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Your search keyword '"Lee, Hyunbeom"' showing total 6 results
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2. Cover Image

Author

Oh, Hyun‐A, primary, Lee, Hyunbeom, additional, Kang, Keon Wook, additional, Im, Ji Hye, additional, Kim, Donghak, additional, Yang, Hyun Ok, additional, and Jung, Byung Hwa, additional

Published
2019
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6. Ornithine aminotransferase versus GABA aminotransferase: implications for the design of new anticancer drugs.

Author

Lee H, Juncosa JI, and Silverman RB

Subjects
4-Aminobutyrate Transaminase antagonists & inhibitors, 4-Aminobutyrate Transaminase chemistry, Amino Acid Sequence, Animals, Catalytic Domain, Humans, Ornithine-Oxo-Acid Transaminase antagonists & inhibitors, Ornithine-Oxo-Acid Transaminase chemistry, Substrate Specificity drug effects, 4-Aminobutyrate Transaminase metabolism, Antineoplastic Agents pharmacology, Drug Design, Ornithine-Oxo-Acid Transaminase metabolism
Abstract

Ornithine aminotransferase (OAT) and γ-aminobutyric acid aminotransferase (GABA-AT) are classified under the same evolutionary subgroup and share a large portion of structural, functional, and mechanistic features. Therefore, it is not surprising that many molecules that bind to GABA-AT also bind well to OAT. Unlike GABA-AT, OAT had not been viewed as a potential therapeutic target until recently; consequently, the number of therapeutically viable molecules that target OAT is very limited. In this review the two enzymes are compared with respect to their active-site structures, catalytic and inactivation mechanisms, and selective inhibitors. Insight is offered that could aid in the design and development of new selective inhibitors of OAT for the treatment of cancer., (© 2014 Wiley Periodicals, Inc.)

Published
2015
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