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1. Synthesis and SAR of 2-Arylbenzoxazoles, Benzothiazoles and Benzimidazoles as Inhibitors of Lysophosphatidic Acid Acyltransferase-β

Author

Cory Kohm, Lynn Bonham, Peter S. Klein, Feng Hong, and Baoqing Gong

Subjects
Gene isoform, Clinical Biochemistry, Pharmaceutical Science, Tumor cells, Biochemistry, Chemical synthesis, Lysophosphatidic acid acyltransferase, Structure-Activity Relationship, Cell Line, Tumor, Drug Discovery, Structure–activity relationship, Humans, Benzothiazoles, Enzyme Inhibitors, Cytotoxicity, Molecular Biology, chemistry.chemical_classification, Benzoxazoles, biology, Chemistry, Organic Chemistry, General Medicine, In vitro, Thiazoles, Enzyme, Cell culture, Enzyme inhibitor, biology.protein, Molecular Medicine, Benzimidazoles, Acyltransferases
Abstract

2-Arylbenzoxazoles, benzothiazoles and benzimidazoles were identified as new classes of potent, isoform specific inhibitors of lysophosphatidic acid acyltransferase-beta (LPAAT-beta). Effects of selected inhibitors on proliferation of tumor cells in vitro were investigated.

Published
2004
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