61 results on '"Maroli AS"'
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2. Nanostructure Tuning of Gold Nanoparticles Films via Click Sintering
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Urban, Massimo, primary, Rosati, Giulio, additional, Maroli, Gabriel, additional, Pelle, Flavio Della, additional, Bonini, Andrea, additional, Sajti, Laszlo, additional, Fedel, Mariangela, additional, and Merkoçi, Arben, additional
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- 2023
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3. Tunable Anticancer Activity of Furoylthiourea‐Based Ru II –Arene Complexes and Their Mechanism of Action
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Maroli Nikhil, Ponmalai Kolandaivel, Krishna Kadirvelu, Naveen Kumar Kalagatur, Jebiti Haribabu, Nattamai Bhuvanesh, Ramasamy Karvembu, Nithya Balakrishnan, and Srividya Swaminathan
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Aqueous solution ,010405 organic chemistry ,Ligand ,Stereochemistry ,Organic Chemistry ,Substituent ,Biological activity ,General Chemistry ,010402 general chemistry ,01 natural sciences ,Catalysis ,0104 chemical sciences ,chemistry.chemical_compound ,Mechanism of action ,chemistry ,Cancer cell ,medicine ,Electronic effect ,medicine.symptom ,Receptor - Abstract
Fourteen new RuII -arene (p-cymene/benzene) complexes (C1-C14) have been synthesized by varying the N-terminal substituent in the furoylthiourea ligand and satisfactorily characterized by using analytical and spectroscopic techniques. Electrostatic potential maps predicted that the electronic effect of the substituents was mostly localized, with some influence seen on the labile chloride ligands. The structure-activity relationships of the Ru-p-cymene and Ru-benzene complexes showed opposite trends. All the complexes were found to be highly toxic towards IMR-32 cancer cells, with C5 (Ru-p-cymene complex containing C6 H2 (CH3 )3 as N-terminal substituent) and C13 (Ru-benzene complex containing C6 H4 (CF3 ) as N-terminal substituent) showing the highest activity among each set of complexes, and hence they were chosen for further study. These complexes showed different behavior in aqueous solutions, and were also found to catalytically oxidize glutathione. They also promoted cell death by apoptosis and cell cycle arrest. Furthermore, the complexes showed good binding ability with the receptors Pim-1 kinase and vascular endothelial growth factor receptor 2, commonly overexpressed in cancer cells.
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- 2021
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4. A scoring system to predict a prolonged length of stay after surgery for Crohn’s disease
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Antonino Spinelli, Kapil Sahnan, Dakshitha Wickramasinghe, Michele Carvello, Samuel O Adegbola, Pritesh Morar, Janindra Warusavitarne, Francesca Di Candido, and Annalisa Maroli
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medicine.medical_specialty ,Scoring system ,Multivariate analysis ,medicine.medical_treatment ,Logistic regression ,03 medical and health sciences ,0302 clinical medicine ,Crohn Disease ,medicine ,Strictureplasty ,Humans ,Postoperative Period ,Colectomy ,Retrospective Studies ,Crohn's disease ,Receiver operating characteristic ,business.industry ,Anastomosis, Surgical ,Gastroenterology ,Regression analysis ,Perioperative ,Length of Stay ,medicine.disease ,Surgery ,030220 oncology & carcinogenesis ,030211 gastroenterology & hepatology ,business - Abstract
AIM Many factors influence the postoperative length of stay (LOS) in Crohn's disease (CD). This study aims to identify the factors associated with a prolonged LOS after ileocolic resection (ICR) for CD and to develop a scoring system to predict the postoperative LOS in CD. METHOD Patient data were collected from St Marks Hospital, London, UK, and the Humanitas Clinical and Research Center Milan, Italy, for all patients who underwent an ICR for CD from 2005 to 2017. Logistic regression was used for multivariate analysis. The scoring system was developed from the logistic regression model. The performance of the scoring system was evaluated using the area under the receiver operating characteristic curve (AUROC). RESULTS A total of 628 surgeries were included in the analysis. Eighty eight surgeries were excluded due to missing data. The remaining 543 were divided into two cohorts for the development (n = 418) and validation (n = 125) of the scoring system. The regression model was statistically significant (p
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- 2021
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5. New data about home range and movements of Oligoryzomys flavescens (Rodentia: Cricetidae) help to understand the spread and transmission of Andes virus that causes Hantavirus Pulmonary Syndrome
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Belén Crosignani, Malena Maroli, Carlos Ignacio Piña, Rocío Coelho, Valeria P. Martinez, and Isabel Elisa Gómez Villafañe
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0301 basic medicine ,Orthohantavirus ,Epidemiology ,Home range ,030106 microbiology ,030231 tropical medicine ,Population ,Andes virus ,Argentina ,Zoology ,Hantavirus Pulmonary Syndrome ,03 medical and health sciences ,0302 clinical medicine ,Animals ,Humans ,education ,Disease Reservoirs ,Oligoryzomys ,education.field_of_study ,Hantavirus pulmonary syndrome ,General Veterinary ,General Immunology and Microbiology ,biology ,Arvicolinae ,Public Health, Environmental and Occupational Health ,biology.organism_classification ,Infectious Diseases ,Emerging infectious disease ,Animal Distribution ,Oligoryzomys flavescens ,Cricetidae - Abstract
Hantavirus pulmonary syndrome is an emerging infectious disease caused by viruses of the genus Orthohantavirus. The rodent Oligoryzomys flavescens is distributed along four countries of South America. In Argentina, O. flavescens acts as a reservoir of three genotypes of ANDV orthohantavirus. The aims of this work were to estimate home range size and movements-with spool-and-line and radiotelemetry-of infected and non-infected O. flavescens in order to understand the spread and transmission of the virus. O. flavescens use a wide area to satisfice its requirements, reaching a home range of 1.82 ha during spring. Orthohantavirus infection did not change the behaviour of individuals. We observed a great overlapping in the home range of infected and non-infected individuals resulting in a high probability of virus dispersion on rodent population. These results show that human health risks could be high on island environments and knowledge about the movement ecology of O. flavescens provides useful information on prevention.
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- 2020
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6. Safety of hospital discharge before return of bowel function after elective colorectal surgery
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J Chapman, S, Blanco-Colino, R, Pérez-Ajates, S, O Anabitarte Bautista, Hodson, J, C Glasbey, J, Pata, F, Pellino, G, Sgrò, A, Soares, A, T van Elst, S Van Straten, Nepogodiev, D, Borakati, A, F Bath, M, H Yasin, I, Mclean, K, Arthur, T, Kovacevic, M, Delibegovic, S, Karamanliev, M, Swamad, M, Žebrák, R, Paramasivam, R, Martensen, A, M Larsen, H, Rädeker, L, E Frey, P, Kechagias, A, Venara, A, Duchalais, E, Ioannidis, A, Pasquali, S, Simioni, A, Farina, V, Podda, M, Lorenzon, L, Schaeff, V, Otto, A, Jakubauskas, M, R van Elst, T, Chu, M, Pvb, Fagan, I Wells, C, A Alagoa João, Juloski, J, Y El Kasmy El Kasmi, Espin-Basany, E, Clerc, D, Ciubotaru, C, Popescu, S, Yanishev, A, Lee, S, B Ozkan, B, A Yagız Sen, K Aktas, M, E Baki, B, Yüksek, B, Kamarajah, S, A Khaw, R, Mills, E, Goodson, R, Thakral, N, D Ablett, A, Adra, M, Kwek, I, M Khan, S, Quinn, P, R Manley, L, Badran, A, Ramjeeawon, A, Campbell, A, L Tan, H, S Rye, D, Rajaraman, N, G Norman, J, Vutipongsatorn, K, Solomou, G, Akhbari, M, Ali, A, Murray, V, M Baker, D, D Brandao, B, Stainer, B, Thavayogan, R, Jones, D, O Onafowokan, O, Gharooni, A, Dabab, N, Carlton-Carew, S, Kungwengwe, G, Gabriel, M, Sewart, E, C Shortland, T, Lawday, S, Pockney, P, Dawson, A, D Brumfitt, C, Stewart, P, B, Ng, K Luong, J, Ivanov, V, Borisova, A, Neykov, V, Kunčarová, K, Kološová, B, Antonova, T, Farkašová, M, L Harbjerg, J, Brandsborg, S, Brinck, S, D Kjaer, M, Mark-Christensen, A, P Unbehaun, K, Dalsgaard, P, D Lycke, K, Lenaoures, P, Brigand, C, Dumange, E, Gout, M, Moehwald, C, Prem, M, Alhalabi, O, Sliwinski, S, Krupp, J, Gablenz, E, Schmitzer, L, Kopp, A, Steinle, J, Gsenger, J, J Pohl, L, Riccardi, M, M Christodoulou, I, Konstantinidis, M, Machairas, N, Zoikas, A, Balalis, D, K Manatakis, D, L Aguilera, M, Marano, L, Fleres, F, Lovisetto, F, Sasia, D, Segalini, E, Pata, G, Lucchi, A, Sagnotta, A, Campagnaro, T, Petrelli, F, Gallo, G, Papandrea, M, Testa, V, Sinibaldi, G, F Di Candido, Colombo, F, Perrone, G, Aresu, S, Biancafarina, A, Canonico, G, Pagnanelli, M, Curletti, G, Bini, R, A de Manzoni Garberini, Impellizzeri, H, Cillara, N, Tutino, R, Picciariello, A, Coletta, D, Savino, G, Ferrara, F, Tamini, N, Talamo, G, Parini, D, Giamundo, P, A Lo Conte, Pagano, G, Ripetti, V, Pesce, A, Menduni, N, Giudicissi, R, Goldin, E, Rega, D, Belli, A, Andriola, V, Gordini, L, Foppa, C, Piccolo, G, Birindelli, A, Ferrari, C, Ballarini, Z, Tirelli, F, Milone, M, M De Rosa, S Pipitone Federico, N, Molteni, B, L Tilocca, P, Sancini, G, N Piozzi, G, Lauretta, A, Poillucci, G, Mulas, S, Simcikas, D, Portelli, L, Jwm van Wijnbergen, L Dinger, T, Sfh Ten Doesschate, Ashm van Dalen, D van den Bos, D, Hansmann, M, J Medina Feliz, Z Kuiper, S, Abdulrahman, Z, R Pruijssers, S, Farik, S, M Elliott, B, P Geneta, V, Wilton, S, Kandelaki, H, L Peng, S, Campbell, S, K Lim, Y, S Yassaie, S, Murray, M, Haran, C, Tan, J, Castro, J, Laranjeira, A, Catarino, S, Neves-Marques, C, G Correia, J, N Vieira, B, C Quintela, A, L Serra, M, Maciel, J, Cunha, M, J Aparício, D, Neves, J, Azevedo, J, Romano, M, Eiró, F, Romano, J, Monteiro, C, Claro, M, R Almeida, M, Peyroteo, M, D Machado, N, Capote, H, Ferreira, M, Sousa, X, Devesa, H, Cavadas, D, Guerreiro, I, Costa, M, Rosete, M, Salman, M, English, C, Mohammed, N, Litvin, A, V Ćuk, V, Mészárosová, K, Jaich, R, H De Lima, Brooks, S, Marx, M, M Nshalati Salvation, J García Cardo, Mora-Guzmán, I, J Sancho Muriel, U de Andres Olabarria, Muriel, P, C Jimenez Viñas, Alconchel, F, O Esteban Sinovas, C Fairén Oro, M López Otero, S Figueroa Jiménez, O Claramonte Bellmunt, J Martínez Caballero, Rubio-Pérez, I, M Aguilar-Martínez, M, J Segura-Sampedro, J, C Olmedo Moreno, D Negre Parra, M Estévez Diz, A, Martín-Balbuena, R, C Bustamante Recuenco, E Licardie Bolaños, R, Fernández, P, A Díaz Padillo, Forero-Torres, A, I Alberdi San Román, H Salvador Rosés, M Merayo Álvarez, P Villarejo Campos, C Lopes Moreira, C, P Uriol Peralta, M Serrano Navidad, Ripollés-Melchor, J, Garcea, A, H Gómez Facundo, P Troncoso Pereira, V Pérez Guarinos, C, Blaser, B, Piazza, G, Gagliardi, B, Serin, H, S Yurdaor, S, Arslan, E, Kopac, O, Uyanik, A, B Ozmen, B, Tiftik, E, Aksoy, B, Yalcinkaya, A, Ozoglu, F, D Kocer, M, Bilicen, G, N Cinar, E, Uslu, Ö, Kaya, Y, Demirci, K, Wong, J, Mmh, Farhan-Alanie, Suresh, G, Asif, A, J Finch, B, Bhahirathan, Y, Herron, J, Z Yi Tew, Obukofe, R, Russell, C, Suchett-Kay, I, Netke, T, Williams, L, Kisiel, A, Y Liu, F, Claireaux, H, James, P, Mondal, A, Kalderon, R, H Nadama, H, Al-Saraff, Z, Jph, Tam, Powell-Chandler, A, Wood, F, Rebecca, Gorgievska, Ragavoodoo, A, Thakrar, C, Rojoa, D, Palmer, C, Davidson, K, Giacci, L, Hale, J, W Gan, F, Makin-Taylor, R, Y Hey, C, Toh, C, M Findlay, J, Griffiths, N, Ganesananthan, S, Jasionowska, S, Poustie, M, Wong, C, Turner, T, Pyc, W, Sloper, W, Warner, C, Coey, J, Mason, D, Sait, S, Kowal, M, Owen, M, Saiyed, A, Ashworth, I, Akbari, K, Curran, M, Martin, P, Parker, D, Kwok, K, Lye, C, Ghaly, M, Sammour, T, Lewis, D, Mundasad, R, Wilkes, A, Ctercteko, G, Maslyankov, S, Dimov, R, Iliev, S, Dimitrov, D, Marek, F, Örhalmi, J, Skalický, P, Skalický, T, Chrz, K, Christensen, P, Worsøe, J, S Kristensen, E, J Emmertsen, K, S Loeve, U, L Mihaljevic, A, Herrle, F, M Konstantinidis, K, Korkolis, D, Karanikas, I, Vincenti, L, Anania, G, Borghi, F, Agresta, F, Maretto, I, Parisi, A, Bucci, L, G De Palma, Guglielmi, A, Cucinotta, E, F La Torre, Cianchi, F, Guerrieri, M, Trompetto, M, Persiani, R, Micheletto, G, Delrio, P, Cantafio, S, Ronconi, M, Pag, Bisagni, M De Prizio, Franceschi, A, Galleano, R, Cavallini, M, Brescia, A, D'Ambra, L, Benevento, A, Niolu, P, Calgaro, M, Colangelo, E, Grottola, T, F Altomare, D, Puleo, S, Salamone, G, Pietrabissa, A, Poggioli, G, Erdas, E, Ottonello, R, Tonini, V, Selvaggi, F, Sammarco, G, Ceccarelli, G, C De Nisco, Surgo, D, Taglietti, L, Ozolins, A, Sivinš, A, Poskus, T, Psaila, J, A Bemelman, W, J Graat, L, Langenhoff, B, Bpl, Wijnhoven, Ahw van de