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1. Endophytic Penicillium species secretes mycophenolic acid that inhibits the growth of phytopathogenic fungi

Author

Neri Azar, Orna Liarzi, Maor Zavitan, Mohamed Samara, Ahmed Nasser, and David Ezra

Subjects
Biotechnology, TP248.13-248.65
Abstract

Abstract The worldwide demand for reduced and restricted use of pesticides in agriculture due to serious environmental effects, health risks and the development of pathogen resistance calls for the discovery of new bioactive compounds. In the medical field, antibiotic‐resistant microorganisms have become a major threat to man, increasing mortality. Endophytes are endosymbiotic microorganisms that inhabit plant tissues without causing any visible damage to their host. Many endophytes secrete secondary metabolites with biological activity against a broad range of pathogens, making them potential candidates for novel drugs and alternative pesticides of natural origin. We isolated endophytes from wild plants in Israel, focusing on endophytes that secrete secondary metabolites with biological activity. We isolated 302 different endophytes from 30 different wild plants; 70 of them exhibited biological activity against phytopathogens. One biologically active fungal endophyte from the genus Penicillium, isolated from a squill (Urginea maritima) leaf, was further examined. Chloroform‐based extraction of its growth medium was similarly active against phytopathogens. High‐performance liquid chromatography separation followed by gas chromatography/mass spectrometry analysis revealed a single compound—mycophenolic acid—as the main contributor to the biological activity of the organic extract.

Published
2023
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2. Diagnostic Accuracy of the Triglyceride and Glucose Index for Insulin Resistance: A Systematic Review

Author

Adriana Sánchez-García, René Rodríguez-Gutiérrez, Leonardo Mancillas-Adame, Victoria González-Nava, Alejandro Díaz González-Colmenero, Ricardo Cesar Solis, Neri Alejandro Álvarez-Villalobos, and José Gerardo González-González

Subjects
Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

Introduction. The triglyceride and glucose (TyG) index has been described as a biochemical marker of insulin resistance (IR); however, its diagnostic accuracy remains uncertain. Objective. To summarize the evidence assessing the diagnostic accuracy of the TyG index regarding IR. Methods. A comprehensive search in MEDLINE, EMBASE, Web of Science, and Scopus was performed without any language restriction. Studies assessing the diagnostic accuracy of the TyG index against the hyperinsulinemic-euglycemic clamp (HIEC) or any other IR biochemical were assessed independently and in duplicate. Diagnostic accuracy measures (sensitivity, specificity, positive predictive value, negative predictive value, and likelihood ratios) were extracted independently and in duplicate. The QUADAS-2 tool was used to assess the risk of bias of independent studies. Results. We identified 15 eligible studies with 69,922 participants and an overall quality of low to moderate. The TyG index was evaluated by HIEC and HOMA as reference tests. The highest achieved sensitivity was 96% using HIEC, and the highest specificity was of 99% using HOMA-IR, with a cutoff value of 4.68. AUC values varied from 0.59 to 0.88. Cutoff values for IR were variable between studies, limiting its comparability. Conclusion. In this systematic review, we found moderate-to-low quality evidence about the usefulness of the TyG index as a surrogate biochemical marker of IR. Due to the lack of a standardized IR definition and heterogeneity between studies, further validation and standardized cutoff values are needed to be used in clinical practice.

Published
2020
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7. Camera trap surveys of Atlantic Forest mammals: A data set for analyses considering imperfect detection (2004–2020)

