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1. The European Insomnia Guideline: An update on the diagnosis and treatment of insomnia 2023

Author

Riemann, Dieter, primary, Espie, Colin A., additional, Altena, Ellemarije, additional, Arnardottir, Erna Sif, additional, Baglioni, Chiara, additional, Bassetti, Claudio L. A., additional, Bastien, Celyne, additional, Berzina, Natalija, additional, Bjorvatn, Bjørn, additional, Dikeos, Dimitris, additional, Dolenc Groselj, Leja, additional, Ellis, Jason G., additional, Garcia‐Borreguero, Diego, additional, Geoffroy, Pierre A., additional, Gjerstad, Michaela, additional, Gonçalves, Marta, additional, Hertenstein, Elisabeth, additional, Hoedlmoser, Kerstin, additional, Hion, Tuuliki, additional, Holzinger, Brigitte, additional, Janku, Karolina, additional, Jansson‐Fröjmark, Markus, additional, Järnefelt, Heli, additional, Jernelöv, Susanna, additional, Jennum, Poul Jørgen, additional, Khachatryan, Samson, additional, Krone, Lukas, additional, Kyle, Simon D., additional, Lancee, Jaap, additional, Leger, Damien, additional, Lupusor, Adrian, additional, Marques, Daniel Ruivo, additional, Nissen, Christoph, additional, Palagini, Laura, additional, Paunio, Tiina, additional, Perogamvros, Lampros, additional, Pevernagie, Dirk, additional, Schabus, Manuel, additional, Shochat, Tamar, additional, Szentkiralyi, Andras, additional, Van Someren, Eus, additional, van Straten, Annemieke, additional, Wichniak, Adam, additional, Verbraecken, Johan, additional, and Spiegelhalder, Kai, additional

Published
2023
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2. Sleep symptoms are essential features of long-COVID - Comparing healthy controls with COVID-19 cases of different severity in the international COVID sleep study (ICOSS-II)

Author

Merikanto, Ilona, Dauvilliers, Yves, Chung, Frances, Wing, Yun Kwok, De Gennaro, Luigi, Holzinger, Brigitte, Bjorvatn, Bjorn, Morin, Charles M., Penzel, Thomas, Benedict, Christian, Bjelajac, Adrijana Koscec, Chan, Ngan Yin, Espie, Colin A., Hrubos-Strom, Harald, Inoue, Yuichi, Korman, Maria, Landtblom, Anne-Marie, Leger, Damien, Matsui, Kentaro, Mota-Rolim, Sergio, Nadorff, Michael R., Plazzi, Giuseppe, Reis, Catia, Yordanova, Juliana, Partinen, Markku, Merikanto, Ilona, Dauvilliers, Yves, Chung, Frances, Wing, Yun Kwok, De Gennaro, Luigi, Holzinger, Brigitte, Bjorvatn, Bjorn, Morin, Charles M., Penzel, Thomas, Benedict, Christian, Bjelajac, Adrijana Koscec, Chan, Ngan Yin, Espie, Colin A., Hrubos-Strom, Harald, Inoue, Yuichi, Korman, Maria, Landtblom, Anne-Marie, Leger, Damien, Matsui, Kentaro, Mota-Rolim, Sergio, Nadorff, Michael R., Plazzi, Giuseppe, Reis, Catia, Yordanova, Juliana, and Partinen, Markku

Abstract

Many people report suffering from post-acute sequelae of COVID-19 or "long-COVID", but there are still open questions on what actually constitutes long-COVID and how prevalent it is. The current definition of post-acute sequelae of COVID-19 is based on voting using the Delphi-method by the WHO post-COVID-19 working group. It emphasizes long-lasting fatigue, shortness of breath and cognitive dysfunction as the core symptoms of post-acute sequelae of COVID-19. In this international survey study consisting of 13,628 subjects aged 18-99 years from 16 countries of Asia, Europe, North America and South America (May-Dec 2021), we show that post-acute sequelae of COVID-19 symptoms were more prevalent amongst the more severe COVID-19 cases, i.e. those requiring hospitalisation for COVID-19. We also found that long-lasting sleep symptoms are at the core of post-acute sequelae of COVID-19 and associate with the COVID-19 severity when COVID-19 cases are compared with COVID-negative cases. Specifically, fatigue (61.3%), insomnia symptoms (49.6%) and excessive daytime sleepiness (35.8%) were highly prevalent amongst respondents reporting long-lasting symptoms after hospitalisation for COVID-19. Understanding the importance of sleep-related symptoms in post-acute sequelae of COVID-19 has a clinical relevance when diagnosing and treating long-COVID.

Published
2023
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4. Efficacy of THN102 (a combination of modafinil and flecainide) on vigilance and cognition during 40‐hour total sleep deprivation in healthy subjects: Glial connexins as a therapeutic target