Ven, Poelman, M, Lps, Stassen, Slooter, G, Yiz, Acherman, Hoff, C, F Gerhards, M, Mwj, Stommel, J Hazebroek, E, Aaw van Geloven, A Schasfoort, R, L van Leeuwen, B, B Tuynman, J, Mwa van Tilburg, G Boerma, E, Sharma, P, Jenkins, B, P Bissett, I, Herd, A, Gordon, A, Vernon, D, Omundsen, M, J, Ly, Reddy, A, Bonnet, G, Harmston, C, Morales, M, Francisco, V, Costa, S, Manso, A, Amorim, E, Pereira, J, Cardoso, J, Ourô, S, Caratão, M, Nascimento, C, B Ribeiro da Silva, Taranu, V, Dias, R, Mendes, J, Allen, M, Silva, A, Carlos, S, Barbosa, E, Carneiro, C, Ramos, L, Lencastre, L, Martins, R, Silva-Vaz, P, F Ridgway, P, A McNamara, D, Cahill, R, Hogan, A, Larkin, J, R O'Connell, P, Negoi, I, Abelevich, A, M Ćuk, V, Vician, M, Ede, C, Sardiwalla, I, Mulira, S, Montwedi, D, Oyomno, M, Sabia, D, V Portugal Porras, Vigorita, V, G Sanz Ortega, García, J, A Espí Macías, F Blanco Antona, A Luján Mompeán, J, S Salvans Ruiz, Villarejo-Campos, P, M Romero Simó, Sánchez-Guillén, L, M Jiménez-Gómez, L, A Sánchez López, Golda, T, D Julià Bergkvist, Nevado, C, F Noguera Aguilar, J, B Ricardo Felipe, Septiem, J, A Rodríguez Sánchez, Cañete-Gómez, J, I Ruiz Montesinos, Millán-Scheiding, M, Prieto-Nieto, I, Frasson, M, D García Olmo, Hübner, M, Petermann, D, O Sauvain, M, Ozben, V, E Geçim, I, Disçi, E, Rencuzogullari, A, Kurt, A, Bisgin, T, Pehlivan, M, Isik, A, Onur, E, Leventoglu, S, C Haksal, M, S Erturk, M, Keskin, M, Guner, A, S Tutcu Sahin, S Ozbalci, G, Pergel, A, Albayrak, D, Bruce, D, Fearnhead, N, Arthur, J, Harron, M, Beattie, G, Titu, L, Saunders, M, Phillips, J, Dindyal, S, Cresswell, B, Gercek, Y, Lee, J, Linn, T, Faulkner, G, Lockwood, S, Rees, J, Charalabopoulos, A, Campbell, B, Kontovounisios, C, Amarnath, T, Johnson, M, Epanomeritakis, E, Vigs, S, Nastro, P, Gilliam, A, Smolarek, S, Wilson, T, Orbell, J, Mcintyre, R, Agarwal, T, Hainsworth, P, Patel, P, Vijay, J, Liu, B, P Dhruva Rao, Roxburgh, C, Vipond, M, Youssef, H, Thorn, C, Schizas, A, Denley, S, Bowley, D, Das, K, Cuming, T, Saha, A, Chung, L, Pitt, J, Davis, P, Jones, O, Taylor, M, Bhargava, A, Haji, A, Watson, N, Bloom, I, Singh, B, Norwood, M, Gurjar, S, Stylianides, N, Mirza, S, Evans, M, Williams, G, Patil, P, Hernon, J, Finch, G, Green, S, Chapple, K, Fafemi, O, Warusavitarne, J, Samee, A, Carden, C, Ong, L, Verma, K, Joseph, A, Rawat, N, Pinkney, T, Oke, O, Glen, P, Maxwell-Armstrong, C, Oliphant, R, Garner, J, J Moug, S, Middleton, S, N Lund, J, J Smart, N, Osborn, G, Moore, T, Raymond, T, H Knowles, C, S Hany, T, Clarke, R, Khera, G, Brady, R, Sellahewa, C, Mason, C, Torrance, A, Lasithiotakis, K, Knight, J, Pullybank, A, Ainsworth, P, Reid, F, Ramwell, A, Maslekar, S, George, R, Skull, A, Holtham, S, Muhammad, K, Lal, R, Varcada, M, M Smith, F, Howlader, M, Defriend, D, Kirk, S, Richards, T, Evans, C, M Borg, C, Telford, K, Sarfraz, N, Busby, K, Hollingshead, J, Speake, D, Pawa, N, West, D, Chadwick, M, Komolafe, O, Richardson, S, Thornton, M, Goede, A, Osborne, C, Bandyopadhyay, D, Foong, J, J Lee, Y, Liebenberg, P, Mijalkov, D, Wells, A, Bull, N, Ajmera, A, Warburton, T, Morgan, S, Mahmoud, A, Schachtel, M, Mikhail, B, Fomin, I, Mekaeil, B, Taylor, N, Stevenson, C, Drane, A, Pahalawatta, U, T Lai, L, Debiasio, A, Hjs, Jun, Hengpoonthana, R, M Mendis, D, M Robb, P, J Lee, H, Aab, Wyche, T Davis, L, Chrimes, A, Agarwal, A, Zhao, J, Williams, S, Jmsn, Jayalath, Khor, S, Muddasani, T, Childs, S, Ridgway, S, Nda, Blefari, Tam, H, Puchalski, N, Ngai, C, Mackenzie, J, Johnson, N, Holmes, M, Zuzek, R, Saluja, T, Gould, T, K Goh, Y, Selvaraj, T, Z Beh, Y, N Dudi-Venkata, N, Horne, D, L Borrow, J, Campbell, C, Cousins, G, Jackson, L, Maheepala, K, Zhao, S, Holden, E, Tutt, L, Thompson, B, Collins, H, Louie, F, Buckland, B, Smith, D, Chong, C, H Chua, T, Nayak, C, Redmond, J, R Tan, R, Gramlick, M, S Teh, J, Y Ng, S, Britten-Jones, P, R Mohd Rosli, Hdv, Pham, Jegathees, T, Smcj, Coulter-Nile, P Gosselink, M, L Wang, Y, Maciaszek, M, S Chrapko, P, Nair, A, Thirugnanasundralingam, V, Muir, K, Salibasic, M, Pavlov, V, Paycheva, T, Lyulenina, E, Kolev, N, Nguen, D, Mitkov, Y, Mitkov, E, Vladova, P, Dimitrov, V, Hussain, M, Gabarski, A, Ivanov, T, Yotsov, T, Ilieva, I, Akisheva, A, Shoshkova, M, Nawaz, E, Feradova, H, Mladenov, T, Jozaf, V, Klail, T, Pös, M, Adel, A, Sotona, O, Bartoš, M, Amjad, T, Malý, O, Berec, S, Hanušová, M, Hurný, M, Riško, J, Ludvik, M, Stercz, M, Treskoň, R, Pospíšil, M, Hlaváčová, L, Tomanová, D, Chodora, S, Houdek, O, Novický, R, Sobotková, K, Cha, S, K Šuta Kimle, Jirankova, K, Bujda, M, Paclík, A, Trap, A, Jürgens-Lahnstein, J, Storm, M, Damgaard, I, Olawi, F, Ehlern, F, Raos, M, P Kristensen, F, Bønnerup, K, Amiri, S, Enevoldsen, M, J Højgaard Pedersen, N Jepsen, B, K Hillgaard, T, B Erichsen, S, V Nielsen, C, P Madsen, C, Bjerke, J, D Skejø, C, R Aabling, R, S Sørensen, J, Turunen, A, Katunin, J, Niskakangas, M, Vignaud, T, Frey, S, Ricolleau, C, Chanut, F, Magnin, J, Seiboldt, T, Beck, L, Zamzow, K, Betge, F, Poncelet, A, Truant, M, Hauschild, H, Neugebauer, N, Schöning, L, S Cs Simon, Galata, C, Karampinis, I, Thäwel, T, M Seckler, A, Kerem, C, Durdevic, S, Antonakopoulos, F, Mathioulaki, A, Chrysoheris, P, G Athanasopoulos, P, Kalles, V, Spyrou, I, Barkolias, C, Paspala, A, Papaconstantinou, D, Spartalis, E, Arkadopoulos, N, Prodromidou, A, Garoufalia, Z, Mendez, D, Rosales, J, Flores, M, Garcia, M, Garcia, A, Noriega, Z, Torselli, D, Rodriguez, J, Lafranceschina, S, Artioli, E, Giaccari, S, Nevoso, V, Schimera, A, Marino, S, Geretto, P, Pellegrino, L, Borghi, B, Marano, A, Corino, C, Cannata, G, C Giuffrida, M, Landra, F, Ongaro, D, Baronio, G, Raimondo, S, Casiraghi, S, Salvadori, R, Finotti, E, Ciccioli, E, Galgano, A, Zuin, M, Bettella, A, Barina, A, Vendramin, E, Palano, G, Schiavone, D, A Di Cintio, Gemini, A, Trastulli, S, M De Luca, Desiderio, J, Gubbiotti, F, Cigognini, M, Zaffaroni, G, Maffioli, A, Colombo, S, Bondurri, A, Sampietro, G, Foschi, D, Manigrasso, M, Danzi, M, Amato, R, Anastasio, L, Mastella, F, Basile, R, Peltrini, R, Marra, E, Luglio, G, Giglio, M, Anoldo, P, Vertaldi, S, Grimaldi, L, Tammaro, N, Pedrazzani, C, Turri, G, Lazzarini, E, Conti, C, Vulcano, I, Bertilone, E, Pintabona, G, Viscosi, F, Cerasari, S, Galiffa, G, Lapolla, P, C Del Basso, Cirillo, B, G De Toma, Fazzi, K, Bini, S, Coratti, F, Montanelli, P, Grandi, S, Nelli, T, N Ben Khaled, Cammelli, F, Ferrini, E, E Billo, M, G Marrosu, A, Scognamillo, F, Pala, C, Attene, F, Carboni, L, W Ruggiu, M, Gabbas, G, Marziali, I, Mazzocato, S, Vergari, R, Piazzai, F, Kubolli, I, Aggiusti, A, Paolucci, A, Ortenzi, M, Olivieri, M, Belluco, C, D Antona, A, Basso, S, Morino, M, Mistrangelo, M, Clerico, G, G De Santi, F Bitonti, M, Frattalone, M, Fico, V, Santullo, F, Belia, F, Spinelli, A, Marco, M, Bevilacqua, M, Tringali, D, Bevilacqua, E, Panizzo, V, V La Manna, Migliore, G, Aversano, A, A Fares Bucci, Marino, F, Carbone, F, Incollingo, P, M Romano, F, Zalla, T, Baraghini, M, Romoli, L, Calussi, M, Vellei, S, Genzano, C, Feroci, F, Vita, M, Barberis, A, Serra, D, Grassia, M, Romelli, M, Ruggiero, S, Percassi, A, A Magri Piccinini, Monti, M, Magnoli, M, Romano, S, Gaetano, P, Pilotta, F, Baldassarre, L, Bonati, E, Saba, A, Moretto, G, Bacchion, M, Casaril, A, Inama, M, Creciun, M, Stella, M, Gobatti, D, Angelini, M, Andolfi, E, Miranda, E, Scricciolo, M, Provenza, G, Cavallina, G, Frezza, B, Fontani, A, Malatesti, R, A Pellicanò, G, Anania, M, Pulighe, F, Cruccu, A, L Murru, M, Massaiu, C, Balestra, F, Pazzona, M, Giannella, A, Santangelo, M, Frangella, F, Magagnano, D, Liberatore, P, Brenna, R, Giani, A, Tirotta, F, Famularo, S, Angrisani, M, Ceresoli, M, Rondelli, F, P Angelucci, G, Scaramuzzo, R, Larcinese, A, Fioriti, C, Picone, E, Nardi, M, Castagnoli, G, Bartoli, A, Bellochi, R, Spaziani, A, Conti, D, Poponesi, V, Trippetti, M, Amicucci, S, Tazza, G, Procacci, P, Giovannini, F, Basile, E, Caristo, G, P De Nardi, Rosati, R, Marcocci, G, Vignali, A, Malerba, M, Percivale, A, Ghazouani, 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H., Buari, M., Ahmed, K., Sheikh, Z., Monks, M., Lehmann, J., Rotimi, O., Bell, T., Limnatitou, D., Gormley, S., Taleongpong, P., Patel, V., Macgregor, L., Amini, S., Turner, C., Dwyer-Hemmings, L., Busuttil, A., Powell, J., Hensher, C., Vivian, F., Wcislo, K., Millar, Z., Hirosue, S., Ogunmwonyi, I., Nakakande, D., Gaze, H., Pillai, S., Khoury, G., Powell, T., Maleyko, I., Sangheli, A., Ransome, M., Isse, M., Aromolaran, O., Bholah, H., Anbarasan, J., Rehman, S., Hu, E., Timms, S., Reynolds, W., Hotchkies, A., Misra, V., Murray, V., Theocharidou, L., Malik, T., Janmohamed, I., Carhart, B., Khan, A., Hullait, R., Rylance, A., Butt, S., Leathes, J., Rajathasan, T. P., Jeddy, H., Kyaw, H. A., Wong, N., Karelia, S., Clements, J. M., Rainey, M., Joshi, N., Rahman, A., Gallagher, M., Rebuffa, N., Abdelgalil, R., Lai, R. S. Y., Laurence, N., Thomas, S., Green, C., Frostick, R., Khera, R., Povey, M., Wong, H. L., Mccusker, C., Hlukha, L., Pike, G., Kamel, F., Thakkar, R., Donaldson, C., Campos, M. S., Bradbury, M., Osunronbi, T., Tam, L. Y. C., Kaabneh, A. K., Lawther, J., Fisher, P., Tribedi, T., Moosa, A., Ramdin, A., Goble, M., Downs, E., Wheldon, L., Baggus, E., Mandal, A., Nayeem, A., Ahmed, S., Fradley, W., Wilson, C., Gallagher, S., Criswell, T., Ward, J., Mukkavilli, A., Stubbs, B., Fordyce, W., Suchdev, N., Lim, S. W., Sookramanien, S. R., Chan, A., Bointas, G., Paul, M., Ward, K. L., Bagnall, M., Pherwani, S. A., Wang, K., Mitchell, L., Heyworth, J., Ayyar, S., Polson, R., Mackenzie, E., Doyle, N., Habib, Z., Zardab, M., Sartaj, F., Farooq, H., Tabibi, M., Drury, D. J., James, S. J., Barnett, R., Cahya, E., Lou, G., Coyle, M., Homyer, K., Zhu, L. Y., Woods, M., Chang, J., O'Callaghan, H., Suchett-Kaye, I., Mihailidis, T. H., Alawattegama, H., Seite, E., Barrett, A., Riordan, E., Lam, W., Dowdeswell, M., Mulvenna, C., Awokoya, O., Gurowich, L., Dhera, K., Hayat, S., Tincknell, L., Spazzapan, M., Teeling, F., Sysum, K., Latter, J., Latter, M., Khan, S., Woodmass, M., Hayden, H., Ali, Y., Husain, S., Arnold, A., Pedersen, A. C., Cunha, P., Ahmed, M., Al Zawawi, S., Kudva, V., Theodoropoulou, K., Miscampbell, M., Robinson, A. V., Johnston, J., Dharni, A., Lamb, S., Westerman, T., Evans, E., Campbell, L., Gillespie, M., Cheong, C. M., Kulathevanayagam, K., Varghese, A., Ike, S. I., Chu, T. S. M., Baljer, B., Mogg, J. A. W., Rai, P., Claireaux, H. A., Williams, M., Smillie, R., Goetz, J., Appleby, E., Fadipe, T., Vaughan-Burleigh, S., Jovaisaite, A., Shah, S. M., Khalid, N., Gutmann, D., Davison, S., Alame, Y. J., Syed, L., Owen, W. J., Ahsan, S. D., Anthony-Uzoeto, U., Hall, C. M., Zheng, S., Wynter, K., James, C., Sapre, D., Ghosh, R., Baird, J., Cockburn, L., Blackwood, O., Simpson, W., Jeong, S., Bishop, S., Bate, R., Hobson, C., Adam, A. H., Redclift, C., Do, J., Adeleye, O., Poli, F., Batterham, A., Brown, S., Parekh, J. N., Clay, W., Pieri, K., Jackson, A., Saxena, A., Gurung, B., Oyebola, T., O'Brien, F., Djeugam, B., Gardezi, S., Ul-Hasan, S., Martin-Hernandez, M. P., Sisley, M., Modi, S., Antakia, R., Elbayouk, A., Soh, Y. J., Mather, J., Yusuf, Z., Al-Sarraf, Z., Naja, M., Rassool, S. B., Convill, J., Nikookam, Y., Warsame, A., Pace, C., Kiandee, M., Ridwan, R., Carey, C., Hirri, F., Mcmillan, M. J. A., Ling, J. J., Pendelbury, L., Kerimzade, K., Tang, A., Howard, E. O., Humayun, S., Wadsworth, O. J., Tan, K., Abdelhameed, F., Haglund, C., Radnaeva, I., Hu, N., Rambhatla, S., Waldron, D., Madahar, P., Malik, S., Meney, L. C., Ibrahim, I., Kang, C. K., Chiu, J. Z. J., Livie, V., Ibrahim, B., Khalil, M., Pooley, G., Shishkin, B., Docherty, J., Southgate, A., Coomes, A., Mcgee, F., Flanagan, S., Tan, Q. J., Anwar, H., Clough, R., Chrisp, B., Cassels, J., Cross, G. W. V., Mercer, L., Mercer, C., Refalo, A., Hadley, R., Mctighe, A., Farrow, F., Brodie, A., Davis, G., Shah, D. R., Bowers, C., Patel, S., Morice, O., Burzic, A., Cheung, J., Shashidhara, A., Theodoraki, G., Birk, J., Ong, A., Ng, M. P. E., Wong, R. T. W., Maese, S., Yeap, B., Iqbal, Z., Melaugh, T., Perchard, W., Scurr, T., Campbell, E., Kelk, L., Ghosh, A., Gibbins, A., Mala, D., Loizidou, A., Hall, O., Mecia, L., Hew, C., Varathan, K., Tong, L., Chandrasekar, B., Buchanan, E., O'Connell, M., Kwak, S. Y., Ong, E. H., Gardner, S., Lim, J., Maden, C., Illahi, M., Tan, Z. X., Edwards, S., Stahl, R., Stahl, J., Hickman, A., Collett, D., Goolam-Mahomed, Z., Allen, B., Atiyah, A., Ahmad, H., Jones, J., Mcgregor, O., Ogundiya, E., Boulbadaoui, A., Kirnon-Jackman, O., Lim, Q. X., Peckham, H., Yeoh, T., Yong, S. Q., Chen, J. Y., Siva, S., Sam, Z. H., Gilani, M., Goh, Y. N., Muthukumar, M. G., Phillips, S., Tjoakarfa, J., Giri, A., Suresan, S., Thomas, P., Johnson, T. A., Williams, R. I., Rashid, A., Kushairi, A., Rais, A., James, A., Bugelli, M., Chechelnitskaya, Y., Sandhu, N., Tandon, R., Gray, M., Kumar, A., Ciurleo, C., Nyamali, I., Hiremath, S., Sinha, S., Chowdhary, M., Bradley, E., Mctiernan, M., Macdonald, S., Sharkey, S., Mclaughlin, N., Amey, C., Kraria, L., Skan, O., Kind, C., Tupper, P., Van