Author

Franceschi, Ingridi Camboim, primary, Dornas, Rubem Augusto da Paixão, additional, Lermen, Isabel Salgueiro, additional, Coelho, Artur Vicente Pfeifer, additional, Vilas Boas, Ademir Henrique, additional, Chiarello, Adriano Garcia, additional, Paglia, Adriano Pereira, additional, de Souza, Agnis Cristiane, additional, Borsekowsky, Alana Rafaela, additional, Rocha, Alessandro, additional, Bager, Alex, additional, de Souza, Alexander Zaidan, additional, Lopes, Alexandre Martins Costa, additional, de Moura, Aloysio Souza, additional, Ferreira, Aluane Silva, additional, García‐Olaechea, Alvaro, additional, Delciellos, Ana Cláudia, additional, Bacellar, Ana Elisa de Faria, additional, Campelo, Ana Kellen Nogueira, additional, Paschoal, Ana Maria Oliveira, additional, Rolim, Anderson Claudino, additional, da Silva, André Luiz Ferreira, additional, Lanna, Andre Monnerat, additional, da Silva, André Pereira, additional, Guimarães, Andresa, additional, Cardoso, Ângela, additional, Cassol, Angelica Soligo, additional, da Costa‐Pinto, Anna Ludmilla, additional, do Nascimento, Ariel Guilherme Santos, additional, Fernandes, Arthur Soares, additional, Clyvia, Aryanne, additional, Santos, Aureo Banhos dos, additional, Lima‐Silva, Barbara, additional, Beisiegel, Beatriz de Mello, additional, Luciano, Beatriz Fernandes Lima, additional, Leopoldo, Bernardo de Faria, additional, Krobel, Bruna Nunes, additional, Kubiak, Bruno Busnello, additional, Saranholi, Bruno Henrique, additional, Correa, Bruno Senna, additional, Sant Anna Teixeira, Caio, additional, Ayroza, Camila Rezende, additional, Cassano, Camila Righetto, additional, Benitez‐Riveros, Camilo, additional, Gestich, Carla Cristina, additional, Tedesco, Carla Denise, additional, Gheler‐Costa, Carla, additional, Hegel, Carla Grasiele Zanin, additional, Evangelista Junior, Carlito da Silva, additional, Ferreira, Carlos Eduardo Morando Faria, additional, Grelle, Carlos Eduardo Viveiros, additional, Esteves, Carolina Franco, additional, Espinosa, Caroline da Costa, additional, Leuchtenberger, Caroline, additional, Sanchéz‐Lalinde, Catalina, additional, Machado, Cauanne Iglesias Campos, additional, Andreazzi, Cecilia, additional, Bueno, Cecília, additional, Cronemberger de Faria, Cecilia, additional, Novaes, Claudio, additional, Widmer, Cynthia Elisa, additional, Santos, Cyntia Cavalcante, additional, Ferraz, Daniel da Silva, additional, Galiano, Daniel, additional, Bôlla, Daniela Aparecida Savariz, additional, Behs, Daniela, additional, Rodrigues, Daniele Pereira, additional, de Melo, Danielle Picão, additional, Ramos, Déborah Maria Soares, additional, de Mattia, Denise Lidório, additional, Pavei, Diego Dias, additional, Loretto, Diogo, additional, Huning, Douglas da Silva, additional, Dias, Douglas de Matos, additional, Paetzhold, Éder Ricardo, additional, Rios, Elaine, additional, Setz, Eleonore Zulnara Freire, additional, Cazetta, Eliana, additional, Cafofo Silva, Emanuel Giovani, additional, Pasa, Emanuelle, additional, Saito, Erica Naomi, additional, de Aguiar, Erick Francisco Silva, additional, Castro, Érika Paula, additional, Viveiros de Castro, Ernesto Bastos, additional, Pedó, Ezequiel, additional, Pereira, Fabiane de Aguiar, additional, Bolzan, Fábio, additional, Roque, Fábio de Oliveira, additional, Mazim, Fábio Dias, additional, Comin, Fábio Henrique, additional, Maffei, Fábio, additional, Peters, Felipe Bortolotto, additional, Fantacini, Felipe Moreli, additional, da Silva, Felipe Pessoa, additional, Machado, Felipe Santana, additional, Vélez‐Garcia, Felipe, additional, Lage, Fernanda Stussi Duarte, additional, Perini, Fernando Araújo, additional, Passos, Fernando Camargo, additional, Carvalho, Fernando, additional, de Azevedo, Fernando Cesar Cascelli, additional, Ferreira, Fernando, additional, de Pinho, Fernando Ferreira, additional, Chaves, Flávia Guimarães, additional, Miranda, Flavia Regina, additional, Rodrigues, Flavio Henrique Guimarães, additional, Ubaid, Flávio Kulaif, additional, Gabriel, Francisco Homem, additional, de Souza, Franco Leandro, additional, de Oliveira, Fred Victor, additional, Cupolillo, Gabriel, additional, Moreira, Gabriela de Araújo Pires, additional, Mette, Gabriela, additional, Duarte, Gabriela Teixeira, additional, Beca, Gabrielle, additional, Corso, Gilberto, additional, Perbiche‐Neves, Gilmar, additional, Souto, Glauber Henrique Borges de Oliveira, additional, Vilarroel, Glenda Jéssica da Silva, additional, Batista, Graziele O., additional, Ferreira, Guilherme Braga, additional, Toledo, Gustavo Alves da Costa, additional, Senger, Gustavo, additional, Bergallo, Helena de Godoy, additional, dos Santos, Hellen Cristina Pinheiro, additional, Gazola, Humberto Angelo, additional, Melo, Isabel, additional, Brack, Ismael Verrastro, additional, Veríssimo, Iuri, additional, Viana, Ivan Réus, additional, Laurentino, Izabela