1. Microwave-Assisted Synthesis, Hypolipidemic and Hypoglycemic Activity of Some Novel 2-(4-(2-Amino-6-(4-substituted phenyl)-pyrimidin-4-yl)-phenoxy)-2-methyl Propanoic Acid Derivatives
- Author
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Nikhil S. Sakle, Devanand B. Shinde, Rupali D. Elgire, and Santosh N. Mokale
- Subjects
Blood Glucose ,Male ,Propanoic Acid Derivatives ,Pyrimidine ,Administration, Oral ,Pharmaceutical Science ,Chemistry Techniques, Synthetic ,Diet, High-Fat ,Microwave assisted ,Isobutyric acid ,Structure-Activity Relationship ,chemistry.chemical_compound ,Drug Discovery ,Hyperlipidemia ,medicine ,Animals ,Hypoglycemic Agents ,Organic chemistry ,Rats, Wistar ,Microwaves ,Hypolipidemic Agents ,Fenofibrate ,Molecular Structure ,Fibric Acids ,medicine.disease ,Lipids ,Rats ,chemistry ,Drug Design ,Pharmacophore ,medicine.drug - Abstract
A novel series of aminopyrimidines containing the phenoxy isobutyric acid group as a pharmacophore was synthesized using conventional and microwave assisted methods of synthesis. The compounds were synthesized in good yields (70-89%) by the microwave-assisted one-pot protocol in much shorter reaction times. The synthesized compounds were evaluated for their hypolipidemic and hypoglycemic activity by high-fat diet-induced hyperlipidemia and hyperglycemia in male Sprague-Dawley rats. The present investigation showed significant antihyperlipidemic and antihyperglycemic activity for all compounds of the series when compared with the standard drug. Structure-activity relationship (SAR) for the series were developed by comparing total lipid profile data of synthesized compounds with fenofibrate as standard drug.
- Published
- 2011
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