional, Falgàs, Neus, additional, Sarto, Jordi, additional, Tort‐Merino, Adrià, additional, Castellví, Magdalena, additional, Bosch, Beatriz, additional, Fernández‐Villullas, Guadalupe, additional, Balasa, Mircea, additional, Antonell, Anna, additional, Sala‐ Llonch, Roser, additional, Sanchez‐Valle, Raquel, additional, Hornberger, Michael, additional, and Lladó, Albert, additional

Published
2022
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9. Sex differences in early‐onset Alzheimer's disease

Author

Contador, José, primary, Pérez‐Millan, Agnès, additional, Guillén, Nuria, additional, Sarto, Jordi, additional, Tort‐Merino, Adrià, additional, Balasa, Mircea, additional, Falgàs, Neus, additional, Castellví, Magdalena, additional, Borrego‐Écija, Sergi, additional, Juncà‐Parella, Jordi, additional, Bosch, Beatriz, additional, Fernández‐Villullas, Guadalupe, additional, Ramos‐Campoy, Oscar, additional, Antonell, Anna, additional, Bargalló, Nuria, additional, Sanchez‐Valle, Raquel, additional, Sala‐Llonch, Roser, additional, and Lladó, Albert, additional

Published
2022
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10. Contribution of CSF biomarkers to early‐onset Alzheimer's disease and frontotemporal dementia neuroimaging signatures

Author

Falgàs, Neus, primary, Ruiz‐Peris, Mariona, additional, Pérez‐Millan, Agnès, additional, Sala‐Llonch, Roser, additional, Antonell, Anna, additional, Balasa, Mircea, additional, Borrego‐Écija, Sergi, additional, Ramos‐Campoy, Oscar, additional, Augé, Josep Maria, additional, Castellví, Magdalena, additional, Tort‐Merino, Adrià, additional, Olives, Jaume, additional, Fernández‐Villullas, Guadalupe, additional, Blennow, Kaj, additional, Zetterberg, Henrik, additional, Bargalló, Núria, additional, Lladó, Albert, additional, and Sánchez‐Valle, Raquel, additional

Published
2020
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11. The APOE4 effect: structural brain differences in Alzheimer's disease according to the age at symptom onset.

Author

Forno G, Contador J, Pérez-Millan A, Guillen N, Falgàs N, Sarto J, Tort-Merino A, Castellví M, Bosch B, Fernández-Villullas G, Balasa M, Antonell A, Sala-Llonch R, Sanchez-Valle R, Hornberger M, and Lladó A

Subjects
Humans, Apolipoprotein E4 genetics, Magnetic Resonance Imaging methods, Age of Onset, Brain pathology, Atrophy pathology, Biomarkers, Alzheimer Disease diagnostic imaging, Alzheimer Disease genetics, Alzheimer Disease pathology
Abstract

Background and Purpose: How the APOE genotype can differentially affect cortical and subcortical memory structures in biomarker-confirmed early-onset (EOAD) and late-onset (LOAD) Alzheimer's disease (AD) was assessed., Method: Eighty-seven cerebrospinal fluid (CSF) biomarker-confirmed AD patients were classified according to their APOE genotype and age at onset. 28 were EOAD APOE4 carriers (+EOAD), 21 EOAD APOE4 non-carriers (-EOAD), 23 LOAD APOE4 carriers (+LOAD) and 15 LOAD APOE4 non-carriers (-LOAD). Grey matter (GM) volume differences were analyzed using voxel-based morphometry in Papez circuit regions. Multiple regression analyses were performed to determine the relation between GM volume loss and cognition., Results: Significantly more mammillary body atrophy in +EOAD compared to -EOAD is reported. The medial temporal and posterior cingulate cortex showed less GM in +LOAD compared to -LOAD. Medial temporal GM volume loss was also found in +EOAD compared to -LOAD. With an exception for +EOAD, medial temporal GM was strongly associated with episodic memory in the three groups, whilst posterior cingulate cortex GM volume was more related with visuospatial abilities. Visuospatial abilities and episodic memory were also associated with the anterior thalamic nucleus in -LOAD., Conclusions: Our results show that the APOE genotype has a significant effect on GM integrity as a function of age of disease onset. Specifically, whilst LOAD APOE4 genotype is mostly associated with increased medial temporal and parietal atrophy compared to -LOAD, for EOAD APOE4 might have a more specific effect on subcortical (mammillary body) structures. The findings suggest that APOE genotype needs to be taken into account when classifying patients by age at onset., (© 2022 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology.)

Published
2023
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