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1. Burden and outcomes of postpartum haemorrhage in Nigerian referral‐level hospitals

Author

Adebayo, Tajudeen, primary, Adefemi, Ayodeji, additional, Adewumi, Idowu, additional, Akinajo, Opeyemi, additional, Akinkunmi, Bola, additional, Awonuga, David, additional, Aworinde, Olufemi, additional, Ayegbusi, Ekundayo, additional, Dedeke, Iyabode, additional, Fajolu, Iretiola, additional, Imam, Zainab, additional, Jagun, Olusoji, additional, Kuku, Olumide, additional, Ogundare, Ezra, additional, Oluwasola, Timothy, additional, Oyeneyin, Lawal, additional, Adebanjo‐Aina, Damilola, additional, Adenuga, Emmanuel, additional, Adeyanju, Alaruru, additional, Akinsanya, Olufemi, additional, Campbell, Ibijoke, additional, Kuti, Bankole, additional, Olofinbiyi, Babatunde, additional, Salau, Qasim, additional, Tongo, Olukemi, additional, Ezekwe, Bosede, additional, Lavin, Tina, additional, Oladapo, Olufemi T., additional, Tukur, Jamilu, additional, and Adesina, Olubukola, additional

Published
2024
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2. Perceptions and experiences of the prevention, detection, and management of postpartum haemorrhage: a qualitative evidence synthesis

Author

Akter, Shahinoor, additional, Forbes, Gillian, additional, Vazquez Corona, Martha, additional, Miller, Suellen, additional, Althabe, Fernando, additional, Coomarasamy, Arri, additional, Gallos, Ioannis D, additional, Oladapo, Olufemi T, additional, Vogel, Joshua P, additional, Lorencatto, Fabiana, additional, and Bohren, Meghan A, additional

Published
2023
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5. A core outcome set for trials in miscarriage management and prevention: An international consensus development study

Author

Dhillon‐Smith, Rima K., primary, Melo, Pedro, additional, Devall, Adam James, additional, Smith, Paul Philip, additional, Al‐Memar, Maya, additional, Barnhart, Kurt, additional, Condous, George, additional, Christiansen, Ole Bjarne, additional, Goddijn, Mariëtte, additional, Jurkovic, Davor, additional, Lissauer, David, additional, Maheshwari, Abha, additional, Oladapo, Olufemi T., additional, Preisler, Jessica, additional, Regan, Lesley, additional, Small, Rachel, additional, Stephenson, Mary, additional, Wijeyaratne, Chandrika, additional, Quenby, Siobhan, additional, Bourne, Tom, additional, and Coomarasamy, Arri, additional

Published
2023
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6. Methods of induction of labour: a network meta-analysis

Author

Rattanakanokchai, Siwanon, additional, Gallos, Ioannis D, additional, Kietpeerakool, Chumnan, additional, Eamudomkarn, Nuntasiri, additional, Alfirevic, Zarko, additional, Oladapo, Olufemi T, additional, Chou, Doris, additional, Mol, Ben Willem J, additional, Li, Wentao, additional, Lumbiganon, Pisake, additional, Coomarasamy, Arri, additional, and Price, Malcolm J, additional

Published
2023
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7. Tranexamic acid at cesarean delivery: Drug‐error deaths

Author

Moran, Neil F., primary, Bishop, David G., additional, Fawcus, Susan, additional, Morris, Edward, additional, Shakur‐Still, Haleema, additional, Devall, Adam J., additional, Gallos, Ioannis D., additional, Widmer, Mariana, additional, Oladapo, Olufemi T., additional, Coomarasamy, Arri, additional, and Hofmeyr, G. Justus, additional

Published
2022
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8. Tocolytics for delaying preterm birth: a network meta-analysis (0924)

Author

Wilson, Amie, additional, Hodgetts-Morton, Victoria A, additional, Marson, Ella J, additional, Markland, Alexandra D, additional, Larkai, Eva, additional, Papadopoulou, Argyro, additional, Coomarasamy, Arri, additional, Tobias, Aurelio, additional, Chou, Doris, additional, Oladapo, Olufemi T, additional, Price, Malcolm J, additional, Morris, Katie, additional, and Gallos, Ioannis D, additional

Published
2022
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10. Tocolytics for delaying preterm birth: a network meta-analysis

Author

Wilson, Amie, additional, Hodgetts-Morton, Victoria A, additional, Marson, Ella J, additional, Markland, Alexandra D, additional, Larkai, Eva, additional, Papadopoulou, Argyro, additional, Coomarasamy, Arri, additional, Tobias, Aurelio, additional, Chou, Doris, additional, Oladapo, Olufemi T, additional, Price, Malcolm J, additional, Morris, Katie, additional, and Gallos, Ioannis D, additional