Rhee, C., Honeyman, S. I., Menon, G., Jegatheeswaran, L., Madhavan, A., Warne, M., Malcolm, F. L., Lessware, T., Wilkerson, H. T., Chatterjee-Woolman, S., Yoong, A., Ahmed, W. U. R., Longshaw, A., Flannery, O., Green, R., Leaning, M., Cragg, J., Sharriff, H., Doherty, C., Kwan, K. W. L., Sanders-Crook, L., Bhatia, S., Eames, S., Lewis, F., Kirupananthan, P., Boh, Z. Y., Dass, S., Soma, A., Newton, A., Hill, M., Shafiq, Y., Brkljac, M., Boyce, L., English, W. J., Lam, S., Chipeta, C., Jain, C., Garofalidou, T., Novotny, S. A., Locke, S., Bowman, C., Begaj, A., Murphy, C., Radcliffe, K., Chong, J. T., Jeffrey, E., Chaudhury, N., Rajendran, K., Akbar, Z., Walters, B., Kulendrarajah, B., Tran, N., Shrestha, S., Parmar, S., Gallagher, C., Hennessy, L., Pentti, E., Badhrinarayanan, S., Fung, A., Mansoor, M., Kenny, R., Kan, P., Lee, D. E., Khosla, S., Samake, M., Shaban, F., Aftab, R., Gough, M., Woodburn, B., Vayalapra, S., Mcmurrugh, K., Jimulia, D., Deol, S., Pike, S., Embury-Young, Y., Patel, M., Kilgallon, E., Keating, R., Walsh, A., Khan, H., Logue, G., Orekoya, M., Alasmar, M., Charalambides, M., Llavall, A. C., Williamson, E., Bharwada, Y., Zearmal, S., Evans, H., Panikkar, M., de la Cruz, G., Caplan, J., Ruparelia, A., Tanvir, T., Soare, C., Pang, Y. L., Trotter, J., Zaidi, A., Thakrar, V., Pulickal, P., Ahmed, H., Parnell, J., Lennock, S., Ford, V., Brignall, R., O'Neill, D., Hanna, R., Kane, R., Nicola, M., Rajput, K., Xiao, Y., Michael, S., Wright, E., Juniper, S., Thompson, E., Hoskyns, L., Kanitkar, A., Ross, C., Unsworth, A., Rshaidat, H., Demarre, K., Chiang, A., Bareh, A., van Dellen, J., Faqihinejad, C., Gadhvi, A., Grant, R., Lewsey, J., Morris, A., Martin, H., Mcclarty, C., Sanyal, S., Alsaif, A., Palkhi, A., Bhopal, S., Burford, C., Huq, T., Irwin, E., Matthews, L., Ngu, W. S., Hosfield, T., Muneeb, F., Page, O., Zeb, E., Al-Azzawi, A., Mcintosh, J., Vucicevic, A., Hughes, M., Brooks, L., Fanibi, B., Dixon, M., Njoku, P., Morris, D., Jobson, J., Chowdhury, H., Joseph, N., Zulkefley, N., Hunt, G., Christodoulou, T., Wright, O., Soman, S., Jamal, M., Beqiri, S., Borgas, P., Christie, S., Pereira, F., Browne, S., Yiu, J., Dworkin, A., Brayley, J., Palmer, A., Charalambos, M., Jones, C. S., Toner, S., Cowden, R., Lee, L., Nicol, P., Holman, O., Imtiaz, M., Albert, V., Leung, S. P., Erotocritou, M., Stroud, R., Wilkin, R., Thomson, W., Mackee, L., Kler, A., Reynolds, L., Mohamed, S. H., Majeed, Y., Fakim, B., Jones, A., Liversedge, G., Carrington, Z., Windebank, J., Izzarina, A., Akbani, U., Craven, J., Aldarragi, A., Harding, S., Millward, A., Bedford, M., Gopalan, V., Midgen, A., Khadka, P., Cheng, O., Taneja, S., Manobharath, N., Kok, J. Y., Lim, D. W. E., Buick, T., Boland, M., Piya, S., Devlin, R., Fairfield, C. J., George, R. J., Rahi, M., Zaman, S., Hajiev, S., Ross, T., Crisp, E., Thompson, C., Charalambous, A., Hollywood, J. L., Hammond, R. F. L., Matthews, J., Mendonca, V., Spinty, J., Khan, K., Cheng, J., Glynn, N., Muhammad, U., Khan, M., Anderson, L., Mccormack, K., Mak, J., Patrawala, S., Milinkovic, N., Schofield, R., Chauhan, M., Hartley, L., Hind, J., Nelson, L., Ratnasingham, D., Whitehead, T., Dimitriadis, S., Marshall, K., Flint, E. J., Horner, C., Heybourne, A., Morgan, H., Wickstone, C., Panagiotou, D., O'Connell, E., Dean, K., Iqbal, R., Walsh, L., Yu, N., Rana, N., Massie, E., Ng, J., Jung, M., Lee, Y. D., Harris, M., White, S., Boev, B., Tonchev, P., Prochazka, V., Risko, J., Skalicky, A., Ravn, S., Ojakaar, A., Dorr-Harim, C., Koutserimpas, C., Giraudo, G., Armellini, A., Ruzzenente, A., Mazzeo, C., De Padua, C., Luc, A. R., Maroli, A., Vitali, M., Gusai, G. P., Quattromani, R., Virgilio, E., Berti, S., Di Mola, F. F., Papagni, V., Tuminello, F., Vittori, L., Longheu, A., Loche, G. A., Braccio, B., De Luca, E., Resta, G., Ancans, G., Tamosiunas, A., Petrulionis, M., Abdulrahman, N., van de Pas, K. G. H., Thomas, G., Brandsma, A. M., Davids, J., Rottier, S. J., de Roy van Zuidewijn, D., Hawkins, R., Ong, H. I., Li, Y., Desmond, B., Winstanley, J., Martins, M., Americano, M., Frade, S., Senhorinho, R., Peixoto, R., Alves-Vale, C., Lamas, M., O'Connor, D. B., Hoo, M., Gopaul, A., Scanlon, K., O'Dwyer, N., Jovanovic, M., Panyko, A., Van Vuuren, S., Centeno, A., Bernado, I. R., Senorans, M. P. G., Amor, L. G., Ramirez, A. C., Abrisqueta, J., Gomez, M. E., Arroyo, A., Cerdan, C., Romeu, N. G., Enriquez-Navascues, J. M., Collado-Roura, F., Curchod, P., Gaspar, S., Imadalou, L., Mutlu, D., Akyol, C., Uygur, F. A., Eray, I. C., Biyiklioglu, O., Cetin, M. F., Isik, A. E., Karip, B., Dogan, H., Sarigul, L., Tunc, E., Aydin, T., Bodur, S., Karabulut, K., Francis, A. A., Al-hadithi, A., Lau, I. S. F., Smith, E., Mahapatra, S., Mcauliffe, O., Imam, L., Akram, B., Hossaini, S., Davies, R., Ko, M., Collins, J., Pandya, A., Reilly, S., Archer, J., Livie, J., Chaudhry, F. A., Ntakomyti, E., Diallo, R., Bylinski, T., Wright, J., Masiha, E., Tung, J., Shirazi, B., Neilson, A., Epton, S., Patel, N., Trussell, S., Couldrey, A., and Donnelly, C.
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operative ,Male ,postoperative discharge ,Postoperative Complications ,0302 clinical medicine ,Colostomy ,CRITERIA ,Prospective Studies ,Bowel function ,Colectomy ,IMAGINE ,stoma ,intestines ,Proctectomy ,Ileostomy ,digestive, oral, and skin physiology ,patient discharge ,colorectal surgery, hospital discharge, bowel function ,RECOVERY ,Middle Aged ,adult ,colostomy ,elective surgical procedures ,female ,follow-up studies ,humans ,ileostomy ,ileus ,male ,middle aged ,multivariate analysis ,patient readmission ,patient safety ,postoperative complications ,prospective studies ,recovery of function ,colectomy ,proctectomy ,Patient Discharge ,Colorectal surgery ,ileus - - discharge - bowel function - elective - colorectal surgery ,Elective Surgical Procedures ,030220 oncology & carcinogenesis ,Female ,030211 gastroenterology & hepatology ,Patient Safety ,Cohort study ,safety ,Adult ,medicine.medical_specialty ,Ileus ,Patient Readmission ,defecation ,03 medical and health sciences ,medicine ,Hospital discharge ,Humans ,colorectal surgery ,colorectal resection ,Colorectal resection ,defecation, postoperative complications, colorectal surgery, intestines, patient discharge, patient readmission, safety, surgical procedures, operative, colorectal resection, ileus ,business.industry ,Recovery of Function ,Odds ratio ,medicine.disease ,digestive system diseases ,surgical procedures ,Surgery ,Multivariate Analysis ,Defecation ,business ,Follow-Up Studies - Abstract
Ileus is common after colorectal surgery and is associated with an increased risk of postoperative complications. Identifying features of normal bowel recovery and the appropriateness for hospital discharge is challenging. This study explored the safety of hospital discharge before the return of bowel function.A prospective, multicentre cohort study was undertaken across an international collaborative network. Adult patients undergoing elective colorectal resection between January and April 2018 were included. The main outcome of interest was readmission to hospital within 30 days of surgery. The impact of discharge timing according to the return of bowel function was explored using multivariable regression analysis. Other outcomes were postoperative complications within 30 days of surgery, measured using the Clavien-Dindo classification system.A total of 3288 patients were included in the analysis, of whom 301 (9·2 per cent) were discharged before the return of bowel function. The median duration of hospital stay for patients discharged before and after return of bowel function was 5 (i.q.r. 4-7) and 7 (6-8) days respectively (P 0·001). There were no significant differences in rates of readmission between these groups (6·6 versus 8·0 per cent; P = 0·499), and this remained the case after multivariable adjustment for baseline differences (odds ratio 0·90, 95 per cent c.i. 0·55 to 1·46; P = 0·659). Rates of postoperative complications were also similar in those discharged before versus after return of bowel function (minor: 34·7 versus 39·5 per cent; major 3·3 versus 3·4 per cent; P = 0·110).Discharge before return of bowel function after elective colorectal surgery appears to be safe in appropriately selected patients.El íleo es frecuente tras la cirugía colorrectal y se asocia con un aumento del riesgo de las complicaciones postoperatorias. Identificar las características de una recuperación normal del tránsito y la idoneidad para el alta hospitalaria es una tarea difícil. Este estudio examinó la seguridad del alta hospitalaria antes del restablecimiento de la función intestinal. MÉTODOS: Se llevó a cabo un estudio de cohortes prospectivo y multicéntrico a través de una red de colaboración internacional. Se incluyeron pacientes adultos sometidos a resección electiva colorrectal entre enero y abril 2018. El objetivo principal fue el reingreso hospitalario durante los 30 primeros días tras la intervención. Se utilizó un análisis de regresión multivariable para evaluar el impacto del momento del alta en función del restablecimiento de la función intestinal. El objetivo secundario fue las complicaciones postoperatorias en los primeros 30 días después de la cirugía, valoradas mediante el sistema de clasificación de Clavien-Dindo.Se incluyeron en el análisis 3.288 pacientes, de los cuales 301 (9,2%) fueron dados de alta antes del restablecimiento de la función intestinal. La mediana de la estancia hospitalaria de los pacientes dados de alta antes y después del restablecimiento de la función intestinal fue 5 (rango intercuartílico: 4-7) y 7 (6-8) días, respectivamente (P 0,001). No hubo diferencias significativas en las tasas de reingreso entre estos grupos (6,6% versus 8,0%; P = 0,499), y este resultado se mantuvo en el análisis multivariable tras el ajuste por diferencias basales (razón de opotunidades, odds ratio, OR 0,90; i.c. del 95% 0,55-1,46, P = 0,659). Las tasas de complicaciones postoperarorias fueron similares en aquellos dados de alta antes o después del restablecimiento de la función intestinal (complicaciones menores: 34,7% versus 39,5%; complicaciones mayores 3,3% versus 3,4%; P = 0,110). CONCLUSIÓN: Dar de alta antes del restablecimiento de la función intestinal tras cirugía colorrectal electiva parece ser seguro en pacientes debidamente seleccionados.
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- 2020
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7. Closing the gap between in vivo and in vitro omics: using QA/QC to strengthen ex vivo NMR metabolomics
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Maroli, Amith Sadananda, primary and Powers, Robert, additional
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- 2021
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8. The Influence of Post System Design and Material on the Biomechanical Behavior of Teeth with Little Remaining Coronal Structure
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Vagner Flávio Reginato, Angélica Maroli, Cláudia Lopes Brilhante Bhering, Ataís Bacchi, Gabriel Rodrigues Oliveira, Ricardo Armini Caldas, and Cristiano Lazzari Pinto
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Orthodontics ,Materials science ,Root canal ,0206 medical engineering ,Tooth Fracture ,030206 dentistry ,02 engineering and technology ,020601 biomedical engineering ,Stress (mechanics) ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,Flexural strength ,Coronal plane ,Dentin ,medicine ,Fracture (geology) ,von Mises yield criterion ,General Dentistry - Abstract
Purpose To evaluate the influence of different post systems on the biomechanical behavior of teeth with a severe loss of remaining coronal structure. Materials and methods Fifty standardized bovine teeth (n = 10 per group) were restored with: cast post-and-core (CPC), prefabricated metallic post (PFM), parallel glass-fiber post (P-FP), conical glass-fiber post (C-FP), or composite core (no post, CC). The survival rate during thermomechanical challenging (TC), the fracture strength (FS), and failure patterns (FP) were evaluated. Finite element models evaluated the stress distribution after the application of 100 N. Results All specimens survived TC. Similar FS was observed among post-containing groups. Groups P-FP and CC presented 100% repairable fractures. The von Mises analysis showed the maximum stresses into the root canal in groups restored with metallic posts. Glass-fiber posts and CC presented the maximum stresses at the load contact point. Glass-fiber groups showed lower stresses in the analysis of maximal contact pressure; CPC led to the highest values of contact pressure. The modified von Mises (mvM) stress in dentin did not show differences among groups. Moreover, mvM values did not reach the dentin fracture limit for any group. Conclusions The type of intracanal post had a relevant influence on the biomechanical behavior of teeth with little remaining coronal structure.
