7 results on '"Mitul Gandhi"'
Search Results
2. Impact of oncogene rearrangement patterns on outcomes in patients with double-hit non-Hodgkin lymphoma
- Author
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Andrew D. Zelenetz, Mitul Gandhi, Kevin W. Song, Oliver W. Press, Namrata Shah, David T. Yang, Timothy S. Fenske, Jeremy S. Abramson, Jesse Jaso, Adam M. Petrich, Daniel J. Landsburg, Aliyah R. Sohani, Ryan D. Cassaday, Julio C. Chavez, Chadi Nabhan, and L. Jeffrey Medeiros
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0301 basic medicine ,Oncology ,Cancer Research ,Pathology ,medicine.medical_specialty ,Cell of origin ,Extranodal Disease ,03 medical and health sciences ,0302 clinical medicine ,immune system diseases ,hemic and lymphatic diseases ,Internal medicine ,Medicine ,Oncogene ,medicine.diagnostic_test ,business.industry ,Cancer ,Gene rearrangement ,BCL6 ,medicine.disease ,Lymphoma ,030104 developmental biology ,030220 oncology & carcinogenesis ,business ,Fluorescence in situ hybridization - Abstract
BACKGROUND Double-hit lymphomas (DHLs) are collectively defined as B-cell non-Hodgkin lymphomas harboring rearrangements of MYC as well as B-cell lymphoma 2 (BCL2) and/or B-cell lymphoma 6 (BCL6). To the authors' knowledge, the impact of specific oncogene rearrangements on outcomes of patients with DHL who are treated with immunochemotherapy has not been previously described. METHODS The authors identified patients whose diagnostic tissue specimens underwent metaphase karyotyping or fluorescence in situ hybridization for MYC as well as both BCL2 and BCL6 rearrangements. Cohorts were defined by the presence (+) or absence (−) of rearrangements: MYC+/BCL2+/BCL6− (BCL2-DHL), MYC+/BCL2−/BCL6+ (BCL6-DHL), and MYC+/BCL2+/BCL6+ (triple-hit lymphoma; THL). RESULTS A total of 117 patients were included in the current analysis (76 BCL2-DHL patients, 16 BCL6-DHL patients, and 25 THL patients). Compared with patients with BCL2-DHL, those with BCL6-DHL were more likely to be classified as having a non-germinal center cell of origin, presented with extranodal disease, and appeared to achieve higher rates of complete response despite receiving intensive induction therapy less frequently. However, patients with BCL6-DHL experienced a shorter median overall survival if achieving an initial complete response compared with patients with BCL2-DHL. Patients with THL experienced survival outcomes similar to those of patients with BCL2-DHL. CONCLUSIONS Recognition of the specific oncogene rearrangements may be of prognostic value and potentially guide future therapeutic strategies for patients with DHL. Cancer 2016;122:559–564. © 2015 American Cancer Society.
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- 2015
3. ACALABRUTINIB PLUS PEMBROLIZUMAB IN RELAPSED/REFRACTORY DIFFUSE LARGE B-CELL LYMPHOMA: A PHASE 1/2 STUDY
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Kathryn S. Kolibaba, Bruce D. Cheson, Jennifer E. Vaughn, C. Di Simone, T. E. Witzig, William Jeffery Edenfield, Kami J. Maddocks, Roger M. Lyons, Habte A. Yimer, Mitul Gandhi, Helen Wei, Priti Patel, Felipe Samaniego, Julie M. Vose, Jeffrey P. Sharman, Edward M. Chan, and S. de Vos
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Cancer Research ,business.industry ,Hematology ,General Medicine ,Pembrolizumab ,medicine.disease ,Oncology ,Phase (matter) ,Relapsed refractory ,Cancer research ,Medicine ,Acalabrutinib ,business ,Diffuse large B-cell lymphoma - Published
- 2019
4. Correlation of serum cardiac troponin I and acute phase protein concentrations with clinical staging in dogs with degenerative mitral valve disease
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Malcolm York, Anastasia Dasopoulou, José J. Cerón, Sonal Patel, Christos K. Koutinas, Mitul Gandhi, Ian Roman, Zoe S. Polizopoulou, Asta Tvarijonaviciute, Peter J. O'Brien, and Silvia Martínez-Subiela
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Male ,medicine.medical_specialty ,Pathology ,Heart Valve Diseases ,Asymptomatic ,Gastroenterology ,Dogs ,Blood serum ,Internal medicine ,Mitral valve ,Troponin I ,medicine ,Animals ,Dog Diseases ,Longitudinal Studies ,Heart Failure ,Inflammation ,Haptoglobins ,General Veterinary ,biology ,business.industry ,Haptoglobin ,C-reactive protein ,Acute-phase protein ,Ceruloplasmin ,medicine.disease ,C-Reactive Protein ,Cross-Sectional Studies ,medicine.anatomical_structure ,Heart failure ,cardiovascular system ,biology.protein ,Mitral Valve ,Female ,medicine.symptom ,business ,Biomarkers ,Acute-Phase Proteins - Abstract