Costa, additional, Diehl, Jaime Luis, additional, Zocche, Jairo José, additional, Martins‐Silva, Jimi, additional, Just, João Paulo Gava, additional, Cherem, Jorge José, additional, Nascimento, Jorge Luiz, additional, Marinho, Jorge Reppold, additional, Dantas, José Oliveira, additional, de Matos, Jose Roberto, additional, Pires, José Salatiel Rodrigues, additional, Cerveira, Josi Fernanda, additional, Ruiz‐Esparza, Juan, additional, da Silva, Juliana Paulo, additional, Bogoni, Juliano André, additional, Molina, Karina Theodoro, additional, Pereira, Karla Dayane de Lima, additional, Ceron, Karoline, additional, de Vleeschouwer, Kristel, additional, Lautenschlager, Laís, additional, Bailey, Larissa, additional, Fornitano, Larissa, additional, Rampim, Lilian Elaine, additional, Sforza, Lorena, additional, Bissa, Luan Gonçalves, additional, Santucci, Luca Mattos, additional, da Silva, Lucas Gonçalves, additional, Perillo, Lucas Neves, additional, Correa, Lucas Ribeiro, additional, Hufnagel, Ludmila, additional, Alberti, Luis Fernando, additional, Recalde Mello, Luis Jose, additional, Bernardo, Luis Renato Rezende, additional, Oliveira‐Santos, Luiz Gustavo Rodrigues, additional, Guimarães, Luiza Neves, additional, Benchimol, Maíra, additional, Twardowschy, Manuela Catharina, additional, Ferreira‐Riveros, Marcela, additional, da Silva, Marcelo, additional, Jardim, Márcia Maria de Assis, additional, Fontes, Marco Aurélio Leite, additional, Tortato, Marcos Adriano, additional, do Nascimento, Marcos Tadeu, additional, Sekiama, Margareth Lumy, additional, Nascimento‐Costa, Maria Clara, additional, dos Santos, Maria Ester Bueno, additional, Morini, Maria Santina de Castro, additional, Nagy‐Reis, Mariana Baldy, additional, Kaizer, Mariane da Cruz, additional, Sant'Anna, Mariano José Ribeiro da Silva, additional, Hartmann, Marilia Teresinha, additional, Favarini, Marina Ochoa, additional, Olivo, Marina Oliveira, additional, Montes, Martín Alejandro, additional, Alvaréz, Martin Roberto del Valle, additional, Haddad, Matheus Feldstein, additional, Costa, Maurício Djalles, additional, Graipel, Maurício Eduardo, additional, Konzen, Mauricio Quoos, additional, Galetti, Mauro, additional, Almeida, Meyline de Oliveira Souza, additional, Faria, Michel Barros, additional, Luiz, Micheli Ribeiro, additional, Baptista, Michelle Noronha da Matta, additional, Marini, Miguel Ângelo, additional, Ribeiro, Milton Cezar, additional, Olifiers, Natalie, additional, de Albuquerque, Natasha Moraes, additional, Cantero, Nicolás, additional, Peroni, Nivaldo, additional, Zanella, Noeli, additional, Mendonça‐Furtado, Olívia, additional, Pays, Olivier, additional, Ferretti, Orlando Ednei, additional, Rocha‐Barbosa, Oscar, additional, Santos, Paloma Marques, additional, de Farias, Patrícia Menegaz, additional, da Rocha, Patrício Adriano, additional, Colas‐Rosas, Paul François, additional, Ribeiro‐Souza, Paula, additional, Ferracioli, Paula, additional, Hartmann, Paulo Afonso, additional, Antas, Paulo de Tarso Zuquim, additional, Ribeiro, Paulo, additional, Tomasi Sarti, Paulo, additional, Mônico, Paulo Ivo, additional, de Castilho, Pedro Volkmer, additional, Pereira, Peônia Brito de Moraes, additional, Crawshaw, Peter Gransden, additional, Renaud, Pierre‐Cyril, additional, Romagna, Rafael Spilere, additional, de Sousa, Rafael Turíbio Moraes, additional, Spagnol, Raíssa Soares, additional, Beltrão‐Mendes, Raone, additional, Mariano, Ravi Fernandes, additional, Rocha, Renata Reinoso, additional, Sousa‐Lima, Renata, additional, Pagotto, Renata Valls, additional, de Faria, Rhayssa Terra, additional, Arrais, Ricardo Corassa, additional, Moratelli, Ricardo, additional, Sartorello, Ricardo, additional, Bianchi, Rita de Cassia, additional, Guimarães, Roberto de Carvalho, additional, Massara, Rodrigo Lima, additional, Costa, Romulo Theodoro, additional, Marques, Rosane Vera, additional, Nunes, Ruan Márcio Ruas, additional, Hartz, Sandra Maria, additional, Silvestre de Sousa, Saulo Meneses, additional, Lima, Saulo Ramos, additional, Barbosa, Sergio Lutz, additional, Godoy, Silvia Neri, additional, Ferrari, Stephen Francis, additional, de Araújo‐Piovezan, Talita Guimarães, additional, Góes, Talita Laura, additional, Trigo, Tatiane Campos, additional, de Freitas, Thales R. O., additional, Maccarini, Thiago Bernardes, additional, de Castro, Thiago Marcial, additional, Bella, Thiago Ribas, additional, de Oliveira Junior, Tonny Marques, additional, Cunha, Uslaine Maciel, additional, Kanaan, Vanessa Tavares, additional, Pfannerstill, Vera, additional, Pimentel, Victor Siqueira, additional, Picinatto Filho, Vilmar, additional, Alves, Vinícius Nunes, additional, Rojas‐Bonzi, Viviana, additional, Mottin, Viviane, additional, Rocha, Vlamir José, additional, Kindel, Andreas, additional, and Coelho, Igor Pfeifer, additional