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- 2018
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9. Tunable Anticancer Activity of Furoylthiourea‐Based RuII–Arene Complexes and Their Mechanism of Action
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Swaminathan, Srividya, primary, Haribabu, Jebiti, additional, Kalagatur, Naveen Kumar, additional, Nikhil, Maroli, additional, Balakrishnan, Nithya, additional, Bhuvanesh, Nattamai S. P., additional, Kadirvelu, Krishna, additional, Kolandaivel, Ponmalai, additional, and Karvembu, Ramasamy, additional
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- 2021
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10. A scoring system to predict a prolonged length of stay after surgery for Crohn’s disease
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Wickramasinghe, Dakshitha, primary, Adegbola, Samuel, additional, Sahnan, Kapil, additional, Morar, Pritesh, additional, Carvello, Michele, additional, Di Candido, Francesca, additional, Maroli, Annalisa, additional, Spinelli, Antonino, additional, and Warusavitarne, Janindra, additional
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- 2021
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11. Silver nanoparticles synthesis using Wedelia urticifolia (Blume) DC. flower extract: Characterization and antibacterial activity evaluation
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Rather, Mohd Yousuf, primary, Shincy, Maroli, additional, and Sundarapandian, Somaiah, additional
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- 2020
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12. New data about home range and movements of Oligoryzomys flavescens (Rodentia: Cricetidae) help to understand the spread and transmission of Andes virus that causes Hantavirus Pulmonary Syndrome
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Maroli, Malena, primary, Crosignani, Belén, additional, Piña, Carlos I., additional, Coelho, Rocío, additional, Martínez, Valeria P., additional, and Gómez Villafañe, Isabel Elisa, additional
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- 2020
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13. α9- and α7-containing receptors mediate the pro-proliferative effects of nicotine in the A549 adenocarcinoma cell line
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Cecilia Gotti, Cheryl Dowell, Susanna Pucci, Francesca Fasoli, Roberta Benfante, Michael McIntosh, Annalisa Maroli, Milena Moretti, Marco Pallavicini, Cristiano Bolchi, Francesco Clementi, Simona Di Lascio, and Vanessa Mucchietto
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0301 basic medicine ,Pharmacology ,MAPK/ERK pathway ,A549 cell ,Chemistry ,Cell growth ,Nicotine ,03 medical and health sciences ,030104 developmental biology ,Nicotinic agonist ,Cancer research ,medicine ,Receptor ,Protein kinase B ,medicine.drug ,Acetylcholine receptor - Abstract
Background and purpose Tobacco smoke contains many classes of carcinogens and although nicotine is unable to initiate tumourigenesis in humans and rodents, it promotes tumour growth and metastasis in lung tumours by acting on neuronal nicotinic ACh receptors (nAChRs). The aim of this study was to identify molecularly, biochemically and pharmacologically which nAChR subtypes are expressed and functionally activated by nicotine in lung cancer cell lines. Experimental approach We used A549 and H1975 adenocarcinoma cell lines derived from lung tumours to test the in vitro effects of nicotine, and nAChR subtype-specific peptides and compounds. Key results The two adenocarcinoma cell lines express distinctive nAChR subtypes, and this affects their nicotine-induced proliferation. In A549 cells, nAChRs containing the α7 or α9 subunits not only regulate nicotine-induced cell proliferation but also the activation of the Akt and ERK pathways. Blocking these nAChRs by means of subtype-specific peptides, or silencing their expression by means of subunit-specific siRNAs, abolishes nicotine-induced proliferation and signalling. Moreover, we found that the α7 antagonist MG624 also acts on α9-α10 nAChRs, blocks the effects of nicotine on A549 cells and has dose-dependent cytotoxic activity. Conclusions and implications These results highlight the pathophysiological role of α7- and α9-containing receptors in promoting non-small cell lung carcinoma cell growth and intracellular signalling and provide a framework for the development of new drugs that specifically target the receptors expressed in lung tumours. Linked articles This article is part of a themed section on Nicotinic Acetylcholine Receptors. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v175.11/issuetoc.
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- 2017
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14. Apremilast, an oral phosphodiesterase 4 inhibitor, in the treatment of Japanese patients with moderate to severe plaque psoriasis: Efficacy, safety and tolerability results from a phase 2b randomized controlled trial
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Robert M. Day, Osamu Nemoto, Mayumi Komine, Mamitaro Ohtsuki, Allan Maroli, Peng Chen, Yukari Okubo, Rosemary Petric, and Shinichi Imafuku
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Male ,apremilast ,Administration, Oral ,phosphodiesterase 4 ,Severity of Illness Index ,Gastroenterology ,law.invention ,Placebos ,030207 dermatology & venereal diseases ,Psoriasis Area and Severity Index ,0302 clinical medicine ,Japan ,Randomized controlled trial ,law ,Incidence ,Incidence (epidemiology) ,Anti-Inflammatory Agents, Non-Steroidal ,General Medicine ,Middle Aged ,Thalidomide ,Treatment Outcome ,Tolerability ,030220 oncology & carcinogenesis ,Original Article ,Female ,medicine.drug ,Adult ,Diarrhea ,medicine.medical_specialty ,Dermatology ,Placebo ,03 medical and health sciences ,Double-Blind Method ,Internal medicine ,Psoriasis ,medicine ,Humans ,Adverse effect ,Dose-Response Relationship, Drug ,business.industry ,Original Articles ,medicine.disease ,Surgery ,Nasopharyngitis ,Phosphodiesterase 4 Inhibitors ,Apremilast ,business ,phosphodiesterase 4 inhibitor - Abstract
Apremilast, an oral, small‐molecule phosphodiesterase 4 inhibitor, works intracellularly within immune cells to regulate inflammatory mediators. This phase 2b randomized, placebo‐controlled study evaluated efficacy and safety of apremilast among Japanese patients with moderate to severe plaque psoriasis. In total, 254 patients were randomized to placebo, apremilast 20 mg b.i.d. (apremilast 20) or apremilast 30 mg b.i.d. (apremilast 30) through week 16; thereafter, all placebo patients were re‐randomized to apremilast 20 or 30 through week 68. Efficacy assessments included achievement of 75% or more reduction from baseline in Psoriasis Area and Severity Index score (PASI‐75; primary) and achievement of static Physician Global Assessment (sPGA; secondary) score of 0 (clear) or 1 (minimal) at week 16. Safety was assessed through week 68. At week 16, PASI‐75 response rates were 7.1% (placebo), 23.5% (apremilast 20; P = 0.0032 vs placebo) and 28.2% (apremilast 30; P = 0.0003 vs placebo); sPGA response rates (score of 0 or 1) were 8.8% (placebo), 23.9% (apremilast 20; P = 0.0165 vs placebo) and 29.6% (apremilast 30; P = 0.0020 vs placebo). Responses were maintained with apremilast through week 68. Most common adverse events (AEs) with placebo, apremilast 20 and apremilast 30 (0–16 weeks) were nasopharyngitis (8.3%, 11.8%, 11.8%), diarrhea (1.2%, 8.2%, 9.4%), and abdominal discomfort (1.2%, 1.2%, 7.1%), respectively. Exposure‐adjusted incidence of these AEs did not increase with continued apremilast treatment (up to 68 weeks). Apremilast demonstrated efficacy and safety in Japanese patients with moderate to severe plaque psoriasis through 68 weeks that was generally consistent with prior studies.
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- 2017
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15. Ileal pouch–anal anastomosis with fluorescence angiography: a case‐matched study
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Annalisa Maroli, Paulo Gustavo Kotze, Marco Montorsi, Isacco Montroni, Frédéric Ris, N Buchs, Antonino Spinelli, and Michele Carvello
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Adult ,Male ,medicine.medical_specialty ,Leak ,Databases, Factual ,Colon ,Anastomotic Leak ,Anastomosis ,law.invention ,chemistry.chemical_compound ,stomatognathic system ,Randomized controlled trial ,Ileum ,law ,Fluorescence angiography ,Humans ,Medicine ,Prospective Studies ,Fluorescein Angiography ,Ligation ,Retrospective Studies ,Familial adenomatous polyposis ,ddc:617 ,business.industry ,Proctocolectomy, Restorative ,Pouch surgery ,Gastroenterology ,Restorative proctocolectomy ,Postoperative complication ,Middle Aged ,medicine.disease ,Ulcerative colitis ,Indocyanine green ,Surgery ,stomatognathic diseases ,Treatment Outcome ,chemistry ,Case-Control Studies ,Female ,Pouch ,business - Abstract
Aim An anastomotic leak in ileoanal pouch surgery may lead to pouch failure. Constructing a tension-free ileal pouch-anal anastomosis (IPAA) reduces this risk but can be technically challenging, balancing pouch vascularization with ileal mesenteric length and site of vessel ligation. Fluorescence angiography (FA) may help the clinician make a more balanced judgement. Methods Thirty-two patients undergoing minimally invasive completion proctectomy with FA-guided IPAA at two academic centres were matched and compared on a 1:1 basis to a historical group undergoing the same procedure without the use of this technique. Results Ligation of the ileocolic vessels was safely performed in 15/32 (47%) of FA patients compared with 5/32 (16%) of historical controls. One patient underwent intra-operative IPAA reconstruction after FA detected ischaemia. No anastomotic leak occurred with FA but there was only one in the historical controls (P = 0.31). The postoperative complication rate was similar between the two groups (P = 0.60). Conclusion FA is applicable to IPAA surgery and may help to reduce perfusion-related anastomotic leaks. A prospective randomized trial is warranted.
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- 2019
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16. Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic
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Li, Elizabeth, Glasbey, James C., Nepogodiev, Dmitri, Simoes, Joana F. F., Omar, Omar M., Venn, Mary L., Evans, Jonathan P., Futaba, Kaori, Knowles, Charles H., Minaya‐bravo, Ana, Mohan, Helen, Chand, Manish, Pockney, Peter, Di Saverio, Salomone, Smart, Neil, Vallance, Abigail, Vimalachandran, Dale, Wilkin, Richard J. W., Siaw‐acheampong, Kwabena, Benson, Ruth A., Bywater, Edward, Chaudhry, Daoud, Dawson, Brett E., Gujjuri, Rohan R., Heritage, Emily, Jones, Conor S., Kamarajah, Sivesh K., Khatri, Chetan, Khaw, Rachel A., Keatley, James M., Knight, Andrew, Lawday, Samuel, Mann, Harvinder S., Marson, Ella J., Mclean, Kenneth A., Mckay, Siobhan C., Mills, Emily C., Pellino, Gianluca, Picciochi, Maria, Taylor, Elliott H., Tiwari, Abhinav, Trout, Isobel M., Smart, Neil J., Gallo, Gaetano, Moug, Susan, Pata, Francesco, Vimalchandran, Dale, Abbott, Tom E. F., Abukhalaf, Sadi, Adamina, Michel, Ademuyiwa, Adesoji O., Agarwal, Arnav, Akkulak, Murat, Alameer, Ehab, Alderson, Derek, Alakaloko, Felix, Albertsmeiers, Marku, Alser, Osaid, Alshaar, Muhammad, Alshryda, Sattar, Arnaud, Alexis P., Magne Augestad, Knut, Ayasra, Fari, Azevedo, José, Bankhead‐kendall, Brittany K., Barlow, Emma, Beard, David, Blanco‐colino, Ruth, Brar, Amanpreet, Breen, Kerry A., Bretherton, Chri, Lima Buarque, Igor, Burke, Joshua, Caruana, Edward J., Chaar, Mohammad, Chakrabortee, Sohini, Christensen, Peter, Cox, Daniel, Cukier, Moise, Cunha, Miguel F., Davidson, Giana H., Desai, Anant, Drake, Thomas M., Edwards, John G., Elhadi, Muhammed, Emile, Sameh, Farik, Shebani, Fiore, Marco, Edward Fitzgerald, J., Ford, Samuel, Garmanova, Tatiana, Ghosh, Dhruv, Gomes, Mendonça Ataíde Gustavo, Grecinos, Gustavo, Griffiths, Ewen A., Gründl, Madalegna, Halkias, Constantine, Harrison, Ewen M., Hisham, Intisar, Hutchinson, Peter J., Hwang, Shelley, Isik, Arda, Jenkinson, Michael D., Jonker, Pascal, Kaafarani, Haytham M. A., Keller, Debby, Kolias, Angelo, Kruijff, Schelto, Lawani, Ismail, Lederhuber, Han, Leventoglu, Sezai, Litvin, Andrey, Loehrer, Andrew, Löffler, Markus W., Lorena, Aguilera Maria, Modolo, Marta Maria, Major, Piotr, Martin, Janet, Mashbari, Hassan N., Mazingi, Denni, Metallidis, Symeon, Mohan, Helen M., Moore, Rachel, Moszkowicz, David, Ng‐kamstra, Joshua S., Maimbo, Mayaba, Negoi, Ionut, Niquen, Milagro, Ntirenganya, Faustin, Olivos, Maricarmen, Oussama, Kacimi, Outani, Oumaima, Dione Parreno‐Sacdalanm, Marie, Rivera, Jose Perez Carlo, Pinkney, Thomas D., Plas, Willemijn, Qureshi, Ahmad, Radenkovic, Dejan, Ramos‐De la Medina, Antonio, Roberts, Keith, Roslani, April C., Rutegård, Martin, Santos, Irène, Satoi, Sohei, Sayyed, Raza, Schache, Andrew, Schnitzbauer, Andreas A., Seyi‐olajide, Justina O., Sharma, Neil, Shaw, Richard, Shu, Sebastian, Soreide, Kjetil, Spinelli, Antonino, Stewart, Grant D., Sund, Malin, Sundar, Sudha, Tabiri, Stephen, Townend, Philip, Tsoulfas, Georgio, Ramshorst, Gabrielle H., Vidya, Raghavan, Warren, Oliver