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Your search keyword '"Liu, Zhenghui"' showing total 28 results
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28 results on '"Liu, Zhenghui"'

2. Manipulating Surface Band Bending of III‐Nitride Nanowires with Ambipolar Charge‐Transfer Characteristics: A Pathway Toward Advanced Photoswitching Logic Gates and Encrypted Optical Communication (Adv. Mater. 1/2024)

Author

Chen, Wei, primary, Wang, Danhao, additional, Wang, Weiyi, additional, Kang, Yang, additional, Liu, Xin, additional, Fang, Shi, additional, Li, Liuan, additional, Luo, Yuanmin, additional, Liang, Kun, additional, Liu, Yuying, additional, Luo, Dongyang, additional, Memon, Muhammad Hunain, additional, Yu, Huabin, additional, Gu, Wengang, additional, Liu, Zhenghui, additional, Hu, Wei, additional, and Sun, Haiding, additional

Published
2024
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3. Manipulating Surface Band Bending of III‐Nitride Nanowires with Ambipolar Charge‐Transfer Characteristics: A Pathway Toward Advanced Photoswitching Logic Gates and Encrypted Optical Communication

Author

Chen, Wei, primary, Wang, Danhao, additional, Wang, Weiyi, additional, Kang, Yang, additional, Liu, Xin, additional, Fang, Shi, additional, Li, Liuan, additional, Luo, Yuanmin, additional, Liang, Kun, additional, Liu, Yuying, additional, Luo, Dongyang, additional, Memon, Muhammad Hunain, additional, Yu, Huabin, additional, Gu, Wengang, additional, Liu, Zhenghui, additional, Hu, Wei, additional, and Sun, Haiding, additional

Published
2023
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6. Balancing the Photo‐Induced Carrier Transport Behavior at Two Semiconductor Interfaces for Dual‐Polarity Photodetection

Author

Fang, Shi, primary, Wang, Danhao, additional, Kang, Yang, additional, Liu, Xin, additional, Luo, Yuanmin, additional, Liang, Kun, additional, Li, Liuan, additional, Yu, Huabin, additional, Zhang, Haochen, additional, Memon, Muhammad Hunain, additional, Liu, Boyang, additional, Liu, Zhenghui, additional, and Sun, Haiding, additional

Published
2022
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23. Aqueous-Processable Noncovalent Chemically Converted Graphene-Quantum Dot Composites for Flexible and Transparent Optoelectronic Films

Author

Geng, Xiumei, primary, Niu, Liang, additional, Xing, Zhenyuan, additional, Song, Rensheng, additional, Liu, Guangtong, additional, Sun, Mengtao, additional, Cheng, Guosheng, additional, Zhong, Haijian, additional, Liu, Zhenghui, additional, Zhang, Zhijun, additional, Sun, Lianfeng, additional, Xu, Hongxing, additional, Lu, Li, additional, and Liu, Liwei, additional

Published
2010
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26. Mice lacking Axl and Mer tyrosine kinase receptors are susceptible to experimental autoimmune orchitis induction.

Author

Li N, Liu Z, Zhang Y, Chen Q, Liu P, Cheng CY, Lee WM, Chen Y, and Han D

Subjects
Animals, Autoantibodies immunology, Autoantigens immunology, Autoimmune Diseases genetics, Blood-Testis Barrier immunology, Disease Models, Animal, Humans, Immune Tolerance, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Orchitis genetics, Proto-Oncogene Proteins genetics, Receptor Protein-Tyrosine Kinases genetics, c-Mer Tyrosine Kinase, Axl Receptor Tyrosine Kinase, Autoimmune Diseases immunology, Macrophages immunology, Orchitis immunology, Proto-Oncogene Proteins metabolism, Receptor Protein-Tyrosine Kinases metabolism, T-Lymphocytes immunology, Testis immunology
Abstract

The mammalian testis is an immunoprivileged organ where male germ cell autoantigens are immunologically ignored. Both systemic immune tolerance to autoantigens and local immunosuppressive milieu contribute to the testicular immune privilege. Testicular immunosuppression has been intensively studied, but information on systemic immune tolerance to autoantigens is lacking. In the present study, we aimed to determine the role of Axl and Mer receptor tyrosine kinases in maintaining the systemic tolerance to male germ cell antigens using the experimental autoimmune orchitis (EAO) model. Axl and Mer double-knockout (Axl(-/-)Mer(-/-)) mice developed evident EAO after a single immunization with germ cell homogenates emulsified with complete Freund's adjuvant. EAO was characterized by the accumulation of macrophages and T lymphocytes in the testis. Damage to the seminiferous epithelium was also observed. EAO induction was associated with pro-inflammatory cytokine upregulation in the testes, impaired permeability of the blood-testis barrier and generation of autoantibodies against germ cell antigens in Axl(-/-)Mer(-/-) mice. Immunization also induced mild EAO in Axl or Mer single-gene-knockout mice. By contrast, a single immunization failed to induce EAO in wild-type mice. The results indicate that Axl and Mer receptors cooperatively regulate the systemic immune tolerance to male germ cell antigens.

