1,000 results on '"McCluskey A"'
Search Results
2. Assessing habitat connectivity of rare species to inform urban conservation planning
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Eric M. McCluskey, Faith C. Kuzma, Helen D. Enander, Ashley Cole‐Wick, Michela Coury, David L. Cuthrell, Caley Johnson, Marianne Kelso, Yu Man Lee, Diana Methner, Logan Rowe, Alyssa Swinehart, and Jennifer A. Moore
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bees ,Circuitscape ,conservation ,landscape ecology ,reptiles ,urban ecology ,Ecology ,QH540-549.5 - Abstract
Abstract Urbanization is commonly associated with biodiversity loss and habitat fragmentation. However, urban environments often have greenspaces that can support wildlife populations, including rare species. The challenge for conservation planners working in these systems is identifying priority habitats and corridors for protection before they are lost. In a rapidly changing urban environment, this requires prompt decisions informed by accurate spatial information. Here, we combine several approaches to map habitat and assess connectivity for a diverse set of rare species in seven urban study areas across southern Michigan, USA. We incorporated multiple connectivity tools for a comprehensive appraisal of species‐habitat patterns across these urban landscapes. We observed distinct differences in connectivity by taxonomic group and site. The three turtle species (Blanding's, Eastern Box, and Spotted) consistently had more habitat predicted to be suitable per site than other evaluated species. This is promising for this at‐risk taxonomic group and allows conservation efforts to focus on mitigating threats such as road mortality. Grassland and prairie‐associated species (American Bumble Bee, Black and Gold Bumble Bee, and Henslow's Sparrow) had the least amount of habitat on a site‐by‐site basis. Kalamazoo and the northern Detroit sites had the highest levels of multi‐species connectivity across the entire study area based on the least cost paths. These connectivity results have direct applications in urban planning. Kalamazoo, one of the focal urban regions, has implemented a Natural Features Protection (NFP) plan to bolster natural area protections within the city. We compared our connectivity results to the NFP area and show where this plan will have an immediate positive impact and additional areas for potential consideration in future expansions of the protection network. Our results show that conservation opportunities exist within each of the assessed urban areas for maintaining rare species, a key benefit of this multi‐species and multi‐site approach.
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- 2024
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3. Whither Goeth agricultural economics?
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Mittelhammer, Ron C., primary, Goodwin, Barry K., additional, McCluskey, Jill J., additional, and Zilberman, David, additional
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- 2024
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4. Potent Immunomodulators Developed from an Unstable Bacterial Metabolite of Vitamin B2 Biosynthesis
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Mak, Jeffrey Y. W., primary, Rivero, Ryan J. D., additional, Hoang, Huy N., additional, Lim, Xin Yi, additional, Deng, Jieru, additional, McWilliam, Hamish E. G., additional, Villadangos, Jose A., additional, McCluskey, James, additional, Corbett, Alexandra J., additional, and Fairlie, David P, additional
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- 2024
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5. Genetic variation for endosperm carbohydrates and total soluble solids in shrunken2, sugary1, waxy1, and wild‐type near‐isogenic corn lines across three harvest dates
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Wilson, Alexa R., primary, Fiore, Isabella G., additional, McCluskey, Cathleen, additional, and Tracy, William F., additional
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- 2024
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6. Product differentiation in the fruit industry: Lessons from trademarked apples
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Amin, Modhurima Dey, primary, Badruddoza, Syed, additional, McCluskey, Jill J., additional, and Astill, Gregory, additional
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- 2024
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7. Landscape dynamics of a vector‐borne disease in the western US: How vector–habitat relationships inform disease hotspots
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Emile Elias, Heather M. Savoy, Dustin A. Swanson, Lee W. Cohnstaedt, Debra P. C. Peters, Justin D. Derner, Angela Pelzel‐McCluskey, Barbara Drolet, and Luis Rodriguez
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livestock ,nidus ,patch analysis ,vector‐borne disease ,vesicular stomatitis virus ,Ecology ,QH540-549.5 - Abstract
Abstract Vesicular stomatitis (VS) is a vector‐borne viral disease that causes lesions in livestock, premises, county and state quarantines, and important economic losses. We investigated vector–habitat characteristics for vectors associated with VS in regions of recurrent disease within the western United States (US) that consistently lead to the environment where vector, host, and pathogen populations intersect to enable pathogen transmission. We analyzed the habitats of previously identified insect vectors, including black flies (BFs) (Simulium vittatum complex), biting midges (BMs) (Culicoides variipennis complex, which includes Culicoides sonorensis), and sand flies (SFs) (Lutzomyia shannoni) in six regions of interest (ROIs) containing hotspots of VS ranging from Texas (TX) to Wyoming. This analysis broadened the understanding of (1) how regions of reoccurring VS differ from the broader western US, (2) how geographically separated regions and hotspots are similar across time, and (3) how vector–environment habitat a priori knowledge relates to observed hotspots. Analysis of watershed factors (livestock densities, land‐cover proportions, stream and lake densities, and irrigation methods) indicated a complex system separating areas with high, recurring VS from the broader western US. Although no single characteristic separated the six ROIs from other areas, we found two distinct emerging groups (northern ROI and TX). Hotspots, estimated from monthly VS concentrations, evolved northward throughout the year and most hotspots were closer to flowing water and agricultural land than the broader ROI. All ROIs contained environmental conditions suitable for multiple vectors at some point in the year, but BFs had the highest suitability scores, whereas BM scores were lower and varied annually with higher suitability in summer. SFs had the lowest suitability score in all ROIs, consistent with their low likelihood of being vectors. BM habitat patches were often orders of magnitude smaller than BF patches, and hotspot patches reinforce the likelihood that BF may be the most critical vector in northern ROI, whereas both BM and BF have similar likelihood in southern ROI. Given limited existing vector data, this analysis provides an alternate pathway for using habitat information to associate likely vectors responsible for transmission. Results could support early warning and mitigation efforts to reduce the incidence of VS.
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- 2022
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8. Assessing habitat connectivity of rare species to inform urban conservation planning
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McCluskey, Eric M., primary, Kuzma, Faith C., additional, Enander, Helen D., additional, Cole‐Wick, Ashley, additional, Coury, Michela, additional, Cuthrell, David L., additional, Johnson, Caley, additional, Kelso, Marianne, additional, Lee, Yu Man, additional, Methner, Diana, additional, Rowe, Logan, additional, Swinehart, Alyssa, additional, and Moore, Jennifer A., additional
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- 2024
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9. Intact landscape promotes gene flow and low genetic structuring in the threatened Eastern Massasauga Rattlesnake
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Nathan Kudla, Eric M. McCluskey, Vijay Lulla, Ralph Grundel, and Jennifer A. Moore
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dispersal ,fragmentation ,Island ,reptile ,Snake ,spatial genetics ,Ecology ,QH540-549.5 - Abstract
Abstract Genetic structuring of wild populations is dependent on environmental, ecological, and life‐history factors. The specific role environmental context plays in genetic structuring is important to conservation practitioners working with rare species across areas with varying degrees of fragmentation. We investigated fine‐scale genetic patterns of the federally threatened Eastern Massasauga Rattlesnake (Sistrurus catenatus) on a relatively undisturbed island in northern Michigan, USA. This species often persists in habitat islands throughout much of its distribution due to extensive habitat loss and distance‐limited dispersal. We found that the entire island population exhibited weak genetic structuring with spatially segregated variation in effective migration and genetic diversity. The low level of genetic structuring contrasts with previous studies in the southern part of the species’ range at comparable fine scales (~7 km), in which much higher levels of structuring were documented. The island population's genetic structuring more closely resembles that of populations from Ontario, Canada, that occupy similarly intact habitats. Intrapopulation variation in effective migration and genetic diversity likely corresponds to the presence of large inland lakes acting as barriers and more human activity in the southern portion of the island. The observed genetic structuring in this intact landscape suggests that the Eastern Massasauga is capable of sufficient interpatch movements to reduce overall genetic structuring and colonize new habitats. Landscape mosaics with multiple habitat patches and localized barriers (e.g., large water bodies or roads) will promote gene flow and natural colonization for this declining species.
