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Your search keyword '"Mould, T"' showing total 10 results
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10 results on '"Mould, T"'

1. Benchmarking of surgical complications in gynaecological oncology: prospective multicentre study

Author

Burnell, M, primary, Iyer, R, additional, Gentry‐Maharaj, A, additional, Nordin, A, additional, Liston, R, additional, Manchanda, R, additional, Das, N, additional, Gornall, R, additional, Beardmore‐Gray, A, additional, Hillaby, K, additional, Leeson, S, additional, Linder, A, additional, Lopes, A, additional, Meechan, D, additional, Mould, T, additional, Nevin, J, additional, Olaitan, A, additional, Rufford, B, additional, Shanbhag, S, additional, Thackeray, A, additional, Wood, N, additional, Reynolds, K, additional, Ryan, A, additional, and Menon, U, additional

Published
2016
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2. Risk of epithelial ovarian cancer in asymptomatic women with ultrasound-detected ovarian masses: a prospective cohort study within the UK collaborative trial of ovarian cancer screening (UKCTOCS)

Author

Sharma, A., primary, Apostolidou, S., additional, Burnell, M., additional, Campbell, S., additional, Habib, M., additional, Gentry-Maharaj, A., additional, Amso, N., additional, Seif, M. W., additional, Fletcher, G., additional, Singh, N., additional, Benjamin, E., additional, Brunell, C., additional, Turner, G., additional, Rangar, R., additional, Godfrey, K., additional, Oram, D., additional, Herod, J., additional, Williamson, K., additional, Jenkins, H., additional, Mould, T., additional, Woolas, R., additional, Murdoch, J., additional, Dobbs, S., additional, Leeson, S., additional, Cruickshank, D., additional, Fourkala, E.-O., additional, Ryan, A., additional, Parmar, M., additional, Jacobs, I., additional, and Menon, U., additional

Published
2012
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9. The <scp>WID‐EC</scp> test for the detection and risk prediction of endometrial cancer

Author

James E. Barrett, Allison Jones, Iona Evans, Chiara Herzog, Daniel Reisel, Adeola Olaitan, Tim Mould, Nicola MacDonald, Konstantinos Doufekas, Claire Newton, Emma J. Crosbie, Line Bjørge, Nicoletta Colombo, Lukas Dostalek, Laura Costas, Paula Peremiquel‐Trillas, Jordi Ponce, Xavier Matias‐Guiu, Michal Zikan, David Cibula, Jiangrong Wang, Karin Sundström, Joakim Dillner, Martin Widschwendter, Barrett, J, Jones, A, Evans, I, Herzog, C, Reisel, D, Olaitan, A, Mould, T, Macdonald, N, Doufekas, K, Newton, C, Crosbie, E, Bjorge, L, Colombo, N, Dostalek, L, Costas, L, Peremiquel-Trillas, P, Ponce, J, Matias-Guiu, X, Zikan, M, Cibula, D, Wang, J, Sundstrom, K, Dillner, J, and Widschwendter, M

Subjects
risk prediction, Cancer Research, DNA methylation, cervical sample, Oncology, endometrial cancer, epigenetic
Abstract

The incidence of endometrial cancer is rising. Measures to identify women at risk and to detect endometrial cancer earlier are required to reduce the morbidity triggered by the aggressive treatment required for advanced endometrial cancer. We developed the WID-EC (Women's cancer risk IDentification-Endometrial Cancer) test, which is based on DNA methylation at 500 CpG sites, in a discovery set of cervical liquid-based cytology samples from 1,086 women with and without an endometrial cancer (217 cancer cases and 869 healthy controls) with a worse prognosis (grade 3 or ≥stage IB). We validated the WID-EC test in an independent external validation set of 64 endometrial cancer cases and 225 controls. We further validated the test in 150 healthy women (prospective set) who provided a cervical sample as part of the routine Swedish cervical screening programme, 54 of whom developed endometrial cancer within three years of sample collection. The WID-EC test identified women with endometrial cancer with a receiver operator characteristic area under the curve (AUC) of 0.92 (95% CI: 0.88-0.97) in the external set and of 0.82 (95% CI: 0.74-0.89) in the prospective validation set. Using an optimal cutoff, cancer cases were detected with a sensitivity of 86% and a specificity of 90% in the external validation set, and a sensitivity and specificity of 52% and 98% respectively in the prospective validation set. The WID-EC test can identify women with or at risk of endometrial cancer. This article is protected by copyright. All rights reserved.

Published
2023
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