Published
2024
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10. Molecular characterization of diffuse large B‐cell lymphomas associated with hepatitis C virus infection

Author

Sciarra, Roberta, primary, Merli, Michele, additional, Cristinelli, Caterina, additional, Lucioni, Marco, additional, Zibellini, Silvia, additional, Riboni, Roberta, additional, Furlan, Daniela, additional, Uccella, Silvia, additional, Zerbi, Caterina, additional, Bianchi, Benedetta, additional, Gotti, Manuel, additional, Ferretti, Virginia Valeria, additional, Varraso, Chiara, additional, Fraticelli, Sara, additional, Lazic, Tanja, additional, Defrancesco, Irene, additional, Mora, Barbara, additional, Libera, Laura, additional, Mazzacane, Alessandro, additional, Carpi, Federico, additional, Berliner, Martha, additional, Neri, Giuseppe, additional, Rizzo, Ettore, additional, De Paoli, Federica, additional, Sessa, Fausto, additional, Passamonti, Francesco, additional, Paulli, Marco, additional, and Arcaini, Luca, additional

Published
2024
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14. The ‘More Than Maps’ framework for building research capacity among young people in coastal climate change adaptation

Author

van der Plank, Sien, primary, Appeaning Addo, Kwasi, additional, Anderson, Romario, additional, Boruff, Bryan, additional, Bruce, Eleanor, additional, Chambers, Kishna, additional, Duncan, John, additional, Davies, Kevin, additional, Escoffery, Damoi, additional, Fidai, Yanna, additional, Fletcher, Darren, additional, Hickey, Sharyn, additional, Jayson‐Quashigah, Philip‐Neri, additional, Maxam, Ava, additional, Pauli, Natasha, additional, Schlenker, Marie, additional, Sowah, Winnie Naa Adjorkor, additional, and Dash, Jadu, additional

Published
2024
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16. Ibrutinib as first line therapy in chronic lymphocytic leukemia patients over 80 years old: A retrospective real‐life multicenter Italian cohort

Author

Martino, Enrica Antonia, primary, Mauro, Francesca Romana, additional, Reda, Gianluigi, additional, Laurenti, Luca, additional, Visentin, Andrea, additional, Frustaci, Annamaria, additional, Vigna, Ernesto, additional, Pepe, Sara, additional, Catania, Gioacchino, additional, Loseto, Giacomo, additional, Murru, Roberta, additional, Chiarenza, Annalisa, additional, Sportoletti, Paolo, additional, Del Principe, Maria Ilaria, additional, Laureana, Roberta, additional, Coscia, Marta, additional, Galimberti, Sara, additional, Ferretti, Eleonora, additional, Zucchetto, Antonella, additional, Bomben, Riccardo, additional, Polesel, Jerry, additional, Tedeschi, Alessandra, additional, Rossi, Davide, additional, Trentin, Livio, additional, Neri, Antonino, additional, Morabito, Fortunato, additional, Gattei, Valter, additional, and Gentile, Massimo, additional

Published
2024
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17. Molecular characterization of chronic cutaneous wounds reveals subregion‐ and wound type‐specific differential gene expression

