1. An Iron Oxide Nanocarrier for dsRNA to Target Lymph Nodes and Strongly Activate Cells of the Immune System
- Author
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Géraldine Pastor, Anja Bernecker, Boguslaw Szczupak, Jordi Llop, Juan C. Mareque-Rivas, Malou Henriksen-Lacey, Maite Jauregui-Osoro, Levente K. Meszaros, Ane Ruiz de Angulo, Vanessa Gómez Vallejo, Sandra Plaza-García, and Macarena Cobaleda-Siles
- Subjects
Materials science ,medicine.medical_treatment ,Ferric Compounds ,Cell Line ,Biomaterials ,Mice ,Immune system ,Spect imaging ,medicine ,Animals ,General Materials Science ,Antigen-presenting cell ,RNA, Double-Stranded ,Drug Carriers ,Mice, Inbred BALB C ,General Chemistry ,Immunotherapy ,Immune System ,Drug delivery ,Immunology ,TLR3 ,Cancer research ,Nanoparticles ,Lymph Nodes ,Molecular imaging ,Nanocarriers ,Biotechnology - Abstract
The success of nanoparticle-based therapies will depend in part on accurate delivery to target receptors and organs. There is, therefore, considerable potential in nanoparticles which achieve delivery of the right drug(s) using the right route of administration to the right location at the right time, monitoring the process by non-invasive molecular imaging. A challenge is harnessing immunotherapy via activation of Toll-like receptors (TLRs) for the development of vaccines against major infectious diseases and cancer. In immunotherapy, delivery of the vaccine components to lymph nodes (LNs) is essential for effective stimulation of the immune response. Although some promising advances have been made, delivering therapeutics to LNs remains challenging. It is here shown that iron-oxide nanoparticles can be engineered to combine in a single and small (
- Published
- 2014