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35 results on '"Martemyanov, Kirill A"'

1. The Concise Guide to PHARMACOLOGY 2023/24: Introduction and Other Protein Targets

Author

Alexander, Stephen P. H., primary, Kelly, Eamonn, additional, Mathie, Alistair A., additional, Peters, John A., additional, Veale, Emma L., additional, Armstrong, Jane F., additional, Buneman, O. Peter, additional, Faccenda, Elena, additional, Harding, Simon D., additional, Spedding, Michael, additional, Cidlowski, John A., additional, Fabbro, Doriano, additional, Davenport, Anthony P., additional, Striessnig, Jörg, additional, Davies, Jamie A., additional, Ahlers‐Dannen, Katelin E., additional, Alqinyah, Mohammed, additional, Arumugam, Thiruma V., additional, Bodle, Christopher, additional, Dagner, Josephine Buo, additional, Chakravarti, Bandana, additional, Choudhuri, Shreoshi P., additional, Druey, Kirk M., additional, Fisher, Rory A., additional, Gerber, Kyle J., additional, Hepler, John R., additional, Hooks, Shelley B., additional, Kantheti, Havish S., additional, Karaj, Behirda, additional, Layeghi‐Ghalehsoukhteh, Somayeh, additional, Lee, Jae‐Kyung, additional, Luo, Zili, additional, Martemyanov, Kirill, additional, Mascarenhas, Luke D., additional, McNabb, Harrison, additional, Montañez‐Miranda, Carolina, additional, Ogujiofor, Osita, additional, Phan, Hoa, additional, Roman, David L., additional, Shaw, Vincent, additional, Sjogren, Benita, additional, Sobey, Christopher, additional, Spicer, Mackenzie M., additional, Squires, Katherine E., additional, Sutton, Laurie, additional, Wendimu, Menbere, additional, Wilkie, Thomas, additional, Xie, Keqiang, additional, Zhang, Qian, additional, and Zolghadri, Yalda, additional

Published
2023
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2. Recent changes in the British Journal of Pharmacology: widening scope and improving author and editor experience

Author

Papapetropoulos, Andreas, primary, Alexander, Steve P. H., additional, Cortese‐Krott, Miriam, additional, Kendall, Dave A., additional, Martemyanov, Kirill, additional, Mauro, Claudio, additional, Panettieri, Reynold A., additional, Patel, Hemal H., additional, Schulz, Rainer, additional, Stefanska, Barbara, additional, Stephens, Gary J., additional, Teixeira, Mauro M., additional, Vergnolle, Nathalie, additional, Wang, Xin Joy, additional, and Ferdinandy, Péter, additional

Published
2023
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4. Visualizing an orphan receptor GPR158 and it complex with neuronal regulator RGS7‐Gβ5 via cryoEM

Author

Patil, Dipak N., primary, Singh, Shikha, additional, Laboute, Thibaut, additional, Strutzenberg, Timothy, additional, Qiu, Xingyu, additional, Wu, Di, additional, Novick, Scott, additional, Robinson, Carol, additional, Griffin, Patrick, additional, Hunt, John, additional, Izard, Tina, additional, Singh, Appu, additional, and Martemyanov, Kirill, additional

Published
2022
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5. Community guidelines for GPCR ligand bias: IUPHAR review 32

Author

Kolb, Peter, primary, Kenakin, Terry, additional, Alexander, Stephen P. H., additional, Bermudez, Marcel, additional, Bohn, Laura M., additional, Breinholt, Christian S., additional, Bouvier, Michel, additional, Hill, Stephen J., additional, Kostenis, Evi, additional, Martemyanov, Kirill A., additional, Neubig, Rick R., additional, Onaran, H. Ongun, additional, Rajagopal, Sudarshan, additional, Roth, Bryan L., additional, Selent, Jana, additional, Shukla, Arun K., additional, Sommer, Martha E., additional, and Gloriam, David E., additional

Published
2022
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6. THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Introduction and Other Protein Targets