Author

Richards, Shola Michelle, primary, Gubser Keller, Caroline, additional, Kreutzer, Robert, additional, Greiner, Géraldine, additional, Ley, Svenja, additional, Doelemeyer, Arno, additional, Dubost, Valerie, additional, Flandre, Thierry, additional, Kirkland, Susan, additional, Carbone, Walter, additional, Pandya, Rishika, additional, Knehr, Judith, additional, Roma, Guglielmo, additional, Schuierer, Sven, additional, Bouchez, Laure, additional, Seuwen, Klaus, additional, Aebi, Alexandra, additional, Westhead, David, additional, Hintzen, Gabriele, additional, Jurisic, Giorgia, additional, Hossain, Imtiaz, additional, Neri, Marilisa, additional, Manevski, Nenad, additional, Balavenkatraman, Kamal Kumar, additional, Moulin, Pierre, additional, Begrich, Annette, additional, Bertschi, Barbara, additional, Huber, Roland, additional, Bouwmeester, Tewis, additional, Driver, Vickie R., additional, von Schwabedissen, Moritz, additional, Schaefer, Dirk, additional, Wettstein, Barbara, additional, Wettstein, Reto, additional, and Ruffner, Heinz, additional

Published
2023
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20. Innovation in direct care worker training: preparing a workforce to provide in‐home care to older adults living with Alzheimer’s disease and related dementias

Author

Yeh, Jarmin, primary, Beld, Matthew, additional, Pond, Brittney, additional, Neri, Mel, additional, Martinez, Suzanna, additional, Hollister, Brooke, additional, Garcia, Andrea, additional, Mauricio, Juvenal, additional, Mata‐Pacheco, Juliana, additional, Emelle, Michelle, additional, Castaneda, Moraima, additional, Eldridge, Corinne, additional, and Ross, Leslie, additional

Published
2023
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22. Teclistamab‐cqyv in multiple myeloma

Author

Martino, Enrica Antonia, primary, Bruzzese, Antonella, additional, Labanca, Caterina, additional, Mendicino, Francesco, additional, Lucia, Eugenio, additional, Olivito, Virginia, additional, Neri, Antonino, additional, Morabito, Fortunato, additional, Vigna, Ernesto, additional, and Gentile, Massimo, additional

Published
2023
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23. Tagraxofusp in myeloid malignancies

Author

Bruzzese, Antonella, primary, Martino, Enrica Antonia, additional, Labanca, Caterina, additional, Mendicino, Francesco, additional, Lucia, Eugenio, additional, Olivito, Virginia, additional, Neri, Antonino, additional, Imovilli, Annalisa, additional, Morabito, Fortunato, additional, Vigna, Ernesto, additional, and Gentile, Massimo, additional

Published
2023
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29. Effectiveness of perampanel as the only add‐on: Retrospective, multicenter, observational real‐life study on epilepsy patients

Author

Gasparini S., Ferlazzo E., Neri S., Cianci V., Iudice A., Bisulli F., Bonanni P., Caggia E., D'Aniello A., Di Bonaventura C., Di Francesco J. C., Domina E., Dono F., Gambardella A., Marini C., Marrelli A., Matricardi S., Morano A., Paladin F., Renna R., Striano P., Pascarella A., Ascoli M., Aguglia U., PEROC Study Group, Gasparini S., Ferlazzo E., Neri S., Cianci V., Iudice A., Bisulli F., Bonanni P., Caggia E., D'Aniello A., Di Bonaventura C., Di Francesco J.C., Domina E., Dono F., Gambardella A., Marini C., Marrelli A., Matricardi S., Morano A., Paladin F., Renna R., Striano P., Pascarella A., Ascoli M., Aguglia U., and PEROC Study Group

Subjects
real-world, perampanel, Neurology, seizure freedom, early add-on, Neurology (clinical)
Abstract