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- 2021
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10. RT‐CGM in conjunction with CSII vs MDI in optimizing glycaemic control in T1DM: Systemic review and meta‐analysis
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Jimmy William, Jane McCluskey, and Nigel Gleeson
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continuous glucose monitoring ,continuous subcutaneous insulin infusions ,glycaemic control ,multiple daily injections ,type 1 diabetes ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Abstract Introduction To determine the impact of real‐time continuous glucose monitoring (RT‐CGM) in conjunction with ‘Open loop’‐ continuous subcutaneous insulin infusion (CSII) as compared to conventional multiple daily injections (MDI) in type 1 diabetes. Methods We explored the COCHRANE database, MEDLINE, WEB OF SCIENCE, GOOGLE SCHOLARS, PUBMED, EMBASE, and cited literature in articles retrieved (2010–2021) for all randomized controlled trials and real‐world trials of more than 6 months duration in patients with type 1 diabetes that compared RT‐CGM+CSII vs RT‐ CGM+MDI. A total of 1645 publications have been identified; however, only 3 trials fulfilled our inclusion criteria with a total number of 150 patients (72 patients using RT‐CGM+CSII and 78 patients on RT‐CGM+MDI). A Systematic Review and Meta‐analysis were carried out. Results No statistically significant reduction in HbA1c was found on comparing RT‐CGM+CSII vs RT‐ CGM + MDI, with p‐value = .75. Likewise, impact on TIR, weight and insulin usage was found to be statistically insignificant with p‐value of 0.15, 0.75 and 0.20 respectively. There was an overall homogeneity between the 3 trials in respect to all previous variables with I2 being 0%. Conclusions Real‐time continuous glucose monitors in conjunction with MDI open‐loop CSII had a similar impact on HbA1c, weight, insulin usage and TIR. In addition, RT‐CGM when combined with CSII was associated with higher costs and reduced quality of life, hence RT‐ CGM+MDI can be considered as a cheaper, safer yet equivalent substitute. Review Registration This study was registered in PROSPERO (International prospective register of systematic reviews). Registration Name: RT‐CGM in conjunction with CSII vs MDI in optimizing glycaemic control in T1DM: a systematic review. Registration No: CRD42021255333. Accessible at: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021255333. Amendments: Few amendments to the above‐mentioned registration were made: (1) Title (Meta‐analysis was added). (2) Prof. Gleeson was added as an author. (3) Real‐world trials were included. (4) Outcomes required in studies as per our inclusion criteria amended to include at least 1 outcome. (5) Bias risk was assessed by the CASP tool.
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- 2022
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11. Evolution and expansion dynamics of a vector‐borne virus: 2004–2006 vesicular stomatitis outbreak in the western USA
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Rachel Palinski, Steven J. Pauszek, John M. Humphreys, Debra P.C. Peters, D. Scott McVey, Angela M. Pelzel‐McCluskey, Justin D. Derner, N. Dylan Burruss, Jonathan Arzt, and Luis L. Rodriguez
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geospatial analyses ,phylogeny ,phylogeography ,vesicular stomatitis virus ,Ecology ,QH540-549.5 - Abstract
Abstract Vesicular stomatitis (VS) is an arthropod‐borne viral disease that negatively impacts domestic livestock and wildlife hosts, and economically impacts both private animal owners and the commercial livestock industry. Previous phylogenetic studies, based on partial P gene sequences, suggested that outbreak cycles of the virus (VSV) exhibit a two‐phase dynamic (i.e., incursion and expansion). A single viral lineage from endemic areas of Mexico introduced into the southern United States during an incursion year (2004), can overwinter, and then expand throughout the western United States during the subsequent spring and summer seasons (2005). Our objective was to build on this past research using full‐length viral genomic sequences from Mexico and the United States from the same outbreak, and a large suite of geospatial data to identify the environmental factors that influence VSV evolution in the United States and potentially drive the incursion–expansion dynamics. Our phylogeographic analysis confirmed that a single VS New Jersey virus (VSNJV) lineage initiated the 2004 incursion year outbreak was subject to decreasing genetic divergence during the 2004–2006 outbreak cycle, and likely overwintered between the 2004–2006 outbreak seasons. However, rather than a simple geographic relationship, viral genetic sublineages or patristic groups identified as part of our study, were found to be associated with seasonally varying evaporative demand, soil moisture, and precipitation. Our results suggest a functional role for these environmental factors in shaping the evolution and ecology of VSNJV. We speculate a nexus to insect‐vector switching and possible adaptation to local environmental conditions to help explain the observed incursion–expansion dynamic in the United States in the 2004–2006 outbreak. Our approach of linking the phylogeography of a virus with the ecology of insect vectors can be applied to other vector‐borne diseases.
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- 2021
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12. Long term outcome and prognostic indicators in Posner Schlossman syndrome
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Joseph, Danica M., primary, Lim, Lyndell L., additional, Samalia, Priya D., additional, Wells, Jane M., additional, McCluskey, Peter J., additional, Paul, Eldho, additional, and Hall, Anthony J., additional
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- 2023
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13. Expansion of a Synthesized Library of N‐Benzyl Sulfonamides Derived from an Indole Core to Target Pancreatic Cancer
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Hopkins, Megan D., primary, Costello, Ian J., additional, Brandeburg, Zachary C., additional, Slay, Emily L., additional, Zanders, Levi A., additional, Dunn, Caroline E., additional, Derewonko, Carina A., additional, Davitt, Colin L., additional, Reeder, Madison A., additional, Prichard, Kate, additional, Chiew, Beatrice, additional, McCluskey, Adam, additional, Sheaff, Robert J., additional, and Lamar, Angus A., additional
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- 2023
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14. The allopurinol metabolite, oxypurinol, drives oligoclonal expansions of drug‐reactive T cells in resolved hypersensitivity cases and drug‐naïve healthy donors
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Mifsud, Nicole A., primary, Illing, Patricia T., additional, Ho, Rebecca, additional, Tuomisto, Johanna E., additional, Fettke, Heidi, additional, Mullan, Kerry A., additional, McCluskey, James, additional, Rossjohn, Jamie, additional, Vivian, Julian, additional, Reantragoon, Rangsima, additional, and Purcell, Anthony W., additional
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- 2023
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15. Cloud‐Nucleating Particles Over the Southern Ocean in a Changing Climate
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Cynthia H. Twohy, Paul J. DeMott, Lynn M. Russell, Darin W. Toohey, Bryan Rainwater, Roy Geiss, Kevin J. Sanchez, Savannah Lewis, Gregory C. Roberts, Ruhi S. Humphries, Christina S. McCluskey, Kathryn A. Moore, Paul W. Selleck, Melita D. Keywood, Jason P. Ward, and Ian M. McRobert
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aerosol particles ,Antarctica ,climate change ,clouds ,phytoplankton ,Southern Ocean ,Environmental sciences ,GE1-350 ,Ecology ,QH540-549.5 - Abstract
Abstract Stratocumulus clouds over the Southern Ocean have fewer droplets and are more likely to exist in the predominately supercooled phase than clouds at similar temperatures over northern oceans. One likely reason is that this region has few continental and anthropogenic sources of cloud‐nucleating particles that can form droplets and ice. In this work, we present an overview of aerosol particle types over the Southern Ocean, including new measurements made below, in and above clouds in this region. These measurements and others indicate that biogenic sulfur‐based particles >0.1 μm diameter contribute the majority of cloud condensation nuclei number concentrations in summer. Ice nucleating particles tend to have more organic components, likely from sea‐spray. Both types of cloud nucleating particles may increase in a warming climate likely to have less sea ice, more phytoplankton activity, and stronger winds over the Southern Ocean near Antarctica. Taken together, clouds over the Southern Ocean may become more reflective and partially counter the region's expected albedo decrease due to diminishing sea ice. However, detailed modeling studies are needed to test this hypothesis due to the complexity of ocean‐cloud‐climate feedbacks in the region.
