Search

Your search keyword '"Liu, Shi-Jie"' showing total 11 results
Start Over Author "Liu, Shi-Jie" Publisher wiley
11 results on '"Liu, Shi-Jie"'

3. Effective tracking of bone mesenchymal stem cells in vivo by magnetic resonance imaging using melanin‐based gadolinium3+ nanoparticles

Author

Cai, Wen‐Wen, primary, Wang, Ling‐Jie, additional, Li, Si‐Jin, additional, Zhang, Xi‐Ping, additional, Li, Ting‐Ting‐, additional, Wang, Ying‐Hua, additional, Yang, Xi, additional, Xie, Jun, additional, Li, Jian‐Ding, additional, Liu, Shi‐Jie, additional, Xu, Wen, additional, He, Sheng, additional, Cheng, Zhen, additional, Fan, Qu‐Li, additional, and Zhang, Rui‐Ping, additional

Published
2016
Full Text
View/download PDF

11. Blood-spinal cord barrier permeability in experimental spinal cord injury: dynamic contrast-enhanced MRI.

Author

Cohen DM, Patel CB, Ahobila-Vajjula P, Sundberg LM, Chacko T, Liu SJ, and Narayana PA

Subjects
Albumins, Animals, Blood-Brain Barrier drug effects, Blood-Brain Barrier pathology, Extravasation of Diagnostic and Therapeutic Materials, Gadolinium administration & dosage, Gadolinium pharmacology, Male, Permeability drug effects, Rats, Rats, Sprague-Dawley, Reproducibility of Results, Sodium Chloride administration & dosage, Sodium Chloride pharmacology, Spinal Cord drug effects, Spinal Cord Injuries chemically induced, Spinal Cord Injuries diagnosis, Time Factors, Contrast Media, Magnetic Resonance Imaging, Spinal Cord pathology, Spinal Cord Injuries blood, Spinal Cord Injuries pathology
Abstract

After a primary traumatic injury, spinal cord tissue undergoes a series of pathobiological changes, including compromised blood-spinal cord barrier (BSCB) integrity. These vascular changes occur over both time and space. In an experimental model of spinal cord injury (SCI), longitudinal dynamic contrast-enhanced MRI (DCE-MRI) studies were performed up to 56 days after SCI to quantify spatial and temporal changes in the BSCB permeability in tissue that did not show any visible enhancement on the post-contrast MRI (non-enhancing tissue). DCE-MRI data were analyzed using a two-compartment pharmacokinetic model. These studies demonstrate gradual restoration of BSCB with post-SCI time. However, on the basis of DCE-MRI, and confirmed by immunohistochemistry, the BSCB remained compromised even at 56 days after SCI. In addition, open-field locomotion was evaluated using the 21-point Basso-Beattie-Bresnahan scale. A significant correlation between decreased BSCB permeability and improved locomotor recovery was observed.

Published
2009
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results