Published
2021
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11. Perceptions and experiences of the prevention, identification and management of postpartum haemorrhage: a qualitative evidence synthesis

Author

Akter, Shahinoor, additional, Lorencatto, Fabiana, additional, Forbes, Gillian, additional, Miller, Suellen, additional, Althabe, Fernando, additional, Coomarasamy, Arri, additional, Gallos, Ioannis D, additional, Oladapo, Olufemi T, additional, Vogel, Joshua P, additional, Thomas, Eleanor, additional, and Bohren, Meghan A, additional

Published
2020
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12. Uterotonic agents for first-line treatment of postpartum haemorrhage: a network meta-analysis

Author

Parry Smith, William R, additional, Papadopoulou, Argyro, additional, Thomas, Eleanor, additional, Tobias, Aurelio, additional, Price, Malcolm J, additional, Meher, Shireen, additional, Alfirevic, Zarko, additional, Weeks, Andrew D, additional, Hofmeyr, G Justus, additional, Gülmezoglu, Ahmet Metin, additional, Widmer, Mariana, additional, Oladapo, Olufemi T, additional, Vogel, Joshua P, additional, Althabe, Fernando, additional, Coomarasamy, Arri, additional, and Gallos, Ioannis D, additional

Published
2020
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13. Usability, acceptability, and feasibility of the World Health Organization Labour Care Guide: A mixed‐methods, multicountry evaluation

Author

Vogel, Joshua P., primary, Comrie‐Thomson, Liz, additional, Pingray, Veronica, additional, Gadama, Luis, additional, Galadanci, Hadiza, additional, Goudar, Shivaprasad, additional, Laisser, Rose, additional, Lavender, Tina, additional, Lissauer, David, additional, Misra, Sujata, additional, Pujar, Yeshita, additional, Qureshi, Zahida P., additional, Amole, Taiwo, additional, Berrueta, Mabel, additional, Dankishiya, Faisal, additional, Gwako, George, additional, Homer, Caroline S. E., additional, Jobanputra, Jonathan, additional, Meja, Sam, additional, Nigri, Carolina, additional, Mohaptra, Vandana, additional, Osoti, Alfred, additional, Roberti, Javier, additional, Solomon, Dennis, additional, Suleiman, Maryam, additional, Robbers, Gianna, additional, Sutherland, Shireen, additional, Vernekar, Sunil, additional, Althabe, Fernando, additional, Bonet, Mercedes, additional, and Oladapo, Olufemi T., additional

Published
2020
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18. Alternative Magnesium Sulfate Dosing Regimens for Women With Preeclampsia: A Population Pharmacokinetic Exposure‐Response Modeling and Simulation Study

Author

Du, Lihong, primary, Wenning, Larissa A., additional, Carvalho, Brendan, additional, Duley, Lelia, additional, Brookfield, Kathleen F., additional, Witjes, Han, additional, Greef, Rik, additional, Lumbiganon, Pisake, additional, Titapant, Vitaya, additional, Kongwattanakul, Kiattisak, additional, Long, Qian, additional, Sangkomkamhang, Ussanee S., additional, Gülmezoglu, Ahmet M., additional, and Oladapo, Olufemi T., additional

Published
2019
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20. Uterotonic agents for preventing postpartum haemorrhage: a network meta-analysis

Author

Gallos, Ioannis D, primary, Papadopoulou, Argyro, additional, Man, Rebecca, additional, Athanasopoulos, Nikolaos, additional, Tobias, Aurelio, additional, Price, Malcolm J, additional, Williams, Myfanwy J, additional, Diaz, Virginia, additional, Pasquale, Julia, additional, Chamillard, Monica, additional, Widmer, Mariana, additional, Tunçalp, Özge, additional, Hofmeyr, G Justus, additional, Althabe, Fernando, additional, Gülmezoglu, Ahmet Metin, additional, Vogel, Joshua P, additional, Oladapo, Olufemi T, additional, and Coomarasamy, Arri, additional

Published
2018
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21. Population Pharmacokinetic Modeling to Evaluate Standard Magnesium Sulfate Treatments and Alternative Dosing Regimens for Women With Preeclampsia

Author

Du, Lihong, primary, Wenning, Larissa, additional, Migoya, Elizabeth, additional, Xu, Yan, additional, Carvalho, Brendan, additional, Brookfield, Kathleen, additional, Witjes, Han, additional, Greef, Rik, additional, Lumbiganon, Pisake, additional, Sangkomkamhang, Ussanee, additional, Titapant, Vitaya, additional, Duley, Lelia, additional, Long, Qian, additional, and Oladapo, Olufemi T., additional

Published
2018
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26. Negotiating quality standards for effective delivery of labor and childbirth care in Nigeria and Uganda