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- 2021
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16. Ureteroarterial Fistula: A Diagnosis Which Is Not Always Black and White
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A. Haffar, T. Trump, A. A. Elbakry, K. McCluskey, M. W. Salkini, and A. Luchey
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Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Ureteroiliac artery fistulas are a rare, life-threatening condition that requires a high index of suspicion for prompt diagnosis. Presurgical diagnosis is challenging as this condition can lie hidden despite advanced imaging modalities. We present two cases of patients presenting with gross hematuria and exsanguination in the setting of a ureteroiliac artery fistula. These cases highlight the difficulties in timely diagnosis and treatment in a multidisciplinary team.
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- 2021
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17. A metal dependent conformational change provides a structural basis for the inhibition of CTP synthase by gemcitabine‐5'‐triphosphate
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McLeod, Matthew J., primary, Tran, Norman, additional, McCluskey, Gregory D., additional, Gillis, Tom D., additional, Bearne, Stephen L., additional, and Holyoak, Todd, additional
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- 2023
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18. PeterHoward, NicholasTerpstra, and RiccardoSaccenti, eds.: Renaissance Religions: Modes and Meanings in History. Europa Sacra, Volume 26. Turnhout: Brepols, 2021; pp. 400
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Karen McCluskey
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History ,Religious studies - Published
- 2023
19. Calibrating states' emissions reduction due diligence obligations with reference to the right to life
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Susan McCluskey
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Geography, Planning and Development ,Management, Monitoring, Policy and Law ,Law - Published
- 2022
20. A metal‐dependent conformational change provides a structural basis for the inhibition of CTP synthase by gemcitabine‐5′‐triphosphate
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Matthew J. McLeod, Norman Tran, Gregory D. McCluskey, Tom D. Gillis, Stephen L. Bearne, and Todd Holyoak
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Molecular Biology ,Biochemistry - Published
- 2023
21. The balance of interleukin‐12 and interleukin‐23 determines the bias of MAIT1versusMAIT17 responses during bacterial infection
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Huimeng Wang, Adam G Nelson, Bingjie Wang, Zhe Zhao, Xin Yi Lim, Mai Shi, Lucy J Meehan, Xiaoxiao Jia, Katherine Kedzierska, Bronwyn S Meehan, Sidonia BG Eckle, Michael NT Souter, Troi J Pediongco, Jeffrey YW Mak, David P Fairlie, James McCluskey, Zhongfang Wang, Alexandra J Corbett, and Zhenjun Chen
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Mice ,Histocompatibility Antigens Class I ,Immunology ,Animals ,Cytokines ,Immunology and Allergy ,Bacterial Infections ,Cell Biology ,Interleukin-12 ,Interleukin-23 ,Mucosal-Associated Invariant T Cells - Abstract
Mucosal-associated invariant T (MAIT) cells are a major subset of innate-like T cells mediating protection against bacterial infection through recognition of microbial metabolites derived from riboflavin biosynthesis. Mouse MAIT cells egress from the thymus as two main subpopulations with distinct functions, namely, T-bet-expressing MAIT1 and RORγt-expressing MAIT17 cells. Previously, we reported that inducible T-cell costimulator and interleukin (IL)-23 provide essential signals for optimal MHC-related protein 1 (MR1)-dependent activation and expansion of MAIT17 cells in vivo. Here, in a model of tularemia, in which MAIT1 responses predominate, we demonstrate that IL-12 and IL-23 promote MAIT1 cell expansion during acute infection and that IL-12 is indispensable for MAIT1 phenotype and function. Furthermore, we showed that the bias toward MAIT1 or MAIT17 responses we observed during different bacterial infections was determined and modulated by the balance between IL-12 and IL-23 and that these responses could be recapitulated by cytokine coadministration with antigen. Our results indicate a potential for tailored immunotherapeutic interventions via MAIT cell manipulation.
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- 2022
22. Implementation of a standardized voiding protocol after minimally invasive surgery: A quality improvement initiative
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Soyoun Rachel Kim, Stéphane Laframboise, Gregg Nelson, Stuart A. McCluskey, Lisa Avery, Nastasia Kujbid, Aysha Zia, Marcus Q. Bernardini, Sarah E. Ferguson, Taymaa May, Liat Hogen, Paulina Cybulska, and Geneviève Bouchard‐Fortier
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Postoperative Complications ,Urinary Tract Infections ,Humans ,Urination ,Minimally Invasive Surgical Procedures ,Obstetrics and Gynecology ,Female ,General Medicine ,Urinary Retention ,Urinary Catheterization ,Quality Improvement - Abstract
To assess the effects of the implementation of a standardized voiding protocol in patients undergoing minimally invasive hysterectomy at a single cancer center in terms of the urinary tract infection (UTI) rate, time to first void, and overnight stays secondary to urinary retention.We enrolled 102 consecutive patients undergoing minimally invasive hysterectomy at a single cancer center during a 12-month period. A pre-intervention cohort of 100 consecutive patients was identified for comparison. A multidisciplinary team developed and implemented a standardized voiding protocol using quality improvement methodology. We compared the demographics, time to first void, rate of urinary retention, and UTI rates between the pre- and post-intervention cohorts.Our intervention led to a significant reduction in the time to first void (289 min vs. 566 min; P 0.001), rate of urinary retention (2% vs. 10%; P = 0.015), and postoperative UTI (4% vs. 8%; P = 0.249). There was a similar rate of patients going home with a Foley catheter (9% vs. 11%; P = 0.850).Implementation of a standardized voiding protocol was associated with a reduction in rate of UTI, time to first void, and overnight stays secondary to urinary retention.
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- 2022
23. Promotional achievement of economists: Does being agricultural or female matter?
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Zarrina Juraqulova, Jill J. McCluskey, and Ron C. Mittelhammer
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Economics and Econometrics ,Development - Published
- 2022
24. Optic nerve sheath fenestration for treating papilloedema in the era of cerebral venous sinus stenting
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McCluskey, Peter J., primary, Lam, Danny, additional, Ang, Timothy, additional, Todd, Michael J., additional, and Halmágyi, Gábor M., additional
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- 2023
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25. Tuning Local Conductance to Enable Demonstrator Ferroelectric Domain Wall Diodes and Logic Gates
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Suna, Ahmet, primary, McCluskey, Conor Joseph, additional, Maguire, Jesi Rit, additional, Holsgrove, Kristina Mary, additional, Kumar, Amit, additional, McQuaid, Raymond Gerard Peter, additional, and Gregg, John Marty, additional
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- 2023
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26. PeterHoward, NicholasTerpstra, and RiccardoSaccenti, eds.: Renaissance Religions: Modes and Meanings in History. Europa Sacra, Volume 26. Turnhout: Brepols, 2021; pp. 400.