Published
2015
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27. p204-Mediated innate antiviral responses in mouse adipose cells and their effects on cell functions.

Author

Yu L, Liu P, Liu Z, Zhu W, Yan K, Chen Q, and Han D

Subjects
Animals, Cell Differentiation immunology, Cell Proliferation, Cytosol metabolism, DNA metabolism, Female, Interferon Regulatory Factor-3 metabolism, Mice, Inbred C57BL, Signal Transduction, Adipocytes immunology, Adipocytes virology, Antiviral Agents immunology, Immunity, Innate immunology, Nuclear Proteins metabolism, Phosphoproteins metabolism, Simplexvirus immunology
Abstract

Viruses can infect adipose tissues. However, innate antiviral responses in adipose cells and their effects on adipocyte function have not yet been intensively investigated. In this study, p204-initiated innate antiviral responses in mouse adipose cells were examined. Cytosolic DNA sensor p204 and its signaling adaptor stimulator of interferon (IFN) genes (STING) were constitutively expressed in primary preadipocytes. Synthetic herpes simplex viral DNA (HSV60), a p204 ligand, induced type I IFN expression by activating IFN regulatory factor 3. Major antiviral proteins, including IFN-stimulating gene 15, 2',5'-oligoadenylate synthetase and Mx GTPase 1, in preadipocytes were upregulated by HSV60. HSV60-triggered innate antiviral responses were significantly reduced by inhibition of p204 signaling with specific small interfering RNA targeting p204 or STING. HSV60 inhibited the differentiation of preadipocytes to mature adipocytes and enhanced the proliferation of adipose cells. Moreover, HSV60 induced innate antiviral responses in mature adipocytes and inhibited expressions of several adipokines, including leptin, adiponectin and resistin. These results indicated that p204 initiated innate antiviral responses in adipose cells, thereby modulating adipocyte function.

Published
2015
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28. Pattern recognition receptor-initiated innate antiviral response in mouse adipose cells.

Author

Yu L, Yan K, Liu P, Li N, Liu Z, Zhu W, Chen Y, and Han D

Subjects
Adipocytes pathology, Adipocytes virology, Animals, Cell Differentiation genetics, Cell Differentiation immunology, DEAD Box Protein 58, DEAD-box RNA Helicases genetics, Interferon Inducers pharmacology, Interferon-Induced Helicase, IFIH1, Interleukin-6 genetics, Interleukin-6 immunology, Mice, Mice, Knockout, Poly I-C pharmacology, Toll-Like Receptor 3 genetics, Tumor Necrosis Factor-alpha genetics, Tumor Necrosis Factor-alpha immunology, Virus Diseases genetics, Virus Diseases pathology, Viruses genetics, Adipocytes immunology, DEAD-box RNA Helicases immunology, Immunity, Innate, Toll-Like Receptor 3 immunology, Virus Diseases immunology, Viruses immunology
Abstract

Although wide range of viruses can infect adipose tissues, innate antiviral response of adipose cells has not been investigated. This study focused on innate antiviral system in mouse adipose cells. Major virus sensors including Toll-like receptor 3 (TLR3), melanoma differentiation-associated antigen 5 (MDA5) and retinoic acid-inducible gene I (RIG-I) are constitutively expressed in preadipocytes and adipocytes. Poly(I:C), a common agonist of TLR3, MDA5 and RIG-I, induced the expression of type I interferons (IFN-α/β) in the two types of adipose cells through the activation of IFN-regulatory factor 3 and upregulated pro-inflammatory factors such as TNF-α and IL-6 through the activation nuclear factor kappa B. Moreover, poly(I:C) induced multiple antiviral proteins including IFN-stimulating gene 15, 2'5'-oligoadenylate synthetase and Mx GTPase 1 in preadipocytes and adipocytes. The poly(I:C)-induced innate antiviral response was reduced by TLR3 deficiency and knockdown of MDA5 or RIG-I. Poly(I:C) also inhibited the differentiation of preadipocytes to adipocytes and suppressed the expression of leptin, adiponectin and resistin in mature adipocytes. The results demonstrated that adipose cells are equipped with innate antiviral system, which may modulate the function of adipocytes.

Published
2014
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