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2. Vale Dave McGavin

Author

Barrett, K, primary, Oxenford, C, additional, Canfield, P, additional, Armstrong, S, additional, and Malik, R, additional

Published
2024
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15. Latent autoimmune diabetes of adulthood ( LADA ) is associated with small fibre neuropathy

Author

Alam, U., primary, Jeziorska, M., additional, Petropoulos, I. N., additional, Pritchard, N., additional, Edwards, K., additional, Dehghani, C., additional, Srinivasan, S., additional, Asghar, O., additional, Ferdousi, M., additional, Ponirakis, G., additional, Marshall, A., additional, Boulton, A. J. M., additional, Efron, N., additional, and Malik, R. A., additional

Published
2019
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18. Antimicrobial Prescribing in Dogs and Cats in Australia: Results of the Australasian Infectious Disease Advisory Panel Survey

Author

Hardefeldt, LY, Holloway, S, Trott, DJ, Shipstone, M, Barrs, VR, Malik, R, Burrows, M, Armstrong, S, Browning, GF, Stevenson, M, Hardefeldt, LY, Holloway, S, Trott, DJ, Shipstone, M, Barrs, VR, Malik, R, Burrows, M, Armstrong, S, Browning, GF, and Stevenson, M

Abstract

BACKGROUND: Investigations of antimicrobial use in companion animals are limited. With the growing recognition of the need for improved antimicrobial stewardship, there is urgent need for more detailed understanding of the patterns of antimicrobial use in this sector. OBJECTIVES: To investigate antimicrobial use for medical and surgical conditions in dogs and cats by Australian veterinarians. METHODS: A cross-sectional study was performed over 4 months in 2011. Respondents were asked about their choices of antimicrobials for empirical therapy of diseases in dogs and cats, duration of therapy, and selection based on culture and susceptibility testing, for common conditions framed as case scenarios: 11 medical, 2 surgical, and 8 dermatological. RESULTS: A total of 892 of the 1,029 members of the Australian veterinary profession that completed the survey satisfied the selection criteria. Empirical antimicrobial therapy was more common for acute conditions (76%) than chronic conditions (24%). Overall, the most common antimicrobial classes were potentiated aminopenicillins (36%), fluoroquinolones (15%), first- and second-generation cephalosporins (14%), and tetracyclines (11%). Third-generation cephalosporins were more frequently used in cats (16%) compared to dogs (2%). Agreement with Australasian Infectious Disease Advisory Panel (AIDAP) guidelines (generated subsequently) was variable ranging from 0 to 69% between conditions. CONCLUSIONS AND CLINICAL IMPORTANCE: Choice of antimicrobials by Australian veterinary practitioners was generally appropriate, with relatively low use of drugs of high importance, except for the empirical use of fluoroquinolones in dogs, particularly for otitis externa and 3rd-generation cephalosporins in cats. Future surveys will determine whether introduction of the 2013 AIDAP therapeutic guidelines has influenced prescribing habits.

Published
2017

19. Genetic Variation at 16q24.2 Is Associated With Small Vessel Stroke

Author

Traylor, M, Malik, R, Nalls, MA, Cotlarciuc, I, Radmanesh, F, Thorleifsson, G, Hanscombe, KB, Langefeld, C, Saleheen, D, Rost, NS, Yet, I, Spector, TD, Bell, JT, Hannon, E, Mill, J, Chauhan, G, Debette, S, Bis, JC, Longstreth, WT, Ikram, MA, Launer, LJ, Seshadri, S, Hamilton-Bruce, MA, Jimenez-Conde, J, Cole, JW, Schmidt, R, Slowik, A, Lemmens, R, Lindgren, A, Melander, O, Grewal, RP, Sacco, RL, Rundek, T, Rexrode, K, Arnett, DK, Johnson, JA, Benavente, OR, Wasssertheil-Smoller, S, Lee, J-M, Pulit, SL, Wong, Q, Rich, SS, de Bakker, PIW, McArdle, PF, Woo, D, Anderson, CD, Xu, H, Heitsch, L, Fornage, M, Jern, C, Stefansson, K, Thorsteinsdottir, U, Gretarsdottir, S, Lewis, CM, Sharma, P, Sudlow, CLM, Rothwell, PM, Boncoraglio, GB, Thijs, V, Levi, C, Meschia, JF, Rosand, J, Kittner, SJ, Mitchell, BD, Dichgans, M, Worrall, BB, Markus, HS, Traylor, M, Malik, R, Nalls, MA, Cotlarciuc, I, Radmanesh, F, Thorleifsson, G, Hanscombe, KB, Langefeld, C, Saleheen, D, Rost, NS, Yet, I, Spector, TD, Bell, JT, Hannon, E, Mill, J, Chauhan, G, Debette, S, Bis, JC, Longstreth, WT, Ikram, MA, Launer, LJ, Seshadri, S, Hamilton-Bruce, MA, Jimenez-Conde, J, Cole, JW, Schmidt, R, Slowik, A, Lemmens, R, Lindgren, A, Melander, O, Grewal, RP, Sacco, RL, Rundek, T, Rexrode, K, Arnett, DK, Johnson, JA, Benavente, OR, Wasssertheil-Smoller, S, Lee, J-M, Pulit, SL, Wong, Q, Rich, SS, de Bakker, PIW, McArdle, PF, Woo, D, Anderson, CD, Xu, H, Heitsch, L, Fornage, M, Jern, C, Stefansson, K, Thorsteinsdottir, U, Gretarsdottir, S, Lewis, CM, Sharma, P, Sudlow, CLM, Rothwell, PM, Boncoraglio, GB, Thijs, V, Levi, C, Meschia, JF, Rosand, J, Kittner, SJ, Mitchell, BD, Dichgans, M, Worrall, BB, and Markus, HS