J., Wedderburn, Duane, Wright, Naomi, Alurralde, C., Caram, E. L., Eskinazi, D., Badra, R., García, J. S., Lucchini, S. M., Cecire, J., Salindera, S., Sutherland, A., Ahn, J. H., Chen, S., Gauri, N., Jang, S., Jia, F., Mulligan, C., Yang, W., Ye, G., Zhang, H., Moss, J., Richards, T., Thian, A., Vo, U. G., Bagraith, K., Chan, E., Ho, D., Jeyarajan, E., Jordan, S., Nolan, G. J., Von Papen, M., Wullschleger, M., Egoroff, N., Gani, J., Lott, N., Pockney, P., Phan, D., Townend, D., Bong, C., Gundara, J., Bowman, S., Guerra, G. R., Dudi‐venkata, N. N., Kroon, H. M., Sammour, T., Mitchell, D., Swinson, B., Messner, F., Öfner, D., Emmanuel, K., Grechenig, M., Gruber, R., Harald, M., Öhlberger, L., Presl, J., Wimmer, A., Barker, D., Boyce, R., Doyle, A., Eastmond, A., Gill, R., O’Shea, M., Padmore, G., Paquette, N., Phillips, E., St. John, S., Walkes, K., Flamey, N., Pattyn, P., Oosterlinck, W., Van den Eynde, J., Van den Eynde, R., Sokolov, M., Boutros, M., Caminsky, N. G., Ghitulescu, G., Demyttenaere, S., Garfinkle, R., Nessim, C., Stevenson, J., Bačić, G., Karlović, D., Kršul, D., Zelić, M., Bakmaz, B., Ćoza, I., Dijan, E., Katusic, Z., Mihanovic, J., Rakvin, I., Frantzeskou, K., Gouvas, N., Kokkinos, G., Papatheodorou, P., Pozotou, I., Stavrinidou, O., Yiallourou, A., Martinek, L., Skrovina, M., Szubota, I., Ebbehøj, A. L., Krarup, P., Schlesinger, N., Smith, H., AL Sayed, M., Ashoush, F., Elazzazy, E., Essam, E., Eweda, M., Hassan, E., Metwalli, M., Qatora Mourad, M., Sabry, M. S. A., Samih, A., Samir Abdelaal, A., Shehata, S., Shenit, K., Attia, D., Kamal, N., Osman, N., Alaa, S., Hamza, H. M., Melghazaly, S., Mohammed, M. M., Nageh, M. A., Saad, M. M., Yousof, E. A., Eldaly, A. S., Amira, G., Sallam, I., Sherief, M., Sherif, A., Ghaly, G., Hamdy, R., Morsi, A., Salem, H., Sherif, G., Abdeldayem, H., Abdelkader Salama, I., Balabel, M., Fayed, Y., Sherif, A. E., Kauppila, J. H., Sarjanoja, E., Helminen, O., Huhta, H., Beyrne, C., Jouffret, L., Marie‐macron, L., Lakkis, Z., Manfredelli, S., Chebaro, A., El Amrani, M., Lecolle, K., Piessen, G., Pruvot, F. R., Zerbib, P., Ballouhey, Q., Barrat, B., Taibi, A., Bergeat, D., Merdrignac, A., Le Roy, B., Perotto, L. O., Scalabre, A., Aimé, A., Ezanno, A., Malgras, B., Bouche, P. A., Tzedakis, S., Cotte, E., Glehen, O., Kepenekian, V., Passot, G., D’Urso, A., Mutter, D., Seeliger, B., Bonnet, S., Denet, C., Fuks, D., Laforest, A., Pourcher, G., Seguin‐givelet, A., Tribillon, E., Duchalais, E., Bork, U., Fritzmann, J., Praetorius, C., Weitz, J., Welsch, T., Beyer, K., Kamphues, C., Lauscher, J. C., Loch, F. N., Schineis, C., Becker, R., Jonescheit, J., Pergolini, I., Reim, D., Boeker, C., Hakami, I., Mall, J., Albertsmeier, M., Kappenberger, A., Schiergens, T., Werner, J., Nowak, K., Reinhard, T., Kleeff, J., Michalski, C., Ronellenfitsch, U., Bertolani, E., Königsrainer, A., Löffler, M. W., Quante, M., Steidle, C., Überrück, L., Yurttas, C., Izbicki, J., Nitschke, C., Perez, D., Uzunoglu, F. G., Antonakis, P., Contis, I., Dellaportas, D., Gklavas, A., Konstadoulakis, M., Memos, N., Papaconstantinou, I., Polydorou, A., Theodosopoulos, T., Vezakis, A., Antonopoulou, M. I., Manatakis, D. K., Tasis, N., Arkadopoulos, N., Danias, N., Economopoulou, P., Frountzas, M., Kokoropoulos, P., Larentzakis, A., Michalopoulos, N., Parasyris, S., Selmani, J., Sidiropoulos, T., Vassiliu, P., Bouchagier, K., Klimopoulos, S., Paspaliari, D., Stylianidis, G., Baxevanidou, K., Bouliaris, K., Chatzikomnitsa, P., Efthimiou, M., Giaglaras, A., Kalfountzos, C., Koukoulis, G., Ntziovara, A. M., Petropoulos, K., Soulikia, K., Tsiamalou, I., Zervas, K., Zourntou, S., Baloyiannis, I, Diamantis, A., Perivoliotis, K., Tzovaras, G., Christidis, P., Ioannidis, O., Loutzidou, L., Karaitianos, I., Tsirlis, T., Charalabopoulos, A., Liakakos, T., Baili, E., Schizas, D., Spartalis, E., Syllaios, A., Zografos, C., Athanasakis, E., Chrysos, E., Tsiaoussis, I., Xenaki, S., Xynos, E., Futaba, K., Ho, M. F., Hon, S. F., Mak, T. W. C., Ng, S. S. M., Foo, C. C., Banky, B., Suszták, N., Bhat, G. A., Chowdri, N. A., Mehraj, A., Parray, F., Shah, Z. A., Wani, R., Ahmed, Z., Bali, R., Laharwal, A., Mahmood, M., Mir, I., Mohammad, Z., Muzamil, J., Rashid, A., Aremu, M., Canas‐martinez, A., Cullivan, O., Murphy, C., Owens, P., Pickett, L., Corrigan, M., Daly, A., Fleming, C., Jordan, P., Killeen, S., Lynch, N., O’Brien, N., Syed, W. A. S., Vernon, L., Fahey, B. A., Larkin, J. O., Mccormick, P., Mehigan, B. J., Mohan, H., Shokuhi, P., Smith, J., Bashir, Y., Bass, G. A., Connelly, T. M., Creavin, B., Earley, H., Elliott, J. A., Gillis, A. E., Kavanagh, D. O., Neary, P. C., O’Riordan, J. M., Reynolds, I. S., Rice, D., Ridgway, P. F., Umair, M., Whelan, M., Corless, K., Finnegan, L., Fowler, A., Hogan, A., Lowery, A., Mckevitt, Kv, Ryan, Év, Coffey, J. C., Cunningham, R. M., Devine, M., Nally, D., Peirce, C., Hardy, N. P., Neary, P. M., O’Malley, S., Ryan, M., Macina, S., Mariani, N. M., Opocher, E., Pisani Ceretti, A., Bianco, F., Marino, M. V., Mirabella, A., Vaccarella, G., Agostini, C., Alemanno, G., Bartolini, I., Bergamini, C., Bruscino, A., Vincenti, R., Di Bella, A., Fortuna, L., Maltinti, G., Muiesan, P., Prosperi, P., Ringressi, M. N., Risaliti, M., Taddei, A., Tucci, R., Campagnaro, T., Guglielmi, A., Pedrazzani, C., Rattizzato, S., Ruzzenente, A., Turri, G., Bellora, P., D’Aloisio, Gv, Ferrari, M., Francone, E., Gentilli, S., Nikaj, H., Bianchini, M., Chiarugi, M., Coccolini, F., Di Franco, G., Furbetta, N., Gianardi, D., Guadagni, S., Morelli, L., Palmeri, M., Tartaglia, D., Anania, G., Carcoforo, P., Chiozza, M., De Troia, A., Koleva Radica, M., Portinari, M., Sibilla, M. G., Urbani, A., Fabbri, N., Feo, C. V., Gennari, S., Parini, S., Righini, E., Annessi, V., Castro Ruiz, C., Montella, M. T., Zizzo, M., Grossi, U., Novello, S., Romano, M., Rossi, S., Zanus, G., Esposito, G., Frongia, F., Pisanu, A., Podda, M., Belluco, C., Lauretta, A., Montori, G., Moras, L., Olivieri, M., Feo, C. F., Perra, T., Porcu, A., Scanu, A. M., Aversano, A., Carbone, F., Delrio, P., Di Lauro, K., Fares Bucci, A., Rega, D., Spiezio, G., Calabrò, M., Farnesi, F., Lunghi, E. G., Muratore, A., Pipitone Federico, N. S., De Palma, G. D., Luglio, G., Pagano, G., Tropeano, F. P., Baldari, L., Boni, L., Cassinotti, E., Cosimelli, M., Fiore, M., Guaglio, M., Sorrentino, L., Agnes, A., Alfieri, S., Belia, F., Biondi, A., Cozza, V., D'Ugo, Domenico, De Simone, V., Litta, F., Lorenzon, L., Marra, A. A., Marzi, F., Parello, A., Persiani, R., Ratto, Carlo, Rosa, Fausto, Scrima, O., Sganga, G., Belli, A., Izzo, F., Patrone, R., Carrano, F. M., Carvello, M. M., Di Candido, F., Maroli, A., Spinelli, A., Aprile, A., Batistotti, P., Massobrio, A., Pertile, D., Scabini, S., Soriero, D., De Manzoni Garberini, A., Federico, P., Maida, P., Marra, E., Marte, G., Petrillo, A., Tammaro, P., Tufo, A., Berselli, M., Borroni, G., Cocozza, E., Conti, L., Desio, M., Rizzi, A., Baldi, C., Corbellini, C., Sampietro, G. M., Baldini, E., Capelli, P., Isolani, S. M., Ribolla, M., Bondurri, A., Colombo, F., Ferrario, L., Guerci, C., Maffioli, A., Armao, T., Ballabio, M., Bisagni, P., Gagliano, A., Longhi, M., Madonini, M., Pizzini, P., Mochet, S., Usai, A., Incollingo, P., Mancini, S., Marino Cosentino, L., Sagnotta, A., Nespoli, L. C., Tamini, N., Anastasi, A., Bartalucci, B., Bellacci, A., Canonico, G., Capezzuoli, L., Di Martino, C., Ipponi, P., Linari, C., Montelatici, M., Nelli, T., Spagni, G., Tirloni, L., Vitali, A., Abate, E., Casati, M., Casiraghi, T., Laface, L., Schiavo, M., Arminio, A., Cotoia, A., Lizzi, V., Vovola, F., Vergari, R., D’Ugo, S., Depalma, N., Spampinato, M. G., Brachini, G., Chiappini, A., Cicerchia, P. M., Cirillo, B., De Toma, G., Fiori, E., Fonsi, G. B., Iannone, I., La Torre, F., Lapolla, P., Meneghini, S., Mingoli, A., Sapienza, P., Zambon, M., Capolupo, G. T., Mazzotta, E., Gattolin, A., Migliore, M., Rimonda, R., Sasia, D., Travaglio, E., Cervellera, M., Gori, A., Sartarelli, L., Tonini, V., Chessa, A., Fiorini, A., Norcini, C., Colletti, G., Confalonieri, M., Costanzi, A., Frattaruolo, C., Mari, G., Monteleone, M., De Nardi, P., Parise, P., Vignali, A., Belvedere, A., Bernante, P., Jovine, E., Neri, J., Parlanti, D., Pezzuto, A. P., Poggioli, G., Rottoli, M., Tanzanu, M., Violante, T., Borghi, F., Cianflocca, D., Di Maria Grimaldi, S., Donati, D., Gelarda, E., Giraudo, G., Giuffrida, M. C., Marano, A., Palagi, S., Pellegrino, L., Peluso, C., Testa, V., Agresta, F., Prando, D., Zese, M., Armatura, G., Frena, A., Scotton, G., Gallo, G., Sammarco, G., Vescio, G., Di Marzo, F., Fontana, T., Kanemitsu, Y., Moritani, K., Al Abdallah, M., Ayasra, F., Ayasra, Y., Qasem, A., Fahmawee, T., Hmedat, A., Obeidat, K., Abou Chaar, M. K., Al‐masri, M., Al‐najjar, H., Alawneh, F., Alkadeeki, G., Al Maadany, F. S., Aldokali, N., Senossi, O., Subhi, M. T., Burgan, D., Kamoka, E., Kilani, A. I., Ellojli, I., Kredan, A., Bradulskis, S., Dainius, E., Kubiliute, E., Kutkevičius, J., Parseliunas, A., Subocius, A., Venskutonis, D., Rasoaherinomenjanahary, F., Razafindrahita, J. B., Samison, L. H., Hamdan, K. H., Ibrahim, M. R., Tan, J. A., Thanapal, M. R., Amin Sahid, N., Hayati, F., Jayasilan, J., Sriram, R. K., Che Jusoh, Null, Subramaniam, S. M. A., Hussain, A. H., Mohamed Sidek, A. S., Mohd Yunus, M. F., Soh, J. Y., Wong, M., Zakaria, A. D., Zakaria, Z., Fathi, N. Q., Xavier, R. G., Roslani, A. C., Buerba, G. A., Mercado, M. Á., Posadas‐trujillo, O. E., Salgado‐nesme, N., Sarre, C., Amrani, L., El Ahmadi, B., El Bouazizi, Y., Majbar, A. M., Benkabbou, A., Mohsine, R., Souadka, A., Hompes, R., Meima‐van Praag, E. M., Pronk, A. J. M., Sharabiany, S., Grotenhuis, B., Hartveld, L., Posma‐bouman, L., Derksen, T., Franken, J., Oosterling, S., Konsten, J., Van Heinsbergen, M., Olaogun, J., Abdur‐rahman, L., Adeyeye, A., Bello, J., Olasehinde, O., Popoola, A., Jamal, A., Kerawala, A. A., Memon, A. S., Nafees Ahmed, R., Rai, L., Ayub, B., Ramesh, P., Sayyed, R., Butt, U. I., Kashif, M., Qureshi, A., Farooka, M. W., Ayyaz, M., Ayubi, A., Waqar, S. H., Major, P., Azevedo, C., Machado, D., Mendes, F., De Sousa, X., Fernandes, U., Ferreira, C., Guidi, G., Marçal, A., Marques, R., Martins, D., Vaz Pereira, R., Vieira, B., Almeida, J. I., Ferraz, I., Ribeiro, C. G., Lima da Silva, C., Lopes, L., Marialva, J., Pereira, C., Almeida‐reis, R., Ribeiro, A., Tavares, F., Teixeira, M., Correia de Sá, T., Costa, M. J. M. A., Fernandes, V., Machado, N., Nunes Coelho, M., Afonso, J., Santos, R., Saraiva, P., Silva, R., Almeida, A. C., Amaral, M. J., Andrade, R., Camacho, C., Costa, M., Lázaro, A., Nogueira, O., Oliveira, A, Ruivo, A, Silva, M, Simões, J, Devezas, V, Jácome, F, Nogueiro, J, Pereira, A., Santos‐sousa, H., Vaz, S., Pinto, J., Tojal, A., Cardoso, P., Cardoso, N., Domingos, J. C., Henriques, P., Manso, M. I., Martins dos Santos, G., Martins, R., Morais, H., Pereira, R., Revez, T., Ribeiro, R., Ribeiro, V. I., Soares, A. P., Sousa, S., Teixeira, J., Amorim, E., Baptista, V. H., Cunha, M. F., Bandovas, J. P., Borges, N., Chumbinho, B., Figueiredo de Barros, I., Frade, S., Gomes, J., Kam da Silva Andrade, A., Pereira Rodrigues, A., Pina, S., Silva, N., Silveira Nunes, I., Sousa, R., Azevedo, P., Costeira, B., Cunha, C., Garrido, R., Miranda, P., Peralta Ferreira, M., Sousa Fernandes, M., Galvão, D., Vieira, A., Patrício, B., Santos, P. M. D. D., Vieira Paiva Lopes, A. C., Cunha, R., Faustino, A., Freitas, A., Mendes, J. R., Parreira, R., Abreu da Silva, A., Claro, M., Costa Santos, D., Deus, A. C., Grilo, J. V., Borges, F., Corte Real, J., Henriques, S., Lima, M. J., Matos Costa, P., Brito da Silva, F., Caiado, A., Fonseca, F., Ângelo, M., Baiao, J. M., Martins Jordão, D., Vieira Caroço, T., Baía, C., Canotilho, R., Correia, A. M., Ferreira Pinto, A. P., Peyroteo, M., Videira, J. F., Kassir, R., Sauvat, F., Bezede, C., Chitul, A., Ciofic, E., Cristian, D., Grama, F., Bonci, E., Gata, V., Titu, S., Garmanova, T., Kazachenko, E., Markaryan, D., Rodimov, S., Tsarkov, P., Tulina, I., Litvina, Y., Provozina, A., Agapov, M., Galliamov, E., Kakotkin, V., Kubyshkin, V., Kamalov, A., Semina, E., Alshahrani, M., Alsharif, F., Eskander, M., Alharthi, M., Aljiffry, M., Basendowah, M., Malibary, N., Nassif, M., Saleem, A., Samkari, A., Trabulsi, N., Al Awwad, S., Alghamdi, M., Alnumani, T., Al Habes, H., Alqannas, M., Alyami, M., Alzamanan, M., Cortés Guiral, D., Elawad, A., Alaamer, O., Alselaim, N., Al‐khayal, K., Alhassan, N., Alobeed, O., Alshammari, S., Bin Nasser, A., Bin Traiki, T., Nouh, T., Zubaidi, A. M., Aleksić, L., Antic, A., Barisic, G., Ceranic, M., Grubač, Ž., Jelenkovic, J., Kecmanović, D., Kmezić, S., Knezevic, D., Krivokapic, Z., Latinčić, S., Markovic, V., Matić, S., Miladinov, M., Pavlov, M., Pejovic, I., Tadic, B., Vasljević, J., Velickovic, D., Buta, M., Cvetkovic, A., Gacic, S., Goran, M., Jeftic, N., Markovic, I., Milanović, M., Nikolic, S., Pejnovic, L., Savković, N., Stevic, D., Vucic, N., Zegarac, M., Karamarkovic, A., Kenic, M., Kovacevic, B., Krdzic, I., Lieske, B., Almgla, N., Boutall, A., Herman, A., Kloppers, C., Nel, D., Rayamajhi, S., Paniagua García Señorans, M., Vigorita, V., Acrich, E., Baena Sanfeliu, E., Barrios, O., Golda, T., Santanach, C., Serrano‐navidad, M., Sorribas Grifell, M., Vives, R. V., Escolà, D., Jiménez, A., Cayetano Paniagua, L., Gómez Fernández, L., Collera, P., Diaz Del Gobbo, R., Farre Font, R., Flores Clotet, R., Gómez Díaz, C. J., Guàrdia, N., Guariglia, C. A., Osorio, A., Sanchez Jimenez, R., Sanchon, L., Soto Montesinos, C., Alonso‐lamberti, L., García‐quijada, J., Jimenez