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Your search keyword '"Matiasek, K."' showing total 22 results
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22 results on '"Matiasek, K."'

1. Clinical use of a new frameless optical neuronavigation system for brain biopsies: 10 cases (2013–2020)

Author

Gutmann, S., Tästensen, C., Böttcher, I.C., Dietzel, J., Loderstedt, S., Kohl, S., Matiasek, K., Flegel, T., Gutmann, S., Tästensen, C., Böttcher, I.C., Dietzel, J., Loderstedt, S., Kohl, S., Matiasek, K., and Flegel, T.

Abstract

Objectives: The aim of the retrospective study was to describe the brain biopsy procedure using a new frameless optical neuronavigation system and to report diagnostic yield and complications associated with the procedure. Materials and Methods: The medical records for all dogs with forebrain lesions that underwent brain biopsy with a frameless optical neuronavigation system in a single referral hospital between 2013 and 2020 were retrospectively analysed. Following data were collected: signalment, neurological signs, diagnostic findings, number of brain biopsy samples, sampled region, complications, duration of hospitalisation, whether the samples were diagnostic and histopathological diagnoses. The device consists of a computer workstation with navigation software, an infrared camera, patient tracker and reflective instruments. The biopsy needle was equipped with reflective spheres, so the surgeon could see the position of the needle during sampling the intracranial lesion free handed through a mini-burr hole. Results: Ten dogs were included. Absolute diagnostic yield based on specific histopathological diagnosis was 73.9%. Three dogs had immune-mediated necrotizing encephalitis, two dogs showed a necrotizing leukoencephalitis and two dogs a meningoencephalitis of unknown origin. In two dogs, the brain specimen showed unspecific changes. In one dog, the samples were non-diagnostic. Seven dogs showed no neurological deterioration, one dog mild temporary ataxia and two dogs died within 36 hours post brain biopsy. Clinical Significance: In these 10 dogs, the frameless optical neuronavigation system employed was useful to gain diagnostic brain biopsy samples. Considering the mortality rate observed, further studies are needed to confirm the safety of this procedure and prove its actual clinical effectiveness.

Published
2022

22. Anti-GM2 ganglioside antibodies are a biomarker for acute canine polyradiculoneuritis.

Author

Rupp A, Galban-Horcajo F, Bianchi E, Dondi M, Penderis J, Cappell J, Burgess K, Matiasek K, McGonigal R, and Willison HJ

Subjects
Acute Disease, Animals, Chromatography, Thin Layer, Diagnostic Imaging, Dogs, Electric Stimulation, Electromyography, Enzyme-Linked Immunosorbent Assay, Evoked Potentials, Motor physiology, Female, Magnetic Resonance Imaging, Male, Neurologic Examination, Polyradiculoneuropathy diagnosis, Polyradiculoneuropathy physiopathology, Sciatic Nerve pathology, Spinal Cord pathology, Statistics as Topic, Biomarkers blood, G(M2) Ganglioside immunology, Immunoglobulin G blood, Polyradiculoneuropathy blood, Polyradiculoneuropathy veterinary
Abstract

Acute canine polyradiculoneuritis (ACP) is considered to be the canine equivalent of the human peripheral nerve disorder Guillain-Barré syndrome (GBS); an aetiological relationship, however, remains to be demonstrated. In GBS, anti-glycolipid antibodies (Abs) are considered as important disease mediators. To address the possibility of common Ab biomarkers, the sera of 25 ACP dogs, 19 non-neurological, and 15 epileptic control dogs were screened for IgG Abs to 10 glycolipids and their 1 : 1 heteromeric complexes using combinatorial glycoarrays. Anti-GM2 ganglioside Abs were detected in 14/25 ACP dogs, and anti-GA1 Abs in one further dog. All controls except for one were negative for anti-glycolipid Abs. In this cohort of cases and controls, the glycoarray screen reached a diagnostic sensitivity of 60% and a specificity of 97%; a lower sensitivity (32%) was reported using a conventional glycolipid ELISA. To address the possible pathogenic role for anti-GM2 Abs in ACP, we identified GM2 in canine sciatic nerve by both mass spectrometry and thin layer chromatography overlay. In immunohistological studies, GM2 was localized predominantly to the abaxonal Schwann cell membrane. The presence of anti-GM2 Abs in ACP suggests that it may share a similar pathophysiology with GBS, for which it could thus be considered a naturally occurring animal model., (© 2013 Peripheral Nerve Society.)

Published
2013
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