1. Genetic and phenotypic characterization of HIV-associated aggressive B-cell non-Hodgkin lymphomas, that do not occur specifically in this population: diagnostic and prognostic implications
- Author
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Baptista M, Tapia G, Munoz-Marmol A, Muncunill J, Garcia O, Montoto S, Gribben J, Calaminici M, Martinez A, Veloza L, Martinez-Trillos A, Aldamiz T, Menarguez J, Terol M, Ferrandez A, Alcoceba M, Briones J, Gonzalez-Barca E, Climent F, Muntanola A, Moraleda J, Provencio M, Abrisqueta P, Abella E, Colomo L, Garcia-Ballesteros C, Garcia-Caro M, Sancho J, Ribera J, Mate J, and Navarro J
- Abstract
AIMS: The frequency of aggressive subtypes of B-cell non-Hodgkin lymphoma (B-NHL), such as high-grade B-cell lymphomas (HGBL) with MYC and BCL2 and/or BCL6 rearrangement (HGBL-DH/TH) or Burkitt-like lymphoma (BL) with 11q aberration is not well known in the HIV-setting. We aimed to characterize HIV-associated aggressive B-NHL according to the 2017 WHO criteria and to identify genotypic and phenotypic features with prognostic impact. Methods and results Seventy-five HIV-associated aggressive B-NHL were studied by immunohistochemistry (CD10, BCL2, BCL6, MUM1, MYC and CD30), EBERs, and FISH to evaluate the status of the MYC, BCL2 and BCL6 genes and chromosome 11q. The 2017 WHO classification criteria and the Hans algorithm, for the cell-of-origin classification of diffuse large B-cell lymphomas (DLBCL), were applied. In DLBCL cases, the frequencies of MYC and BCL6 rearrangements (14.9 and 27.7%, respectively) were similar to those described in HIV-negative patients, but BCL2 rearrangements were infrequent (4.3%). MYC expression was identified in 23.4% of DLBCL cases, and co-expression of MYC and BCL2 in 13.0%, which was associated with a worse prognosis. As for BL cases, the expression of MUM1 (30.4%) conferred a worse prognosis. Finally, the prevalence of HGBL-DH/TH and BL-like with 11q aberration are reported in the HIV-setting.; CONCLUSIONS: The phenotypic and genotypic characteristics of HIV-associated aggressive B-NHL are similar to those of the general population, except for the low frequency of BCL2 rearrangements in DLBCL. MYC and BCL2 co-expression in DLBCL, and MUM-1 expression in BL have negative prognostic impact in HIV-infected individuals. This article is protected by copyright. All rights reserved.
- Published
- 2022