Author

Alexander, Stephen P H, primary, Kelly, Eamonn, additional, Mathie, Alistair, additional, Peters, John A, additional, Veale, Emma L, additional, Armstrong, Jane F, additional, Faccenda, Elena, additional, Harding, Simon D, additional, Pawson, Adam J, additional, Southan, Christopher, additional, Buneman, O Peter, additional, Cidlowski, John A, additional, Christopoulos, Arthur, additional, Davenport, Anthony P, additional, Fabbro, Doriano, additional, Spedding, Michael, additional, Striessnig, Jörg, additional, Davies, Jamie A, additional, Ahlers‐Dannen, Katelin E., additional, Alqinyah, Mohammed, additional, Arumugam, Thiruma V., additional, Bodle, Christopher, additional, Dagner, Josephine Buo, additional, Chakravarti, Bandana, additional, Choudhuri, Shreoshi P., additional, Druey, Kirk M., additional, Fisher, Rory A., additional, Gerber, Kyle J., additional, Hepler, John R., additional, Hooks, Shelley B., additional, Kantheti, Havish S., additional, Karaj, Behirda, additional, Layeghi‐Ghalehsoukhteh, Somayeh, additional, Lee, Jae‐Kyung, additional, Luo, Zili, additional, Martemyanov, Kirill, additional, Mascarenhas, Luke D., additional, McNabb, Harrison, additional, Montañez‐Miranda, Carolina, additional, Ogujiofor, Osita, additional, Phan, Hoa, additional, Roman, David L., additional, Shaw, Vincent, additional, Sjogren, Benita, additional, Sobey, Christopher, additional, Spicer, Mackenzie M., additional, Squires, Katherine E., additional, Sutton, Laurie, additional, Wendimu, Menbere, additional, Wilkie, Thomas, additional, Xie, Keqiang, additional, Zhang, Qian, additional, and Zolghadri, Yalda, additional

Published
2021
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12. Using C. elegans Genetics to Identify Regulators of μ‐Opioid Receptor Signaling

Author

Wang, Dandan, primary, Stoveken, Hannah M., additional, Zucca, Stefano, additional, Dao, Maria, additional, Orlandi, Cesare, additional, Song, Chenghui, additional, Masuho, Ikuo, additional, Johnston, Caitlin, additional, Opperman, Karla J., additional, Giles, Andrew C., additional, Gill, Matthew S., additional, Lundquist, Erik A., additional, Grill, Brock, additional, and Martemyanov, Kirill A., additional

Published
2020
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14. Clarin‐1 expression in adult mouse and human retina highlights a role of Müller glia in Usher syndrome

Author

Xu, Lei, primary, Bolch, Susan N, additional, Santiago, Clayton P, additional, Dyka, Frank M, additional, Akil, Omar, additional, Lobanova, Ekaterina S, additional, Wang, Yuchen, additional, Martemyanov, Kirill A, additional, Hauswirth, William W, additional, Smith, W Clay, additional, Handa, James T, additional, Blackshaw, Seth, additional, Ash, John D, additional, and Dinculescu, Astra, additional

Published
2019
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33. Natural product pharmacology: the British Journal of Pharmacology perspective.

Author

Wang X, Izzo AA, Papapetropoulos A, Alexander SPH, Cortese-Krott M, Kendall DA, Martemyanov KA, Mauro C, Panettieri RA Jr, Patel HH, Schulz R, Stefanska B, Stephens GJ, Teixeira MM, Vergnolle N, and Ferdinandy P

Subjects
Animals, Humans, Drug Development, Periodicals as Topic, Pharmacology, Proteomics, Biological Products pharmacology, Biological Products chemistry
Abstract

Natural products (NPs) have long been used as a rich source of bioactive compounds for drug development. Recent technological advancements have revitalised natural products research as evidenced by increased publications in this field. In this editorial review, we highlight key points from the 2020 British Journal of Pharmacology (BJP) practical guide, which outlines standards for natural products research reports, and provide papers published in BJP between years 2020 to 2023 that demonstrate adherence to these guidelines. Looking ahead, we discuss the potential of chemical proteomics approaches to elucidate natural products mechanisms of action and identify therapeutic targets for future research. By fostering innovation, we aim to advance natural products research and contribute to the development of novel therapeutics that will have a significant impact on healthcare., (© 2024 The Author(s). British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society.)

Published
2024
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34. Novel drugs approved by the EMA, the FDA, and the MHRA in 2023: A year in review.

