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Your search keyword '"Miao, Yi‐Liang"' showing total 18 results
Start Over Author "Miao, Yi‐Liang" Publisher wiley
18 results on '"Miao, Yi‐Liang"'

2. Hierarchical Accumulation of Histone Variant H2A.Z Regulates Transcriptional States and Histone Modifications in Early Mammalian Embryos

Author

Liu, Xin, primary, Zhang, Jingjing, additional, Zhou, Jilong, additional, Bu, Guowei, additional, Zhu, Wei, additional, He, Hainan, additional, Sun, Qiaoran, additional, Yu, Zhisheng, additional, Xiong, Wenjing, additional, Wang, Liyan, additional, Wu, Danya, additional, Dou, Chengli, additional, Yu, Longtao, additional, Zhou, Kai, additional, Wang, Shangke, additional, Fan, Zhengang, additional, Wang, Tingting, additional, Hu, Ruifeng, additional, Hu, Taotao, additional, Zhang, Xia, additional, and Miao, Yi‐Liang, additional

Published
2022
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4. Histone demethylase complexes KDM3A and KDM3B cooperate with OCT4/SOX2 to define a pluripotency gene regulatory network

Author

Zhu, Zhenshuo, Wu, Xiaolong, Li, Qun, Zhang, Juqing, Yu, Shuai, Shen, Qiaoyan, Zhou, Zhe, Pan, Qin, Yue, Wei, Qin, Dezhe, Zhang, Ying, Zhao, Wenxu, Zhang, Rui, Peng, Sha, Li, Na, Zhang, Shiqiang, Lei, Anmin, Miao, Yi-Liang, Liu, Zhonghua, Chen, Xingqi, Wang, Huayan, Liao, Mingzhi, Hua, Jinlian, Zhu, Zhenshuo, Wu, Xiaolong, Li, Qun, Zhang, Juqing, Yu, Shuai, Shen, Qiaoyan, Zhou, Zhe, Pan, Qin, Yue, Wei, Qin, Dezhe, Zhang, Ying, Zhao, Wenxu, Zhang, Rui, Peng, Sha, Li, Na, Zhang, Shiqiang, Lei, Anmin, Miao, Yi-Liang, Liu, Zhonghua, Chen, Xingqi, Wang, Huayan, Liao, Mingzhi, and Hua, Jinlian

Abstract

The pluripotency gene regulatory network of porcine induced pluripotent stem cells(piPSCs), especially in epigenetics, remains elusive. To determine the biological function of epigenetics, we cultured piPSCs in different culture conditions. We found that activation of pluripotent gene- and pluripotency-related pathways requires the erasure of H3K9 methylation modification which was further influenced by mouse embryonic fibroblast (MEF) served feeder. By dissecting the dynamic change of H3K9 methylation during loss of pluripotency, we demonstrated that the H3K9 demethylases KDM3A and KDM3B regulated global H3K9me2/me3 level and that their co-depletion led to the collapse of the pluripotency gene regulatory network. Immunoprecipitation-mass spectrometry (IP-MS) provided evidence that KDM3A and KDM3B formed a complex to perform H3K9 demethylation. The genome-wide regulation analysis revealed that OCT4 (O) and SOX2 (S), the core pluripotency transcriptional activators, maintained the pluripotent state of piPSCs depending on the H3K9 hypomethylation. Further investigation revealed that O/S cooperating with histone demethylase complex containing KDM3A and KDM3B promoted pluripotency genes expression to maintain the pluripotent state of piPSCs. Together, these data offer a unique insight into the epigenetic pluripotency network of piPSCs., Correction in: The FASEB Journal, Volume: 35, Issue: 7, July 2021, Article number: e21736

Published
2021
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5. Histone demethylase complexes KDM3A and KDM3B cooperate with OCT4/SOX2 to define a pluripotency gene regulatory network

Author

Zhu, Zhenshuo, primary, Wu, Xiaolong, additional, Li, Qun, additional, Zhang, Juqing, additional, Yu, Shuai, additional, Shen, Qiaoyan, additional, Zhou, Zhe, additional, Pan, Qin, additional, Yue, Wei, additional, Qin, Dezhe, additional, Zhang, Ying, additional, Zhao, Wenxu, additional, Zhang, Rui, additional, Peng, Sha, additional, Li, Na, additional, Zhang, Shiqiang, additional, Lei, Anmin, additional, Miao, Yi‐Liang, additional, Liu, Zhonghua, additional, Chen, Xingqi, additional, Wang, Huayan, additional, Liao, Mingzhi, additional, and Hua, Jinlian, additional

Published
2021
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11. Characterization of porcine extraembryonic endoderm cells

Author

Shen, Qiao‐Yan, primary, Yu, Shuai, additional, Zhang, Ying, additional, Zhou, Zhe, additional, Zhu, Zhen‐Shuo, additional, Pan, Qin, additional, Lv, Shan, additional, Niu, Hui‐Min, additional, Li, Na, additional, Peng, Sha, additional, Liao, Ming‐zhi, additional, Wang, Hua‐Yan, additional, Lei, An‐Min, additional, Miao, Yi‐Liang, additional, Liu, Zhong‐Hua, additional, and Hua, Jin‐Lian, additional

Published
2019
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