Background Cardiac troponin I (cTnI) correlates with severity of myocardial injury. Nonspecific inflammation in congestive heart failure (CHF) could be assessed by C-reactive protein (CRP), haptoglobin (Hp), and ceruloplasmin (Cp) measurements. Objectives The aim of the study was to determine whether serum cTnI, CRP, Hp, and Cp concentrations differ among various stages of mitral valve disease (MVD) in dogs. Materials and methods Dogs with MVD were allocated to 3 groups (I – asymptomatic; II – mild to moderate CHF; III advanced CHF) according to the scheme of the International Small Animal Cardiac Healthy Council (ISACHC). Concentrations of cTnI, CRP, Cp, and Hp were measured in all dogs upon admission, and cTnI and CRP were measured bimonthly during a 4-month follow-up period. Results In total 46 dogs with MVD were enrolled for the cross-sectional part (21 Group I, 11 Group II, 14 Group III), and 35 dogs were included in the longitudinal study. Initial mean Cp concentrations were similar among all groups. There was a statistically significant difference in Hp and CRP concentrations between group I (n = 21, P = .019) and III (n = 14, P
- Published
- 2015
5. Serial analysis of serum cardiac troponin I changes and correlation with clinical findings in 46 dogs with mitral valve disease
- Author
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Mitul Gandhi, Ian Roman, Alexander F. Koutinas, Malcolm York, Christos K. Koutinas, Michael Patsikas, Zoe S. Polizopoulou, Anastasia Dasopoulou, Peter J. O'Brien, and Sonal Patel
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Male ,medicine.medical_specialty ,Cardiac troponin ,Heart Valve Diseases ,macromolecular substances ,Disease ,Severity of Illness Index ,Correlation ,Dogs ,Blood serum ,Internal medicine ,Mitral valve ,Troponin I ,medicine ,Animals ,Dog Diseases ,Longitudinal Studies ,Prospective Studies ,Heart Failure ,General Veterinary ,business.industry ,medicine.disease ,medicine.anatomical_structure ,Heart failure ,Chronic Disease ,Disease Progression ,cardiovascular system ,Cardiology ,Mitral Valve ,Biomarker (medicine) ,Female ,business ,Biomarkers ,Blood Chemical Analysis - Abstract
Background Cardiac troponin I (cTnI) is a biomarker correlated with the severity of myocardial injury. It is hypothesized that serial assessment of cTnI could provide information about the disease progression in chronic heart failure. Objective The purpose of the study was to correlate serial serum cTnI concentrations with clinical scoring and select diagnostic imaging findings in dogs managed for mitral valve degeneration (MVD) for a period of 6 months. Methods Client-owned dogs with MVD were prospectively recruited for the study. The dogs were allocated into 3 groups (I, II, III) according to the severity of their clinical signs based on the classification suggested by the International Small Animal Cardiac Health Council. During the 6-month study period, serum specimens for biochemical testing were obtained biweekly, clinical progression and response to treatment were also evaluated biweekly, and radiographic reevaluation was performed every 2 months. Results A total of 46 dogs were evaluated. There was a marked decrease in cTnI values during the first 2 weeks after initial diagnosis, more pronounced in group III, and corresponding to the initiation of therapy and clinical stabilization of animals. Serum cTnI was significantly different (P
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- 2014
6. Nephrotoxicity of hexachloro‐1:3‐butadiene in the male Hanover Wistar rat; correlation of minimal histopathological changes with biomarkers of renal injury
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Michael R. Munday, Rosemary Smyth, Malcolm York, John Turton, Jennifer Woodfine, David P. Maguire, Mitul Gandhi, Ines Pereira, John Bowles, Cheryl L. Scudamore, Surjit Sondh, Ian Francis, Aubrey Swain, Sofia Freitas, Clare Stamp, and Holly Ashall
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Male ,medicine.medical_specialty ,Urinary system ,Gene Expression ,Apoptosis ,Nephron ,Urine ,Biology ,Kidney ,Real-Time Polymerase Chain Reaction ,Toxicology ,medicine.disease_cause ,Nephrotoxicity ,Kidney Tubules, Proximal ,Internal medicine ,Butadienes ,medicine ,Albuminuria ,Animals ,Rats, Wistar ,Glutathione Transferase ,Dose-Response Relationship, Drug ,Albumin ,Organ Size ,Fungicides, Industrial ,Rats ,Isoenzymes ,Oxidative Stress ,medicine.anatomical_structure ,Endocrinology ,Liver ,Toxicity ,Kidney Diseases ,Cell Adhesion Molecules ,Biomarkers ,Injections, Intraperitoneal ,Oxidative stress - Abstract