Miramón, J., Jimenez, V., Jover, J. M., Leon, R., Rodriguez, J. L., Salazar, A., Valle Rubio, A., Aguado, H., Bravo Infante, R., De Lacy, F. B., Lacy, A. M., Otero, A., Turrado‐rodriguez, V., Valverde, S., Anula, R., Cano‐valderrama, O., Del Campo Martín, M., Díez‐valladares, L., Domínguez, I., Dziakova, J., García Alonso, M., García Romero, E., Gómez Latorre, L., Muguerza, J. M., Pizarro, M. J., Saez Carlin, P., Sánchez del Pueblo, C., Sánchez‐pernaute, A., Sanz Ortega, G., Sanz‐lopez, R., Torres, A., Garcés‐albir, M., Lopez, F., Martín‐arévalo, J., Moro‐valdezate, D., Pla‐marti, V., Beltrán de Heredia, J., De Andrés Asenjo, B., Gómez Sanz, T., Jezieniecki, C., Nuñez Del Barrio, H., Ortiz de Solórzano Aurusa, F. J., Romero de Diego, A., Ruiz Soriano, M., Trujillo Díaz, J., Vázquez Fernández, A., Lora‐cumplido, P., Sosa, M. V., Gonzalez‐gonzalez, E., Minaya Bravo, A. M., Alonso de la Fuente, N., Jimenez Toscano, M., Grau‐talens, E. J., Martin‐perez, B., Benavides Buleje, J. A., Carrasco Prats, M., Giménez FrancésFrancés, C., Muñoz Camarena, J. M., Parra Baños, P. A., Peña, E., Ramirez Faraco, M., Ruiz‐marín, M., Valero Soriano, M., Estaire Gómez, M., Fernández Camuñas, Á., Garcia Santos, E. P., Jimenez Higuera, E., Martínez‐pinedo, C., Muñoz‐atienza, V., Padilla‐valverde, D., Picón Rodríguez, R., Sánchez‐garcía, S., Sanchez‐pelaez, D., Colombari, R. C., Del Valle, E., Fernández, M., Lozano Lominchar, P., Martín, L., Rey Valcarcel, C., Zorrilla Ortúzar, J., Alcaide Matas, F., García Pérez, J. M., Troncoso Pereira, P., Mora‐guzmán, I., Achalandabaso Boira, M., Sales Mallafré, R., Marín, H., Prieto Calvo, M., Villalabeitia Ateca, I., De Andres Olabarria, U., Durán Ballesteros, M., Fernández Pablos, F. J., Ibáñez‐aguirre, F. J., Sanz Larrainzar, A., Ugarte‐sierra, B., Correa Bonito, A., Delgado Búrdalo, L., Di Martino, M., García Septiem, J., Maqueda González, R., Martin‐perez, E., Calvo Espino, P., Guillamot Ruano, P., Colao García, L., Díaz Pérez, D., Esteban Agustí, E., Galindo Jara, P., Gutierrez Samaniego, M., Hernandez Bartolome, M. A., Serrano González, J., Alonso Poza, A., Diéguez, B., García‐conde, M., Hernández‐garcía, M., Losada, M., Alvarez, E., Chavarrias, N., Gegúndez Simón, A., Gortázar, S., Guevara, J., Prieto Nieto, M. I., Ramos‐martín, P., Rubio‐perez, I., Saavedra, J., Urbieta, A., Cantalejo diaz, M., De Miguel Ardevines, M. D. C., Duque‐mallén, V., Gascon Ferrer, I., González‐Nicolás Trébol, M. T., Gracia‐roche, C., Herrero Lopez, M., Martinez German, A., Matute, M., Sánchez Fuentes, N., Sánchez‐rubio, M., Saudí, S., Blazquez Martin, A., Diez Alonso, M., Hernandez, P., Mendoza‐moreno, F., Ovejero Merino, E., Vera Mansilla, C., Acebes García, F., Bailón, M., Bueno Cañones, A. 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P., Cervera, I., Díaz Peña, P., Gonzalez, J., Marqueta De Salas, M., Perez Gonzalez, M., Ramos Bonilla, A., Rodríguez Gómez, L., Blanco‐colino, R., Espin‐basany, E., Pellino, G., Arulanantham, A., Bandara, G. B. K. D., Jayarajah, U., Ravindrakumar, S., Rodrigo, V. S. D., Srishankar, S., Ali Adil, A. K., Älgå, A., Heinius, G., Nordberg, M., Pieniowski, E., Löfgren, N., Rutegård, M., Arigoni, M., Bernasconi, M., Christoforidis, D., Di Giuseppe, M., La Regina, D., Mongelli, F., Chevallay, M., Dwidar, O., Gialamas, E., Sauvain, M., Adamina, M., Crugnale, A. S., Guglielmetti, L., Peros, G., Aghayeva, A., Hamzaoglu, I., Sahin, I., Akaydin, E., Aliyeva, Z., Aytac, E., Baca, B., Ozben, V., Ozmen, B. B., Arikan, A. E., Bilgin, I. A., Kara, H., Karahasanoğlu, T., Uras, C., Dincer, H. A., Erol, T., Alhamed, A., Ergün, S., Ozcelık, M. F., Sanli, A. N., Uludağ, S. S., Velidedeoglu, M., Zengin, A. K., Kara, Y., Kocataş, A., Azamat, I. F., Balik, E., Buğra, D., Bozkurt, M. A., Kulle, C. B., Gözal, K., Güler, S. A., Köken, H., Tatar, O. C., Utkan, N. Z., Yıldırım, A., Yüksel, E., Akin, E., Altintoprak, F., Cakmak, G., Çelebi, F., Demir, H., Dikicier, E., Firat, N., Gönüllü, E., Kamburoğlu, M. B., Küçük, I. F., Mantoglu, B., Çolak, E., Kucuk, G. O., Göksoy, B., Bozkurt, E., Mihmanli, M., Tanal, M., Yetkin, S. G., Akalin, M., Arican, C., Avci, E. K., Aydin, C., Demirli Atıcı, S., Emiroglu, M., Kaya, T., Kebabçı, E., Kilinc, G., Kirmizi, Y., Öğücü, H., Salimoğlu, S., Sert, I., Tugmen, C., Tuncer, K., Uslu, G., Yeşilyurt, D., Yildiz, A., Lule, H., Oguttu, B., Agilinko, J., Ahmeidat, A., Bekheit, M., Cheung, L. K., Kamera, B. S., Mignot, G., Shaikh, S., Sharma, P., Al‐mohammad, A., Ali, S., Ashcroft, J., Baker, O., Coughlin, P., Davies, R. J., Kyriacou, H., Mitrofan, C. G., Morris, A., Raby‐smith, W., Rooney, S., Singh, A., Tan, X. S., Townson, A., Tweedle, E., Angelou, D., Choynowski, M., Mcaree, B., Mccanny, A., Neely, D., Mosley, F., Arrowsmith, L., Campbell, W., Grove, T., Kontovounisios, C., Warren, O., Clifford, R., Eardley, N., Krishnan, E., Manu, N., Martin, E., Roy Mahapatra, S., Serevina, O. L., Smith, C., Vimalachandran, D., Emslie, K., Labib, P., Minto, G., Natale, J., Panahi, P., Rogers, L., Abubakar, A., Akhter Rahman, M. M., O’Brien, H., Sasapu, K., Ng, H. J., Day, A., Hunt, A., Laskar, N., Gupta, A., Steinke, J., Thrumurthy, S., Massie, E., Mcgivern, K., Rutherford, D., Wilson, M., Handa, S., Kaushal, M., Kler, A., Patel, P., Redfern, J., Tezas, S., Aawsaj, Y., Barry, C., Blackwell, L., Emerson, H., Fisher, A., Katory, M., Mustafa, A., Kretzmer, L., Lalou, L., Manku, B., Parwaiz, I., Stafford, J., Abdelkarim, M., Asqalan, A., Gala, T., Ibrahim, S., Maw, A., Mithany, R., Morgan, R., Sundaram Venkatesan, G., Boulton, A. J., Hardie, C., Mcnaught, C., Karandikar, S., Naumann, D., Ayorinde, J., Chase, T., Cuming, T., Ghanbari, A., Humphreys, L., Tayeh, S., Aboelkassem Ibrahim, A., Evans, C., Ikram, H., Loubani, M., Nazir, S., Robinson, A., Sehgal, T., Wilkins, A., Dixon, J., Jha, M., Thulasiraman, S. V., Viswanath, Y. K. S., Curl‐roper, T., Delimpalta, C., Liao, C. C. L., Velchuru, V., Westwood, E., Bond‐smith, G., Mastoridis, S., Tebala, G. D., Verberne, C., Bhatti, M. I., Boyd‐carson, H., Elsey, E., Gemmill, E., Herrod, P., Jibreel, M., Lenzi, E., Saafan, T., Sapre, D., Sian, T., Watson, N., Athanasiou, A., Burke, J., Costigan, F., Elkadi, H., Johnstone, J., Nahm, C., Annamalai, S., Ashmore, C., Kourdouli, A., Askari, A., Cirocchi, N., Kudchadkar, S., Patel, K., Sagar, J., Talwar, R., Abdalla, M., Ismail, O., Newton, K., Stylianides, N., Aderombi, A., Bajomo, O., Beatson, K., Garrett, W., Ng, V., Al‐habsi, R., Divya, G. S., Keeler, B., Egan, R., Fabre, I., Harries, R., Li, Z., Parkins, K., Spencer, N., Thompson, D., Gemmell, C., Grieco, C., Hunt, L., Mahmoud Ali, F., Seebah, K., Shaikh, I., Sreedharan, L., Youssef, M., Shah, J., Mclarty, N., Mills, S., Shenfine, A., Sahnan, K., Michel, M., Patil, S., Ravindran, S., Sarveswaran, J., Scott, L., Bhangu, A., Cato, L. D., Kamal, M., Kulkarni, R., Parente, A., Saeed, S., Vijayan, D., Kaul, S., Khan, A. H., Khan, F., Mukherjee, S., Patel, M., Sarigul, M., Singh, S., Adiamah, A., Brewer, H., Chowdhury, A., Evans, J., Humes, D., Jackman, J., Koh, A., Lewis‐lloyd, C., Oyende, O., Reilly, J., Worku, D., Bisset, C., Moug, S. J., Math, S., Sarantitis, I., Timbrell, S., Vitone, L., Faulkner, G., Brixton, G., Findlay, L., Majkowska, A., Manson, J., Potter, R., Bhalla, A., Chia, Z., Daliya, P., Grimley, E., Malcolm, F. L., Theophilidou, E., Daniels, I. 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R., Long, C., Malapati, H., Margalit, A., Rapaport, S., Rose, J., Stevens, K., Tsai, L., Vervoort, D., Yesantharao, P., Bigelow, B., Klaristenfeld, D., Huynh, K., Azam, M., Choudhry, A., Marx, W., Abel, M. K., Boeck, M., Chern, H., Kornblith, L., Nunez‐garcia, B., Ozgediz, D., Glencer, A., Sarin, A., Varma, M., Abbott, D., Acher, A., Aiken, T., Barrett, J., Foley, E., Schwartz, P., Zafar, S. N., Hawkins, A., Maiga, A., Bhat, M. A., Uyanik, M. S., D’Ugo, D. (ORCID:0000-0001-6657-6318), Ratto, C. (ORCID:0000-0002-0556-0037), Rosa, F. (ORCID:0000-0002-7280-8354), Li, Elizabeth, Glasbey, James C., Nepogodiev, Dmitri, Simoes, Joana F. F., Omar, Omar M., Venn, Mary L., Evans, Jonathan P., Futaba, Kaori, Knowles, Charles H., Minaya‐bravo, Ana, Mohan, Helen, Chand, Manish, Pockney, Peter, Di Saverio, Salomone, Smart, Neil, Vallance, Abigail, Vimalachandran, Dale, Wilkin, Richard J. 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L., Eskinazi, D., Badra, R., García, J. S., Lucchini, S. M., Cecire, J., Salindera, S., Sutherland, A., Ahn, J. H., Chen, S., Gauri, N., Jang, S., Jia, F., Mulligan, C., Yang, W., Ye, G., Zhang, H., Moss, J., Richards, T., Thian, A., Vo, U. G., Bagraith, K., Chan, E., Ho, D., Jeyarajan, E., Jordan, S., Nolan, G. J., Von Papen, M., Wullschleger, M., Egoroff, N., Gani, J., Lott, N., Pockney, P., Phan, D., Townend, D., Bong, C., Gundara, J., Bowman, S., Guerra, G. R., Dudi‐venkata, N. N., Kroon, H. M., Sammour, T., Mitchell, D., Swinson, B., Messner, F., Öfner, D., Emmanuel, K., Grechenig, M., Gruber, R., Harald, M., Öhlberger, L., Presl, J., Wimmer, A., Barker, D., Boyce, R., Doyle, A., Eastmond, A., Gill, R., O’Shea, M., Padmore, G., Paquette, N., Phillips, E., St. John, S., Walkes, K., Flamey, N., Pattyn, P., Oosterlinck, W., Van den Eynde, J., Van den Eynde, R., Sokolov, M., Boutros, M., Caminsky, N. 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P., Cervera, I., Díaz Peña, P., Gonzalez, J., Marqueta De Salas, M., Perez Gonzalez, M., Ramos Bonilla, A., Rodríguez Gómez, L., Blanco‐colino, R., Espin‐basany, E., Pellino, G., Arulanantham, A., Bandara, G. B. K. D., Jayarajah, U., Ravindrakumar, S., Rodrigo, V. S. D., Srishankar, S., Ali Adil, A. K., Älgå, A., Heinius, G., Nordberg, M., Pieniowski, E., Löfgren, N., Rutegård, M., Arigoni, M., Bernasconi, M., Christoforidis, D., Di Giuseppe, M., La Regina, D., Mongelli, F., Chevallay, M., Dwidar, O., Gialamas, E., Sauvain, M., Adamina, M., Crugnale, A. S., Guglielmetti, L., Peros, G., Aghayeva, A., Hamzaoglu, I., Sahin, I., Akaydin, E., Aliyeva, Z., Aytac, E., Baca, B., Ozben, V., Ozmen, B. B., Arikan, A. E., Bilgin, I. A., Kara, H., Karahasanoğlu, T., Uras, C., Dincer, H. A., Erol, T., Alhamed, A., Ergün, S., Ozcelık, M. F., Sanli, A. N., Uludağ, S. S., Velidedeoglu, M., Zengin, A. K., Kara, Y., Kocataş, A., Azamat, I. F., Balik, E., Buğra, D., Bozkurt, M. A., Kulle, C. B., Gözal, K., Güler, S. A., Köken, H., Tatar, O. C., Utkan, N. Z., Yıldırım, A., Yüksel, E., Akin, E., Altintoprak, F., Cakmak, G., Çelebi, F., Demir, H., Dikicier, E., Firat, N., Gönüllü, E., Kamburoğlu, M. B., Küçük, I. F., Mantoglu, B., Çolak, E., Kucuk, G. O., Göksoy, B., Bozkurt, E., Mihmanli, M., Tanal, M., Yetkin, S. G., Akalin, M., Arican, C., Avci, E. K., Aydin, C., Demirli Atıcı, S., Emiroglu, M., Kaya, T., Kebabçı, E., Kilinc, G., Kirmizi, Y., Öğücü, H., Salimoğlu, S., Sert, I., Tugmen, C., Tuncer, K., Uslu, G., Yeşilyurt, D., Yildiz, A., Lule, H., Oguttu, B., Agilinko, J., Ahmeidat, A., Bekheit, M., Cheung, L. K., Kamera, B. S., Mignot, G., Shaikh, S., Sharma, P., Al‐mohammad, A., Ali, S., Ashcroft, J., Baker, O., Coughlin, P., Davies, R. J., Kyriacou, H., Mitrofan, C. G., Morris, A., Raby‐smith, W., Rooney, S., Singh, A., Tan, X. S., Townson, A., Tweedle, E., Angelou, D., Choynowski, M., Mcaree, B., Mccanny, A., Neely, D., Mosley, F., Arrowsmith, L., Campbell, W., Grove, T., Kontovounisios, C., Warren, O., Clifford, R., Eardley, N., Krishnan, E., Manu, N., Martin, E., Roy Mahapatra, S., Serevina, O. L., Smith, C., Vimalachandran, D., Emslie, K., Labib, P., Minto, G., Natale, J., Panahi, P., Rogers, L., Abubakar, A., Akhter Rahman, M. M., O’Brien, H., Sasapu, K., Ng, H. J., Day, A., Hunt, A., Laskar, N., Gupta, A., Steinke, J., Thrumurthy, S., Massie, E., Mcgivern, K., Rutherford, D., Wilson, M., Handa, S., Kaushal, M., Kler, A., Patel, P., Redfern, J., Tezas, S., Aawsaj, Y., Barry, C., Blackwell, L., Emerson, H., Fisher, A., Katory, M., Mustafa, A., Kretzmer, L., Lalou, L., Manku, B., Parwaiz, I., Stafford, J., Abdelkarim, M., Asqalan, A., Gala, T., Ibrahim, S., Maw, A., Mithany, R., Morgan, R., Sundaram Venkatesan, G., Boulton, A. J., Hardie, C., Mcnaught, C., Karandikar, S., Naumann, D., Ayorinde, J., Chase, T., Cuming, T., Ghanbari, A., Humphreys, L., Tayeh, S., Aboelkassem Ibrahim, A., Evans, C., Ikram, H., Loubani, M., Nazir, S., Robinson, A., Sehgal, T., Wilkins, A., Dixon, J., Jha, M., Thulasiraman, S. V., Viswanath, Y. K. S., Curl‐roper, T., Delimpalta, C., Liao, C. C. L., Velchuru, V., Westwood, E., Bond‐smith, G., Mastoridis, S., Tebala, G. D., Verberne, C., Bhatti, M. I., Boyd‐carson, H., Elsey, E., Gemmill, E., Herrod, P., Jibreel, M., Lenzi, E., Saafan, T., Sapre, D., Sian, T., Watson, N., Athanasiou, A., Burke, J., Costigan, F., Elkadi, H., Johnstone, J., Nahm, C., Annamalai, S., Ashmore, C., Kourdouli, A., Askari, A., Cirocchi, N., Kudchadkar, S., Patel, K., Sagar, J., Talwar, R., Abdalla, M., Ismail, O., Newton, K., Stylianides, N., Aderombi, A., Bajomo, O., Beatson, K., Garrett, W., Ng, V., Al‐habsi, R., Divya, G. S., Keeler, B., Egan, R., Fabre, I., Harries, R., Li, Z., Parkins, K., Spencer, N., Thompson, D., Gemmell, C., Grieco, C., Hunt, L., Mahmoud