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Your search keyword '"Mazarati, Andrey"' showing total 32 results
Start Over Author "Mazarati, Andrey" Publisher wiley
32 results on '"Mazarati, Andrey"'

7. A companion to the preclinical common data elements on neurobehavioral comorbidities of epilepsy: a report of the TASK3 behavior working group of the ILAE/AES Joint Translational Task Force

Author

Mazarati, Andrey, primary, Jones, Nigel C., additional, Galanopoulou, Aristea S., additional, Harte‐Hargrove, Lauren C., additional, Kalynchuk, Lisa E., additional, Lenck‐Santini, Pierre‐Pascal, additional, Medel‐Matus, Jesús‐Servando, additional, Nehlig, Astrid, additional, de la Prida, Liset Menendez, additional, Sarkisova, Karine, additional, and Veliskova, Jana, additional

Published
2018
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28. REPLY

Author

Wasterlain, Claude G., primary and Mazarati, Andrey M., additional

Published
2000
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29. Self-Sustaining Status Epilepticus: A Condition Maintained by Potentiation of Glutamate Receptors and by Plastic Changes in Substance P and Other Peptide Neuromodulators

Author

Wasterlain, Claude G., primary, Liu, Hantao, additional, Mazarati, Andrey M., additional, Baldwin, Roger A., additional, Shirasaka, Yukiyoshi, additional, Katsumori, Hiroshi, additional, Thompson, Kerry W., additional, Sankar, Raman, additional, Vasconselos, Anne Pereira, additional, and Nehlig, Astrid, additional

Published
2000
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32. WONOEP appraisal: Biomarkers of epilepsy-associated comorbidities

Author

ONAT, FİLİZ, Ravizza, Teresa, Onat, Filiz Y., Brooks-Kayal, Amy R., Depaulis, Antoine, Galanopoulou, Aristea S., Mazarati, Andrey, Numis, Adam L., Sankar, Raman, and Friedman, Alon

Subjects
Neurobehavioral comorbidities, Epilepsy, JAK/STAT PATHWAY, Depression, STATUS EPILEPTICUS, CHILDREN, COGNITIVE IMPAIRMENT, C-REACTIVE PROTEIN, Imaging, Cognition, TEMPORAL-LOBE EPILEPSY, RISK-FACTORS, TUBEROUS SCLEROSIS COMPLEX, PSYCHIATRIC COMORBIDITY, BRAIN, Polymorphisms
Abstract

Neurologic and psychiatric comorbidities are common in patients with epilepsy. Diagnostic, predictive, and pharmacodynamic biomarkers of such comorbidities do not exist. They may share pathogenetic mechanisms with epileptogenesis/ictogenesis, and as such are an unmet clinical need. The objectives of the subgroup on biomarkers of comorbidities at the XIII Workshop on the Neurobiology of Epilepsy (WONOEP) were to present the state-of-the- art recent research findings in the field that highlighting potential biomarkers for comorbidities in epilepsy. We review recent progress in the field, including molecular, imaging, and genetic biomarkers of comorbidities as discussed during theWONOEP meeting on August 31-September 4, 2015, in Heybeliada Island (Istanbul, Turkey). Wefurther highlight new directions and concepts from studies on comorbidities and potential new biomarkers for the prediction, diagnosis, and treatment of epilepsy-associated comorbidities. The activation of various molecular signaling pathways such as the Janus Kinase/Signal Transducer and Activator of Transcription, mammalian Target of Rapamycin, and oxidative stress have been shown to correlate with the presence and severity of subsequent cognitive abnormalities. Furthermore, dysfunction in serotonergic transmission, hyperactivity of the hypothalamic-pituitary-adrenocortical axis, the role of the inflammatory cytokines, and the contributions of genetic factors have all recently been regarded as relevant for understanding epilepsy-associated depression and cognitive deficits. Recent evidence supports the utility of imaging studies as potential biomarkers. The role of such biomarker may be far beyond the diagnosis of comorbidities, as accumulating clinical data indicate that comorbidities can predict epilepsy outcomes. Future research is required to reveal whether molecular changes in specific signaling pathways or advanced imaging techniques could be detected in the clinical settings and correlate with epilepsy-associated comorbidities. A reliable biomarker will allow a more accurate diagnosis and improved treatment of epilepsy-associated comorbidities.

Published
2017

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