1. Large‐scale production of extracellular vesicles: Report on the 'massivEVs' ISEV workshop
- Author
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Lucia Paolini, Marta Monguió‐Tortajada, Marta Costa, Fabio Antenucci, Mario Barilani, Marta Clos‐Sansalvador, André Cronemberger Andrade, Tom A. P. Driedonks, Sara Giancaterino, Stephanie M. Kronstadt, Rachel R. Mizenko, Muhammad Nawaz, Xabier Osteikoetxea, Carla Pereira, Surya Shrivastava, Anders Toftegaard Boysen, Simonides Immanuel van deWakker, Martijn J. C. vanHerwijnen, Xiaoqin Wang, Dionysios C. Watson, Mario Gimona, Maria Kaparakis‐Liaskos, Konstantin Konstantinov, Sai Kiang Lim, Nicole Meisner‐Kober, Michiel Stork, Peter Nejsum, Annalisa Radeghieri, Eva Rohde, Nicolas Touzet, Marca H. M. Wauben, Kenneth W. Witwer, Antonella Bongiovanni, and Paolo Bergese
- Subjects
EV‐based products ,extracellular vesicles ,ISEV workshop ,large‐scale production ,manufacturing ,processing ,Cytology ,QH573-671 - Abstract
Abstract Extracellular vesicles (EVs) large‐scale production is a crucial point for the translation of EVs from discovery to application of EV‐based products. In October 2021, the International Society for Extracellular Vesicles (ISEV), along with support by the FET‐OPEN projects, “The Extracellular Vesicle Foundry” (evFOUNDRY) and “Extracellular vesicles from a natural source for tailor‐made nanomaterials” (VES4US), organized a workshop entitled “massivEVs” to discuss the potential challenges for translation of EV‐based products. This report gives an overview of the topics discussed during “massivEVs”, the most important points raised, and the points of consensus reached after discussion among academia and industry representatives. Overall, the review of the existing EV manufacturing, upscaling challenges and directions for their resolution highlighted in the workshop painted an optimistic future for the expanding EV field.
- Published
- 2022
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