Objective: Perampanel (PER) is indicated as adjunctive antiseizure medication (ASM) in adolescents and adults with epilepsy. Data from clinical trials show good efficacy and tolerability, while limited information is available on the routine clinical use of PER, especially when used as only add-on treatment. Methods: We performed an observational, retrospective, multicenter study on people with focal or generalized epilepsy aged >12 years, consecutively recruited from 52 Italian epilepsy centers. All patients received PER as the only add-on treatment to a background ASM according to standard clinical practice. Retention rate, seizure frequency, and adverse events were recorded at 3, 6, and 12months after PER introduction. Subanalyses by early or late use of PER and by concomitant ASM were also conducted. Results: Five hundred and three patients were included (age 36.5 ± 19.9 years). Eighty-one percent had focal epilepsy. Overall, the retention rate was very high in the whole group (89% at 12months) according with efficacy measures. No major differences were observed in the subanalyses, although patients who used PER as early add-on, as compared with late add-on, more often reached early seizure freedom at 3-month follow-up (66% vs 53%, P=.05). Treatment-emergent adverse events occurred in 25%, far less commonly than in PER randomized trials. Significance: This study confirms the good efficacy and safety of PER for focal or generalized epilepsy in real-life conditions. We provide robust data about its effectiveness as only add-on treatment even in patients with a long-standing history of epilepsy and previously treated with many ASMs.

Published
2022

30. Elotuzumab plus lenalidomide and dexamethasone in relapsed/refractory multiple myeloma: Extended 3‐year follow‐up of a multicenter, retrospective clinical experience with 319 cases outside of controlled clinical trials

Author

Antonella Bruzzese, Daniele Derudas, Monica Galli, Enrica Antonia Martino, Stefano Rocco, Concetta Conticello, Catello Califano, Nicola Giuliani, Silvia Mangiacavalli, Giuliana Farina, Alessandra Lombardo, Marino Brunori, Elena Rossi, Elisabetta Antonioli, Roberto Ria, Renato Zambello, Nicola Di Renzo, Giuseppe Mele, Gianpaolo Marcacci, Giuseppe Pietrantuono, Gaetano Palumbo, Nicola Cascavilla, Claudio Cerchione, Angelo Belotti, Clelia Criscuolo, Giuseppina Uccello, Paola Curci, Ernesto Vigna, Francesco Mendicino, Enrico Iaccino, Selena Mimmi, Cirino Botta, Donatella Vincelli, Nicola Sgherza, Angela Bonalumi, Luca Cupelli, Raffaella Stocchi, Massimo Martino, Stelvio Ballanti, Dominella Gangemi, Alfredo Gagliardi, Barbara Gamberi, Alessandra Pompa, Giovanni Tripepi, Ferdinando Frigeri, Ugo Consoli, Sara Bringhen, Elena Zamagni, Francesca Patriarca, Valerio De Stefano, Francesco Di Raimondo, Salvatore Palmieri, Maria Teresa Petrucci, Massimo Offidani, Pellegrino Musto, Mario Boccadoro, Michele Cavo, Antonino Neri, Fortunato Morabito, Massimo Gentile, Bruzzese, Antonella, Derudas, Daniele, Galli, Monica, Martino, Enrica Antonia, Rocco, Stefano, Conticello, Concetta, Califano, Catello, Giuliani, Nicola, Mangiacavalli, Silvia, Farina, Giuliana, Lombardo, Alessandra, Brunori, Marino, Rossi, Elena, Antonioli, Elisabetta, Ria, Roberto, Zambello, Renato, Di Renzo, Nicola, Mele, Giuseppe, Marcacci, Gianpaolo, Pietrantuono, Giuseppe, Palumbo, Gaetano, Cascavilla, Nicola, Cerchione, Claudio, Belotti, Angelo, Criscuolo, Clelia, Uccello, Giuseppina, Curci, Paola, Vigna, Ernesto, Mendicino, Francesco, Iaccino, Enrico, Mimmi, Selena, Botta, Cirino, Vincelli, Donatella, Sgherza, Nicola, Bonalumi, Angela, Cupelli, Luca, Stocchi, Raffaella, Martino, Massimo, Ballanti, Stelvio, Gangemi, Dominella, Gagliardi, Alfredo, Gamberi, Barbara, Pompa, Alessandra, Tripepi, Giovanni, Frigeri, Ferdinando, Consoli, Ugo, Bringhen, Sara, Zamagni, Elena, Patriarca, Francesca, De Stefano, Valerio, Di Raimondo, Francesco, Palmieri, Salvatore, Petrucci, Maria Teresa, Offidani, Massimo, Musto, Pellegrino, Boccadoro, Mario, Cavo, Michele, Neri, Antonino, Morabito, Fortunato, and Gentile, Massimo

Subjects
Cancer Research, lenalidomide, dexamethasone, elotuzumab, multiple myeloma, salvage therapy, Hematology, General Medicine, Antibodies, Monoclonal, Humanized, Thalidomide, Oncology, Antineoplastic Combined Chemotherapy Protocols, Humans, Settore MED/15 - Malattie del Sangue, Follow-Up Studies, Retrospective Studies
Abstract

