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103 results on '"Murray, Joseph"'

7. Peritoneal carcinomatosis after risk-reducing surgery in BRCA1/2 mutation carriers

Author

Marc van Beurden, Jurgen M.J. Piek, Timothy R. Rebbeck, Leon F.A.G. Massuger, Mark H. Greene, Murray Joseph Casey, Nicoline Hoogerbrugge, Marline G. Harmsen, Joanne A. de Hullu, Brigitte F. M. Slangen, Johan Bulten, and Marian J.E. Mourits

Subjects
0301 basic medicine, Cancer Research, medicine.medical_specialty, Serous carcinoma, business.industry, medicine.medical_treatment, Cancer, Serous Tubal Intraepithelial Carcinoma, medicine.disease, Gastroenterology, 03 medical and health sciences, Serous fluid, Peritoneal Neoplasm, 030104 developmental biology, 0302 clinical medicine, Oncology, 030220 oncology & carcinogenesis, Internal medicine, Salpingectomy, Ovarian carcinoma, medicine, business, Cystadenocarcinoma
Abstract

BACKGROUND Risk-reducing salpingo-oophorectomy (RRSO) is recommended for BRCA1/2 mutation carriers because of their increased risk of ovarian carcinoma. Despite RRSO, metachronous peritoneal carcinomatosis occasionally is diagnosed. METHODS The literature was searched for BRCA1/2 mutation carriers with peritoneal carcinomatosis after risk-reducing surgery. The authors were asked for additional data. Clinical and histopathological data were descriptively analyzed. Cases were compared with a single-institution control cohort. RESULTS Of 36 cases, 86.1% concerned BRCA1 mutation carriers. The median age of the patients was 52 years (range, 30-71 years) at the time of risk-reducing surgery and 60 years (range, 37-75 years) at the time of diagnosis of peritoneal carcinomatosis. The median interval between the 2 events was 54.5 months (range, 11-292 months). Peritoneal carcinomatosis was mostly high-grade serous carcinoma. Histopathological details of the RRSO specimens were retrieved in 8 cases; 5 (62.5%) were found to have serous tubal intraepithelial carcinoma and 1 had epithelial atypia. Cases were older (P = .025) at the time of risk-reducing surgery and harbored more serous tubal intraepithelial carcinomas (P

Published
2018

20. Reply

Author

Marietta, Eric, primary, Mangalam, Ashutosh, additional, Murray, Joseph, additional, and Taneja, Veena, additional

Published
2017
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21. Moderate alcohol drinking in pregnancy increases risk for children's persistent conduct problems: causal effects in a Mendelian randomisation study

Author

Murray, Joseph, Burgess, Stephen, Zuccolo, Luisa, Hickman, Matthew, Gray, Ron, Lewis, Sarah J., Burgess, Stephen [0000-0001-5365-8760], and Apollo - University of Cambridge Repository

Subjects
Conduct Disorder, Male, Adolescent, Alcohol Drinking, longitudinal study, Infant, Newborn, Infant, Original Articles, ALSPAC, mendelian randomization analysis, Random Allocation, Foetal alcohol effects, Pregnancy, Child, Preschool, Prenatal Exposure Delayed Effects, Humans, Original Article, Female, Child, health care economics and organizations
Abstract

BACKGROUND: Heavy alcohol use during pregnancy can cause considerable developmental problems for children, but effects of light-moderate drinking are uncertain. This study examined possible effects of moderate drinking in pregnancy on children's conduct problems using a Mendelian randomisation design to improve causal inference. METHODS: A prospective cohort study (ALSPAC) followed children from their mother's pregnancy to age 13 years. Analyses were based on 3,544 children whose mothers self-reported either not drinking alcohol during pregnancy or drinking up to six units per week without binge drinking. Children's conduct problem trajectories were classified as low risk, childhood-limited, adolescence-onset or early-onset-persistent, using six repeated measures of the Strengths and Difficulties Questionnaire between ages 4-13 years. Variants of alcohol-metabolising genes in children were used to create an instrumental variable for Mendelian randomisation analysis. RESULTS: Children's genotype scores were associated with early-onset-persistent conduct problems (OR = 1.29, 95% CI = 1.04-1.60, p = .020) if mothers drank moderately in pregnancy, but not if mothers abstained from drinking (OR = 0.94, CI = 0.72-1.25, p = .688). Children's genotype scores did not predict childhood-limited or adolescence-onset conduct problems. CONCLUSIONS: This quasi-experimental study suggests that moderate alcohol drinking in pregnancy contributes to increased risk for children's early-onset-persistent conduct problems, but not childhood-limited or adolescence-onset conduct problems.

Published
2016

23. North Central Cancer Treatment Group N0543 (Alliance): A phase 2 trial of pharmacogenetic-based dosing of irinotecan, oxaliplatin, and capecitabine as first-line therapy for patients with advanced small bowel adenocarcinoma

Author

McWilliams, Robert R., primary, Foster, Nathan R., additional, Mahoney, Michelle R., additional, Smyrk, Thomas C., additional, Murray, Joseph A., additional, Ames, Matthew M., additional, Horvath, L. Elise, additional, Schneider, Daniel J., additional, Hobday, Timothy J., additional, Jatoi, Aminah, additional, Meyers, Jeffrey P., additional, and Goetz, Matthew P., additional

Published
2017
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38. Perinatal and sociodemographic factors at birth predicting conduct problems and violence to age 18 years: comparison of Brazilian and British birth cohorts

Author

Murray, Joseph, primary, Maughan, Barbara, additional, Menezes, Ana M. B., additional, Hickman, Matthew, additional, MacLeod, John, additional, Matijasevich, Alicia, additional, Gonçalves, Helen, additional, Anselmi, Luciana, additional, Gallo, Erika A. G., additional, and Barros, Fernando C., additional

Published
2014
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