Hexachloro-1:3-butadiene (HCBD) causes damage specifically to the renal proximal tubule in rats. In the present study, injury to the nephron of male Hanover Wistar rats was characterized at 24 h following dosing with HCBD in the range 5–90 mg kg−1 to determine the most sensitive biomarkers of damage, that is, the biomarkers demonstrating significant changes at the lowest dose of HCBD, using a range of measurements in serum and urine, renal histopathology, and renal and hepatic gene expression. Histologically, kidney degeneration was noted at doses as low as 10 mg kg−1 HCBD. Significant changes in the hepatic and renal gene expression categories of xenobiotic metabolism and oxidative stress were observed at 5 mg kg−1 HCBD, and in the kidney alone, evidence of inflammation at 90 mg kg−1 HCBD. Increases in the urinary excretion of α-glutathione S-transferase (α-GST) and kidney injury molecule-1 (KIM-1) were seen at 10 mg kg−1 HCBD, and increases in urinary excretion of albumin and total protein were evident at 15 mg kg−1 HCBD. The most sensitive, noninvasive biomarkers of HCBD-induced renal toxicity in Hanover Wistar rats were urinary α-GST and KIM-1. Urinary albumin measurement is also recommended as, although it is not the most sensitive biomarker, together with α-GST, albumin showed the largest relative increase of all the biomarkers investigated, and the protein is easily measured. Copyright © 2011 John Wiley & Sons, Ltd.
- Published
- 2011
7. Urinary biomarkers in hexachloro-1:3-butadiene-induced acute kidney injury in the female Hanover Wistar rat; correlation ofα-glutathioneS-transferase, albumin and kidney injury molecule-1 with histopathology and gene expression
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Michael R. Munday, Surjit Sondh, Ines Pereira, Cheryl L. Scudamore, Neeti Viswanathan, Aubrey Swain, John Turton, Rosemary Smyth, Malcolm York, Mitul Gandhi, and Fiona McClure
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Pathology ,medicine.medical_specialty ,Urinary system ,Gene Expression ,Nephron ,Biology ,Kidney ,Kidney Function Tests ,Toxicology ,Nephrotoxicity ,Necrosis ,Butadienes ,medicine ,Albuminuria ,Animals ,Immunoassay ,Reverse Transcriptase Polymerase Chain Reaction ,Gene Expression Profiling ,Acute kidney injury ,Albumin ,Rats, Inbred Strains ,Acute Kidney Injury ,medicine.disease ,Rats ,medicine.anatomical_structure ,Liver ,Toxicity ,Female ,Cell Adhesion Molecules ,Biomarkers ,Kidney disease - Abstract
Hexachloro-1:3-butadiene (HCBD) causes kidney injury specific to the pars recta of the proximal tubule. In the present studies, injury to the nephron was characterized at 24 h following a single dose of HCBD, using a range of quantitative urinary measurements, renal histopathology and gene expression. Multiplexed renal biomarker measurements were performed using both the Meso Scale Discovery (MSD) and Rules Based Medicine platforms. In a second study, rats were treated with a single nephrotoxic dose of HCBD and the time course release of a range of traditional and newer urinary biomarkers was followed over a 25 day period. Urinary albumin (a marker of both proximal tubular function and glomerular integrity) and α-glutathione S-transferase (α-GST, a proximal tubular cell marker of cytoplasmic leakage) showed the largest fold change at 24 h (day 1) after dosing. Most other markers measured on either the MSD or RBM platforms peaked on day 1 or 2 post-dosing, whereas levels of kidney injury molecule-1 (KIM-1), a marker of tubular regeneration, peaked on day 3/4. Therefore, in rat proximal tubular nephrotoxicity, the measurement of urinary albumin, α-GST and KIM-1 is recommended as they potentially provide useful information about the function, degree of damage and repair of the proximal tubule. Gene expression data provided useful confirmatory information regarding exposure of the kidney and liver to HCBD, and the response of these tissues to HCBD in terms of metabolism, oxidative stress, inflammation, and regeneration and repair.
- Published
- 2010
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