- Author
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McCluskey, Karen, primary
- Published
- 2023
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27. A clean and discreet service: The role of corruption and secrecy in profit shifting by multinational firms
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Binhadab, Nouf, primary, Gillanders, Robert, additional, and McCluskey, Thomas, additional
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- 2023
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28. Antigiardial Activity of Novel Guanidine Compounds
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Stevens, Andrew J., primary, Abraham, Rebecca, additional, Young, Kelly A., additional, Russell, Cecilia C., additional, McCluskey, Siobhann N., additional, Baker, Jennifer R., additional, Rusdi, Bertha, additional, Page, Stephen W., additional, O'Handley, Ryan, additional, O'Dea, Mark, additional, Abraham, Sam, additional, and McCluskey, Adam, additional
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- 2022
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29. Optic nerve sheath fenestration for treating papilloedema in the era of cerebral venous sinus stenting
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Peter J. McCluskey, Danny Lam, Timothy Ang, Michael J. Todd, and Gábor M. Halmágyi
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Ophthalmology - Published
- 2023
30. Tuning Local Conductance to Enable Demonstrator Ferroelectric Domain Wall Diodes and Logic Gates
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Ahmet Suna, Conor Joseph McCluskey, Jesi Rit Maguire, Kristina Mary Holsgrove, Amit Kumar, Raymond Gerard Peter McQuaid, and John Marty Gregg
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Fundamentally, lithium niobate is an extremely good electrical insulator. However, this can change dramatically when 180o domain walls are present, as they are often found to be strongly conducting. Absolute conductivities depend on the inclination angles of the walls with respect to the [001] polarisation axis and so, if these inclination angles can be altered, then electrical conduction can be tuned, or even toggled on and off. In ~500nm thick z-cut ion-sliced thin films, localised wall angle variations can be controlled by both the sense and magnitude of applied electrical bias. We show that this results in a diode-like charge transport response which is effective for half-wave rectification at modest frequencies. Importantly, we experimentally demonstrate that such domain wall diodes can be used to construct “AND” and inclusive “OR” logic gates, where “0” and “1” output states are clearly distinguishable. An extrapolation of experimental results for the operation of these domain wall diodes in more complex arrangements was done using realistic modelling and, although non-ideal, output states can still be distinguished even in two-level cascade logic. Our insights hence show that simple logic gates can be realised by localised manipulation of domain wall conductivity, resulting from changes in the magnitude of the polarisation discontinuity supported at the wall (changing the wall inclination angle with respect to the polar axis). Our insights complement those published very recently by Jie Sun et al. (Adv. Funct. Mater. 2207418 (2022)) where NOT, NOR and NAND gates were realised by moving conducting domain walls to make or break electrical contacts.
- Published
- 2023
31. A clean and discreet service: the role of corruption and secrecy in profit shifting by multinational firms
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Nouf Binhadab, Robert Gillanders, and Thomas McCluskey
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History ,Polymers and Plastics ,taxation ,profit shifting ,corruption ,secrecy ,multinational corporations (MNCs) and enterprises (MNEs) ,Geography, Planning and Development ,Business ethics ,Development ,Business and International Management ,Industrial and Manufacturing Engineering - Abstract
We investigate the importance of corruption in shaping the profit-shifting behaviour of multinational firms. Using country-level panel data, we find a significant and positive correlation between corruption and profit shifting. Our findings are consistent with several theoretical arguments predicting that corruption may both facilitate and provide an incentive to firm behaviour that deprives poorer countries of much needed tax revenues. Our findings are robust across a number of corruption and profit shifting measures, as well as to an instrumental variable approach that controls for the potential endogeneity between profit shifting and corruption. Our findings also indicate a negative and significant relationship between financial secrecy and outward profit shifting. We conclude that corruption and financial secrecy undermine global efforts to tackle profit shifting by multinational firms.
- Published
- 2023
32. Nutrition access, income, and race
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Jill J. McCluskey
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Economics and Econometrics ,Agricultural and Biological Sciences (miscellaneous) - Published
- 2022
33. Differential antigenic requirements by diverse MR1‐restricted T cells
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Rebecca Seneviratna, Samuel J Redmond, Hamish EG McWilliam, Rangsima Reantragoon, Jose A Villadangos, James McCluskey, Dale I Godfrey, and Nicholas A Gherardin
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Minor Histocompatibility Antigens ,Receptors, Antigen, T-Cell, alpha-beta ,Histocompatibility Antigens Class I ,Immunology ,Receptors, Antigen, T-Cell ,Immunology and Allergy ,Cell Biology ,Mucosal-Associated Invariant T Cells - Abstract
MHC-related protein 1 (MR1) presents microbial riboflavin metabolites to mucosal-associated invariant T (MAIT) cells for surveillance of microbial presence. MAIT cells express a semi-invariant T-cell receptor (TCR), which recognizes MR1-antigen complexes in a pattern-recognition-like manner. Recently, diverse populations of MR1-restricted T cells have been described that exhibit broad recognition of tumor cells and appear to recognize MR1 in association with tumor-derived self-antigens, though the identity of these antigens remains unclear. Here, we have used TCR gene transfer and engineered MR1-expressing antigen-presenting cells to probe the MR1 restriction and antigen reactivity of a range of MR1-restricted TCRs, including model tumor-reactive TCRs. We confirm MR1 reactivity by these TCRs, show differential dependence on lysine at position 43 of MR1 (K43) and demonstrate competitive inhibition by the MR1 ligand 6-formylpterin. TCR-expressing reporter lines, however, failed to recapitulate the robust tumor specificity previously reported, suggesting an importance of accessory molecules for MR1-dependent tumor reactivity. Finally, MR1-mutant cell lines showed that distinct residues on the α1/α2 helices were required for TCR binding by different MR1-restricted T cells and suggested central but distinct docking modes by the broad family of MR1-restricted αβ TCRs. Collectively, these data are consistent with recognition of distinct antigens by diverse MR1-restricted T cells.
