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The conventional assessment of preterm somatosensory functions using averaged cortical responses to electrical stimulation ignores the characteristic components of preterm somatosensory evoked responses (SERs). Our study aimed to systematically evaluate the occurrence and development of SERs after tactile stimulus in preterm infants. We analysed SERs performed during 45 electroencephalograms (EEGs) from 29 infants at the mean post-menstrual age of 30.7 weeks. Altogether 2,087 SERs were identified visually at single trial level from unfiltered signals capturing also their slowest components. We observed salient SERs with a high amplitude slow component at a high success rate after hand (95%) and foot (83%) stimuli. There was a clear developmental change in both the slow wave and the higher frequency components of the SERs. Infants with intraventricular haemorrhage (IVH; eleven infants) had initially normal SERs, but those with bilateral IVH later showed a developmental decrease in the ipsilateral SER occurrence after 30 weeks of post-menstrual age. Our study shows that tactile stimulus applied at bedside elicits salient SERs with a large slow component and an overriding fast oscillation, which are specific to the preterm period. Prior experimental research indicates that such SERs allow studying both subplate and cortical functions. Our present findings further suggest that they might offer a window to the emergence of neurodevelopmental sequalae after major structural brain lesions and, hence, an additional tool for both research and clinical neurophysiological evaluation of infants before term age.

Research using electroencephalography (EEG) as a measure of brain function and maturation has demonstrated links between cortical activity and cognitive processes during infancy and early childhood. The current study examines whether neonatal EEG is correlated with later atypical socioemotional behaviors or neurocognitive delays. Parental-report developmental assessments were administered to families with children ages 24 to 36 months who had previously participated in a neonatal EEG study (N = 129). Significant associations were found between neonatal EEG (higher frequencies in the frontal-polar, temporal, and parietal brain regions) and BITSEA ASD risk scores. Infants with lower EEG power in these brain areas were more likely to have higher risk of socio-emotional problems. When examining sex differences, significant links were found for males but not for females. These results demonstrate some promising associations between early neural biomarkers and later risk for atypical behaviors, which may shape early neurobehavioral development and could lead to earlier identification and intervention.

1.Department of Children’s Clinical Neurophysiology, Helsinki University Central Hospital, Helsinki, Finland2.Department of Neurological Sciences, University of Helsinki, Helsinki, FinlandCorrespondenceS Vanhatalo, Department of Clinical Neurophysiol-ogy, Children’s Hospital, Helsinki University CentralHospital, PO Box 280, FIN-00029 HUS, Helsinki, Fin-land.Email: sampsa.vanhatalo@helsinki.fiReceived15 March 2012; accepted 2 May 2012.DOI:10.1111/j.1651-2227.2012.02724.x

Aim: To investigate factors that influenced parental consent/non-consent in a non-therapeutic electroencephalogram (EEG) study in healthy newborns. Methods: Parents of healthy newborns were approached to participate in a neonatal EEG study within 36 h of birth. The rationale and risks/benefits of the study were explained. Any concerns were discussed, and detailed information about the EEG study was provided in the consent form. In the case of refusing/withdrawing consent, an informal interview was used to investigate the reasons, which were subsequently analysed and grouped according to the four principles of the consent process. Results: A total of 123 parents were included in the study. Parental consent was obtained in 72/123 (59%) cases, 10/123 (8%) parents subsequently withdrew their consent and 41/123 (33%) parents refused to participate in the study. Consent was more likely if both parents were present (p

The neonatal EEG is a thread that has linked past and present studies of neonatal seizures that have emerged over the last several decades. Instead of experiencing a waning of value or interest, the neonatal EEG has grown in significance for characterization and quantification of seizures in the neonate. At present, it serves as the ideal theoretical end point of antiepileptic drug (AED) therapy and provides invaluable prognostic information in the analysis of its interictal EEG background. The needs of the near future are to learn the real behavior of the electrographic neonatal seizure (ENS) burden as it erupts on the scene of an acute encephalopathy. The response of the neonatal seizure burden to AED treatment requires careful quantitative description and reliable, automated ENS detection by cerebral function monitors, which are on the technologic horizon.