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42 results on '"Maurin, M."'

12. PCR identification of Rhizobium radiobacter in post-operative endophthalmitis

Author

VINH, V, primary, ROMANET, JP, additional, CREUZOT-GARCHER, C, additional, BRON, AM, additional, GAIN, PG, additional, CORNUT, PL, additional, PALOMBI, K, additional, DENIS, P, additional, THURET, G, additional, CROIZE, J, additional, MAURIN, M, additional, PECHINOT, A, additional, VANDENESCH, F, additional, and CHIQUET, C, additional

Published
2007
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15. Optical Measurements in MOVPE-Grown ZnSe/InP Epilayers

Author

Coquillat, D., primary, Bouchara, D., additional, Abounadi, A., additional, Ribayrol, A., additional, Lascaray, J. P., additional, Calas, J., additional, Haidoux, A., additional, Tomasini, P., additional, Tédenac, J. C., additional, and Maurin, M., additional

Published
1993
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41. Mediation of Interleukin-23 and Tumor Necrosis Factor-Driven Reactive Arthritis by Chlamydia-Infected Macrophages in SKG Mice.

Author

Romand X, Liu X, Rahman MA, Bhuyan ZA, Douillard C, Kedia RA, Stone N, Roest D, Chew ZH, Cameron AJ, Rehaume LM, Bozon A, Habib M, Armitage CW, Nguyen MVC, Favier B, Beagley K, Maurin M, Gaudin P, Thomas R, Wells TJ, and Baillet A

Subjects
Animals, Arthritis, Experimental genetics, Arthritis, Reactive genetics, Chlamydia muridarum, Endoplasmic Reticulum Chaperone BiP, Female, Gene Expression Profiling, Heat-Shock Proteins genetics, Heat-Shock Proteins immunology, Interleukin-12 Subunit p40 genetics, Interleukin-12 Subunit p40 immunology, Interleukin-17 genetics, Interleukin-17 immunology, Interleukin-23 Subunit p19 genetics, Macrophages microbiology, Mice, Mice, Inbred BALB C, Monomeric GTP-Binding Proteins genetics, Monomeric GTP-Binding Proteins immunology, Tumor Necrosis Factor-alpha genetics, ZAP-70 Protein-Tyrosine Kinase genetics, Arthritis, Reactive immunology, Chlamydia Infections immunology, Interleukin-23 immunology, Interleukin-23 Subunit p19 immunology, Macrophages immunology, Tumor Necrosis Factor-alpha immunology
Abstract

Objective: ZAP-70 W163C BALB/c (SKG) mice develop reactive arthritis (ReA) following infection with Chlamydia muridarum. Since intracellular pathogens enhance their replicative fitness in stressed host cells, we examined how myeloid cells infected with C muridarum drive arthritis., Methods: SKG, Il17a-deficient SKG, and BALB/c female mice were infected with C muridarum or C muridarum luciferase in the genitals. C muridarum dissemination was assessed by in vivo imaging or genomic DNA amplification. Macrophages were depleted using clodronate liposomes. Anti-tumor necrosis factor (anti-TNF) and anti-interleukin-23p19 (anti-IL-23p19) were administered after infection or arthritis onset. Gene expression of Hspa5, Tgtp1, Il23a, Il17a, Il12b, and Tnf was compared in SKG mice and BALB/c mice., Results: One week following infection with C muridarum, macrophages and neutrophils were observed to have infiltrated the uteri of mice and were also shown to have carried C muridarum DNA to the spleen. C muridarum load was higher in SKG mice than in BALB/c mice. Macrophage depletion was shown to reduce C muridarum load and prevent development of arthritis. Compared with BALB/c mice, expression of Il23a and Il17a was increased in the uterine and splenic neutrophils of SKG mice. The presence of anti-IL-23p19 during infection or Il17a deficiency suppressed arthritis. Tnf was overexpressed in the joints of SKG mice within 1 week postinfection, and persisted beyond the first week. TNF inhibition during infection or at arthritis onset suppressed the development of arthritis. Levels of endoplasmic reticulum stress were constitutively increased in the joints of SKG mice but were induced, in conjunction with immunity-related GTPase, by C muridarum infection in the uterus., Conclusion: C muridarum load is higher in SKG mice than in BALB/c mice. Whereas proinflammatory IL-23 produced by neutrophils contributes to the initiation of C muridarum-mediated ReA, macrophage depletion reduces C muridarum dissemination to other tissues, tissue burden, and the development of arthritis. TNF inhibition was also shown to suppress arthritis development. Our data suggest that enhanced bacterial dissemination in macrophages of SKG mice drives the TNF production needed for persistent arthritis., (© 2021, American College of Rheumatology.)

