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Your search keyword '"Miettinen, Tatu"' showing total 30 results
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30 results on '"Miettinen, Tatu"'

12. Visceral Obesity is Associated with High Levels of Serum Squalene*

Author

Peltola, Paula, primary, Pihlajamäki, Jussi, additional, Koutnikova, Hana, additional, Ruotsalainen, Eija, additional, Salmenniemi, Urpu, additional, Vauhkonen, Ilkka, additional, Kainulainen, Sakari, additional, Gylling, Helena, additional, Miettinen, Tatu A., additional, Auwerx, Johan, additional, and Laakso, Markku, additional

Published
2006
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29. Parenteral plant sterols and intestinal failure-associated liver disease in neonates.

Author

Kurvinen A, Nissinen MJ, Andersson S, Korhonen P, Ruuska T, Taimisto M, Kalliomäki M, Lehtonen L, Sankilampi U, Arikoski P, Saarela T, Miettinen TA, Gylling H, and Pakarinen MP

Subjects
Adolescent, Alanine Transaminase blood, Aspartate Aminotransferases blood, Bilirubin blood, Child, Child, Preschool, Cholesterol analogs & derivatives, Cholesterol blood, Dietary Fats adverse effects, Dietary Fats blood, Fat Emulsions, Intravenous adverse effects, Fat Emulsions, Intravenous chemistry, Female, Finland epidemiology, Humans, Infant, Infant, Newborn, Intestinal Diseases blood, Intestinal Diseases therapy, Liver Diseases blood, Liver Diseases epidemiology, Male, Olive Oil, Parenteral Nutrition methods, Plant Oils chemistry, Prevalence, Prospective Studies, Soybean Oil adverse effects, Soybean Oil chemistry, Stigmasterol blood, Age Factors, Cholestanol blood, Intestinal Diseases complications, Liver Diseases etiology, Parenteral Nutrition adverse effects, Phytosterols blood, Plant Oils adverse effects
Abstract

Objectives: We prospectively evaluated incidence of prolonged (>28 days) parenteral nutrition (PN), associated complications, and significance of parenteral plant sterols (PS) in neonatal intestinal failure-associated liver disease (IFALD) compared with children., Methods: We recruited 28 neonates (mean age 50 days, range 28-126) and 11 children (6.9 y, 2.1-16.6) in all of Finland. Patients underwent repeated measurements of serum cholesterol, noncholesterol sterols, including PS, cholestanol and cholesterol precursors, and liver biochemistry during and 1 month after discontinuation of PN. Healthy matched neonates (n=10) and children (n=22) served as controls., Results: IFALD occurred more frequently among neonates (63%) than children (27%; P<0.05). Ratios of serum PS, including stigmasterol, sitosterol, avenasterol, and campesterol, and total PS were increased among neonates compared with healthy controls and children on PN by 2- to 22- and 2- to 5-fold (P<0.005), respectively. Neonates with IFALD had significantly higher ratios of serum PS and cholestanol compared with neonates without IFALD (P<0.05). Total duration of PN associated with serum cholestanol, stigmasterol, avenasterol, alanine aminotransferase, and aspartate aminotransferase (r=0.472-0.636, P<0.05). Cholestanol and individual serum PS, excluding campesterol, reflected direct bilirubin (r=0.529-0.688, P<0.05). IFALD persisted after discontinuation of PN in 25% of neonates with 4.2- and 2.2-times higher ratios of serum stigmasterol and cholestanol compared with neonates without IFALD (P<0.05)., Conclusions: Frequent occurrence of IFALD among neonates on PN displays an association to duration of PN and markedly increased serum PS, especially stigmasterol, in comparison to healthy neonates and children on PN. Striking accumulation of parenteral PS may contribute to IFALD among neonates.

Published
2012
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30. Effects of long-term parenteral nutrition on serum lipids, plant sterols, cholesterol metabolism, and liver histology in pediatric intestinal failure.

Author

Kurvinen A, Nissinen MJ, Gylling H, Miettinen TA, Lampela H, Koivusalo AI, Rintala RJ, and Pakarinen MP

Subjects
Adolescent, Biomarkers blood, Case-Control Studies, Child, Child, Preschool, Cholestasis pathology, Cholesterol blood, Female, Follow-Up Studies, Humans, Infant, Lipid Metabolism drug effects, Liver enzymology, Liver Failure metabolism, Male, Olive Oil, Plant Oils administration & dosage, Prospective Studies, Cholesterol analogs & derivatives, Intestines pathology, Lipids blood, Liver pathology, Parenteral Nutrition adverse effects, Phytosterols blood, Sitosterols blood
Abstract

Background and Objective: Plant sterols (PS) in parenteral nutrition (PN) may contribute to intestinal failure-associated liver disease. We investigated interrelations between serum PS, liver function and histology, cholesterol metabolism, and characteristics of PN., Patients and Methods: Eleven patients with intestinal failure (mean age 6.3 years) receiving long-term PN were studied prospectively (mean 254 days) and underwent repeated measurements of serum lipids, noncholesterol sterols, including PS, and liver enzymes. PS contents of PN were analyzed. Liver biopsy was obtained in 8 patients. Twenty healthy children (mean age 5.7 years) served as controls., Results: Median percentage of parenteral energy of total daily energy (PN%) was 48%, including 0.9 g · kg(-1) · day(-1) of lipids. Respective amounts of PN sitosterol, campesterol, avenasterol, and stigmasterol were 683, 71, 57, and 45 μg · kg(-1) · day(-1). Median serum concentrations of sitosterol (48 vs 7.5 μmol/L, P < 0.001), avenasterol (2.9 vs 1.9, P < 0.01), stigmasterol (1.9 vs 1.2, P < 0.005), but not that of campesterol (9.8 vs 12, P = 0.22), were increased among patients in relation to controls, and correlated with PN% (r = 0.81-0.88, P < 0.005), but not with PN fat. Serum cholesterol precursors were higher in patients than in controls. Serum liver enzymes remained close to normal range. Glutamyl transferase correlated with serum PS (r = 0.61-0.62, P < 0.05). Liver fibrosis in 5 patients reflected increased serum PS (r = 0.55-0.60, P = 0.16-0.12)., Conclusions: Serum PS moderately increase during olive oil-based PN, and correlate positively with PN% and glutamyl transferase. Despite well-preserved liver function, histology often revealed significant liver damage.

Published
2011
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