Ali, F., Seebah, K., Shaikh, I., Sreedharan, L., Youssef, M., Shah, J., Mclarty, N., Mills, S., Shenfine, A., Sahnan, K., Michel, M., Patil, S., Ravindran, S., Sarveswaran, J., Scott, L., Bhangu, A., Cato, L. D., Kamal, M., Kulkarni, R., Parente, A., Saeed, S., Vijayan, D., Kaul, S., Khan, A. H., Khan, F., Mukherjee, S., Patel, M., Sarigul, M., Singh, S., Adiamah, A., Brewer, H., Chowdhury, A., Evans, J., Humes, D., Jackman, J., Koh, A., Lewis‐lloyd, C., Oyende, O., Reilly, J., Worku, D., Bisset, C., Moug, S. J., Math, S., Sarantitis, I., Timbrell, S., Vitone, L., Faulkner, G., Brixton, G., Findlay, L., Majkowska, A., Manson, J., Potter, R., Bhalla, A., Chia, Z., Daliya, P., Grimley, E., Malcolm, F. L., Theophilidou, E., Daniels, I. R., Fowler, G., Massey, L., Mcdermott, F., Rajaretnam, N., Beamish, A., Magowan, D., Nassa, H., Price, C., Smith, L., Solari, F., Tang, A. M., Williams, G., Davies, E., Hawkin, P., Raymond, T., Ryska, O., Baron, R. D., Gahunia, S., Mcnicol, F., Russ, J., Szatmary, P., Thomas, A., Jayasinghe, J. D., Knowles, C., Ledesma, F. S., Minicozzi, A., Navaratne, L., Ramamoorthy, R., Sohrabi, C., Thaha, M., Venn, M., Atherton, R., Brocklehurst, M., Mcaleer, J., Parkin, E., Aladeojebi, A., Ali, M., Gaunt, A., Hammer, C., Stebbing, J., Bhasin, S., Bodla, A. S., Burahee, A., Crichton, A., Fossett, R., Yassin, N., Brown, S., Lee, M., Newman, T., Steele, C., Baker, A., Konstantinou, C., Ramcharan, S., Wilkin, R. J. W., Lawday, S., Lyons, A., Chung, E., Hagger, R., Hainsworth, A., Karim, A., Owen, H., Ramwell, A., Williams, K., Hall, J., Harris, G., Royle, T., Watson, L. J., Asaad, P., Brown, B., Duff, S., Khan, A., Moura, F., Wadham, B., Mccluney, S., Parmar, C., Shah, S., Babar, M. S., Goodrum, S., Whitmore, H., Balasubramaniam, D., Jayasankar, B., Kapoor, S., Ramachandran, A., Beech, N., Chand, M., Green, L., Kiconco, H., Mcewen, R., Pereca, J., Gash, K., Gourbault, L., Maccabe, T., Newton, C., Baig, M., Bates, H., Dunne, N., Khajuria, A., Sarma, D. R., Shortland, T., Tewari, N., Akhtar, M. A., Brunt, A., Mcintyre, J., Milne, K., Rashid, M. M., Sgrò, A., Stewart, K. E., Turnbull, A., Aguilar Gonzalez, M., Talukder, S., Eskander, P., Hanna, M., Olivier, J., Magee, C., Powell, S., Flindall, I., Hanson, A., Mahendran, V., Green, S., Lim, M., Macdonald, L., Miu, V., Onos, L., Sheridan, K., Young, R., Alam, F., Griffiths, O., Houlden, C., Kolli, V. S., Lala, A. K., Seymour, Z., Haynes, A., Hill, C., Leede, E., Mcelhinney, K., Olson, K. A., Riley, C., Thornhill, M., Etchill, E., Gabre‐kidan, A., Jenny, H., Kent, A., Ladd, M. R., Long, C., Malapati, H., Margalit, A., Rapaport, S., Rose, J., Stevens, K., Tsai, L., Vervoort, D., Yesantharao, P., Bigelow, B., Klaristenfeld, D., Huynh, K., Azam, M., Choudhry, A., Marx, W., Abel, M. K., Boeck, M., Chern, H., Kornblith, L., Nunez‐garcia, B., Ozgediz, D., Glencer, A., Sarin, A., Varma, M., Abbott, D., Acher, A., Aiken, T., Barrett, J., Foley, E., Schwartz, P., Zafar, S. N., Hawkins, A., Maiga, A., Bhat, M. A., Uyanik, M. S., D’Ugo, D. (ORCID:0000-0001-6657-6318), Ratto, C. (ORCID:0000-0002-0556-0037), and Rosa, F. (ORCID:0000-0002-7280-8354)
- Abstract
Aim This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic.Method This was an international cohort study of patients undergoing elective resection of colon or rectal cancer without preoperative suspicion of SARS-CoV-2. Centres entered data from their first recorded case of COVID-19 until 19 April 2020. The primary outcome was 30-day mortality. Secondary outcomes included anastomotic leak, postoperative SARS-CoV-2 and a comparison with prepandemic European Society of Coloproctology cohort data.Results From 2073 patients in 40 countries, 1.3% (27/2073) had a defunctioning stoma and 3.0% (63/2073) had an end stoma instead of an anastomosis only. Thirty-day mortality was 1.8% (38/2073), the incidence of postoperative SARS-CoV-2 was 3.8% (78/2073) and the anastomotic leak rate was 4.9% (86/1738). Mortality was lowest in patients without a leak or SARS-CoV-2 (14/1601, 0.9%) and highest in patients with both a leak and SARS-CoV-2 (5/13, 38.5%). Mortality was independently associated with anastomotic leak (adjusted odds ratio 6.01, 95% confidence interval 2.58-14.06), postoperative SARS-CoV-2 (16.90, 7.86-36.38), male sex (2.46, 1.01-5.93), age >70 years (2.87, 1.32-6.20) and advanced cancer stage (3.43, 1.16-10.21). Compared with prepandemic data, there were fewer anastomotic leaks (4.9% versus 7.7%) and an overall shorter length of stay (6 versus 7 days) but higher mortality (1.7% versus 1.1%).Conclusion Surgeons need to further mitigate against both SARS-CoV-2 and anastomotic leak when offering surgery during current and future COVID-19 waves based on patient, operative and organizational risks.
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- 2020
17. Ileal pouch–anal anastomosis with fluorescence angiography: a case‐matched study
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Spinelli, A., primary, Carvello, M., additional, Kotze, P. G., additional, Maroli, A., additional, Montroni, I., additional, Montorsi, M., additional, Buchs, N. C., additional, and Ris, F., additional
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- 2019
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18. Redo pouch and re-stapled anastomosis after intra-operative detection of pouch ischaemia by fluorescence angiography - a video vignette
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M. Carvello, A. Sharif, Antonino Spinelli, Paulo Gustavo Kotze, Annalisa Maroli, and M. Sacchi
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Stapled anastomosis ,medicine.medical_specialty ,Intra operative ,Proctocolectomy ,business.industry ,Fluorescence angiography ,medicine.medical_treatment ,Gastroenterology ,Ischemia ,Anastomosis ,medicine.disease ,Surgery ,Vignette ,medicine ,Pouch ,business - Published
- 2019
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19. Redo pouch and re-stapled anastomosis after intra-operative detection of pouch ischaemia by fluorescence angiography - a video vignette
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Carvello, M., primary, Sacchi, M., additional, Maroli, A., additional, Sharif, A., additional, Kotze, P., additional, and Spinelli, A., additional
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- 2019
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20. The Influence of Post System Design and Material on the Biomechanical Behavior of Teeth with Little Remaining Coronal Structure
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Pinto, Cristiano Lazzari, primary, Bhering, Claudia Lopes Brilhante, additional, de Oliveira, Gabriel Rodrigues, additional, Maroli, Angélica, additional, Reginato, Vagner Flávio, additional, Caldas, Ricardo Armini, additional, and Bacchi, Atais, additional
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- 2018
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21. Communicative Behavior of the Grasshopper Syrbula fuscovittata (Thomas) (Gomphocerinae) with Particular Consideration of the male Courtship1
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Werner Loher and Maroli K. Chandrashekaran
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Communication ,biology ,business.industry ,biology.organism_classification ,Communicative behavior ,Developmental psychology ,Gomphocerinae ,General Earth and Planetary Sciences ,Animal Science and Zoology ,Psychology ,Grasshopper ,business ,Ecology, Evolution, Behavior and Systematics ,General Environmental Science - Published
- 2010
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22. Reduction of plasma urate levels following treatment with multiple doses of pegloticase (polyethylene glycol-conjugated uricase) in patients with treatment-failure gout: Results of a phase II randomized study
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Larry W. Moreland, André Barkhuizen, William Huang, Pegloticase Phase Study Investigators, Herbert S B Baraf, Allan N. Maroli, Royce W. Waltrip, John S. Sundy, Zeb Horowitz, and Michael Becker
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Adult ,Male ,medicine.medical_specialty ,Gout ,Urate Oxidase ,Immunology ,Gastroenterology ,Drug Administration Schedule ,Polyethylene Glycols ,chemistry.chemical_compound ,Rheumatology ,Pharmacokinetics ,Internal medicine ,Blood plasma ,medicine ,Humans ,Immunology and Allergy ,Pharmacology (medical) ,Hyperuricemia ,Adverse effect ,Contraindication ,Aged ,Dose-Response Relationship, Drug ,business.industry ,Patient Selection ,Middle Aged ,medicine.disease ,Intention to Treat Analysis ,Uric Acid ,Surgery ,Treatment Outcome ,Pegloticase ,chemistry ,Uric acid ,Female ,business ,medicine.drug - Abstract
Objective To assess the efficacy of pegloticase in achieving and maintaining plasma urate levels of
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- 2008
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23. Population Pharmacokinetic and Pharmacodynamic Analysis of Pegloticase in Subjects With Hyperuricemia and Treatment-Failure Gout
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Marika Di Marco, Michelle Alton, Corinne Seng Yue, David Erick Wright, William Huang, Royce W. Waltrip, and Allan N. Maroli
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Adult ,Male ,Gout ,Urate Oxidase ,Population ,Hyperuricemia ,Pharmacology ,Models, Biological ,Drug Administration Schedule ,Gout Suppressants ,Polyethylene Glycols ,chemistry.chemical_compound ,Pharmacokinetics ,Humans ,Medicine ,Tissue Distribution ,Pharmacology (medical) ,Treatment Failure ,Infusions, Intravenous ,education ,Aged ,Aged, 80 and over ,Volume of distribution ,education.field_of_study ,Dose-Response Relationship, Drug ,business.industry ,Body Weight ,Middle Aged ,medicine.disease ,Uric Acid ,chemistry ,Pegloticase ,Pharmacodynamics ,Uric acid ,Female ,business ,medicine.drug - Abstract
Pegloticase is designed to convert urate into the easily excretable allantoin to treat hyperuricemia in gout. The aim of this analysis was to describe the pharmacokinetics and pharmacodynamics of pegloticase in 40 gout patients. Pegloticase was administered as intravenous infusions every 2 weeks at 4- and 8-mg doses or every 4 weeks at 8- or 12-mg doses for 12 weeks. Serum pegloticase concentrations, plasma urate, and serum antibody response were determined. Population pharmacokinetics and pharmacodynamics analyses were performed. Data were modeled simultaneously, and covariates were investigated (age, gender, race, body weight, ideal body weight, and antibody response). The dosing regimens to maintain uric acid levels below the therapeutic target of 6 mg/dL were then predicted by the model. The pharmacokinetics were best described by a 1-compartment linear model, while the pharmacodynamics model was fitted as a direct effect of pegloticase on uric acid concentrations with a suppressive maximum effect attributed to drug (E(max)) function. Pegloticase suppressed uric acid levels up to 83%. Weight only affected clearance and volume of distribution. No covariates affected pharmacodynamics. Simulation suggests pegloticase administered at 8 mg every 2 or 4 weeks as 2-hour intravenous infusions will maintain uric acid levels well under 6 mg/dL.
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- 2008
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24. The northward spread of leishmaniasis in Italy: evidence from retrospective and ongoing studies on the canine reservoir and phlebotomine vectors
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Ezio Ferroglio, Raffaella Baldelli, Marina Gramiccia, Luca Rossi, Michele Mortarino, Gioia Capelli, Michele Maroli, Mario Pietrobelli, Luigi Gradoni, and Claudio Genchi
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Veterinary medicine ,biology ,Incidence (epidemiology) ,Public Health, Environmental and Occupational Health ,Leishmaniasis ,biology.organism_classification ,medicine.disease ,Sandfly ,Infectious Diseases ,Visceral leishmaniasis ,Vector (epidemiology) ,medicine ,Canine leishmaniasis ,Seroprevalence ,Parasitology ,Leishmania infantum - Abstract
Visceral leishmaniasis (VL) incidence has been increased in Italy in humans and dogs since the 1990s, with new foci being detected within traditional boundaries of endemic transmission but also in northern regions previously regarded as non-endemic. To monitor the putative VL spreading, surveillance was implemented in northern continental Italy comprising: analysis of human cases recorded from 1990 through 2005; retrospective literature analysis of canine leishmaniasis (CanL) and phlebotomine sandfly records through 2002; prospective investigations in dogs from 2003 through 2005 and surveys on sandflies in 2003 and 2004. Two-hundred-thirty human cases (11% of Italian cases) were recorded. Their stratification by age and HIV status disclosed a sharp decrease of HIV/VL co-infections paralleled by concomitant increase of paediatric and HIV-negative adult patients during the study period. Four patients had no travel history. Seven leishmaniasis foci were retrospectively identified since 1990, whereas prospective investigations in dogs disclosed 47 autochthonous clinical cases and 106 autochthonous seropositives among 5442 dogs (2.1%) from 16 foci of six regions. Parasites were typed as Leishmania infantum MON-1. Four vector species were identified among 1696 Phlebotomus (Larroussius) collected specimens. Comparisons with historical data showed that P. perniciosus and P. neglectus have increased in density and expanded their geographic range in the study area. Northern continental Italy is now focally endemic for VL and a moderate risk for human disease does exist, although the intensity of transmission seems to be lower than in traditional settings of Mediterranean VL.
