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3 results on '"Lofiego C"'

1. Ventricular remodeling in Loeffler endocarditis: Implications for therapeutic decision making

Author

Carla Lofiego, Enrica Perugini, Angelo Branzi, Guido Rocchi, Marinella Ferlito, Claudio Rapezzi, Elena Biagini, Lofiego C, Ferlito M, Rocchi G, Biagini E, Perugini E, Branzi A, and Rapezzi C.

Subjects
Adult, Male, medicine.medical_specialty, Decision Making, Endomyocardial fibrosis, Loeffler endocarditis, Doppler echocardiography, Risk Assessment, Severity of Illness Index, Sampling Studies, Ventricular Function, Left, Internal medicine, Hypereosinophilic Syndrome, medicine, Humans, LOEFFLER ENDOCARDITIS, Ventricular remodeling, HYPEREOSINOPHILIA, Endocardium, Ventricular Remodeling, medicine.diagnostic_test, business.industry, ENDOMYOCARDIAL FIBROSIS, Middle Aged, medicine.disease, Thrombosis, Echocardiography, Doppler, Color, THROMBOSIS, medicine.anatomical_structure, Ventricle, Heart failure, Disease Progression, Cardiology, Female, Hypertrophy, Left Ventricular, Radiology, Cardiology and Cardiovascular Medicine, business, Follow-Up Studies, DOPPLER ECHOCARDIOGRAPHY
Abstract

Background: Little is known about the morphological and functional evolution of ventricular abnormalities in Loeffler endocarditis. Methods and Results: We describe 5 patients, including 3 with long-term echocardiographic follow-up, in whom apical obliteration due to fibro-thrombotic thickening of the endocardium showed favorable patterns of evolution. In one patient there was almost complete resolution of the obliterative process with consequently increased effective ventricular volume. In two patients formation of a flow-passage in the fibrocalcific apical ‘floor’ between the main medioventricular cavity and the apical chamber, leading to a ‘double-chambered’ left ventricle was observed. Conclusions: Medical therapy and appropriate anticoagulation, can induce favorable long-term ventricular remodeling in Loeffler endocarditis.

Published
2005
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2. Real-world candidacy to mavacamten in a contemporary hypertrophic obstructive cardiomyopathy population.

Author

Bertero E, Chiti C, Schiavo MA, Tini G, Costa P, Todiere G, Mabritto B, Dei LL, Giannattasio A, Mariani D, Lofiego C, Santolamazza C, Monda E, Quarta G, Barbisan D, Mandoli GE, Mapelli M, Sguazzotti M, Negri F, De Vecchi S, Ciabatti M, Tomasoni D, Mazzanti A, Marzo F, de Gregorio C, Raineri C, Vianello PF, Marchi A, Biagioni G, Insinna E, Parisi V, Ditaranto R, Barison A, Giammarresi A, De Ferrari GM, Priori S, Metra M, Pieroni M, Patti G, Imazio M, Perugini E, Agostoni P, Cameli M, Merlo M, Sinagra G, Senni M, Limongelli G, Ammirati E, Vagnarelli F, Crotti L, Badano L, Calore C, Gabrielli D, Re F, Musumeci G, Emdin M, Barbato E, Musumeci B, Autore C, Biagini E, Porto I, Olivotto I, and Canepa M

Subjects
Humans, Stroke Volume, Ventricular Function, Left, Benzylamines, Cardiomyopathy, Hypertrophic drug therapy, Heart Failure, Uracil analogs & derivatives
Abstract

Aims: In the EXPLORER-HCM trial, mavacamten reduced left ventricular outflow tract obstruction (LVOTO) and improved functional capacity of symptomatic hypertrophic obstructive cardiomyopathy (HOCM) patients. We sought to define the potential use of mavacamten by comparing real-world HOCM patients with those enrolled in EXPLORER-HCM and assessing their eligibility to treatment., Methods and Results: We collected information on HOCM patients followed up at 25 Italian HCM outpatient clinics and with significant LVOTO (i.e. gradient ≥30 mmHg at rest or ≥50 mmHg after Valsalva manoeuvre or exercise) despite pharmacological or non-pharmacological therapy. Pharmacological or non-pharmacological therapy resolved LVOTO in 1044 (61.2%) of the 1706 HOCM patients under active follow-up, whereas 662 patients (38.8%) had persistent LVOTO. Compared to the EXPLORER-HCM trial population, these real-world HOCM patients were older (62.1 ± 14.3 vs. 58.5 ± 12.2 years, p = 0.02), had a lower body mass index (26.8 ± 5.3 vs. 29.7 ± 4.9 kg/m 2 , p < 0.0001) and a more frequent history of atrial fibrillation (21.5% vs. 9.8%, p = 0.027). At echocardiography, they had lower left ventricular ejection fraction (LVEF, 66 ± 7% vs. 74 ± 6%, p < 0.0001), higher left ventricular outflow tract gradients at rest (60 ± 27 vs. 52 ± 29 mmHg, p = 0.003), and larger left atrial volume index (49 ± 16 vs. 40 ± 12 ml/m 2 , p < 0.0001). Overall, 324 (48.9%) would have been eligible for enrolment in the EXPLORER-HCM trial and 339 (51.2%) for treatment with mavacamten according to European guidelines., Conclusions: Real-world HOCM patients differ from the EXPLORER-HCM population for their older age, lower LVEF and larger atrial volume, potentially reflecting a more advanced stage of the disease. About half of real-world HOCM patients were found eligible to mavacamten., (© 2023 The Authors. European Journal of Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.)

Published
2024
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3. Ventricular remodeling in Loeffler endocarditis: implications for therapeutic decision making.

Author

Lofiego C, Ferlito M, Rocchi G, Biagini E, Perugini E, Branzi A, and Rapezzi C

Subjects
Adult, Decision Making, Disease Progression, Female, Follow-Up Studies, Humans, Hypereosinophilic Syndrome physiopathology, Hypertrophy, Left Ventricular physiopathology, Male, Middle Aged, Risk Assessment, Sampling Studies, Severity of Illness Index, Ventricular Function, Left physiology, Echocardiography, Doppler, Color methods, Hypereosinophilic Syndrome diagnostic imaging, Hypereosinophilic Syndrome therapy, Hypertrophy, Left Ventricular diagnostic imaging, Ventricular Remodeling physiology
Abstract

Background: Little is known about the morphological and functional evolution of ventricular abnormalities in Loeffler endocarditis., Methods and Results: We describe 5 patients, including 3 with long-term echocardiographic follow-up, in whom apical obliteration due to fibro-thrombotic thickening of the endocardium showed favorable patterns of evolution. In one patient there was almost complete resolution of the obliterative process with consequently increased effective ventricular volume. In two patients formation of a flow-passage in the fibrocalcific apical 'floor' between the main medioventricular cavity and the apical chamber, leading to a 'double-chambered' left ventricle was observed., Conclusions: Medical therapy and appropriate anticoagulation, can induce favorable long-term ventricular remodeling in Loeffler endocarditis.

Published
2005
Full Text
View/download PDF

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