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15 results on '"Norman, Gary L."'

1. Calprotectin Impairs Platelet Survival in Patients With Primary Antiphospholipid Syndrome

Author

Hoy, Claire K., primary, NaveenKumar, Somanathapura K., additional, Navaz, Sherwin A., additional, Sugur, Kavya, additional, Yalavarthi, Srilakshmi, additional, Sarosh, Cyrus, additional, Smith, Tristin, additional, Kmetova, Katarina, additional, Chong, Emily, additional, Peters, Noah F., additional, Rysenga, Christine E., additional, Norman, Gary L., additional, Figueroa‐Parra, Gabriel, additional, Nelson, Dava, additional, Girard, Jennifer, additional, Ahmed, Asra Z., additional, Schaefer, Jordan K., additional, Gudjonsson, Johann E., additional, Kahlenberg, J. Michelle, additional, Madison, Jacqueline A., additional, Knight, Jason S., additional, Crowson, Cynthia S., additional, Duarte‐García, Alí, additional, and Zuo, Yu, additional

Published
2024
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2. Clinical utility of circulating calprotectin to assist prediction and monitoring of COVID‐19 severity: An Italian study

Author

Infantino, Maria, primary, Manfredi, Mariangela, additional, Alessio, Maria Grazia, additional, Previtali, Giulia, additional, Grossi, Valentina, additional, Benucci, Maurizio, additional, Faraone, Antonio, additional, Fortini, Alberto, additional, Grifoni, Elisa, additional, Masotti, Luca, additional, Russo, Edda, additional, Amedei, Amedeo, additional, FitzGerald, Emily, additional, Albesa, Roger, additional, Norman, Gary L., additional, and Mahler, Michael, additional

Published
2022
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3. Anti‐glycoprotein 2 (anti‐GP2) IgA and anti‐neutrophil cytoplasmic antibodies to serine proteinase 3 (PR3‐ANCA): antibodies to predict severe disease, poor survival and cholangiocarcinoma in primary sclerosing cholangitis

Author

Wunsch, Ewa, primary, Norman, Gary L., additional, Milkiewicz, Malgorzata, additional, Krawczyk, Marcin, additional, Bentow, Chelsea, additional, Shums, Zakera, additional, Mahler, Michael, additional, Lopens, Steffi, additional, Reinhold, Dirk, additional, Franke, Andre, additional, Schramm, Christoph, additional, Roggenbuck, Dirk, additional, and Milkiewicz, Piotr, additional

Published
2020
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4. Association between serum soluble CD14 and IL-8 levels and clinical outcome in primary biliary cholangitis

Author

Umemura, Takeji, Sekiguchi, Tomohiro, Joshita, Satoru, Yamazaki, Tomoo, Shibata, Soichiro, Ichikawa, Yuki, Komatsu, Michiharu, Matsumoto, Akihiro, Shums, Zakera, Norman, Gary L., Tanaka, Eiji, and Ota, Masao

Subjects
microbial translocation, decompensation, primary biliary cholangitis, liver‐related death, transplantation
Abstract

Background & AimsPrimary biliary cholangitis (PBC) is an autoimmune liver disease characterized by portal inflammation and immune‐mediated destruction of intrahepatic bile ducts that often leads to liver decompensation and liver failure. Although the biochemical response to ursodeoxycholic acid (UDCA) can predict disease outcome in PBC, few biomarkers have been identified as prognostic tools applicable prior to UDCA treatment. We therefore sought to identify such indicators of long‐term outcome in PBC in the Japanese population.MethodsThe prebiopsy serum samples and subsequent clinical data of 136 patients with PBC treated with UDCA were analysed over a median follow‐up period of 8.8 years. Serum levels of biomarkers related to microbial translocation (sCD14, EndoCAb and I‐FABP) were measured along with those of 33 cytokines and chemokines and additional auto‐antibodies. Associations between the tested parameters and the clinical outcomes of liver decompensation and liver‐related death/liver transplantation were evaluated using the Cox proportional hazards model with stepwise methods and Kaplan‐Meier analysis.ResultsElevated levels of serum IL‐8, and sCD14 before UDCA therapy were significantly associated with both liver decompensation and liver‐related death/liver transplantation. In multivariate analyses, IL‐8≥46.5 pg/mL or sCD14≥2.0 μg/mL at enrolment demonstrated the same results. Kaplan‐Meier analysis also revealed IL‐8 and sCD14 to be significantly associated with a poor outcome. sCD14 was significantly correlated with IL‐8. EndoCAb and I‐FABP were not related to disease outcome.ConclusionsSerum IL‐8 and sCD14 levels before UDCA therapy represent noninvasive surrogate markers of prognosis in patients with PBC., Article, LIVER INTERNATIONAL.37(6):897-905(2016)