Author

Papapetropoulos A, Topouzis S, Alexander SPH, Cortese-Krott M, Kendall DA, Martemyanov KA, Mauro C, Nagercoil N, Panettieri RA Jr, Patel HH, Schulz R, Stefanska B, Stephens GJ, Teixeira MM, Vergnolle N, Wang X, and Ferdinandy P

Subjects
Humans, Europe, United States, Drug Approval, United States Food and Drug Administration
Abstract

In 2023, seventy novel drugs received market authorization for the first time in either Europe (by the EMA and the MHRA) or in the United States (by the FDA). Confirming a steady recent trend, more than half of these drugs target rare diseases or intractable forms of cancer. Thirty drugs are categorized as "first-in-class" (FIC), illustrating the quality of research and innovation that drives new chemical entity discovery and development. We succinctly describe the mechanism of action of most of these FIC drugs and discuss the therapeutic areas covered, as well as the chemical category to which these drugs belong. The 2023 novel drug list also demonstrates an unabated emphasis on polypeptides (recombinant proteins and antibodies), Advanced Therapy Medicinal Products (gene and cell therapies) and RNA therapeutics, including the first-ever approval of a CRISPR-Cas9-based gene-editing cell therapy., (© 2024 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society.)

Published
2024
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35. Association of Rgs7/Gβ5 complexes with Girk channels and GABAB receptors in hippocampal CA1 pyramidal neurons.

Author

Fajardo-Serrano A, Wydeven N, Young D, Watanabe M, Shigemoto R, Martemyanov KA, Wickman K, and Luján R

Subjects
Animals, Biophysics, Cell Line, Transformed, Dendritic Spines metabolism, Dendritic Spines ultrastructure, Electric Stimulation, G Protein-Coupled Inwardly-Rectifying Potassium Channels genetics, GTP-Binding Protein beta Subunits genetics, GTP-Binding Protein beta Subunits ultrastructure, Humans, Imaging, Three-Dimensional, Immunoprecipitation, Membrane Potentials drug effects, Membrane Potentials genetics, Mice, Microscopy, Immunoelectron, Neurons ultrastructure, Patch-Clamp Techniques, RGS Proteins genetics, RGS Proteins ultrastructure, Receptors, GABA genetics, Receptors, GABA ultrastructure, Transfection, CA1 Region, Hippocampal cytology, G Protein-Coupled Inwardly-Rectifying Potassium Channels metabolism, GTP-Binding Protein beta Subunits metabolism, Neurons metabolism, RGS Proteins metabolism, Receptors, GABA metabolism
Abstract

In the hippocampus, signaling through G protein-coupled receptors is modulated by Regulators of G protein signaling (Rgs) proteins, which act to stimulate the rate of GTP hydrolysis, and consequently, G protein inactivation. The R7-Rgs subfamily selectively deactivates the G(i/o)-class of Gα subunits that mediate the action of several GPCRs. Here, we used co-immunoprecipitation, electrophysiology and immunoelectron microscopy techniques to investigate the formation of macromolecular complexes and spatial relationship of Rgs7/Gβ5 complexes and its prototypical signaling partners, the GABAB receptor and Girk channel. Co-expression of recombinant GABAB receptors and Girk channels in combination with co-immunoprecipitation experiments established that the Rgs7/Gβ5 forms complexes with GABAB receptors or Girk channels. Using electrophysiological experiments, we found that GABAB -Girk current deactivation kinetics was markedly faster in cells coexpressing Rgs7/Gβ5. At the electron microscopic level, immunolabeling for Rgs7 and Gβ5 proteins was found primarily in the dendritic layers of the hippocampus and showed similar distribution patterns. Immunoreactivity was mostly localized along the extrasynaptic plasma membrane of dendritic shafts and spines of pyramidal cells and, to a lesser extent, to that of presynaptic terminals. Quantitative analysis of immunogold particles for Rgs7 and Gβ5 revealed an enrichment of the two proteins around excitatory synapses on dendritic spines, virtually identical to that of Girk2 and GABAB1 . These data support the existence of macromolecular complexes composed of GABAB receptor-G protein-Rgs7-Girk channels in which Rgs7 and Gβ5 proteins may preferentialy modulate GABAB receptor signaling through the deactivation of Girk channels on dendritic spines. In contrast, Rgs7 and Girk2 were associated but mainly segregated from GABAB1 in dendritic shafts, where Rgs7/Gβ5 signaling complexes might modulate Girk-dependent signaling via a different metabotropic receptor(s)., (Copyright © 2013 Wiley Periodicals, Inc.)

Published
2013
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