Abstract

OBJECTIVE: Genome-wide association studies (GWAS) have been successful at identifying associations with stroke and stroke subtypes, but have not yet identified any associations solely with small vessel stroke (SVS). SVS comprises one quarter of all ischemic stroke and is a major manifestation of cerebral small vessel disease, the primary cause of vascular cognitive impairment. Studies across neurological traits have shown that younger-onset cases have an increased genetic burden. We leveraged this increased genetic burden by performing an age-at-onset informed GWAS meta-analysis, including a large younger-onset SVS population, to identify novel associations with stroke. METHODS: We used a three-stage age-at-onset informed GWAS to identify novel genetic variants associated with stroke. On identifying a novel locus associated with SVS, we assessed its influence on other small vessel disease phenotypes, as well as on messenger RNA (mRNA) expression of nearby genes, and on DNA methylation of nearby CpG sites in whole blood and in the fetal brain. RESULTS: We identified an association with SVS in 4,203 cases and 50,728 controls on chromosome 16q24.2 (odds ratio [OR; 95% confidence interval {CI}] = 1.16 [1.10-1.22]; p = 3.2 × 10-9 ). The lead single-nucleotide polymorphism (rs12445022) was also associated with cerebral white matter hyperintensities (OR [95% CI] = 1.10 [1.05-1.16]; p = 5.3 × 10-5 ; N = 3,670), but not intracerebral hemorrhage (OR [95% CI] = 0.97 [0.84-1.12]; p = 0.71; 1,545 cases, 1,481 controls). rs12445022 is associated with mRNA expression of ZCCHC14 in arterial tissues (p = 9.4 × 10-7 ) and DNA methylation at probe cg16596957 in whole blood (p = 5.3 × 10-6 ). INTERPRETATION: 16q24.2 is associated with SVS. Associations of the locus with expression of ZCCHC14 and DNA methylation suggest the locus acts through changes to regulatory elements. Ann Neurol 2017;81:383-394.

Published
2017

32. Further Furoclerodanes fromTeucrium 'maghrebinum'

Author

Franco Piozzi, Sergio Rosselli, Maurizio Bruno, Kaddour Lamara, Segni Ladjel, Malik R. Y. Al-Hillo, and Maria Luisa Bondì

Subjects
Terpene, Teucrium, biology, Stereochemistry, Chemistry, Organic Chemistry, Nanotechnology, Physical and Theoretical Chemistry, Subspecies, biology.organism_classification
Abstract

Two more pairs of C-12 epimeric neoclerodanes were isolated from the aerial parts of Teucrium “maghrebinum” (Teucriumpolium subspecies still unidentified). They are the known teukotschyn 1, the new 12-epi-teukotschyn 2, the new teughrebin 3 and the new 12-epi-teughrebin 4. The structures of the new products were elucidated mainly by spectroscopic methods.

Published
2001

34. ChemInform Abstract: Further Furoclerodanes from Teucrium 'maghrebinum'

Author

Maria Luisa Bondì, Malik R. Y. Al-Hillo, Sergio Rosselli, Kaddour Lamara, Maurizio Bruno, Segni Ladjel, and Franco Piozzi

Subjects
Terpene, Teucrium, biology, Chemistry, Botany, General Medicine, Subspecies, biology.organism_classification
Abstract

Two more pairs of C-12 epimeric neoclerodanes were isolated from the aerial parts of Teucrium “maghrebinum” (Teucriumpolium subspecies still unidentified). They are the known teukotschyn 1, the new 12-epi-teukotschyn 2, the new teughrebin 3 and the new 12-epi-teughrebin 4. The structures of the new products were elucidated mainly by spectroscopic methods.

Published
2010

39. Paul Gotis‐Graham

Author

Malik, R, primary, Chiu, A, additional, Klupiec, C, additional, Lee, W, additional, Tisdall, P, additional, DeMaere, K, additional, and Canfield, PJ, additional

Published
2014
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