Author

Oladapo, Olufemi T., primary, Bohren, Meghan A., additional, Fawole, Bukola, additional, Mugerwa, Kidza, additional, Ojelade, Olubunmi A., additional, Titiloye, Musibau A., additional, Alu, Francis E., additional, Mambya, Musana O., additional, Oyeneyin, Lawal, additional, Bataale, Salim, additional, Akintan, Adesina, additional, Alabi, Olubunmi, additional, Adebayo, Amos, additional, Okike, Ola, additional, Idris, Hadiza A., additional, Wilfred, Sanni, additional, Bello, Halima, additional, Kyaddondo, David, additional, Olutayo, Akinpelu O., additional, Byamugisha, Josaphat, additional, Souza, Joao Paulo, additional, and Gülmezoglu, A. Metin, additional

Published
2017
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30. Defining quality of care during childbirth from the perspectives of Nigerian and Ugandan women: A qualitative study

Author

Bohren, Meghan A., primary, Titiloye, Musibau A., additional, Kyaddondo, David, additional, Hunter, Erin C., additional, Oladapo, Olufemi T., additional, Tunçalp, Özge, additional, Byamugisha, Josaphat, additional, Olutayo, Akinpelu O., additional, Vogel, Joshua P., additional, Gülmezoglu, A. Metin, additional, Fawole, Bukola, additional, and Mugerwa, Kidza, additional

Published
2017
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33. Increases in Caesarean Delivery Rates and Change of Perinatal Outcomes in Low- and Middle-Income Countries: A Hospital-Level Analysis of Two WHO Surveys

Author

Zhao, Yanjun, primary, Zhang, Jun, additional, Zamora, Javier, additional, Vogel, Joshua Peter, additional, Souza, João P., additional, Jayaratne, Kapila, additional, Ganchimeg, Togoobaatar, additional, Ortiz-Panozo, Eduardo, additional, Hernandez, Bernardo, additional, Oladapo, Olufemi T., additional, Torloni, Maria R., additional, Morisaki, Naho, additional, Mori, Rintaro, additional, Pileggi-Castro, Cynthia, additional, Tunçalp, Özge, additional, Shen, Xiaoming, additional, and Betrán, Ana Pilar, additional

Published
2017
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49. Tranexamic acid at cesarean delivery: Drug-error deaths.

Author

Moran NF, Bishop DG, Fawcus S, Morris E, Shakur-Still H, Devall AJ, Gallos ID, Widmer M, Oladapo OT, Coomarasamy A, and Hofmeyr GJ

Subjects
Pregnancy, Female, Humans, Cesarean Section, Tranexamic Acid adverse effects, Antifibrinolytic Agents adverse effects, Postpartum Hemorrhage drug therapy, Anesthesia, Spinal
Abstract

The use of tranexamic acid for postpartum hemorrhage has entered obstetrical practice globally with the evidence-based expectation of saving lives. This improvement in the care of women with postpartum hemorrhage has come at a price. For the anesthetist, having tranexamic acid ampoules close at hand would seem an obvious strategy to facilitate its use during cesarean delivery, an important setting for severe hemorrhage. Tragically, we have identified a number of recent instances of inadvertent intrathecal administration of tranexamic acid instead of local anesthetic for spinal anesthesia. Reported cases of this catastrophic error seem to be increasing. The profound neurotoxicity of tranexamic acid causes rapid-onset convulsions, with mortality of 50%. How can these tragic errors be averted? Drug safety alerts have been issued by the US Food and Drug Administration and the World Health Organization, but that is not enough. We recommend extensive dissemination of information to raise awareness of this potential hazard, and local hospital protocols to ensure that tranexamic acid is stored separately from anesthetic drugs, preferably outside the operating room and with an auxiliary warning label. Implementation of safety strategies on a very large scale will be needed to ensure that the life-saving potential of tranexamic acid is not eclipsed by drug-error mortality., (© 2022 The Author(s). Published by Elsevier Inc /Elsevier B.V./ Wiley on behalf of The International Federation of Gynecology and Obstetrics (FIGO) / John Wiley & Son Ltd. All rights reserved.)

Published
2023
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50. Intravenous versus intramuscular prophylactic oxytocin for the third stage of labour.

