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3. Central Role of Semaphorin 3B in a Serum‐Induced Arthritis Model and Reduced Levels in Patients With Rheumatoid Arthritis

Author

Igea, Ana, primary, Carvalheiro, Tiago, additional, Malvar‐Fernández, Beatriz, additional, Martinez‐Ramos, Sara, additional, Rafael‐Vidal, Carlos, additional, Niemantsverdriet, Ellis, additional, Varadé, Jezabel, additional, Fernández‐Carrera, Andrea, additional, Jimenez, Norman, additional, McGarry, Trudy, additional, Rodriguez‐Trillo, Angela, additional, Veale, Douglas, additional, Fearon, Ursula, additional, Conde, Carmen, additional, Pego‐Reigosa, Jose M., additional, González‐Fernández, África, additional, Reedquist, Kris A., additional, Radstake, Timothy R. D. J., additional, van der Helm‐Van Mil, Annette, additional, and García, Samuel, additional

Published
2022
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4. Diagnostic performance of automated MRI volumetry by icobrain DM for Alzheimer's disease in a clinical setting: A REMEMBER study

Author

Wittens, Mandy M.J., primary, Sima, Diana M., additional, Houbrechts, Ruben, additional, Ribbens, Annemie, additional, Niemantsverdriet, Ellis, additional, Fransen, Erik, additional, Bastin, Christine, additional, Benoit, Florence, additional, Bergmans, Bruno, additional, Bier, Jean‐Christophe, additional, Deyn, Peter Paul, additional, Deryck, Olivier, additional, Hanseeuw, Bernard J., additional, Ivanoiu, Adrian, additional, Lemper, Jean‐Claude, additional, Mormont, Eric, additional, Picard, Gaëtane, additional, Salmon, Eric, additional, Segers, Kurt, additional, Sieben, Anne, additional, Smeets, Dirk, additional, Struyfs, Hanne, additional, Thiery, Evert, additional, Tournoy, Jos, additional, Triau, Eric, additional, Vanbinst, Anne‐Marie, additional, Versijpt, Jan, additional, Bjerke, Maria, additional, and Engelborghs, Sebastiaan, additional

Published
2021
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6. 18F-FDG PET, the early phases and the delivery rate of18F-AV45 PET as proxies of cerebral blood flow in Alzheimer's disease: Validation against15O-H2O PET

Author

Ottoy, Julie, primary, Verhaeghe, Jeroen, additional, Niemantsverdriet, Ellis, additional, De Roeck, Ellen, additional, Wyffels, Leonie, additional, Ceyssens, Sarah, additional, Van Broeckhoven, Christine, additional, Engelborghs, Sebastiaan, additional, Stroobants, Sigrid, additional, and Staelens, Steven, additional

Published
2019
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7. P1-237: IMPROVED DIAGNOSTIC ACCURACY USING THE CEREBROSPINAL FLUID AMYLOID BETA 1-42/1-40 RATIO

Author

Bjerke, Maria, primary, Somers, Charisse, additional, De Roeck, Naomi, additional, Sieben, Anne, additional, Niemantsverdriet, Ellis, additional, Vermeiren, Yannick, additional, Struyfs, Hanne, additional, Vanderstichele, Hugo Marcel, additional, Timmers, Maarten, additional, Herbst, Victor, additional, Acx, Hermien, additional, Brix, Britta, additional, Van Broeckhoven, Christine, additional, De Deyn, Peter Paul, additional, Martin, Jean-Jacques, additional, and Engelborghs, Sebastiaan, additional

Published
2019
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11. The impact of automated hippocampal volumetry on diagnostic confidence in patients with suspected Alzheimer's disease: A European Alzheimer's Disease Consortium study

Author

Bosco, Paolo, primary, Redolfi, Alberto, additional, Bocchetta, Martina, additional, Ferrari, Clarissa, additional, Mega, Anna, additional, Galluzzi, Samantha, additional, Austin, Mark, additional, Chincarini, Andrea, additional, Collins, D. Louis, additional, Duchesne, Simon, additional, Maréchal, Bénédicte, additional, Roche, Alexis, additional, Sensi, Francesco, additional, Wolz, Robin, additional, Alegret, Montserrat, additional, Assal, Frederic, additional, Balasa, Mircea, additional, Bastin, Christine, additional, Bougea, Anastasia, additional, Emek‐Savaş, Derya Durusu, additional, Engelborghs, Sebastiaan, additional, Grimmer, Timo, additional, Grosu, Galina, additional, Kramberger, Milica G., additional, Lawlor, Brian, additional, Mandic Stojmenovic, Gorana, additional, Marinescu, Mihaela, additional, Mecocci, Patrizia, additional, Molinuevo, José Luis, additional, Morais, Ricardo, additional, Niemantsverdriet, Ellis, additional, Nobili, Flavio, additional, Ntovas, Konstantinos, additional, O'Dwyer, Sarah, additional, Paraskevas, George P., additional, Pelini, Luca, additional, Picco, Agnese, additional, Salmon, Eric, additional, Santana, Isabel, additional, Sotolongo‐Grau, Oscar, additional, Spiru, Luiza, additional, Stefanova, Elka, additional, Popovic, Katarina Surlan, additional, Tsolaki, Magda, additional, Yener, Görsev G., additional, Zekry, Dina, additional, and Frisoni, Giovanni B., additional