Author

Sauvet, Fabien, Erblang, Mégane, Gomez-Merino, Danielle, Rabat, Arnaud, Guillard, Mathias, Dubourdieu, Dominique, Lefloch, Hervé, Drogou, Catherine, van Beers, Pascal, Bougard, Clément, Bourrrilhon, Cyprien, Arnal, Pierrick, Rein, Werner, Mouthon, Franck, Brunner-Ferber, Francoise, Leger, Damien, Dauvilliers, Yves, Chennaoui, Mounir, Charvériat, Mathieu, Gomez‐merino, Danielle, Brunner‐ferber, Francoise, Nowak, Cécile, Sommeil-Vigilance-Fatigue et Santé Publique (VIFASOM (URP_7330)), Institut de Recherche Biomédicale des Armées (IRBA)-Université Paris Cité (UPCité), Institut de Recherche Biomédicale des Armées (IRBA), Hôpital d'instruction des Armées Percy, Service de Santé des Armées, Theranexus [Lyon], Hôpital Hôtel-Dieu [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Neuropsychiatrie : recherche épidémiologique et clinique (PSNREC), Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Institut de Recherche Biomédicale des Armées (IRBA)-Université de Paris (UP), and Université Montpellier 1 (UM1)-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Male, 030226 pharmacology & pharmacy, Connexins, Cognition, 0302 clinical medicine, Pharmacology (medical), 030212 general & internal medicine, media_common, Cross-Over Studies, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Wakefulness-Promoting Agents, Healthy Volunteers, flecainide, 3. Good health, Drug Combinations, Memory, Short-Term, Treatment Outcome, Anesthesia, modafinil, medicine.symptom, Arousal, Neuroglia, Somnolence, medicine.drug, Vigilance (psychology), Adult, safety, media_common.quotation_subject, psychomotor vigilance task, Placebo, working memory, Young Adult, 03 medical and health sciences, mental disorders, Tower of London test, Cardiac conduction, Reaction Time, medicine, Humans, Wakefulness, Pharmacology, business.industry, Modafinil, Psychomotor vigilance task, Original Articles, sleep deprivation, sustained attention, Sleep deprivation, executive function, business, Psychomotor Performance, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

Aims THN102 is a novel combination of modafinil and low‐dose flecainide, targeting glial connexin activity to modulate modafinil effects. We investigated THN102 efficacy compared to modafinil and to placebo on vigilance and cognitive function during 40‐hour total sleep deprivation (TSD). Methods Twenty healthy men participated in a double‐blind, randomized, incomplete‐block 3‐period cross‐over trial with 5 treatments (n = 12 per group): placebo (PBO), modafinil 100 mg (MOD100), THN102 100/1, 100/3, 100/9 (modafinil 100 mg and flecainide 1, 3 or 9 mg). Each period included a baseline day and a TSD day with treatments administered 3 times (01:00, 09:00 and 19:00). Reaction time in psychomotor vigilance test, subjective somnolence and vital signs were assessed before and during treatment. Working memory (2‐Back) and executive processes (Go/noGo for vigilance and inhibition, Wisconsin card sorting task for mental flexibility, and Tower of London test for planning) were evaluated at 16:30. Results At 5 hours postdose−1 (after 23 hours TSD, primary endpoint), THN102 100/1 resulted in statistically higher psychomotor vigilance test speed vs MOD100 (3.97 ± 0.09 vs 3.74 ± 0.14, P < .05). No increase in effect was observed with higher flecainide doses in combinations. Most THN102 doses vs MOD100 also improved the number of correct responses in 2‐Back and Go errors in Go/noGo (P < .05 for all doses), and perseverative responses in Wisconsin card sorting task (for 100/1 and 100/9). No impact on cardiac conduction was noted with THN102, and safety was similar to MOD100. Conclusions THN102 seems more efficient than modafinil on vigilance, working memory and executive functions, opening new perspectives in management of hypersomnolence disorders.

Published
2019

5. European guideline for the diagnosis and treatment of insomnia

Author

Riemann, Dieter, primary, Baglioni, Chiara, additional, Bassetti, Claudio, additional, Bjorvatn, Bjørn, additional, Dolenc Groselj, Leja, additional, Ellis, Jason G., additional, Espie, Colin A., additional, Garcia‐Borreguero, Diego, additional, Gjerstad, Michaela, additional, Gonçalves, Marta, additional, Hertenstein, Elisabeth, additional, Jansson‐Fröjmark, Markus, additional, Jennum, Poul J., additional, Leger, Damien, additional, Nissen, Christoph, additional, Parrino, Liborio, additional, Paunio, Tiina, additional, Pevernagie, Dirk, additional, Verbraecken, Johan, additional, Weeß, Hans‐Günter, additional, Wichniak, Adam, additional, Zavalko, Irina, additional, Arnardottir, Erna S., additional, Deleanu, Oana‐Claudia, additional, Strazisar, Barbara, additional, Zoetmulder, Marielle, additional, and Spiegelhalder, Kai, additional

Published
2017
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9. Diagnostic indicators of restless legs syndrome in primary care consultations: The DESYR study

Author

Crochard, Anne, primary, El Hasnaoui, Abdelkader, additional, Pouchain, Denis, additional, Huas, Dominique, additional, Arnulf, Isabelle, additional, Krieger, Jean, additional, Lainey, Eric, additional, Le Jeunne, Philippe, additional, Leger, Damien, additional, Schuck, Stéphane, additional, Texier, Nathalie, additional, Tison, François, additional, and Montplaisir, Jacques, additional

Published
2007
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10. The 3111 Clock gene polymorphism is not associated with sleep and circadian rhythmicity in phenotypically characterized human subjects

Author

Robilliard, Donna L., primary, Archer, Simon N., additional, Arendt, Josephine, additional, Lockley, Steven W., additional, Hack, Lisa M., additional, English, Judie, additional, Leger, Damien, additional, Smits, Marcel G., additional, Williams, Adrian, additional, Skene, Debra J., additional, and Von Schantz, Malcolm, additional

Published
2002
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12. Sleep disorders in children with blindness

Author

Leger, Damien, primary, Prevot, Elisabeth, additional, Philip, Pierre, additional, Yence, Charlotte, additional, Labaye, Nadine, additional, Paillard, Michel, additional, and Guilleminault, Christian, additional

Published
1999
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