Published
2016

5. Clinical performance of automated chemiluminescent methods for anticardiolipin and anti‐β2‐glycoprotein I antibodies detection in a large cohort of Chinese patients with antiphospholipid syndrome

Author

Wan, Li‐yan, primary, Gu, Jie‐yu, additional, Liu, Ting‐ting, additional, Hu, Qiong‐yi, additional, Jia, Jin‐chao, additional, Teng, Jia‐lin, additional, Sun, Yue, additional, Liu, Hong‐lei, additional, Cheng, Xiao‐bing, additional, Ye, Jun‐na, additional, Su, Yu‐tong, additional, Wu, Xin‐yao, additional, Chi, Hui‐hui, additional, Zhou, Zhuo‐chao, additional, Wang, Zhi‐hong, additional, Zhou, Jin‐feng, additional, Norman, Gary L., additional, Dai, Jing, additional, Yang, Cheng‐de, additional, and Shi, Hui, additional

Published
2020
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6. Autoantibodies in patients with interleukin 12 receptor beta 1 deficiency

Author

Ronca, Vincenzo, primary, Chen, Qu Bo, additional, Lygoura, Vasiliky, additional, Ben‐Mustapha, Imen, additional, Shums, Zakera, additional, Trifa, Mehdi, additional, Carbone, Marco, additional, Mancuso, Clara, additional, Milani, Chiara, additional, Bernuzzi, Francesca, additional, Ma, Xiong, additional, Agrebi, Nourhen, additional, Norman, Gary L., additional, Chang, Christopher, additional, Gershwin, Merrill Eric, additional, Barbouche, Mohamed‐Ridha, additional, and Invernizzi, Pietro, additional

Published
2019
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8. Clinical Characterization of Antiphospholipid Syndrome by Detection of IgG Antibodies Against β2-Glycoprotein I Domain 1 and Domain 4/5: Ratio of Anti-Domain 1 to Anti-Domain 4/5 As a Useful New Biomarker for Antiphospholipid Syndrome

Author

Andreoli, Laura, primary, Chighizola, Cecilia B., additional, Nalli, Cecilia, additional, Gerosa, Maria, additional, Borghi, M. Orietta, additional, Pregnolato, Francesca, additional, Grossi, Claudia, additional, Zanola, Alessandra, additional, Allegri, Flavio, additional, Norman, Gary L., additional, Mahler, Michael, additional, Meroni, Pier Luigi, additional, and Tincani, Angela, additional

Published
2015
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9. Prevalence estimation of celiac disease in the general adult population of Latvia using serology and HLA genotyping

Author

Leja, Marcis, primary, Shums, Zakera, additional, Nikitina-Zake, Liene, additional, Gavars, Mikus, additional, Kikuste, Ilze, additional, Milo, Jay, additional, Daugule, Ilva, additional, Pahomova, Jelena, additional, Pirags, Valdis, additional, Dzerve, Vilnis, additional, Klovins, Janis, additional, Erglis, Andrejs, additional, and Norman, Gary L, additional

Published
2015
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10. Anti-kelch-like 12 and anti-hexokinase 1: novel autoantibodies in primary biliary cirrhosis