The combination of elotuzumab, lenalidomide, and dexamethasone (EloRd) enhanced the clinical benefit over Rd with a manageable toxicity profile in the ELOQUENT-2 trial, leading to its approval in relapsed/refractory multiple myeloma (RRMM). The present study is a 3-year follow-up update of a previously published Italian real-life RRMM cohort of patients treated with EloRd. This revised analysis entered 319 RRMM patients accrued in 41 Italian centers. After a median follow-up of 36 months (range 6-55), 236 patients experienced disease progression or died. Median progression-free survival (PFS) and overall survival (OS) were 18.4 and 34 months, respectively. The updated multivariate analyses showed a significant reduction of PFS and OS benefit magnitude only in cases with ISS stage III. Major adverse events included grade 3/4 neutropenia (18.5%), anemia (15.4%), lymphocytopenia (12.5%), and thrombocytopenia (10.7%), while infection rates and pneumonia were 33.9% and 18.9%, respectively. No new safety signals with longer follow-up have been observed. Of 319 patients, 245 (76.7%) reached at least a partial remission. A significantly lower response rate was found in patients previously exposed to lenalidomide. In conclusion, our study confirms that EloRd is a safe and effective regimen for RRMM patients, maintaining benefits across multiple unfavorable subgroups. This article is protected by copyright. All rights reserved.

Published
2022

32. Iron chelation therapy

Author

Antonella Bruzzese, Enrica Antonia Martino, Francesco Mendicino, Eugenio Lucia, Virginia Olivito, Carlo Bova, Gianfranco Filippelli, Isabella Capodanno, Antonino Neri, Fortunato Morabito, Massimo Gentile, and Ernesto Vigna

Subjects
Hematology, General Medicine
Published
2023

35. Dermatological manifestations, management, and care in RASopathies

Author

Maria Ines Kavamura, Chiara Leoni, and Giovanni Neri

Subjects
Genetics, Genetics (clinical)
Abstract

RASopathies are rare genetic disorders caused by germline pathogenic variants in genes belonging to the RAS/MAPK pathway, which signals cell proliferation, differentiation, survival and death. The dysfunction of such signaling pathway causes syndromes with overlapping clinical manifestations. Skin and adnexal lesions are the cardinal clinical signs of RASopathies, such as cardiofaciocutaneous syndrome, Noonan syndrome with multiple lentigines, formerly known as LEOPARD syndrome, Costello syndrome, neurofibromatosis (NF1), Legius syndrome, Noonan-like syndrome with loose anagen hair (NSLH) and Noonan syndrome. As NF1, one of the most common RASopathies, described in 1882, has its clinical features well delineated, we will focus on the dermatological diagnosis, management and care of non-NF1 RASopathies, which are less known and more recently described. Dermatological manifestations are important clinical diagnostic elements that can aid differential diagnosis among RASopathies. They can affect dermis and epidermis, causing pigmented lesions (melanocytic nevi, café-au-lait spots, and lentigines), hyperkeratosis (keratosis pilaris, ulerythema ophryogenes, and palmoplantar keratosis) or hyperplasia. To date there are rare known links to malignancy, but oftentimes skin lesions require close attention because they can highly affect quality of life.

Published
2022

37. Adapting Neutralizing Antibodies to Viral Variants by Structure‐Guided Affinity Maturation Using Phage Display Technology

Author

Peissert, Frederik, primary, Pedotti, Mattia, additional, Corbellari, Riccardo, additional, Simonelli, Luca, additional, De Gasparo, Raoul, additional, Tamagnini, Elia, additional, Plüss, Louis, additional, Elsayed, Abdullah, additional, Matasci, Mattia, additional, De Luca, Roberto, additional, Cassaniti, Irene, additional, Sammartino, Jose’ Camilla, additional, Piralla, Antonio, additional, Baldanti, Fausto, additional, Neri, Dario, additional, and Varani, Luca, additional

Published
2023
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46. Investigation of ochratoxin A in commercial cheeses and pork meat products by liquid chromatography–tandem mass spectrometry

Author

Daniela Delfino, Dario Lucchetti, Tabita Mauti, Marta Mancuso, Paolo Di Giustino, Daniela Triolone, Stefano Vaccari, Rossana Claudia Bonanni, Bruno Neri, and Katia Russo

Subjects
Swine, Food Contamination, Mycotoxins, Ochratoxins, Meat Products, Red Meat, Tandem Mass Spectrometry, Cheese, Pork Meat, Solvents, Animals, Food Analysis, Chromatography, High Pressure Liquid, Chromatography, Liquid, Food Science
Abstract