Published
2017
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12. Consensus guidelines for lumbar puncture in patients with neurological diseases

Author

Engelborghs, Sebastiaan, primary, Niemantsverdriet, Ellis, additional, Struyfs, Hanne, additional, Blennow, Kaj, additional, Brouns, Raf, additional, Comabella, Manuel, additional, Dujmovic, Irena, additional, Flier, Wiesje, additional, Frölich, Lutz, additional, Galimberti, Daniela, additional, Gnanapavan, Sharmilee, additional, Hemmer, Bernhard, additional, Hoff, Erik, additional, Hort, Jakub, additional, Iacobaeus, Ellen, additional, Ingelsson, Martin, additional, Jan de Jong, Frank, additional, Jonsson, Michael, additional, Khalil, Michael, additional, Kuhle, Jens, additional, Lleó, Alberto, additional, Mendonça, Alexandre, additional, Molinuevo, José Luis, additional, Nagels, Guy, additional, Paquet, Claire, additional, Parnetti, Lucilla, additional, Roks, Gerwin, additional, Rosa‐Neto, Pedro, additional, Scheltens, Philip, additional, Skårsgard, Constance, additional, Stomrud, Erik, additional, Tumani, Hayrettin, additional, Visser, Pieter Jelle, additional, Wallin, Anders, additional, Winblad, Bengt, additional, Zetterberg, Henrik, additional, Duits, Flora, additional, and Teunissen, Charlotte E., additional

Published
2017
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13. P3-209: Impact of Biomarkers On Diagnostic Confidence in Clinical Assessment of Patients with Suspected Alzheimer's Disease and High Diagnostic Uncertainty: An EADC Study

Author

Bosco, Paolo, primary, Redolfi, Alberto, additional, Bocchetta, Martina, additional, Ferrari, Clarissa, additional, Mega, Anna, additional, Galluzzi, Samantha, additional, Assal, Frederic, additional, Balasa, Mircea, additional, Bastin, Christine, additional, Bougea, Anastasia, additional, Emek-Savas, Derya Durusu, additional, Engelborghs, Sebastiaan, additional, Giannakopoulos, Panteleimon, additional, Gold, Gabriel, additional, Grimmer, Timo, additional, Grosu, Galina, additional, Kramberger, Milica G., additional, Lawlor, Brian, additional, Stojmenovic, Gorana Mandic, additional, Marinescu, Mihaela, additional, Mecocci, Patrizia, additional, Molinuevo, Jose Luis, additional, Morais, Ricardo, additional, Niemantsverdriet, Ellis, additional, Nobili, Flavio, additional, Ntovas, Konstantinos, additional, O'Dwyer, Sarah, additional, Paraskevas, George, additional, Pelini, Luca, additional, Picco, Agnese, additional, Salmon, Eric, additional, Santana, Isabel, additional, Sotolongo-Grau, Oscar, additional, Spiru, Luiza, additional, Stefanova, Elka, additional, Popovic, Katarina Surlan, additional, Tsolaki, Magda, additional, Yener, Görsev, additional, Zekry, Dina, additional, and Frisoni, Giovanni B., additional

Published
2016
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14. P4-322: CSF Biomarkers to Predict Rate of Cognitive Decline in Alzheimer’S Disease

Author

Struyfs, Hanne, primary, Vanmechelen, Eugeen, additional, De Roeck, Ellen Elisa, additional, Fransen, Erik, additional, Niemantsverdriet, Ellis, additional, Somers, Charisse, additional, Goossens, Joery, additional, De Vos, Ann, additional, Herbst, Victor, additional, Van den Bossche, Tobi, additional, Van Mossevelde, Sara, additional, Goeman, Johan, additional, de Deyn, Peter Paul, additional, Bjerke, Maria, additional, and Engelborghs, Sebastiaan, additional

Published
2016
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16. P1-170: A Decade of Cerebrospinal Fluid Biomarkers for Alzheimer’s Disease in Belgium

