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21 results on '"Li, Yuyuan"'

3. Effect of peroxisome proliferator-activated receptors-γ and co-activator-1α genetic polymorphisms on plasma adiponectin levels and susceptibility of non-alcoholic fatty liver disease in Chinese people

Author

Yang Hui, Nie Yuqiang, Lai Xiao-Bo, Sha Weihong, Li Yuyuan, Zhou Yongjian, and Du Yan-Lei

Subjects
Genetics, medicine.medical_specialty, Hepatology, Adiponectin, Fatty liver, nutritional and metabolic diseases, Single-nucleotide polymorphism, Biology, medicine.disease, Waist–hip ratio, Endocrinology, Polymorphism (computer science), Internal medicine, Genotype, medicine, Restriction fragment length polymorphism, Allele frequency
Abstract

Background/aims Peroxisome proliferator-activated receptors-gamma (PPAR-gamma) and its co-activator-1alpha (PGC-1alpha) are involved in the regulation of lipid and glucose metabolisms. This study aimed to investigate the genetic polymorphisms of PPAR-gamma and PGC-1alpha in Chinese people and their influence on plasma adiponectin levels and non-alcoholic fatty liver disease (NAFLD) susceptibility. Methods Ninety-six patients with NAFLD and 96 healthy controls were included. The single nucleotide polymorphisms (SNPs) of C161T PPAR-gammaand Gly482Ser PGC-1alpha genes were analysed by polymerase chain reaction and restriction fragment length polymorphism. Result The CC, CT and TT genotypic distributions of the NAFLD group were significantly different from those of controls (55.2, 39.6, 5.2 vs. 74.0, 25.0, 1.0%; P=0.015). The allelic frequencies of C and T were also different between the two groups (P=0.004). As for the PGC-1alpha gene, there was no difference of the genotypic and allelic frequencies between the two groups (P>0.05). In NAFLD patients, the plasma adiponectin concentrations were lower in the PPAR-gamma CT/TT genotypes compared with those in the CC genotype group (3.0+/-0.6 vs. 4.3+/-0.9, P=0.02). Multivariate logistic regression analysis showed that CT/TT genotypes of PPAR-gamma, TG, waist hip ratio, hypoadiponectinaemia and homoeostasis model assessment (HOMA)-IR were the risk factors for NAFLD. Conclusion SNPs in the PPAR-gamma, but not PGC-1alpha, gene are associated with NAFLD susceptibility possibly through the adiponectin pathway.

Published
2007

6. Psychological factors in functional dyspepsia and its treatment

Author

Li Yuyuan, Pan Xiaoping, Sha Weihong, and Yang Fuying

Subjects
medicine.medical_specialty, Fluoxetine, Psychometrics, business.industry, Gastroenterology, Hamilton Rating Scale for Depression, Symptom Checklist 90, Paroxetine, Internal medicine, medicine, Anxiety, Antidepressant, medicine.symptom, Psychiatry, business, Depression (differential diagnoses), medicine.drug
Abstract

OBJECTIVE: To investigate the role of psychological factors in functional dyspepsia (FD) and the effects of antidepressant drugs on FD. METHODS: The psychological status of 24 FD patients and 24 healthy people was analyzed using the Hamilton Rating Scale for Depression (HRSD), the Hamilton Anxiety Scale (HAS) and the Symptom Checklist 90 (SCL-90) scale. Antidepressants were used to treat FD patients for 8 weeks; 13 patients received Prozac, 11 patients received Seroxat. Psychometric analysis was carried out before and after treatment. RESULTS: There were significant differences in somatic and psychometric scores on the HAS and SCL-90 scales in the two groups (P < 0.001). The scores of the FD patients improved significantly after 8 weeks of treatment (P < 0.001). CONCLUSIONS: Psychological factors played a role in the etiology of FD. The patients commonly had depression or anxiety. Antidepressants were effective in the treatment of FD for improving both somatic and psychological symptoms.

Published
2000

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