Ochratoxin A (OTA) is a mycotoxin produced by several species of Aspergillus and Penicillium and commonly detected in a wide range of foodstuffs. The purpose of this work was to monitor the presence of OTA in cheeses and pork meat products. A simple and accurate "dilute and shoot" method with no need of immunoaffinity column and isotopic labeled internal standard, by liquid chromatography-tandem mass spectrometry, was validated in accordance with the criteria set out in Commission Regulation (EC) No. 401/2006. The method showed good linearity in solvent and in matrix (R

Published
2022

47. Confused‐Prism[5]arene: a Conformationally Adaptive Host by Stereoselective Opening of the 1,4‐Bridged Naphthalene Flap

Author

Paolo Della Sala, Rocco del Regno, Amedeo Capobianco, Veronica Iuliano, Carmen Talotta, Silvano Geremia, Neal Hickey, Placido Neri, Carmine Gaeta, Della Sala, Paolo, Del Regno, Rocco, Capobianco, Amedeo, Iuliano, Veronica, Talotta, Carmen, Geremia, Silvano, Hickey, Neal, Neri, Placido, and Gaeta, Carmine

Subjects
directional, prismarenes, molecular recognition, pseudorotaxanes, stereoselectivity, Organic Chemistry, pseudorotaxane, prismarene, General Chemistry, Catalysis
Abstract

The confused-prism[5]arene macrocycle (c-PrS[5](Me)) shows conformational adaptive behavior in the presence of ammonium guests. Upon guest inclusion, the 1,4-bridged naphthalene flap reverses its planar chirality from pS to pR (with reference to the pS(pR)(4) enantiomer). Stereoselective directional threading is also observed in the presence of directional axles, in which up/down stereoisomers of homochiral (pR)(5)-c-PrS[5](Me) pseudorotaxanes are formed.

Published
2022

48. The spectrum of subclonal TP53 mutations in chronic lymphocytic leukemia: A next generation sequencing retrospective study

Author

Giuseppa De Luca, Giannamaria Cerruti, Sonia Lastraioli, Romana Conte, Adalberto Ibatici, Nikki Di Felice, Fortunato Morabito, Paola Monti, Gilberto Fronza, Serena Matis, Monica Colombo, Sonia Fabris, Alessia Ciarrocchi, Antonino Neri, Paola Menichini, Manlio Ferrarini, Paolo Nozza, Franco Fais, Giovanna Cutrona, and Mariella Dono

Subjects
Cancer Research, Oncology, Humans, High-Throughput Nucleotide Sequencing, Hematology, General Medicine, Tumor Suppressor Protein p53, Leukemia, Lymphocytic, Chronic, B-Cell, Retrospective Studies
Abstract

Chronic lymphocytic leukemia (CLL) is a hematological disorder with complex clinical and biological behavior. TP53 mutational status and cytogenetic assessment of the deletion of the corresponding locus (17p13.1) are considered the most relevant biomarkers associated with pharmaco-predictive response, chemo-refractoriness, and worse prognosis in CLL patients. The implementation of Next Generation Sequencing (NGS) methodologies in the clinical laboratory allows for comprehensively analyzing the TP53 gene and detecting mutations with allele frequencies ≤10%, that is, "subclonal mutations". We retrospectively studied TP53 gene mutational status by NGS in 220 samples from 171 CLL patients. TP53 mutations were found in 60/220 (27.3%) samples and 47/171 (27.5%) patients. Interestingly, subclonal mutations could be detected in 31/60 samples (51.7%) corresponding to 25 patients (25/47, 53.2%). We identified 44 distinct subclonal TP53 mutations clustered in the central DNA-binding domain of p53 protein (exons 5-8, codons 133-286). Missense mutations were predominant (80%), whereas indels, nonsense, and splice site variants were less represented. All subclonal TP53 variants but one [p.(Pro191fs)] were already described in NCI and/or Seshat databases as "damaging" and/or "probably damaging" mutations (38/44, 86% and 6/44, 14%, respectively). Longitudinal samples were available for 37 patients. Almost half of them displayed at least one TP53 mutant subclone, which could be alone (4/16, 25%) or concomitant with other TP53 mutant clonal ones (12/16, 75%); different patterns of mutational dynamics overtimes were documented. In conclusion, utilization of NGS in our "real-life" cohort of CLL patients demonstrated an elevated frequency of subclonal TP53 mutations. This finding indicates the need for precisely identifying these mutations during disease since the clones carrying them may become predominant and be responsible for therapy failures.

Published
2022

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