1. Nocturnal dipping of heart rate and blood pressure in people with HIV in Tanzania
- Author
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Nolan, Cody, Reis, Karl, Fadhil, Salama, Etyang, Anthony, Ezeomah, Chiomah, Kingery, Justin R, Desderius, Bernard, Lee, Myung-Hee, Kapiga, Saidi, and Peck, Robert N
- Abstract
People with HIV (PWH) have a >2-fold greater risk for development of cardiovascular disease (CVD), which may be associated with abnormalities in 24-h ambulatory blood pressure measurement (ABPM) profile. We conducted a nested case-control study of ABPM in 137 PWH and HIV-uninfected controls with normal and high clinic blood pressure (BP) in Tanzania. Nocturnal non-dipping of heart rate (HR) was significantly more common among PWH than HIV-uninfected controls (p = .01). Nocturnal non-dipping of BP was significantly more common in PWH with normal clinic BP (p = .048). Clinical correlates of nocturnal non-dipping were similar in PWH and HIV-uninfected adults and included higher BMI, higher CD4+ cell count, and high C-reactive protein for HR and markers of renal disease for BP. In conclusion, nocturnal non-dipping of both BP and HR was more common in PWH but further research is needed to determine causes and consequences of this difference.
- Published
- 2021