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- 2008
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25. α9- and α7-containing receptors mediate the pro-proliferative effects of nicotine in the A549 adenocarcinoma cell line
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Mucchietto, Vanessa, primary, Fasoli, Francesca, additional, Pucci, Susanna, additional, Moretti, Milena, additional, Benfante, Roberta, additional, Maroli, Annalisa, additional, Di Lascio, Simona, additional, Bolchi, Cristiano, additional, Pallavicini, Marco, additional, Dowell, Cheryl, additional, McIntosh, Michael, additional, Clementi, Francesco, additional, and Gotti, Cecilia, additional
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- 2017
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26. Apremilast, an oral phosphodiesterase 4 inhibitor, in the treatment of Japanese patients with moderate to severe plaque psoriasis: Efficacy, safety and tolerability results from a phase 2b randomized controlled trial
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Ohtsuki, Mamitaro, primary, Okubo, Yukari, additional, Komine, Mayumi, additional, Imafuku, Shinichi, additional, Day, Robert M., additional, Chen, Peng, additional, Petric, Rosemary, additional, Maroli, Allan, additional, and Nemoto, Osamu, additional
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- 2017
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27. The application of molecular techniques to the surveillance and control of leishmaniasis in Italy: the facts and doubts
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Trentina Di Muccio, Marina Gramiccia, Giovanni Poglayen, Michele Maroli, Aldo Scalone, Gioia Bongiorno, Luigi Gradoni, and Erika Rossi
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Pathology ,medicine.medical_specialty ,biology ,Phlebotominae ,Leishmaniasis ,biology.organism_classification ,medicine.disease ,Leishmania ,Microbiology ,Virology ,Vector (epidemiology) ,parasitic diseases ,medicine ,Canine leishmaniasis ,Seroprevalence ,Leishmania infantum ,Nested polymerase chain reaction - Abstract
Leishmaniases are parasitic diseases caused by various species of the protozoan Leishmania. In Italy human visceral and cutaneous leishmaniases are caused by Leishmania infantum, which has the dog as domestic reservoir, and different Phlebotominae species as the vector. Several molecular techniques are currently used with success for a rapid, very sensitive and non-invasive detection of Leishmania organisms in specimens of infected organs. The high sensitivity, however, may raise doubts on the significance of target DNA detection, which may represent either an established infection—with or without epidemiological importance—or just a trace of parasite–host contacts. Three examples of the application of nested PCR technique using rDNA sequence primers on different biological samples, are reported here: (a) five different bioptic samples were examined from 153 dogs of an endemic focus of canine leishmaniasis (CanL) (Salina Island, Sicily), giving a Leishmania prevalence of 82.8%, in contrast with 31.4% seroprevalence; (b) in a new CanL focus of Rome province; 60/127 Phlebotomus perniciosus (45.7,0%) were found positive by nested PCR, in contrast with 1.4% microscopically positive; and (c) leishmanial DNA was detected in a natural case of leishmaniasis in a novel mammal host, a domestic ferret (Mustela putorius furo). These results raise the following doubts, respectively: (a) Does the high “infection” prevalence detected in dogs correspond to the “infectiveness-to-the vector” prevalence? (b) Can the positive sandflies transmit infective promastigotes? and (c) Can an infected domestic ferret play a role as parasite reservoir?
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- 2005
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28. Randomized double-blind clinical drug trials of meloxicam in rheumatoid arthritis and osteoarthritis knees: an Indian experience
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D. Gadgil, B. K. Dhaon, S. Maroli, Arvind Chopra, A. B. Goregaonkar, A. G. Rajadhyaksha, and Lata Bichile
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medicine.medical_specialty ,education.field_of_study ,WOMAC ,business.industry ,Population ,Arthritis ,Osteoarthritis ,medicine.disease ,Piroxicam ,Surgery ,Meloxicam ,Diclofenac ,Rheumatoid arthritis ,Internal medicine ,medicine ,business ,education ,medicine.drug - Abstract
Background: Indian data from controlled drug trials on the use of meloxicam (a new preferential COX-2 inhibitor) and other non-steroidal anti-inflammatory drugs (NSAIDs) in arthritis is sparse. Aim: To evaluate the clinical efficacy and safety of meloxicam. Patients and methods: One hundred and twenty-one patients with rheumatoid arthritis (RA) and 133 patients with osteoarthritis (OA) knees were randomized into two different multicentric, double-blind, drug trials of four-weeks duration each. Meloxicam 7.5 mg (OA study) and 15 mg (RA study) was compared to diclofenac 100 mg and piroxicam 20 mg in daily dosages, respectively. Strict eligibility criteria ensured active symptomatic disease. Standard ACR efficacy measures of pain and function (including validated Indian versions of HAQ & WOMAC) were used. Protocol-driven evaluations were carried out throughout the study. An intent-to-treat efficacy analysis (significance at P
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- 2004
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29. Evidence for an impact on the incidence of canine leishmaniasis by the mass use of deltamethrin-impregnated dog collars in southern Italy
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A. D'Orazi, Luigi Gradoni, V. Mizzoni, C. Siragusa, and Michele Maroli
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education.field_of_study ,Veterinary medicine ,General Veterinary ,biology ,Incidence (epidemiology) ,Population ,biology.organism_classification ,medicine.disease ,Sandfly ,Animal science ,Visceral leishmaniasis ,Insect Science ,parasitic diseases ,Canine leishmaniasis ,medicine ,Seroprevalence ,Parasitology ,Psychodidae ,Leishmania infantum ,education ,Ecology, Evolution, Behavior and Systematics - Abstract
Dogs are the domestic reservoir of Leishmania infantum Nicolle (Kinetoplastida: Trypanosomatidae), the agent of zoonotic human visceral leishmaniasis. In southern Europe, where canine leishmaniasis (CanL) is widespread due to L. infantum, killing seropositive dogs is considered unacceptable and drug treatment has low efficacy in preventing transmission. We made a field evaluation of the efficacy of deltamethrin dog collars in a CanL focus of southern Italy, Mount Vesuvius area of Campania region, where the vector is Phlebotomus perniciosus Newstead (Diptera: Psychodidae), by assessing their impact on the incidence of CanL in an intervention town, compared to that in dogs of control towns where no collars were fitted. During two consecutive transmission seasons, collars were fitted to 350 (1998) and 354 (1999) dogs from San Sebastiano al Vesuvio (70% of the canine population). Control dogs (371 and 264 in the 2 years, respectively) were from four towns of the same area. Before each transmission season, the CanL seroprevalence in the intervention and control towns was evaluated by cross-sectional surveys and found to be similar (about 15% in 1998 and 10% in 1999, respectively). After each transmission period, incidence rates of seroconversions were determined in adult dogs that were serologically negative before the season under evaluation, and in puppies. After the 1998 season, 2.7% of the dogs in the intervention town seroconverted compared to 5.4% in the control towns (50% protection, P = 0.15). After the 1999 season, 3.5% of collared dogs seroconverted compared to 25.8% of control dogs (86% protection, P
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- 2001
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30. Morphology and ultrastructure of spiracles in phlebotomine sandfly larvae
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Massimo Mazzini, A. R. Taddei, A. M. Fausto, and Michele Maroli
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Larva ,Morphology (linguistics) ,General Veterinary ,biology ,Respiratory System ,fungi ,Anatomy ,biology.organism_classification ,law.invention ,Sandfly ,Spiracle ,law ,Phlebotomus ,Insect Science ,Ultrastructure ,Animals ,Instar ,Parasitology ,Electron microscope ,Ecology, Evolution, Behavior and Systematics ,Air filter - Abstract
Summary The morphology and ultrastructure of the larval spiracle system of three phlebotomine sandfly species, Phlebotomus perniciosus, P. perfiliewi and P. papatasi, were examined by scanning (SEM) and transmission (TEM) electron microscopy and by confocal scanning laser microscopy (CSLM). During larval development, thoracic and abdominal spiracles show considerable modifications. In fourth instar larvae, the spiracles consist of a plate with a sclerotized central portion and a peripheral circle of papillae. The latter is distinctive in the larvae of P. papatasi, which are readily distinguished from the other species. Opening clefts across the papillae communicate with an internal chamber that encircles an electrondense plug. Many cylindrical projections cross the chamber, uniting the central plug with the larval body, forming an air filter. Spiracular development in successive larval instars has both a taxonomic and adaptive value.
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- 1999
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31. Ambulance referral for emergency obstetric care in remote settings
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Tsegaye, Ademe, primary, Somigliana, Edgardo, additional, Alemayehu, Tadesse, additional, Calia, Federico, additional, Maroli, Massimo, additional, Barban, Paola, additional, Manenti, Fabio, additional, Putoto, Giovanni, additional, and Accorsi, Sandro, additional
- Published
- 2016
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32. Immunoscintigraphy in patients with colorectal, ovarian, and prostate cancer. Results with site‐specific immunoconjugates
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Robert T. Maguire, Joseph Gulfo, Virginia L. Pascucci, and Allan N. Maroli
- Subjects
Cancer Research ,Pathology ,medicine.medical_specialty ,business.industry ,Colorectal cancer ,medicine.disease ,Imaging agent ,Immunoscintigraphy ,Prostate cancer ,chemistry.chemical_compound ,Pendetide ,medicine.anatomical_structure ,Oncology ,chemistry ,Prostate ,medicine ,Carcinoma ,Ovarian cancer ,business - Abstract
Application of monoclonal antibody (MoAb) technology to cancer management is discussed by reviewing the development and clinical evaluation of two MoAb-based immunoscintigraphic agents (111In-satumomab pendetide [OncoScint CR/OV-In] and 111In-CYT-356; Cytogen Corporation, Princeton, NJ). Both agents were prepared using a site-specific MoAb modification method that preserves the immunoreactivity of the radiolabeled immunoconjugate. 111In-satumomab pendetide is an 111In-labeled conjugate of the murine MoAb B72.3, which is directed to TAG-72, an antigen expressed by the majority of adenocarcinomas. By providing information that complements the results of standard radiographic diagnostic modalities, this imaging agent can aid in the treatment of patients with colorectal or ovarian cancer. Immunoscintigraphy with 111In-satumomab pendetide has been shown to assist in medical-surgical management by detecting occult extrahepatic lesions, clarifying equivocal results of other diagnostic imaging tests, and evaluating the extent and resectability of known tumor lesions. 111In-CYT-356 is an 111In-labeled conjugate of the murine MoAb 7E11-C5.3, which is reactive with prostatic carcinoma, benign prostatic hypertrophy, and, to a lesser extent, normal prostatic tissue. Results of preliminary clinical investigations suggest that 111In-CYT-356 immunoscintigraphy can be useful for the presurgical staging of prostatic carcinoma and for the detection of occult distant disease in patients with negative or equivocal results on standard imaging tests. Results with these site-specifically radiolabeled immunconjugates demonstrate the clinical utility of MoAb-based imaging agents in the treatment of patients with solid tumors.
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- 1993
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33. Intraspecific variation in the cuticular hydrocarbons of the sandfly Phlebotomus perfiliewi from Italy
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A. Phillips, G. Broomfield, David H. Molyneux, Shaden Kamhawi, M. Maroli, Paul Milligan, and R. P. Lane
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Chromatography, Gas ,General Veterinary ,biology ,Ecology ,Phlebotomus perfiliewi ,Allopatric speciation ,biology.organism_classification ,Hydrocarbons ,Intraspecific competition ,Insect Vectors ,Sandfly ,Italy ,Phlebotomus ,Insect Science ,Animals ,Female ,Parasitology ,Taxonomy (biology) ,Ecology, Evolution, Behavior and Systematics - Abstract
The cuticular hydrocarbons of Phlebotomus perfiliewi Parrot from representative localities on both sides of Italy show contrasts which support the view of Ward et al. (1981) that there are distinguishable populations of this sandfly on the Adriatic and Tyrrhenian coasts. It is suggested that the Appennine mountains form a barrier between the Adriatic and Tyrrhenian populations. A third distinct hydrocarbon type of P.perfiliewi was detected in Calabria, southern Italy, where contact between the Adriatic and Tyrrhenian types of flies is most likely to occur. P.perfiliewi from a trans-Appennine pass were also of the Calabrian hydrocarbon type. These hydrocarbon contrasts between allopatric populations of P.perfiliewi may result from clinal variation across the Appennines, associated with different host preferences, or they may represent apomictic populations with differential mate recognition systems.
- Published
- 1990
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34. Phlebotomine sandflies and the spreading of leishmaniases and other diseases of public health concern
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MAROLI, M., primary, FELICIANGELI, M. D., additional, BICHAUD, L., additional, CHARREL, R. N., additional, and GRADONI, L., additional
- Published
- 2012
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- View/download PDF
35. Communicative Behavior of the Grasshopper Syrbula fuscovittata (Thomas) (Gomphocerinae) with Particular Consideration of the male Courtship1
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Loher, Werner, primary and Chandrashekaran, Maroli K., additional
- Published
- 2010
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36. Aspects of the bionomics ofPhlebotomus sergentisandflies from an endemic area of anthroponotic cutaneous leishmaniasis in Aleppo Governorate, Syria
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MAROLI, M., primary, JALOUK, L., additional, AL AHMED, M., additional, BIANCHI, R., additional, BONGIORNO, G., additional, KHOURY, C., additional, and GRADONI, L., additional
- Published
- 2009
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37. Resolution of gouty tophi after twelve weeks of pegloticase treatment
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Baraf, Herbert S. B., primary, Matsumoto, Alan K., additional, Maroli, Allan N., additional, and Waltrip, Royce W., additional
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- 2008
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38. Population Pharmacokinetic and Pharmacodynamic Analysis of Pegloticase in Subjects With Hyperuricemia and Treatment‐Failure Gout
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Yue, Corinne Seng, primary, Huang, William, additional, Alton, Michelle, additional, Maroli, Allan N., additional, Waltrip, Royce W., additional, Wright, David, additional, and Di Marco, Marika, additional
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- 2008
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39. The northward spread of leishmaniasis in Italy: evidence from retrospective and ongoing studies on the canine reservoir and phlebotomine vectors
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Maroli, Michele, primary, Rossi, Luca, additional, Baldelli, Raffaella, additional, Capelli, Gioia, additional, Ferroglio, Ezio, additional, Genchi, Claudio, additional, Gramiccia, Marina, additional, Mortarino, Michele, additional, Pietrobelli, Mario, additional, and Gradoni, Luigi, additional
- Published
- 2008
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40. The application of molecular techniques to the surveillance and control of leishmaniasis in Italy: the facts and doubts
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GRAMICCIA, MARINA, primary, MUCCIO, TRENTINA DI, additional, SCALONE, ALDO, additional, ROSSI, ERIKA, additional, BONGIORNO, GIOIA, additional, MAROLI, MICHELE, additional, POGLAYEN, GIOVANNI, additional, and GRADONI, LUIGI, additional
- Published
- 2005
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41. Randomized double-blind clinical drug trials of meloxicam in rheumatoid arthritis and osteoarthritis knees: an Indian experience
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CHOPRA, Arvind, primary, BICHILE, L., additional, RAJADHYAKSHA, A. G., additional, GADGIL, D., additional, MAROLI, S., additional, GOREGAONKAR, A. B., additional, and DHAON, B. K., additional
- Published
- 2004
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42. A mammalian‐like lipase gene is expressed in the female reproductive accessory glands of the sand fly Phlebotomus papatasi (Diptera, Psychodidae)
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Rosetto, M., primary, Belardinelli, M., additional, Fausto, A. M., additional, Marchini, D., additional, Bongiorno, G., additional, Maroli, M., additional, and Mazzini, M., additional
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- 2003
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43. Control of phlebotomine sandflies
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Alexander, B., primary and Maroli, M., additional
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- 2003
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44. Evidence for an impact on the incidence of canine leishmaniasis by the mass use of deltamethrin-impregnated dog collars in southern Italy
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Maroli, M., primary, Mizzoni, V., additional, Siragusa, C., additional, D'Orazi, A., additional, and Gradoni, L., additional
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- 2001
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45. In the field mouse Mus booduga melatonin phase response curves (PRCs) have a different time course and wave form relative to light PRC
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Sharma, Vijay Kumar, primary, Chandrashekaran, Maroli K., additional, Singaravel, Muniyandi, additional, and Subbaraj, Ramanujam, additional
- Published
- 1999
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46. Morphology and ultrastructure of spiracles in phlebotomine sandfly larvae
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Fausto, A. M., primary, Taddei, A. R., additional, Mazzini, M., additional, and Maroli, M., additional
- Published
- 1999
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47. Relationship between light intensity and phase resetting in a mammalian circadian system
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Sharma, Vijay Kumar, primary, Chandrashekaran, Maroli K., additional, Singaravel, Muniyandi, additional, and Subbaraj, Ramanujam, additional
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- 1999
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48. Age-dependent modulation of circadian parameters in the field mouseMus booduga
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Sharma, Vijay Kumar, primary and Chandrashekaran, Maroli K., additional
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- 1998
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49. P300 Grepafoloxacin (G) versus doxycycline (D) in the treatment of uncomplicated chlamydia genital infection in men and women
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MROCZKOWSKI, T, primary, MARTIN, D, additional, BEAN, K, additional, and MAROLI, A, additional
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- 1997
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50. P300 Grepafoloxacin (G) versus doxycycline (D) in the treatment of uncomplicated chlamydia genital infection in men and women
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A.N. Maroli, D.H. Martin, T.F. Mroczkowski, and K.A. Bean
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Doxycycline ,medicine.medical_specialty ,Infectious Diseases ,Chlamydia ,business.industry ,Internal medicine ,medicine ,Sex organ ,Dermatology ,medicine.disease ,business ,medicine.drug - Published
- 1997
- Full Text
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