Published
2021
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42. Due to great variability fixed HKS angle for alignment of the distal cut leads to a significant error in coronal TKA orientation.

Author

Lampart M, Behrend H, Moser LB, and Hirschmann MT

Subjects
Adult, Aged, Aged, 80 and over, Biomechanical Phenomena, Female, Femur diagnostic imaging, Femur surgery, Humans, Lower Extremity diagnostic imaging, Lower Extremity physiopathology, Lower Extremity surgery, Male, Middle Aged, Osteoarthritis, Knee diagnostic imaging, Osteoarthritis, Knee surgery, Prospective Studies, Tomography, X-Ray Computed, Arthroplasty, Replacement, Knee methods, Femur physiopathology, Osteoarthritis, Knee physiopathology
Abstract

Purpose: For coronal alignment in total knee arthroplasty (TKA) most surgeons use the patient's individual hip-knee shaft (HKS) angle (angle between the anatomical axis and the mechanical axis of the femur). The major problem of the sole use of HKS angle is that the individual patient's distal femoral asymmetry is not considered. The purpose of this study was to determine the variability of the HKS angle, the mechanical femoral angle (FMA) and to evaluate whether or not one of the two angles is more important for TKA alignment strategy. It was the hypothesis that HKS and FMA are not directly related to each other and hence HKS should not be considered as guide for coronal alignment., Methods: Prospectively collected CT data of 1480 consecutive patients who underwent 3D reconstructed CT scans before TKA was used for this retrospective registry study [882 women and 598 men, mean age ± standard deviation 71 ± 9 years (34-99 years)]. The CT protocol was modified according to the Imperial Knee Protocol, which is a lowdose CT protocol that includes high-resolution 0.75-mm slices of the knee and 3-mm slices of the hip and ankle joints. All measurements were done using Symbios ® 3D knee preoperative planning's software (Symbios, Yverdon les Bains, Switzerland). The HKS, FMA and hip-knee-ankle (HKA) angles were measured. Angles measured were displayed as mean, standard deviation (SD) and range. In addition, the angles were shown as percentages after categorization. The HKS was categorized between 3° and 9° in 1° increments. The FMA was categorized between 83.5° and 98.5° in 3° increments. The HKA was categorized between 12.5° varus 5.5° valgus in 3° increments. Pearson correlations were used to investigate correlation of HKS and FMA (p < 0.05)., Results: The HKS angle was not constant at 7° but averaged 6°, and ranged from 2.5° to 9°. The FMA angle was on average 93° but varied more than 20°, ranging from 75° (varus) to 104° (valgus). The mean HKA ± SD was - 3.4° ± 5.7° (range - 23.0° to 15.0°). The mean HKSSD was 5.6° ± 0.9° (range 2.5°-8.8°). The mean FMASD was 92.6° ± 2.8° (range 75.2°-103.5°). The Pearson correlations of all measured angles are presented in Table 1. HKS significantly correlated negatively with HKA and FMA (p < 0.001). FMA and HKA were strongly correlated with each other (p < 0.0001). Considering the HKS angle as a constant angle can induce a deviation of up to 5° with respect to an orthogonal distal femoral cutting objective. The great variability of the FMA angle implies that the FMA seems more relevant than the HKS angle to define the strategy of realignment of the lower limb. However, then patient specific instrumentation has to be used to precisely transfer the planning to the surgical technique. Having the aim of a more personalized TKA alignment in mind the individual constitutional knee phenotype should be taken into account.

Published
2019
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