Author

Somers, Charisse, primary, Struyfs, Hanne, additional, Goossens, Joery, additional, Niemantsverdriet, Ellis, additional, Luyckx, Jill, additional, De Roeck, Naomi, additional, De Roeck, Ellen Elisa, additional, De Vil, Bart, additional, Cras, Patrick, additional, Martin, Jean-Jacques, additional, de Deyn, Peter Paul, additional, Bjerke, Maria, additional, and Engelborghs, Sebastiaan, additional

Published
2016
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17. P2-153: Diagnostic Performance of Non-Phosphorylated TAU Fraction (PTAU REL) in CSF as Biomarker for Differential Dementia Diagnosis

Author

Goossens, Joery, primary, Struyfs, Hanne, additional, Niemantsverdriet, Ellis, additional, Van den Bossche, Tobi, additional, Van Mossevelde, Sara, additional, De Vil, Bart, additional, Sieben, Anne, additional, Martin, Jean-Jacques, additional, Cras, Patrick, additional, Goeman, Johan, additional, Paul de Deyn, Peter, additional, Van Broeckhoven, Christine, additional, van der Zee, Julie, additional, and Engelborghs, Sebastiaan, additional

Published
2016
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18. P4‐314: Discordance Between Amyloid‐PET and CSF Amyloid‐β for Diagnosing Alzheimer’S Disease in a Clinical Setting

Author

Niemantsverdriet, Ellis, primary, Van den Bossche, Tobi, additional, Van Mossevelde, Sara, additional, Ottoy, Julie, additional, Verhaeghe, Jeroen, additional, Somers, Charisse, additional, De Roeck, Ellen Elisa, additional, Struyfs, Hanne, additional, Deleye, Steven, additional, Goeman, Johan, additional, Versijpt, Jan, additional, Paul de Deyn, Peter, additional, Mariën, Peter, additional, Wyffels, Leonie, additional, Bjerke, Maria, additional, Ceyssens, Sarah, additional, Stroobants, Sigrid, additional, Staelens, Steven, additional, and Engelborghs, Sebastiaan, additional

Published
2016
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19. P4‐194: Blood Flow–Independent Quantification of [18F]‐AV45 PET Using Model‐Based Kinetics With a Metabolite‐Corrected Arterial Input Function

Author

Ottoy, Julie, primary, Verhaeghe, Jeroen, additional, Niemantsverdriet, Ellis, additional, Wyffels, Leonie, additional, Somers, Charisse, additional, De Roeck, Ellen Elisa, additional, Struyfs, Hanne, additional, Deleye, Steven, additional, Ceyssens, Sarah, additional, Stroobants, Sigrid, additional, Engelborghs, Sebastiaan, additional, and Staelens, Steven, additional

Published
2016
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20. P4-122: Prevalence of Vascular Risk Factors in Different Stages of Prodromal Alzheimer’s Disease and Its Influence on Cognitive Decline

Author

Bos, Isabelle, primary, Vos, Stephanie J.B., additional, Frölich, Lutz, additional, Kornhuber, Johannes, additional, Wiltfang, Jens, additional, Maier, Wolfgang, additional, Peters, Oliver, additional, Rüther, Eckhart, additional, Engelborghs, Sebastiaan, additional, Niemantsverdriet, Ellis, additional, De Roeck, Ellen Elisa, additional, Tsolaki, Magda, additional, Freund-Levi, Yvonne, additional, Johannsen, Peter, additional, Vandenberghe, Rik, additional, Lleó, Alberto, additional, Alcolea, Daniel, additional, Frisoni, Giovanni B., additional, Galluzzi, Samantha, additional, Nobili, Flavio, additional, Morbelli, Silvia, additional, Drzezga, Alexander, additional, Didic, Mira, additional, van Berckel, Bart N.M., additional, Salmon, Eric, additional, Bastin, Christine, additional, Dauby, Solene, additional, Santana, Isabel, additional, Baldeiras, Inês, additional, Mendonça, Alexandre, additional, Silva, Dina, additional, Wallin, Anders, additional, Nordlund, Arto, additional, Foskett, Nadia, additional, Coloma, Preciosa, additional, Alexander, Myriam, additional, Wientzek-Fleischmann, Angelika, additional, Nevado-Holgado, Alejo, additional, Gungabissoon, Usha, additional, Novak, Gerald P., additional, Gordon, Mark Forrest, additional, Wallin, Åsa K., additional, Hampel, Harald, additional, Soininen, Hilkka, additional, Scheltens, Philip, additional, Verhey, Frans R.J., additional, and Visser, Pieter Jelle, additional

Published
2016
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22. P2-072: Development of novel elisas for the quantification of both pan-ApoE and ApoE4 proteins in CSF and blood, and ApoE ε4 phenotyping

