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Your search keyword '"MARSHALL, J. L."' showing total 40 results
Start Over Author "MARSHALL, J. L." Publisher wiley
40 results on '"MARSHALL, J. L."'

39. Influence of endothelins and sarafotoxin 6c and L-NAME on renal vasoconstriction in the anaesthetized rat.

Author

Marshall JL and Johns EJ

Subjects
Anesthesia, Animals, Male, Rats, Rats, Wistar, Regional Blood Flow drug effects, Endothelins pharmacology, Kidney blood supply, NG-Nitroarginine Methyl Ester pharmacology, Vasoconstriction drug effects, Viper Venoms pharmacology
Abstract

1. An investigation was performed in pentobarbitone anaesthetized rats to compare the renal vasoconstrictor actions of endothelin-1 (ET-1), endothelin-3 (ET-3) and sarafotoxin 6c and their dependency on NO production. 2. Intra-renal arterial infusion of ET-1 and ET-3, from 1 - 1000 ng had no effect on blood pressure, but reduced renal blood flow maximally by 82 and 81% with EC50 values of 510+/-18 and 1113+/-17 ng, respectively and correspondingly increased renal vascular resistance and decreased conductance. 3. Direct renal arterial administration of sarafotoxin 6c was without effect on blood pressure but caused a maximum reduction in renal blood flow of 56% at 300 ng and had an EC50 of 86+/-4 ng. 4. Administration of the selective ETA receptor antagonist FR139317 at 0.3 and 1.0 mg kg-1 had no effect on basal levels of blood pressure, renal vascular resistance or renal blood flow. The lower dose of FR139317 had no effect on the ET-1 dose-response curve for renal blood flow while at 1.0 mg kg-1, FR139317 reduced the EC50 to 363+/-32 ng (P<0.05). 5. Infusion of L-NAME, 10 microg kg-1 min-1 increased blood pressure by approximately 15%, increased renal vascular resistance and decreased renal blood flow by some 40%. The EC50 values for renal blood flow were reduced to 358+/-68 ng (P<0.05) for ET-1, 638+/-69 ng (P<0.05) for ET-3 and 55+/-10 ng (P<0.01) for sarafotoxin 6c. The maximal reduction in renal blood flow induced by sarafotoxin 6c was raised (P<0.01) from 56% to approximately 100% and renal vascular resistance increased when NO production was blocked. 6. These results showed that the vasoconstrictor actions of ET-1 and ET-3 on resistance vessels controlling renal blood flow are mediated via ETB rather than ETA receptors. Moreover, both ET-1 and ET-3 dependent vasoconstrictions are slightly attenuated by concomitant NO production. By contrast, sarafotoxin 6c appears much more potent at the renal resistance vasculature and is much more powerfully modulated by NO.

Published
1999
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40. Porous hydrophilic polymer: good and bad news in the orthopedic application of cruciate ligament substitution.

Author

Rubin RM and Marshall JL

Subjects
Animals, Dogs, Knee Joint drug effects, Knee Joint surgery, Polyethylene Terephthalates, Surface Properties, Water, Acrylates, Ligaments, Articular surgery, Methacrylates pharmacology, Prostheses and Implants
Abstract

In the configuration used, the Hydron sponge did not enhance the ingrowth of bone into the Dacron for prosthesis anchorage. In fact, the presence of the Hydron seemed to retard such ingrowth, even though there was bony incorporation of portions of the Hydron polymer. Fixation was more rigid when Dacron was implanted bare. Hydron sponge does not appear to remain intact within a joint. It would not seem suitable for intra-articular protection of a prosthesis or local delivery of antibiotics here. We did not search further for the polymer in the regional lymph nodes. Hydron sponge is capable of eleciting an unusual phenomenon of woven bone formation. This is "good news" for its potential, but realization of such potential will certainly require additional study. Double and triple interval fluorochrome labelling would be especially helpful in further studying the localization and rate of this bone formation.

Published
1975
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