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Your search keyword '"Li, G. L."' showing total 13 results
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13 results on '"Li, G. L."'

9. Validation of Benzene Exposure Assessment

Author

DOSEMECI, M., primary, ROTHMAN, N., additional, YIN, S.-N., additional, LI, G.-L., additional, LINET, M., additional, WACHOLDER, S., additional, CHOW, W.-H., additional, and HAYES, R. B., additional

Published
1997
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11. Cohort study among workers exposed to benzene in China: I. General methods and resources

Author

Yin, S.-N., primary, Linet, M. S., additional, Hayes, R. B., additional, Li, G.-L., additional, Dosemeci, M., additional, Wang, Y.-Z., additional, Chow, W.-H., additional, Jiang, Z.-L., additional, Wacholder, S., additional, Zhang, W.-U., additional, Dai, T.-R., additional, Chao, X.-J., additional, Zhang, X.-C., additional, Ye, P.-Z., additional, Kou, Q.-R., additional, Meng, J.-F., additional, Zho, J.-S., additional, Lin, X.-F., additional, Ding, C.-Y., additional, Kneller, R., additional, and Blot, W. J., additional

Published
1994
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12. Cohort study among workers exposed to benzene in China: II. Exposure assessment

Author

Dosemeci, M., primary, Li, G.-L., additional, Hayes, R. B., additional, Yin, S.-N., additional, Linet, M., additional, Chow, W.-H., additional, Wang, Y.-Z., additional, Jiang, Z.-L., additional, Dai, T.-R., additional, Zhang, W.-U., additional, Chao, X.-J., additional, Ye, P.-Z., additional, Kou, Q.-R., additional, Fan, Y.-H., additional, Zhang, X.-C., additional, Lin, X.-F., additional, Meng, J.-F., additional, Zho, J.-S., additional, Wacholder, S., additional, Kneller, R., additional, and Blot, W. J., additional

Published
1994
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13. A systems pharmacology perspective on the clinical development of Fatty Acid amide hydrolase inhibitors for pain.

Author

Benson N, Metelkin E, Demin O, Li GL, Nichols D, and van der Graaf PH

Abstract

The level of the endocannabinoid anandamide is controlled by fatty acid amide hydrolase (FAAH). In 2011, PF-04457845, an irreversible inhibitor of FAAH, was progressed to phase II clinical trials for osteoarthritic pain. This article discusses a prospective, integrated systems pharmacology model evaluation of FAAH as a target for pain in humans, using physiologically based pharmacokinetic and systems biology approaches. The model integrated physiological compartments; endocannabinoid production, degradation, and disposition data; PF-04457845 pharmacokinetics and pharmacodynamics, and cannabinoid receptor CB1-binding kinetics. The modeling identified clear gaps in our understanding and highlighted key risks going forward, in particular relating to whether methods are in place to demonstrate target engagement and pharmacological effect. The value of this modeling exercise will be discussed in detail and in the context of the clinical phase II data, together with recommendations to enable optimal future evaluation of FAAH inhibitors.CPT: Pharmacometrics Systems Pharmacology (2014) 3, e91; doi:10.1038/psp.2013.72; published online 15 January 2014.

Published
2014
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