Author

Stoops, Erik, primary, Demeyer, Leentje, additional, Engelborghs, Sebastiaan, additional, Struyfs, Hanne, additional, Niemantsverdriet, Ellis, additional, Sleegers, Kristel, additional, Herbst, Victor, additional, Zerr, Inga, additional, Schmitz, Matthias, additional, Van Broeckhoven, Christine, additional, and Vanderstichele, Hugo, additional

Published
2015
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23. P1-115: Consensus guidelines to perform lumbar puncture for CSF sampling in patients with neurological conditions

Author

Niemantsverdriet, Ellis, primary, Engelborghs, Sebastiaan, additional, Struyfs, Hanne, additional, Blennow, Kaj, additional, Brouns, Raf, additional, Comabella, Manuel, additional, Dujmovic, Irena, additional, van der Flier, Wiesje M., additional, Galimberti, Daniela, additional, Gnanapavan, Sharmilee, additional, Hemmer, Bernhard, additional, Hoff, Erik, additional, Hort, Jakub, additional, Iacobaeus, Ellen, additional, Ingelsson, Martin, additional, Jan de Jong, Frank, additional, Jonsson, Michael, additional, Khalil, Michael, additional, Kuhle, Jens, additional, Lleo, Alberto, additional, de Mendonça, Alexandre, additional, Molinuevo, José-Luis, additional, Nagels, Guy, additional, Paquet, Claire, additional, Parnetti, Lucilla, additional, Roks, Gerwin, additional, Scheltens, Philip, additional, Skarsgard, Constance, additional, Stomrud, Erik, additional, Tumani, Hayrettin, additional, Visser, Pieter Jelle, additional, Wall, Anders, additional, Winblad, Bengt, additional, Zetterberg, Henrik, additional, Duits, Flora, additional, and Teunissen, Charlotte E., additional

Published
2015
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25. The Role of Genetics in Clinically Suspect Arthralgia and Rheumatoid Arthritis Development: A Large Cross-Sectional Study.

Author

Maurits MP, Wouters F, Niemantsverdriet E, Huizinga TWJ, van den Akker EB, Le Cessie S, van der Helm-van Mil AHM, and Knevel R

Subjects
Humans, Cross-Sectional Studies, HLA-DRB1 Chains genetics, Arthralgia epidemiology, Arthralgia genetics, Epitopes genetics, Autoantibodies, Arthritis, Rheumatoid epidemiology, Arthritis, Rheumatoid genetics
Abstract

Objective: To investigate whether established genetic predictors for rheumatoid arthritis (RA) differentiate healthy controls, patients with clinically suspect arthralgia (CSA), and RA patients., Methods: Using analyses of variance, chi-square tests, and mean risk difference analyses, we investigated the association of an RA polygenic risk score (PRS) and HLA shared epitope (HLA-SE) with all participant groups, both unstratified and stratified for anti-citrullinated protein antibody (ACPA) status. We used 3 separate data sets sampled from the same Dutch population (1,015 healthy controls, 479 CSA patients, and 1,146 early classified RA patients). CSA patients were assessed for conversion to inflammatory arthritis over a period of 2 years, after which they were classified as either CSA converters (n = 84) or CSA nonconverters (n = 395)., Results: The PRS was increased in RA patients (mean ± SD PRS 1.31 ± 0.96) compared to the complete CSA group (1.07 ± 0.94) and compared to CSA converters (1.12 ± 0.94). In ACPA- strata, PRS distributions differed strongly when comparing the complete CSA group (mean ± SD PRS 1.05 ± 0.94) and CSA converters (0.97 ± 0.87) to RA patients (1.20 ± 0.94), while in the ACPA+ strata, the complete CSA group (1.25 ± 0.99) differed clearly from healthy controls (1.05 ± 0.94) and RA patients (1.41 ± 0.96). HLA-SE was more prevalent in the RA group (prevalence 0.64) than the complete CSA group (0.45), with small differences between RA patients and CSA converters (0.64 versus 0.60) and larger differences between CSA converters and CSA nonconverters (0.60 versus 0.42). HLA-SE prevalence differed more strongly within the ACPA+ strata as follows: healthy controls (prevalence 0.43), CSA nonconverters (0.48), complete CSA group (0.59), CSA converters (0.66), and RA patients (0.79)., Conclusion: We observed that genetic predisposition increased across pre-RA participant groups. The RA PRS differed in early classified RA and inflammatory pre-disease stages, regardless of ACPA stratification. HLA-SE prevalence differed between arthritis patients, particularly ACPA+ patients, and healthy controls. Genetics seem to fulfill different etiologic roles., (© 2022 The Authors. Arthritis & Rheumatology published by Wiley Periodicals LLC on behalf of American College of Rheumatology.)

Published
2023
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