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2. Clinical characteristics of familial schizophrenia

Author

Liu, Na, primary, Zhou, Hui, additional, Xiong, Xiangyu, additional, Li, Qingwei, additional, Jiang, Xuefeng, additional, Zhao, Jingping, additional, Yang, Xiaoxin, additional, Zhang, Mingyuan, additional, Wang, Xiangqun, additional, Wang, Gang, additional, Yang, Fude, additional, Hu, Jian, additional, Zhang, Xinjun, additional, Du, Lingyang, additional, Li, Huichun, additional, Feng, Bing, additional, Hu, Zhenyu, additional, Chen, Zuoming, additional, Wang, Chunxia, additional, Wang, Xilin, additional, Zhang, Jinbei, additional, Liu, Tiebang, additional, Jia, Fujun, additional, Sun, Xueli, additional, Xu, Xiufeng, additional, Meng, Huaqing, additional, Wang, Gaohua, additional, Zhang, Ning, additional, Mei, Qiyi, additional, Tan, Qingrong, additional, Peng, Chunqing, additional, Li, Jing, additional, and Lu, Zheng, additional

Published
2020
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5. Clinical characteristics of familial schizophrenia.

Author

Liu N, Zhou H, Xiong X, Li Q, Jiang X, Zhao J, Yang X, Zhang M, Wang X, Wang G, Yang F, Hu J, Zhang X, Du L, Li H, Feng B, Hu Z, Chen Z, Wang C, Wang X, Zhang J, Liu T, Jia F, Sun X, Xu X, Meng H, Wang G, Zhang N, Mei Q, Tan Q, Peng C, Li J, and Lu Z

Subjects
Hospitalization, Humans, Risk Factors, Psychotic Disorders epidemiology, Psychotic Disorders genetics, Schizophrenia epidemiology, Schizophrenia genetics
Abstract

Introduction: A family history of psychiatric disorders is one of the strongest risk factors for schizophrenia. The characteristics of patients with a family history of psychiatric disorders have not been systematically evaluated., Methods: This multicenter study (26 centers, 2425 cases) was performed in a Chinese population to examine the sociodemographic and clinical characteristics of schizophrenia patients with a family history of psychotic disorders in comparison with those of patients with sporadic schizophrenia., Results: Nineteen percent of patients had a family history of mental disease. Multiple logistic regression analysis revealed that ≥4 hospitalizations (OR = 1.78, P = .004), tobacco dependence (OR = 1.48, P = .006), alcohol dependence (OR = 1.74, P = .013), and physical illness (OR = 1.89, P = .001) were independently and significantly associated with a family history of mental disease., Conclusion: Patients with a family history of mental disorders present different demographics and clinical features than patients without a family history of psychiatric disorders., (© 2020 John Wiley & Sons Australia, Ltd.)

Published
2021
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