- Published
- 2022
34. Foaming up a milk empire? Projected effects of a dairy merger
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Syed Badruddoza, Jill J. McCluskey, and Andrea C. Carlson
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Economics and Econometrics ,Development - Published
- 2022
35. Gram‐Positive and Gram‐Negative Antibiotic Activity of Asymmetric and Monomeric Robenidine Analogues
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Hongfei Pi, Abiodun D. Ogunniyi, Cecilia C. Russell, Jennifer R. Baker, Adam McCluskey, Manouchehr Khazandi, Andrew Stevens, Siobhann N. McCluskey, Darren J. Trott, Kelly A. Young, Stephen W. Page, Russell, Cecilia C, Stevens, Andrew, Pi, Hongfei, Khazandi, Manouchehr, Ogunniyi, Abiodun D, Young, Kelly A, Baker, Jennifer R, McCluskey, Siobhann N, Page, Stephen W, Trott, Darren J, and McCluskey, Adam
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Methicillin-Resistant Staphylococcus aureus ,0301 basic medicine ,Robenidine ,VRE ,medicine.drug_class ,Stereochemistry ,030106 microbiology ,Antibiotics ,Imine ,Chemistry, Medicinal ,Microbial Sensitivity Tests ,MRSA ,Gram-Positive Bacteria ,Hydrazide ,Biochemistry ,antibiotics ,robenidine ,03 medical and health sciences ,chemistry.chemical_compound ,Gram-Negative Bacteria ,Drug Discovery ,Escherichia coli ,medicine ,Humans ,Moiety ,Potency ,Pharmacology & Pharmacy ,General Pharmacology, Toxicology and Pharmaceutics ,Pharmacology ,Indole test ,drug repurposing ,Organic Chemistry ,Bacterial Infections ,Anti-Bacterial Agents ,3. Good health ,030104 developmental biology ,Monomer ,chemistry ,Drug Design ,Pseudomonas aeruginosa ,Molecular Medicine - Abstract
Desymmetrisation of robenidine (1: N ',2-bis((E)-4-chlorobenzylidene)hydrazine-1-carboximidhydrazide) and the introduction of imine alkyl substituents gave good antibiotic activity. Of note was the increased potency of two analogues against vancomycin-resistant Enterococci (VRE), one of which returned a MIC of 0.5 mu g mL(-1). Five analogues were found to be equipotent or more potent than the lead 1. Introduction of an indole moiety resulted in the most active robenidine analogue against methicillin-resistant S. aureus (MRSA), with a MIC of 1.0 mu g mL(-1). Imine C=NH isosteres (C=O/C=S) were inactive. Monomeric analogues were 16-64 mu g mL(-1) active against MRSA and VRE. An analogue that lacks the terminal hydrazide NH moiety showed modest Gram-negative activity at 64 mu g mL(-1). A 4-tert-butyl analogue was shown to be active against both Gram-positive and -negative strains at 16-64 mu g mL(-1). In general, additional modifications with aromatic moieties was poorly tolerated, except with concomitant introduction of an imine C-alkyl group. The activity of these analogues against MRSA and VRE ranged from 8 mu g mL(-1) to inactive (MIC>128 mu g mL(-1)) with the naphthyl and indole analogues. Gram-negative activity was most promising with two compounds at 16 mu g mL(-1) against E. coli. Against P. aeruginosa, the highest activity observed was with MIC values of 32 mu g mL(-1) with another two analogues. Combined, these findings support the further development of the (E)-2-benzylidenehydrazine-1-carboximidamide scaffold as a promising scaffold for the development of antibiotics against Gram-positive and Gram-negative strains. Refereed/Peer-reviewed
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- 2018
36. Risdiplam for the treatment of adults with spinal muscular atrophy: Experience of the Northern Ireland neuromuscular service
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McCluskey, Gavin, primary, Lamb, Siobhan, additional, Mason, Sarah, additional, NicFhirleinn, Grainne, additional, Douglas, Isobel, additional, Tirupathi, Sandya, additional, Morrison, Karen E., additional, and McConville, John, additional
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- 2022
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37. Prodrugs of the Archetypal Dynamin Inhibitor Bis‐T‐22
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Odell, Luke R., primary, Robertson, Mark J, additional, Young, Kelly A, additional, McGeachie, Andrew B., additional, Quan, Annie, additional, Robinson, Phillip J., additional, and McCluskey, Adam, additional
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- 2022
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38. Landscape dynamics of a vector‐borne disease in the western US: How vector–habitat relationships inform disease hotspots
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Elias, Emile, primary, Savoy, Heather M., additional, Swanson, Dustin A., additional, Cohnstaedt, Lee W., additional, Peters, Debra P. C., additional, Derner, Justin D., additional, Pelzel‐McCluskey, Angela, additional, Drolet, Barbara, additional, and Rodriguez, Luis, additional
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- 2022
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39. Polarization Topology at the Nominally Charged Domain Walls in Uniaxial Ferroelectrics
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Tikhonov, Yurii, primary, Maguire, Jesi R., additional, McCluskey, Conor J., additional, McConville, James P. V., additional, Kumar, Amit, additional, Lu, Haidong, additional, Meier, Dennis, additional, Razumnaya, Anna, additional, Gregg, John Martin, additional, Gruverman, Alexei, additional, Vinokur, Valerii M., additional, and Luk'yanchuk, Igor, additional
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- 2022
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40. Epidemiology and survival trends of motor neurone disease in Northern Ireland from 2015 to 2019
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Karen E. Morrison, Colette Donaghy, Stephanie Duguez, Gavin McCluskey, Stephen Haffey, and William Duddy
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Male ,Pediatrics ,medicine.medical_specialty ,education.field_of_study ,business.industry ,Proportional hazards model ,Incidence ,Incidence (epidemiology) ,Amyotrophic Lateral Sclerosis ,Population ,Prevalence ,Northern Ireland ,Confidence interval ,Neurology ,Epidemiology ,medicine ,Humans ,Neurology (clinical) ,Motor Neuron Disease ,Family history ,Age of onset ,education ,business ,Aged - Abstract
BACKGROUND AND PURPOSE This study evaluates the incidence, prevalence and survival trends of motor neurone disease (MND) in Northern Ireland from 2015 to 2019. METHODS A capture-recapture analysis was performed using five independent data sources. Incidence and prevalence rates were standardized to the European Standard Population. Survival outcomes were analysed using Kaplan-Meier curves and Cox regression analysis. RESULTS Amongst 254 total cases of MND, capture-recapture analysis estimated three missing cases (case ascertainment 98.8%). Age standardized incidence of captured cases was 3.12 per 100,000 (2.73, 3.50) and standardized prevalence ranged from 9.45 to 6.49 per 100,000 from 2015 to 2019. Standardized incidence and prevalence rates in 2006 were 1.4 and 3.3 per 100,000 respectively. Of identified cases, 133 (52.4%) were male; 94.5% had amyotrophic lateral sclerosis; median age of onset was 67 years; median time to diagnosis was 12 months (95% confidence interval 11.2, 12.8); survival from diagnosis was 12 months (95% confidence interval 10.6, 15.4); 25 (9.8%) reported a family history of MND or frontotemporal dementia; and a known MND-associated genetic mutation was identified in 7.9% of total cases, of which the most common was C9orf72 (5.7% of all patients). Factors associated with improved survival were younger age at onset, longer time to diagnosis, attendance at regional MND clinic, and initial neurology presentation as outpatient (all p
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- 2021
41. Landscape dynamics of a vector‐borne disease in the western <scp>US</scp> : How vector–habitat relationships inform disease hotspots
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Emile Elias, Heather M. Savoy, Dustin A. Swanson, Lee W. Cohnstaedt, Debra P. C. Peters, Justin D. Derner, Angela Pelzel‐McCluskey, Barbara Drolet, and Luis Rodriguez
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Ecology ,Ecology, Evolution, Behavior and Systematics - Published
- 2022
42. Long‐term dynamics of US organic milk, eggs, and yogurt premiums
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Syed Badruddoza, Andrea Carlson, and Jill J. McCluskey
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Economics and Econometrics ,Animal science ,Geography, Planning and Development ,Economics ,Animal Science and Zoology ,Organic milk ,Agronomy and Crop Science ,Food Science ,Term (time) - Published
- 2021
43. How women saved agricultural economics
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Jill J. McCluskey and Susan Offutt
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Economics and Econometrics ,Sociology ,Development ,Agricultural economics - Published
- 2021
44. Targeting the S100A2‐p53 Interaction with a Series of 3,5‐ Bis (trifluoromethyl)benzene Sulfonamides: Synthesis and Cytotoxicity
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Jennifer R. Baker, Jennette A. Sakoff, Cecilia C. Russell, Peter J. Cossar, Jufeng Sun, Christopher J. Scarlett, Adam McCluskey, Joey I. Ambrus, and Melanie J. Pirinen
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Cell Survival ,Stereochemistry ,In silico ,Triazole ,Antineoplastic Agents ,Biochemistry ,Structure-Activity Relationship ,chemistry.chemical_compound ,Pancreatic cancer ,Drug Discovery ,Tumor Cells, Cultured ,medicine ,Humans ,General Pharmacology, Toxicology and Pharmaceutics ,Cytotoxicity ,Cell Proliferation ,Pharmacology ,Trifluoromethyl ,Chemotactic Factors ,Dose-Response Relationship, Drug ,Molecular Structure ,S100 Proteins ,Organic Chemistry ,Cancer ,medicine.disease ,Molecular Docking Simulation ,chemistry ,Docking (molecular) ,Cell culture ,Molecular Medicine ,Drug Screening Assays, Antitumor ,Tumor Suppressor Protein p53 - Abstract
In silico approaches identified 1, N-(6-((4-bromo- benzyl)amino)hexyl)-3,5-bis(trifluoromethyl)benzene sulfonamide, as a potential inhibitor of the S100A2-p53 protein-protein interaction, a validated pancreatic cancer drug target. Subsequent cytotoxicity screening revealed it to be a 2.97 μM cell growth inhibitor of the MiaPaCa-2 pancreatic cell line. This is in keeping with our hypothesis that inhibiting this interaction would have an anti-pancreatic cancer effect with S100A2, the validated PC drug target. A combination of focused library synthesis (three libraries, 24 compounds total) and cytotoxicity screening identified a propyl alkyl diamine spacer as optimal; the nature of the terminal phenyl substituent had limited impact on observed cytotoxicity, whereas N-methylation was detrimental to activity. In total 15 human cancer cell lines were examined, with most analogues showing broad-spectrum activity. Near uniform activity was observed against a panel of six pancreatic cancer cell lines: MiaPaCa-2, BxPC-3, AsPC-1, Capan-2, HPAC and PANC-1. In all cases there was good to excellent correlation between the predicted docking pose in the S100A2-p53 binding groove and the observed cytotoxicity, especially in the pancreatic cancer cell line with high endogenous S100A2 expression. This supports S100A2 as a pancreatic cancer drug target.
