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101 results on '"Olsen, Richard"'

3. Nurses' perspectives on technical skill requirements in primary and tertiary healthcare services

Author

Leonardsen, Ann‐Chatrin Linqvist, primary, Blågestad, Ina Kristin, additional, Brynhildsen, Siri, additional, Olsen, Richard, additional, Gunheim‐Hatland, Lars, additional, Gregersen, Anne‐Grethe, additional, Kvarsnes, Anne Herwander, additional, Hansen, Wenche Charlotte, additional, Andreassen, Hilde Marie, additional, Martinsen, Mona, additional, Hansen, Mette, additional, Hjelmeland, Inger, additional, and Grøndahl, Vigdis Abrahamsen, additional

Published
2020
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6. Structural Models of Ligand-Gated Ion Channels: Sites of Action for Anesthetics and Ethanol

Author

Olsen, Richard W., Li, Guo-Dong, Wallner, Martin, Trudell, James R., Bertaccini, Edward J., Lindahl, Erik, Miller, Keith W., Phil, D, Alkana, Ronald L., and Davies, Daryl L.

Subjects
Models, Molecular, Cysteine Loop Ligand-Gated Ion Channel Receptors, Ethanol, Molecular Structure, Chemistry, Molecular Sequence Data, Allosteric regulation, GLIC, Central Nervous System Depressants, Medicine (miscellaneous), Molecular Dynamics Simulation, Toxicology, Article, Psychiatry and Mental health, Nicotinic agonist, Biochemistry, Neurotransmitter receptor, Animals, Humans, Ligand-gated ion channel, Amino Acid Sequence, Glycine receptor, Ion channel, Anesthetics
Abstract

The molecular mechanism(s) of action of anesthetic, and especially, intoxicating doses of alcohol (ethanol [EtOH]) have been of interest even before the advent of the Research Society on Alcoholism. Recent physiological, genetic, and biochemical studies have pin-pointed molecular targets for anesthetics and EtOH in the brain as ligand-gated ion channel (LGIC) membrane proteins, especially the pentameric (5 subunit) Cys-loop superfamily of neurotransmitter receptors including nicotinic acetylcholine (nAChRs), GABA(A) (GABA(A)Rs), and glycine receptors (GlyRs). The ability to demonstrate molecular and structural elements of these proteins critical for the behavioral effects of these drugs on animals and humans provides convincing evidence for their role in the drugs' actions. Amino acid residues necessary for pharmacologically relevant allosteric modulation of LGIC function by anesthetics and EtOH have been identified in these channel proteins. Site-directed mutagenesis revealed potential allosteric modulatory sites in both the trans-membrane domain (TMD) and extracellular domain (ECD). Potential sites of action and binding have been deduced from homology modeling of other LGICs with structures known from crystallography and cryo-electron microscopy studies. Direct information about ligand binding in the TMD has been obtained by photoaffinity labeling, especially in GABA(A)Rs. Recent structural information from crystallized procaryotic (ELIC and GLIC) and eukaryotic (GluCl) LGICs allows refinement of the structural models including evaluation of possible sites of EtOH action.

Published
2013

8. Real-Time Trading Models and the Statistical Properties of Foreign Exchange Rates*

Author

GenÇay Ramazan, Pictet Olivier, Olsen Richard, Ballocchi Giuseppe, and Dacorogna Michel

Subjects
Transaction cost, Economics and Econometrics, Foreign exchange rates, Currency, Econometrics, Economics, Probability distribution, Pairs trade, Foreign exchange, Algorithmic trading, Null hypothesis, computer.software_genre, computer
Abstract

The contributions of this article are twofold. First, the performance of a widely used commercial real-time trading model is compared with the performance of systematic currency traders. Second, the real-time trading model is used to evaluate the statistical properties of foreign exchange rates. The out-of-sample test period is seven years of high-frequency data for four major rates. The trading model yields positive annualized returns (net of transaction costs) in all cases. The null hypothesis of whether the real-time performances of the foreign exchange series are consistent with traditional statistical processes is tested under the probability distributions of the performance measures.

Published
2002

13. A response to Honnay et al .

Author

Collier, Sarah M, primary, Brummer, E Charles, additional, Barber, Wesley T, additional, Cox, Thomas S, additional, Johnson, Randy, additional, Murray, Seth C, additional, Olsen, Richard T, additional, Pratt, Richard C, additional, and Thro, Ann Marie, additional

Published
2012
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30. LETTERS TO THE EDITOR

Author

Otis, Thomas S., primary, Hanchar, Harry J., additional, Dodson, Paul D., additional, Olsen, Richard W., additional, and Wallner, Martin, additional

Published
2005
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