Author

Oladapo OT, Okusanya BO, Abalos E, Gallos ID, and Papadopoulou A

Subjects
Bias, Blood Transfusion statistics & numerical data, Confidence Intervals, Female, Humans, Injections, Intramuscular, Injections, Intravenous, Oxytocics adverse effects, Oxytocin adverse effects, Postpartum Hemorrhage epidemiology, Pregnancy, Randomized Controlled Trials as Topic, Labor Stage, Third, Oxytocics administration & dosage, Oxytocin administration & dosage, Postpartum Hemorrhage prevention & control
Abstract

Background: There is general agreement that oxytocin given either through the intravenous or intramuscular route is effective in reducing postpartum blood loss. However, it is unclear whether the subtle differences between the mode of action of these routes have any effect on maternal and infant outcomes. This review was first published in 2012 and last updated in 2018., Objectives: To determine the comparative effectiveness and safety of oxytocin administered intravenously or intramuscularly for prophylactic management of the third stage of labour after vaginal birth., Search Methods: We searched Cochrane Pregnancy and Childbirth's Trials Register, ClinicalTrials.gov, the WHO International Clinical Trials Registry Platform (ICTRP) (19 December 2019), and reference lists of retrieved studies., Selection Criteria: Eligible studies were randomised trials comparing intravenous with intramuscular oxytocin for prophylactic management of the third stage of labour after vaginal birth. We excluded quasi-randomised trials., Data Collection and Analysis: Two review authors independently assessed studies for inclusion and risk of bias, extracted data and checked them for accuracy. We assessed the certainty of the evidence with the GRADE approach., Main Results: Seven trials, involving 7817 women, met the inclusion criteria for this review. The trials compared intravenous versus intramuscular administration of oxytocin just after the birth of the anterior shoulder or soon after the birth of the baby. All trials were conducted in hospital settings and included women with term pregnancies, undergoing a vaginal birth. Overall, the included studies were at moderate or low risk of bias, with two trials providing clear information on allocation concealment and blinding. For GRADE outcomes, the certainty of the evidence was generally moderate to high, except from two cases where the certainty of the evidence was either low or very low. High-certainty evidence suggests that intravenous administration of oxytocin in the third stage of labour compared with intramuscular administration carries a lower risk for postpartum haemorrhage (PPH) ≥ 500 mL (average risk ratio (RR) 0.78, 95% confidence interval (CI) 0.66 to 0.92; six trials; 7731 women) and blood transfusion (average RR 0.44, 95% CI 0.26 to 0.77; four trials; 6684 women). Intravenous administration of oxytocin probably reduces the risk of PPH ≥ 1000 mL, although the 95% CI crosses the line of no-effect (average RR 0.65, 95% CI 0.39 to 1.08; four trials; 6681 women; moderate-certainty evidence). In all studies but one, there was a reduction in the risk of PPH ≥ 1000 mL with intravenous oxytocin. The study that found a large increase with intravenous administration was small (256 women), and contributed only 3% of total events. Once this small study was removed from the meta-analysis, heterogeneity was eliminated and the treatment effect favoured intravenous oxytocin (average RR 0.61, 95% CI 0.42 to 0.88; three trials; 6425 women; high-certainty evidence). Additionally, a sensitivity analysis, exploring the effect of risk of bias by restricting analysis to those studies rated as 'low risk of bias' for random sequence generation and allocation concealment, found that the prophylactic administration of intravenous oxytocin reduces the risk for PPH ≥ 1000 mL, compared with intramuscular oxytocin (average RR 0.64, 95% CI 0.43 to 0.94; two trials; 1512 women). The two routes of oxytocin administration may be comparable in terms of additional uterotonic use (average RR 0.78, 95% CI 0.49 to 1.25; six trials; 7327 women; low-certainty evidence). Although intravenous compared with intramuscular administration of oxytocin probably results in a lower risk for serious maternal morbidity (e.g. hysterectomy, organ failure, coma, intensive care unit admissions), the confidence interval suggests a substantial reduction, but also touches the line of no-effect. This suggests that there may be no reduction in serious maternal morbidity (average RR 0.47, 95% CI 0.22 to 1.00; four trials; 7028 women; moderate-certainty evidence). Most events occurred in one study from Ireland reporting high dependency unit admissions, whereas in the remaining three studies there was only one case of uvular oedema. There were no maternal deaths reported in any of the included studies (very low-certainty evidence). There is probably little or no difference in the risk of hypotension between intravenous and intramuscular administration of oxytocin (RR 1.01, 95% CI 0.88 to 1.15; four trials; 6468 women; moderate-certainty evidence). Subgroup analyses based on the mode of administration of intravenous oxytocin (bolus injection or infusion) versus intramuscular oxytocin did not show any substantial differences on the primary outcomes. Similarly, additional subgroup analyses based on whether oxytocin was used alone or as part of active management of the third stage of labour (AMTSL) did not show any substantial differences between the two routes of administration., Authors' Conclusions: Intravenous administration of oxytocin is more effective than its intramuscular administration in preventing PPH during vaginal birth. Intravenous oxytocin administration presents no additional safety concerns and has a comparable side effects profile with its intramuscular administration. Future studies should consider the acceptability, feasibility and resource use for the intervention, especially in low-resource settings., (Copyright © 2020 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.)

Published
2020
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