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- 2021
45. Cytotoxic 1,2,3‐Triazoles as Potential Leads Targeting the S100A2‐p53 Complex: Synthesis and Cytotoxicity
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Jennette A. Sakoff, Christopher J. Scarlett, Peter J. Cossar, Adam McCluskey, Hong Ngoc Thuy Pham, Jennifer R. Baker, Jufeng Sun, and Cecilia C. Russell
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Cell Survival ,Stereochemistry ,Triazole ,Antineoplastic Agents ,Biochemistry ,Structure-Activity Relationship ,chemistry.chemical_compound ,Pancreatic cancer ,Drug Discovery ,Tumor Cells, Cultured ,medicine ,Humans ,General Pharmacology, Toxicology and Pharmaceutics ,Cytotoxicity ,Cell Proliferation ,Pharmacology ,chemistry.chemical_classification ,Sulfonyl ,Chemotactic Factors ,Dose-Response Relationship, Drug ,Molecular Structure ,S100 Proteins ,Organic Chemistry ,Triazoles ,medicine.disease ,Sulfonamide ,Molecular Docking Simulation ,chemistry ,Cell culture ,Molecular Medicine ,Drug Screening Assays, Antitumor ,Tumor Suppressor Protein p53 ,Growth inhibition ,Acetamide - Abstract
In silico screening predicted 1 (N-(4-((4-(3-(4-(3-methoxyphenyl)-1H-1,2,3-triazol-1-yl)propyl)piperazin-1-yl) sulfonyl)-phenyl)acetamide) as an inhibitor of the S100A2-p53 protein-protein interaction. S100A2 is a validated pancreatic cancer drug target. In the MiaPaCa-2 pancreatic cell line, 1 was a ∼50 μM growth inhibitor. Synthesis of five focused compound libraries and cytotoxicity screening revealed increased activity from the presence of electron withdrawing moieties on the sulfonamide aromatic ring, with the 3,5-bis-CF3 Library 3 analogues the most active, with GI50 values of 0.91 (3-ClPh; 13 i; BxPC-3, Pancreas) to 9.0 μM (4-CH3 ; 13 d; PANC-1, Pancreas). Activity was retained against an expanded pancreatic cancer cell line panel (MiaPaCa-2, BxPC-3, AsPC-1, Capan-2, PANC-1 and HPAC) and the normal cell line MCF10A (breast). Bulky 4-disposed substituents on the terminal phenyl ring enhanced broad spectrum activity with growth inhibition values spanning 1.1 to 3.1 μM (4-C(CH3 )3 ; 13 e; BxPC-3 and AsPC-1 (pancreas), respectively). Central alkyl spacer contraction from propyl to ethyl proved detrimental to activity with Library 4 and 5.5- to 10-fold less cytotoxic than the propyl linked Library 2 and Library 3. The data herein was consistent with the predicted binding poses of the compounds evaluated. The highest levels of cytotoxicity were observed with those analogues best capable of adopting a near identical pose to the p53-peptide in the S100A2-p53 binding groove.
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- 2021
46. Diagnosis and treatment of infected wounds: A multi‐centre audit of current clinical practice across the <scp>UK</scp> , Ireland and Scandinavia
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Jane Hampton, Andrew Sharpe, Pat McCluskey, Tim Styche, Jacqui Hughes, and Emma Woodmansey
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General Medicine ,General Nursing - Abstract
Surveillance of wound infection including signs of infection alongside antimicrobial usage (types, duration, frequency) can highlight knowledge gaps and inconsistencies. This manuscript aims to highlight these, identify and inform opportunities for practice improvement and to show impact of infection management practice may be having on the issue of antimicrobial resistance.Infected wounds pose challenges to healthcare professionals. Balancing risk of wound deterioration and progression to systemic infection with appropriate use of antimicrobials is necessary to minimise development of resistance.Analysis consisted of a practice survey of 9661 wounds across 70 community sites over a period of one week. Data were collected from projects between 2017 and 2020. The form was available to providers within the UK, Ireland, Norway, Denmark, Sweden and Finland. EQUATOR research guidelines were followed; STROBE checklist for observational research reporting was completed.Infection rates of 8.9% were reported from wounds assessed. These data indicate inconsistencies with diagnosis across practice with non-specialists more likely to be unsure of wound infection. Greater confidence in infection identification was observed as number of signs increased. Inconsistencies were also observed in appropriate treatment; antimicrobials were used in 35% of wounds considered not infected and not used in 41% of wounds that were identified as infected.This investigation of infection management practice of over 9000 wounds provides an insight into diagnosis and treatment of infection. Inconsistencies in diagnosis and treatment of wound infections reported highlight the need for increased education, awareness of diagnosis and treatment of infection.Variability in management of infected wounds highlights opportunities to aid more effective diagnosis and treatment of infected wounds. Incorporation of support tools or evidence-based pathways into practice may enhance confidence in management of local infection, balanced with appropriate use, potentially minimising resistance and improving outcomes.
