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Abstract Background In the new therapeutic era, comparisons between regimens containing lenalidomide and bortezomib are needed. Methods In this single‐center, prospective study, patients received four to six cycles of lenalidomide+liposomal doxorubicin+dexamethasone (RAD) or bortezomib+liposomal doxorubicin+dexamethasone (PAD) every 4 weeks, with subsequent autologous stem cell transplantation (ASCT) and maintenance therapy. We compared the efficacy, safety, patients’ quality of life, and doctors’ occupational stress between RAD and PAD induction in newly diagnosed MM patients. Results The complete response (CR) rate was comparable between the RAD and PAD groups after induction (30.8% vs. 32.0%, p = 0.92). Common adverse events, including infections, peripheral neuropathy, and gastrointestinal disturbances, were more frequent in the PAD group, while leukopenia and rashes were more common in the RAD group. Compared with PAD, RAD improved patients’ quality of life more quickly and caused less occupational stress for doctors. However, only 31.6% of patients collected adequate CD34+ cells (≥2 × 106/kg) in the RAD group, which was significantly lower than that in the PAD group (95.5%, p

This paper presents an accurate solution of finite-time Cartesian trajectory tracking control problem of a quadrotor system by designing and implementing a novel robust flight-control algorithm. The quadrotor is subject to nonlinearities, unmodeled dynamics, parameters’ uncertainties, and external time-varying disturbances. To reject the disturbances and enhance the control system’s robustness, a terminal sliding mode-based active antidisturbance control (TSMBAADC) approach is proposed for rotational and translational subsystems. To improve the tracking performance, a nonlinear continuous terminal sliding manifold and a fast reaching law are proposed in this work to quickly drive the systems’ states to the equilibrium point even in the presence of lumped disturbances. The convergence time of the states can be pretuned based on the parameters of the sliding manifold and the reaching law. Lyapunov theorem is used to provide a rigorous stability proof for the feedback control system. Numerical simulations and processor-in-the-loop (PIL) experiments are conducted to validate and implement the designed flight control algorithm on real autopilot hardware. The novelty of the proposed research lies in hardware implementation of a sophisticated version of modern control technique that exhibits a multitude of distinguishing features including but not limited to (i) finite-time tracking stability featuring fast convergence is ensured, (ii) chattering and singularity problems in sliding mode control (SMC) are avoided, and (iii) null steady-state error is achieved along with enhanced robustness. Finally, the proposed control law is compared with two recently reported research works. Results of performance comparison in term of the integral of square error (ISE) and the absolute value of the derivative of the input ut (IADU) dictate that the proposed technique overperforms by precision and chattering alleviation.

This paper proposes a unified system framework based on linear frequency modulation (LFM) and orthogonal frequency-division multiplexing (OFDM) as a solution for resource sharing, especially sharing space and hardware. The proposed OFDM-LFM framework can not only transmit data flow by OFDM but also make it possible to extract features from the signal by LFM. Further, the signal features are used to construct a pseudospectrum related to the target speed and distance, thereby estimating the speed and distance of the target. Unified means using signal features to estimate target speed and distance while ensuring data transmission including communication and remote control data information. Besides the traditional data transmission mode, the ability of estimating target speed and distance is an additional benefit. The proposed unified framework makes control of transmission easier and saves more hardware resources. The simulation results show that the proposed LFM-OFDM framework can not only transmit data information including communication and remote control data information, but also estimate the speed and distance of the target by its signal features.

We give several two-weight extrapolation theorems on Lorentz spaces which extend the results of Cruz-Uribe and Pérez (2000) and some applications for the singular integral operators, the potential type operators, and commutators.