Author

Norman, Gary L., primary, Yang, Chen-Yen, additional, Ostendorff, Heather P., additional, Shums, Zakera, additional, Lim, Mark J., additional, Wang, Jinjun, additional, Awad, Amany, additional, Hirschfield, Gideon M., additional, Milkiewicz, Piotr, additional, Bloch, Donald B., additional, Rothschild, Kenneth J., additional, Bowlus, Christopher L., additional, Adamopoulos, Iannis E., additional, Leung, Patrick S.C., additional, Janssen, Harry J., additional, Cheung, Angela C., additional, Coltescu, Catalina, additional, and Gershwin, M. Eric, additional

Published
2014
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11. Value of Isolated IgA Anti–β2‐Glycoprotein I Positivity in the Diagnosis of the Antiphospholipid Syndrome

Author

Murthy, Vijaya, primary, Willis, Rohan, additional, Romay‐Penabad, Zurina, additional, Ruiz‐Limón, Patricia, additional, Martínez‐Martínez, Laura A., additional, Jatwani, Shraddha, additional, Jajoria, Praveen, additional, Seif, Alan, additional, Alarcón, Graciela S., additional, Papalardo, Elizabeth, additional, Liu, Jigna, additional, Vilá, Luis M., additional, McGwin, Gerald, additional, McNearney, Terry A., additional, Maganti, Rashmi, additional, Sunkureddi, Prashanth, additional, Parekh, Trisha, additional, Tarantino, Michael, additional, Akhter, Ehtisham, additional, Fang, Hong, additional, Gonzalez, Emilio B., additional, Binder, Walter R., additional, Norman, Gary L., additional, Shums, Zakera, additional, Teodorescu, Marius, additional, Reveille, John D., additional, Petri, Michelle, additional, and Pierangeli, Silvia S., additional

Published
2013
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13. Polymorphisms of IL12RB2 May Affect the Natural History of Primary Biliary Cholangitis: A Single Centre Study.

Author

Wasik U, Wunsch E, Norman GL, Rigopoulou EI, Bogdanos DP, Milkiewicz P, and Milkiewicz M

Subjects
Adult, Alleles, DNA, Female, Genetic Predisposition to Disease, Genotype, Homozygote, Humans, Liver Cirrhosis, Biliary diagnosis, Liver Cirrhosis, Biliary immunology, Male, Middle Aged, Phenotype, Autoantibodies blood, Genetic Association Studies, Liver Cirrhosis, Biliary genetics, Mitochondria immunology, Polymorphism, Single Nucleotide, Receptors, Interleukin-12 genetics
Abstract

Background . Recent GWAS in primary biliary cholangitis (PBC) showed strong associations with SNPs located within interleukin-12 receptor (IL12R) beta-2 (IL12RB2) gene. Aims . We assessed whether genetic variation of IL12RB2 is associated with laboratory and clinical features of PBC. Methods . Genomic DNA was isolated from 306 patients with PBC and 258 age/gender-matched controls. PBC-specific anti-mitochondrial antibodies (AMA) were tested in all subjects by ELISA. Two SNPs, rs3790567 and rs6679356, of IL12RB2 were genotyped using the MGB-TaqMan SNP assay. Results . Despite comparable age at diagnosis of cirrhotic and noncirrhotic PBC patients, allele A of rs3790567 and allele C of rs6679356 were overrepresented in the former rather than the latter group ( p = 0.0009 and p = 0.002, resp.). The risk of cirrhosis at presentation increased when allele A and allele C coexisted. AMA-M2 titres were significantly higher in AA homozygotes of rs3790567 compared to GG homozygotes (132 ± 54 versus 103 ± 62, p = 0.02) and in rs6679356 when C allele was present ( p = 0.038). There were no other significant associations between IL12RB2 polymorphisms and laboratory or clinical features. Conclusion . In this first study analyzing phenotypic features of PBC carriers of the IL12RB2 polymorphisms, we found that carriers are more frequently cirrhotic at diagnosis and have significantly higher titres of AMA., Competing Interests: The authors declare that there is no conflict of interests regarding the publication of this paper.