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- 2022
47. Diagnosis and treatment of infected wounds: A multi‐centre audit of current clinical practice across the UK , Ireland and Scandinavia
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Hampton, Jane, primary, Sharpe, Andrew, additional, McCluskey, Pat, additional, Styche, Tim, additional, Hughes, Jacqui, additional, and Woodmansey, Emma, additional
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- 2022
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48. Calibrating states' emissions reduction due diligence obligations with reference to the right to life
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McCluskey, Susan, primary
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- 2022
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49. Ultrahigh Carrier Mobilities in Ferroelectric Domain Wall Corbino Cones at Room Temperature
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McCluskey, Conor J., primary, Colbear, Matthew G., additional, McConville, James P. V., additional, McCartan, Shane J., additional, Maguire, Jesi R., additional, Conroy, Michele, additional, Moore, Kalani, additional, Harvey, Alan, additional, Trier, Felix, additional, Bangert, Ursel, additional, Gruverman, Alexei, additional, Bibes, Manuel, additional, Kumar, Amit, additional, McQuaid, Raymond G. P., additional, and Gregg, J. Marty, additional
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- 2022
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50. Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)
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Andrea Cossarizza, Hyun‐Dong Chang, Andreas Radbruch, Sergio Abrignani, Richard Addo, Mübeccel Akdis, Immanuel Andrä, Francesco Andreata, Francesco Annunziato, Eduardo Arranz, Petra Bacher, Sudipto Bari, Vincenzo Barnaba, Joana Barros‐Martins, Dirk Baumjohann, Cristian G. Beccaria, David Bernardo, Dominic A. Boardman, Jessica Borger, Chotima Böttcher, Leonie Brockmann, Marie Burns, Dirk H. Busch, Garth Cameron, Ilenia Cammarata, Antonino Cassotta, Yinshui Chang, Fernando Gabriel Chirdo, Eleni Christakou, Luka Čičin‐Šain, Laura Cook, Alexandra J. Corbett, Rebecca Cornelis, Lorenzo Cosmi, Martin S. Davey, Sara De Biasi, Gabriele De Simone, Genny del Zotto, Michael Delacher, Francesca Di Rosa, James Di Santo, Andreas Diefenbach, Jun Dong, Thomas Dörner, Regine J. Dress, Charles‐Antoine Dutertre, Sidonia B. G. Eckle, Pascale Eede, Maximilien Evrard, Christine S. Falk, Markus Feuerer, Simon Fillatreau, Aida Fiz‐Lopez, Marie Follo, Gemma A. Foulds, Julia Fröbel, Nicola Gagliani, Giovanni Galletti, Anastasia Gangaev, Natalio Garbi, José Antonio Garrote, Jens Geginat, Nicholas A. Gherardin, Lara Gibellini, Florent Ginhoux, Dale I. Godfrey, Paola Gruarin, Claudia Haftmann, Leo Hansmann, Christopher M. Harpur, Adrian C. Hayday, Guido Heine, Daniela Carolina Hernández, Martin Herrmann, Oliver Hoelsken, Qing Huang, Samuel Huber, Johanna E. Huber, Jochen Huehn, Michael Hundemer, William Y. K. Hwang, Matteo Iannacone, Sabine M. Ivison, Hans‐Martin Jäck, Peter K. Jani, Baerbel Keller, Nina Kessler, Steven Ketelaars, Laura Knop, Jasmin Knopf, Hui‐Fern Koay, Katja Kobow, Katharina Kriegsmann, H. Kristyanto, Andreas Krueger, Jenny F. Kuehne, Heike Kunze‐Schumacher, Pia Kvistborg, Immanuel Kwok, Daniela Latorre, Daniel Lenz, Megan K. Levings, Andreia C. Lino, Francesco Liotta, Heather M. Long, Enrico Lugli, Katherine N. MacDonald, Laura Maggi, Mala K. Maini, Florian Mair, Calin Manta, Rudolf Armin Manz, Mir‐Farzin Mashreghi, Alessio Mazzoni, James McCluskey, Henrik E. Mei, Fritz Melchers, Susanne Melzer, Dirk Mielenz, Leticia Monin, Lorenzo Moretta, Gabriele Multhoff, Luis Enrique Muñoz, Miguel Muñoz‐Ruiz, Franziska Muscate, Ambra Natalini, Katrin Neumann, Lai Guan Ng, Antonia Niedobitek, Jana Niemz, Larissa Nogueira Almeida, Samuele Notarbartolo, Lennard Ostendorf, Laura J. Pallett, Amit A. Patel, Gulce Itir Percin, Giovanna Peruzzi, Marcello Pinti, A. Graham Pockley, Katharina Pracht, Immo Prinz, Irma Pujol‐Autonell, Nadia Pulvirenti, Linda Quatrini, Kylie M. Quinn, Helena Radbruch, Hefin Rhys, Maria B. Rodrigo, Chiara Romagnani, Carina Saggau, Shimon Sakaguchi, Federica Sallusto, Lieke Sanderink, Inga Sandrock, Christine Schauer, Alexander Scheffold, Hans U. Scherer, Matthias Schiemann, Frank A. Schildberg, Kilian Schober, Janina Schoen, Wolfgang Schuh, Thomas Schüler, Axel R. Schulz, Sebastian Schulz, Julia Schulze, Sonia Simonetti, Jeeshan Singh, Katarzyna M. Sitnik, Regina Stark, Sarah Starossom, Christina Stehle, Franziska Szelinski, Leonard Tan, Attila Tarnok, Julia Tornack, Timothy I. M. Tree, Jasper J. P. van Beek, Willem van de Veen, Klaas van Gisbergen, Chiara Vasco, Nikita A. Verheyden, Anouk von Borstel, Kirsten A. Ward‐Hartstonge, Klaus Warnatz, Claudia Waskow, Annika Wiedemann, Anneke Wilharm, James Wing, Oliver Wirz, Jens Wittner, Jennie H. M. Yang, Juhao Yang, Rolf M. Schwiete Foundation, Associazione Italiana per la Ricerca sul Cancro, German Research Foundation, National Institutes of Health (US), European Commission, AII - Inflammatory diseases, Cossarizza, A, Chang, H, Radbruch, A, Abrignani, S, Addo, R, Akdis, M, Andra, I, Andreata, F, Annunziato, F, Arranz, E, Bacher, P, Bari, S, Barnaba, V, Barros-Martins, J, Baumjohann, D, Beccaria, C, Bernardo, D, Boardman, D, Borger, J, Bottcher, C, Brockmann, L, Burns, M, Busch, D, Cameron, G, Cammarata, I, Cassotta, A, Chang, Y, Chirdo, F, Christakou, E, Cicin-Sain, L, Cook, L, Corbett, A, Cornelis, R, Cosmi, L, Davey, M, De Biasi, S, De Simone, G, del Zotto, G, Delacher, M, Di