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25 results on '"Nielsen, G Petur"'

4. Datasets for the reporting of primary tumour in bone: recommendations from the International Collaboration on Cancer Reporting (ICCR)

Author

Bovée, Judith V M G, primary, Webster, Fleur, additional, Amary, Fernanda, additional, Baumhoer, Daniel, additional, Bloem, J L (Hans), additional, Bridge, Julia A, additional, Cates, Justin M M, additional, de Alava, Enrique, additional, Dei Tos, Angelo Paolo, additional, Jones, Kevin B, additional, Mahar, Annabelle, additional, Nielsen, G Petur, additional, Righi, Alberto, additional, Wagner, Andrew J, additional, Yoshida, Akihiko, additional, and Fletcher, Christopher D M, additional

Published
2022
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8. Identification ofEWSR1–NFATC2fusion in simple bone cysts

Author

Hung, Yin P, primary, Fisch, Adam S, additional, Diaz‐Perez, Julio A, additional, Iafrate, A John, additional, Lennerz, Jochen K, additional, Nardi, Valentina, additional, Bredella, Miriam A, additional, Raskin, Kevin A, additional, Lozano‐Calderon, Santiago A, additional, Rosenberg, Andrew E, additional, and Nielsen, G Petur, additional

Published
2021
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9. Thoracic nuclear protein in testis (NUT) carcinoma: expanded pathological spectrum with expression of thyroid transcription factor‐1 and neuroendocrine markers

Author

Hung, Yin P, primary, Chen, Athena L, additional, Taylor, Martin S, additional, Huynh, Tiffany G, additional, Kem, Marina, additional, Selig, Martin K, additional, Nielsen, G Petur, additional, Lennerz, Jochen K, additional, Azzoli, Christopher G, additional, Dagogo‐Jack, Ibiayi, additional, Kradin, Richard L, additional, and Mino‐Kenudson, Mari, additional

Published
2021
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17. EWSR1‐PBX3: A novel gene fusion in myoepithelial tumors

Author

Agaram, Narasimhan P., primary, Chen, Hsiao‐Wei, additional, Zhang, Lei, additional, Sung, Yun‐Shao, additional, Panicek, David, additional, Healey, John H., additional, Nielsen, G. Petur, additional, Fletcher, Christopher D. M., additional, and Antonescu, Cristina R., additional

Published
2014
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19. Long-term results of Phase II study of high dose photon/proton radiotherapy in the management of spine chordomas, chondrosarcomas, and other sarcomas

Author

DeLaney, Thomas F., primary, Liebsch, Norbert J., additional, Pedlow, Frank X., additional, Adams, Judith, additional, Weyman, Elizabeth A., additional, Yeap, Beow Y., additional, Depauw, Nicolas, additional, Nielsen, G. Petur, additional, Harmon, David C., additional, Yoon, Sam S., additional, Chen, Yen-Lin, additional, Schwab, Joseph H., additional, and Hornicek, Francis J., additional

Published
2014
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20. Prognostic significance of miRNA-1 (miR-1) expression in patients with chordoma

Author

Duan, Zhenfeng, primary, Shen, Jacson, additional, Yang, Xiaoqian, additional, Yang, Pei, additional, Osaka, Eiji, additional, Choy, Edwin, additional, Cote, Gregory, additional, Harmon, David, additional, Zhang, Yu, additional, Nielsen, G. Petur, additional, Spentzos, Dimitrios, additional, Mankin, Henry, additional, and Hornicek, Francis, additional

Published
2014
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25. Differential expression of microRNA (miRNA) in chordoma reveals a role for miRNA-1 in Met expression.

Author

Duan Z, Choy E, Nielsen GP, Rosenberg A, Iafrate J, Yang C, Schwab J, Mankin H, Xavier R, and Hornicek FJ

Subjects
Cell Line, Tumor, Cell Proliferation, Chordoma etiology, Gene Expression Profiling, Histone Deacetylases genetics, Humans, MicroRNAs analysis, Repressor Proteins genetics, Reverse Transcriptase Polymerase Chain Reaction, Chordoma genetics, MicroRNAs physiology, Proto-Oncogene Proteins c-met genetics, Receptors, Growth Factor genetics
Abstract

Emerging evidence suggests that microRNA (miRNA) expression signatures in cancer may have important diagnostic, prognostic, and therapeutic value, but there is no data on miRNA expression in chordoma. The purpose of this study was to identify the role of miRNAs in human chordoma. We analyzed miRNA expression in chordoma-derived cell lines and chordoma tissue by using miRNA microarray technology with unsupervised hierarchical clustering analysis. The relative expression levels of these miRNAs were confirmed by real-time quantitative RT-PCR and Northern blot analysis. To characterize the potential role of miRNA-1, miRNA-1 was stably transfected into a chordoma cell line, UCH1. The expression of miRNA-1 targeted gene Met in chordoma tissues was also studied. We observe that human chordoma tissues and cell lines can be distinguished from normal muscle tissue by comparing miRNA expression profiles. Several miRNAs were differentially expressed in chordoma cell lines compared to controls, and similar expression patterns were found in primary chordoma tissues. Importantly, we were able to show for the first time, to our knowledge, that expression of miRNA-1 and miRNA-206, two miRNAs implicated in a number of other cancer types, were markedly decreased in both chordoma tissues and cell lines. When chordoma cell lines were transfected with miRNA-1, downregulation of known miRNA-1 targets was observed. These targets included Met and HDAC4-two genes that were observed to be overexpressed in chordoma. Our results demonstrate that some miRNAs are differentially expressed in chordoma and, in particular, miRNA-1 may have a functional effect on chordoma tumor pathogenesis., ((c) 2009 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.)

Published
2010
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