Published
2017
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14. Analytical and clinical comparison of two fully automated immunoassay systems for the diagnosis of celiac disease.

Author

Lakos G, Norman GL, Mahler M, Martis P, Bentow C, Santora D, and Fasano A

Subjects
Adult, Aged, Aged, 80 and over, Biopsy, Case-Control Studies, Celiac Disease blood, Duodenum pathology, Female, Humans, Immunoglobulin A immunology, Immunoglobulin G immunology, Male, Middle Aged, ROC Curve, Reproducibility of Results, Sensitivity and Specificity, Young Adult, Automation, Laboratory, Celiac Disease diagnosis, Immunoassay methods
Abstract

Objective: Here we compared analytical and clinical performance characteristics of two novel automated assay systems for the detection of celiac disease (CD) specific antibodies: QUANTA Flash (INOVA Diagnostics, Inc.) and EliA (Thermo Scientific)., Methods: A total of 74 biopsy-proven CD patients (2 with IgA deficiency) and 138 controls were tested by both methods., Results: Sensitivities of QUANTA Flash assays ranged from 35.1% to 90.5% and specificities from 96.4% to 99.3%, while sensitivities for EliA assays ranged from 37.8% to 90.5% (equivocal considered positive) and specificities from 97.1% to 100.0%. Good qualitative agreement was found between all assays. Thirty-four (50.0%) of the 68 QUANTA Flash h-tTG IgA positive results were higher than 10 times the upper limit of normal (ULN). In contrast, only 22.8% of the EliA tTG IgA positive samples were >10x ULN. Seventy-three (98.6%) biopsy-proven CD patients were correctly identified with the QUANTA Flash h-tTG IgA+DGP IgG combination, while 64 (86.5%) and 72 (97.3%) (depending on equivocal range) were identified with the same combination of EliA assays., Conclusion: The QUANTA Flash CD assays have outstanding clinical performance. Of particular clinical significance, in light of proposals to decrease the absolute necessity of biopsy, was the demonstration that 50% of the QUANTA Flash h-tTG IgA results were >10x ULN.

Published
2014
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15. Novel clinical and diagnostic aspects of antineutrophil cytoplasmic antibodies.

Author

Schulte-Pelkum J, Radice A, Norman GL, Lόpez Hoyos M, Lakos G, Buchner C, Musset L, Miyara M, Stinton L, and Mahler M

Subjects
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis diagnosis, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis immunology, Biomarkers blood, Humans, Immunoassay methods, Immunoassay standards, Inflammatory Bowel Diseases diagnosis, Inflammatory Bowel Diseases immunology, Antibodies, Antineutrophil Cytoplasmic immunology
Abstract

Antineutrophil cytoplasmic antibodies (ANCA) are the serological hallmark of some idiopathic systemic vasculitides. Besides the investigation of ANCA-associated vasculitis (AAV) and constant effort for a standardized nomenclature and classification of the AAV, a main focus of research during the last few years has been to constantly improve the performance of enzyme immunoassays. With the latest so called third generation ELISA, this goal seemed to be fulfilled. The International Consensus Statement on Testing and Reporting of ANCA gave recommendations for standardized strategies for the serological diagnosis of ANCA. New developments now target the system immanent drawbacks of the respective diagnostic methods, be it the need for batching and the long time to result for ELISA, or the high likelihood of error and subjectivity of indirect immunofluorescence (IIF). Random access technology and multiplexing for solid phase assays as well as digital imaging for IIF are tools which may help to expedite and simplify routine diagnostics in the lab and in emergency settings. Recent findings indicate that PR3-ANCA have clinical utility beyond the diagnosis of AAV. PR3-ANCA can also serve as an aid for the differentiation between ulcerative colitis (UC) and Crohn's disease (CrD) and the stratification of UC patients. This review provides a detailed review of what is known about ANCA and highlights the latest research and state-of-the-art developments in this area.

Published
2014
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