Rosa, F, Santo, J, Diefenbach, A, Dong, J, Dorner, T, Dress, R, Dutertre, C, Eckle, S, Eede, P, Evrard, M, Falk, C, Feuerer, M, Fillatreau, S, Fiz-Lopez, A, Follo, M, Foulds, G, Frobel, J, Gagliani, N, Galletti, G, Gangaev, A, Garbi, N, Garrote, J, Geginat, J, Gherardin, N, Gibellini, L, Ginhoux, F, Godfrey, D, Gruarin, P, Haftmann, C, Hansmann, L, Harpur, C, Hayday, A, Heine, G, Hernandez, D, Herrmann, M, Hoelsken, O, Huang, Q, Huber, S, Huber, J, Huehn, J, Hundemer, M, Hwang, W, Iannacone, M, Ivison, S, Jack, H, Jani, P, Keller, B, Kessler, N, Ketelaars, S, Knop, L, Knopf, J, Koay, H, Kobow, K, Kriegsmann, K, Kristyanto, H, Krueger, A, Kuehne, J, Kunze-Schumacher, H, Kvistborg, P, Kwok, I, Latorre, D, Lenz, D, Levings, M, Lino, A, Liotta, F, Long, H, Lugli, E, Macdonald, K, Maggi, L, Maini, M, Mair, F, Manta, C, Manz, R, Mashreghi, M, Mazzoni, A, Mccluskey, J, Mei, H, Melchers, F, Melzer, S, Mielenz, D, Monin, L, Moretta, L, Multhoff, G, Munoz, L, Munoz-Ruiz, M, Muscate, F, Natalini, A, Neumann, K, Ng, L, Niedobitek, A, Niemz, J, Almeida, L, Notarbartolo, S, Ostendorf, L, Pallett, L, Patel, A, Percin, G, Peruzzi, G, Pinti, M, Pockley, A, Pracht, K, Prinz, I, Pujol-Autonell, I, Pulvirenti, N, Quatrini, L, Quinn, K, Radbruch, H, Rhys, H, Rodrigo, M, Romagnani, C, Saggau, C, Sakaguchi, S, Sallusto, F, Sanderink, L, Sandrock, I, Schauer, C, Scheffold, A, Scherer, H, Schiemann, M, Schildberg, F, Schober, K, Schoen, J, Schuh, W, Schuler, T, Schulz, A, Schulz, S, Schulze, J, Simonetti, S, Singh, J, Sitnik, K, Stark, R, Starossom, S, Stehle, C, Szelinski, F, Tan, L, Tarnok, A, Tornack, J, Tree, T, van Beek, J, van de Veen, W, van Gisbergen, K, Vasco, C, Verheyden, N, von Borstel, A, Ward-Hartstonge, K, Warnatz, K, Waskow, C, Wiedemann, A, Wilharm, A, Wing, J, Wirz, O, Wittner, J, Yang, J, Publica, Cossarizza, A., Chang, H. -D., Radbruch, A., Abrignani, S., Addo, R., Akdis, M., Andra, I., Andreata, F., Annunziato, F., Arranz, E., Bacher, P., Bari, S., Barnaba, V., Barros-Martins, J., Baumjohann, D., Beccaria, C. G., Bernardo, D., Boardman, D. A., Borger, J., Bottcher, C., Brockmann, L., Burns, M., Busch, D. H., Cameron, G., Cammarata, I., Cassotta, A., Chang, Y., Chirdo, F. G., Christakou, E., Cicin-Sain, L., Cook, L., Corbett, A. J., Cornelis, R., Cosmi, L., Davey, M. S., De Biasi, S., De Simone, G., del Zotto, G., Delacher, M., Di Rosa, F., Santo, J. D., Diefenbach, A., Dong, J., Dorner, T., Dress, R. J., Dutertre, C. -A., Eckle, S. B. G., Eede, P., Evrard, M., Falk, C. S., Feuerer, M., Fillatreau, S., Fiz-Lopez, A., Follo, M., Foulds, G. A., Frobel, J., Gagliani, N., Galletti, G., Gangaev, A., Garbi, N., Garrote, J. A., Geginat, J., Gherardin, N. A., Gibellini, L., Ginhoux, F., Godfrey, D. I., Gruarin, P., Haftmann, C., Hansmann, L., Harpur, C. M., Hayday, A. C., Heine, G., Hernandez, D. C., Herrmann, M., Hoelsken, O., Huang, Q., Huber, S., Huber, J. E., Huehn, J., Hundemer, M., Hwang, W. Y. K., Iannacone, M., Ivison, S. M., Jack, H. -M., Jani, P. K., Keller, B., Kessler, N., Ketelaars, S., Knop, L., Knopf, J., Koay, H. -F., Kobow, K., Kriegsmann, K., Kristyanto, H., Krueger, A., Kuehne, J. F., Kunze-Schumacher, H., Kvistborg, P., Kwok, I., Latorre, D., Lenz, D., Levings, M. K., Lino, A. C., Liotta, F., Long, H. M., Lugli, E., Macdonald, K. N., Maggi, L., Maini, M. K., Mair, F., Manta, C., Manz, R. A., Mashreghi, M. -F., Mazzoni, A., Mccluskey, J., Mei, H. E., Melchers, F., Melzer, S., Mielenz, D., Monin, L., Moretta, L., Multhoff, G., Munoz, L. E., Munoz-Ruiz, M., Muscate, F., Natalini, A., Neumann, K., Ng, L. G., Niedobitek, A., Niemz, J., Almeida, L. N., Notarbartolo, S., Ostendorf, L., Pallett, L. J., Patel, A. A., Percin, G. I., Peruzzi, G., Pinti, M., Pockley, A. G., Pracht, K., Prinz, I., Pujol-Autonell, I., Pulvirenti, N., Quatrini, L., Quinn, K. M., Radbruch, H., Rhys, H., Rodrigo, M. B., Romagnani, C., Saggau, C., Sakaguchi, S., Sallusto, F., Sanderink, L., Sandrock, I., Schauer, C., Scheffold, A., Scherer, H. U., Schiemann, M., Schildberg, F. A., Schober, K., Schoen, J., Schuh, W., Schuler, T., Schulz, A. R., Schulz, S., Schulze, J., Simonetti, S., Singh, J., Sitnik, K. M., Stark, R., Starossom, S., Stehle, C., Szelinski, F., Tan, L., Tarnok, A., Tornack, J., Tree, T. I. M., van Beek, J. J. P., van de Veen, W., van Gisbergen, K., Vasco, C., Verheyden, N. A., von Borstel, A., Ward-Hartstonge, K. A., Warnatz, K., Waskow, C., Wiedemann, A., Wilharm, A., Wing, J., Wirz, O., Wittner, J., Yang, J. H. M., and Yang, J.
- Subjects
Immunology ,citometry ,Flow Cytometry ,Infections ,ddc ,Autoimmune Diseases ,Animals ,Chronic Disease ,Humans ,Mice ,Neoplasms ,Practice Guidelines as Topic ,Immunology and Allergy ,ddc:610 ,Function and Dysfunction of the Nervous System ,guideline - Abstract
© 2021 The Authors., The third edition of Flow Cytometry Guidelines provides the key aspects to consider when performing flow cytometry experiments and includes comprehensive sections describing phenotypes and functional assays of all major human and murine immune cell subsets. Notably, the Guidelines contain helpful tables highlighting phenotypes and key differences between human and murine cells. Another useful feature of this edition is the flow cytometry analysis of clinical samples with examples of flow cytometry applications in the context of autoimmune diseases, cancers as well as acute and chronic infectious diseases. Furthermore, there are sections detailing tips, tricks and pitfalls to avoid. All sections are written and peer-reviewed by leading flow cytometry experts and immunologists, making this edition an essential and state-of-the-art handbook for basic and clinical researchers., Hyun-Dong Chang is supported by the Dr. Rolf M. Schwiete Foundation. Susanne Melzer and Attila Tarnok thank De Novo Software for providing FCS Express. Enrico Lugli is supported by a grant from the Associazione Italiana per la Ricerca sul Cancro (AIRC IG20676). Gabriele De Simone and Giovanni Galletti were supported by Fellowships from the Fondazione Italiana per la Ricerca sul Cancro-Associazione Italiana per la Ricerca sul Cancro (FIRC-AIRC). Jun Dong is supported by Deutsche Forschungsgemeinschft (DFG, German Research Foundation) Projektnummer 389687267 and Chinesisch-Deutsches Zentrum für Wissenschaftsförderung [Sino-German Center for Research Promotion (SGC)] grant C-0072. Nicola Gagliani, Samuel Huber and Franziska Muscate are supported by DFG fundings: SFB841,GA 2441/3-1, HU 1714/10-1. The tetramer APC-conjugated H-2K (d) HIV-1 gag197-205 AMQMLKETI used in TDS assay for mouse blood T cells was obtained through the NIH Tetramer Facility. Larissa Nogueira Almeida was supported by DFG research grant MA 2273/14-1. Supported by the following grants: AIRC 5X1000 2018 id. 21147 (Lorenzo Moretta); AIRC IG 2017 id. 19920 (Lorenzo Moretta); RC-2020 OPBG (Lorenzo Moretta); AIRC and European Union's Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No 800924 (Linda Quatrini). Dirk Baumjohann was supported by Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Emmy Noether Programme BA 5132/1-2 (252623821) and Germany's Excellence Strategy EXC2151 (390873048).
- Published
- 2021
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