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46 results on '"Murphy, Michael J."'

28. Idiopathic Hemorrhagic Pericardial Effusion in Cows

Author

Firshman, Anna M., primary, Sage, Abby M., additional, Valberg, Stephanie J., additional, Kaese, Heather J., additional, Hunt, Luanne, additional, Kenney, Dan, additional, Sharkey, Leslie C., additional, and Murphy, Michael J., additional

Published
2006
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35. Superwarfarin ingestion and detection

Author

Routh, Charles R., primary, Triplett, Douglas A., additional, Murphy, Michael J., additional, Felice, Larry J., additional, Sadowski, James A., additional, and Bovill, E. G. Ted, additional

Published
1991
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37. Co-residence with a child and happiness among older widows in Europe: does gender of the child matter?

Author

Grundy, Emily, Murphy, Michael J., Grundy, Emily, and Murphy, Michael J.

Abstract

Both coresidence patterns and the reported well-being of older people vary widely across Europe for a variety of economic, cultural, and historical factors. We investigate how far 2 indicators of well-being, happiness and life satisfaction, vary according to whether or not older women live with their children and, in particular, with son(s) or daughters(s). We compare outcomes for women who are unpartnered widows, the great majority of whom will have had children, so those with and without coresident children may be compared. We use data for 34 countries in Europe by combining 7 waves of the European Social Survey for the period 2002–2014 (N = 18,500). We control for a range of other variables known to be associated with well-being including health status, socioeconomic position, and social support. Results show that widows living with a child were happier than those living without a child (generally alone) but that in Eastern and Southern Europe it was only living with a daughter that had this positive effect. Older age was associated with higher levels of happiness and life satisfaction. Other associations, and regional differences, were as expected with lower levels of happiness in Eastern Europe and for those with poorer health and fewer social resources. These findings indicate the important influence of contextual factors on associations between living arrangements and the well-being of older people and a need for further work on possible negative impacts of living alone on the well-being of older Europeans

42. Pediatric cutaneous Crohn disease: A case series of 89 patients and review.

Author

McKay GE, Liu L, Shaw KS, Shakshouk H, Murphy MJ, Damsky W, Ortega-Loayza AG, Caplan AS, Arkin LM, and Shields BE

Subjects
Humans, Male, Child, Female, Adolescent, Retrospective Studies, Skin Diseases drug therapy, Child, Preschool, Crohn Disease drug therapy
Abstract

Background: Cutaneous (or "Metastatic") Crohn disease (CCD) is a rare and underrecognized disease characterized by cutaneous granulomatous inflammation. We describe patient demographics, clinical characteristics, histology, and treatment of 89 pediatric cases of CCD, including 78 previously reported and 11 new cases seen at four academic institutions. We emphasize the efficacy of biologic mono- and dual therapy., Methods: PubMed identified cases using keywords including "metastatic Crohn disease" and "cutaneous Crohn disease". Patients were identified by retrospective review of the electronic health record including histopathologic diagnosis consistent with CCD. Chart review collected demographic, clinical, and histologic data., Results: Most pediatric patients with CCD are male 55% (49/89), present with edema (73/89, 82%) and erythema (47/89, 53%) of the genitals (33/49, 67%), and have intestinal Crohn disease (69/89, 78%). Oral corticosteroids (53/75, 71%) and metronidazole (29/75, 39%) are the most frequently prescribed medications. Of the 17 patients treated with tumor necrosis factor (TNF)-blockade, 94% (16/17) had partial or total clearance. Ustekinumab resulted in clearance of cutaneous disease in two patients (2/3, 67%) and partial clearance in one patient (1/3, 33%). Two cases achieved total clearance with the use of dual biologic therapy defined as the use of two biologic therapies with differing mechanisms of action or the use of a biologic therapy and small molecule inhibitor., Conclusions: TNF blockade is an effective treatment for pediatric CCD, and interleukin-12/23 inhibitors may be similarly effective. Consideration of dual biologic therapy may be useful in pediatric patients requiring discordant therapies for their intestinal and cutaneous CD., (© 2024 The Author(s). Pediatric Dermatology published by Wiley Periodicals LLC.)

Published
2024
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43. Nivolumab-induced localized genital bullous pemphigoid in a 60-year-old male.

Author

Alvarado SM, Weston G, Murphy MJ, and Stewart CL

Subjects
Autoantibodies, Autoantigens therapeutic use, Blister, Female, Genitalia pathology, Humans, Immunoglobulin G metabolism, Male, Nivolumab adverse effects, Carcinoma, Renal Cell drug therapy, Kidney Neoplasms, Pemphigoid, Bullous
Abstract

A 60-year-old man with metastatic renal cell carcinoma presented with a 6-month history of a pruritic, exquisitely painful genital eruption appearing 3 months after initiation of nivolumab. Examination demonstrated a poorly defined, lichenified scrotal plaque studded with erosions, yellow crust, and tense vesicles. There was no other lesion on the body or mucosae. Histopathology revealed a subepidermal blister with a mixed lymphocytic, neutrophilic, and eosinophilic infiltrate. Direct immunofluorescence of perilesional skin demonstrated subclinical blister and linear/fibrillary patchy IgG and IgA along the dermoepidermal junction. Bullous pemphigoid (BP) serologies revealed normal IgG BP230 antibodies and minimally elevated IgG BP180 antibodies. Indirect immunofluorescence revealed positive IgG at the basement membrane ("epidermal pattern") in human split skin and monkey esophagus substrates; no IgA antibodies were detected. The patient was diagnosed with nivolumab-induced localized genital BP (LGBP). BP is a reported adverse effect of immune checkpoint inhibitors including nivolumab; however, cases are typically generalized. LGBP is a rare BP variant typically presenting in children and females; there are few reports of LGBP in adult males. We report a novel case of nivolumab-induced LGBP with unique histopathologic and clinical challenges. LGBP should be considered in patients on immune checkpoint inhibitor therapy with bullous genital eruptions., (© 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)

Published
2022
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46. Necrotizing palisaded granulomatous dermatitis as a manifestation of familial hemophagocytic lymphohistiocytosis.

Author

Murphy MJ

Subjects
Dermatitis genetics, Dermatitis pathology, Granuloma genetics, Granuloma pathology, Humans, Infant, Lymphohistiocytosis, Hemophagocytic complications, Lymphohistiocytosis, Hemophagocytic genetics, Male, Membrane Proteins genetics, Mutation, Necrosis etiology, Necrosis genetics, Necrosis pathology, Dermatitis etiology, Granuloma etiology, Lymphohistiocytosis, Hemophagocytic pathology
Published
2010
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