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Research Summary: Replication of practices is an important value‐creating strategy for multi‐unit firms, yet they often struggle to share knowledge internally across locations. Drawing on the replication and learning literatures and using data from a Fortune 100 retail chain that implemented a new restocking practice in 280 stores, I examine whether and how templates influence unit learning when replicating new practices. Stores were divided into districts, each with one randomly chosen template and 6–10 replicating stores. A replicating store's prior performance relative to that of its template influences the extent to which the store learns from the template versus from its own experience. These findings suggest that replication involves simultaneously and dynamically learning from both transferred knowledge and knowledge gained from experience. Managerial Summary: Transferring valuable practices within the firm is an important yet difficult task for many firm types, especially multi‐unit firms. One way that firms choose to transfer practices is through the use of templates—working examples of the new practice that act as models. Using data from a Fortune 100 retail chain, I show that the use of templates affects the way in which units learn to implement the practice. Because managers face tradeoffs when devoting attention to implementing the new practice, they must balance learning from the template with incorporating their own local experience with the new practice. Overall, my results suggest that choosing many templates is less important than choosing a few templates with superior performance for firms whose units or contexts are similar.

Funder: Unitaid, Repurposing approved drugs may rapidly establish effective interventions during a public health crisis. This has yielded immunomodulatory treatments for severe coronavirus disease 2019 (COVID-19), but repurposed antivirals have not been successful to date because of redundancy of the target in vivo or suboptimal exposures at studied doses. Nitazoxanide is a US Food and Drug Administration (FDA) approved antiparasitic medicine, that physiologically-based pharmacokinetic (PBPK) modeling has indicated may provide antiviral concentrations across the dosing interval, when repurposed at higher than approved doses. Within the AGILE trial platform (NCT04746183) an open label, adaptive, phase I trial in healthy adult participants was undertaken with high-dose nitazoxanide. Participants received 1,500 mg nitazoxanide orally twice-daily with food for 7 days. Primary outcomes were safety, tolerability, optimum dose, and schedule. Intensive pharmacokinetic (PK) sampling was undertaken day 1 and 5 with minimum concentration (Cmin ) sampling on days 3 and 7. Fourteen healthy participants were enrolled between February 18 and May 11, 2021. All 14 doses were completed by 10 of 14 participants. Nitazoxanide was safe and with no significant adverse events. Moderate gastrointestinal disturbance (loose stools or diarrhea) occurred in 8 participants (57.1%), with urine and sclera discoloration in 12 (85.7%) and 9 (64.3%) participants, respectively, without clinically significant bilirubin elevation. This was self-limiting and resolved upon drug discontinuation. PBPK predictions were confirmed on day 1 but with underprediction at day 5. Median Cmin was above the in vitro target concentration on the first dose and maintained throughout. Nitazoxanide administered at 1,500 mg b.i.d. with food was safe with acceptable tolerability a phase Ib/IIa study is now being initiated in patients with COVID-19.

We report the first well-documented case of a South Island site where Mayor Island obsidian is not the dominant source represented. At the Pūrākaunui site (I44/21), located in coastal Otago, we find that most obsidians come from the Taupo Volcanic Zone, including sources near Lake Taupo (52%) and Rotorua (27.7 %). A small proportion of the collection comes from Mayor Island (10.8%) and the Coromandel Peninsula (9.5%) obsidian. The results point to early effects of regionalisation in source exploitation on the South Island.