1,735 results on '"Lawrence, R."'
Search Results
2. Infection prevention and control across the continuum of COVID‐19 care: A qualitative study of patients', caregivers' and providers' experiences
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Marina B. Wasilewski, Zara Szigeti, Christine L. Sheppard, Jacqueline Minezes, Sander L. Hitzig, Amanda L. Mayo, Lawrence R. Robinson, Maria Lung, and Robert Simpson
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continuum of care ,COVID care quality ,human connection ,infection prevention and control ,patient safety ,rehabilitation ,Medicine (General) ,R5-920 ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Introduction Healthcare facilities adopted restrictive visitor policies as a result of the COVID‐19 (COVID) pandemic. Though these measures were necessary to promote the safety of patients, families and healthcare providers, it led to isolation and loneliness amongst acute care inpatients that can undermine patient rehabilitation and recovery. The study objectives were to (1) explore how infection prevention and control (IP&C) measures impacted stakeholders' perceptions of care quality and interactions with others and (2) investigate how these experiences and perceptions varied across stakeholder groups and care settings. Methods A qualitative descriptive study was conducted. Patients and their families from an inpatient COVID rehabilitation hospital and healthcare providers from an acute or rehabilitation COVID hospital were interviewed between August 2020 and February 2021. Results A total of 10 patients, 5 family members and 12 healthcare providers were interviewed. Four major themes were identified: (1) IP&C measures challenged the psychosocial health of all stakeholders across care settings; (2): IP&C measures precipitated a need for greater relational care from HCPs; (3) infection prevention tenets perpetuated COVID‐related stigma that stakeholders experienced across care settings; and (4) technology was used to facilitate human connection when IP&C limited physical presence. Conclusion IP&C measures challenged psychosocial health and maintenance of vital human connections. Loneliness and isolation were felt by all stakeholders due to physical distancing and COVID‐related stigma. Some isolation was mitigated by the relational care provided by HCPs and technological innovations used. The findings of the study underscore the need to balance safety with psychosocial well‐being across care settings and beyond the patient–provider dyad. Patient and Public Contribution This study was informed by the Patient‐Oriented Research Agenda and developed through consultations with patients and family caregivers to identify priority areas for rehabilitation research. Priority areas identified that informed the current study were (1) the need to focus on the psychosocial aspects of recovery from illness and injury and (2) the importance of exploring patients' recovery experiences and needs across the continuum of care. The study protocol, ethics submission, analysis and manuscript preparation were all informed by healthcare providers with lived experience of working in COVID care settings.
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- 2022
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3. Understanding the role of the lower motor neuron in spinal cord injury and its impact on electrodiagnostic assessment
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Robinson, Lawrence R., primary and Dengler, Jana, additional
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- 2024
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4. Optimal power allocation in nonlinear MDM‐WDM systems using Gaussian noise model
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Mohammad Ali Amirabadi, Mohammad Hossein Kahaei, S. Alireza Nezamalhosseini, and Lawrence R. Chen
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closed‐form Gaussian noise model ,few‐mode fibre ,power allocation ,wavelength division multiplexing ,Applied optics. Photonics ,TA1501-1820 - Abstract
Abstract Mode‐division multiplexing (MDM) using few‐mode fibre (FMF) has received increasing attention to address the exponential growth of data traffic in long‐haul optical communication systems. Also, combining the MDM with wavelength‐division multiplexing (WDM) is a promising approach for dramatically growing the transmission capacity in such systems. However, a major barrier in this regard is the FMF nonlinear effects, which can significantly reduce the link performance. In this paper, in order to alleviate the FMF nonlinear effects, we focus on power allocation in FMF links by optimizing the input power of each optical WDM channel of each spatial mode, which leads to maximizing the total capacity transmission and also the minimum signal to noise ratio (SNR) margin. The FMF nonlinearity has been already modelled as the Gaussian noise (GN) for which no closed‐form formulation has been developed so far. Here, we derive a closed‐form GN model for this problem and verify it by comparing with the integral‐form GN model and split‐step Fourier method. In this approach, an optimal power is independently determined for each channel of each mode by optimizing a capacity maximization and a minimum SNR margin maximization problem in convex forms. The performance of different links including the single mode fibre‐WDM, MDM‐single channel, and MDM‐WDM are compared using computer simulations. These systems are comprehensively investigated in equal/non‐equal required SNR as well as flat/non‐flat amplifier gain scenarios. It is shown that optimized power allocation to each channel of each mode has a significant enhancement in the minimum SNR margin maximization scheme compared to the best equal power allocation. Furthermore, this improvement is much more in non‐equal required SNR and the non‐flat amplifier gain scenarios, showing the efficiency of the established approach in practical communication links.
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- 2022
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5. Postoperative Complication and Reoperation Rates Following Resection of Soft Tissue vs. Bone Malignancies Based on Anatomic Location in the Inpatient Setting
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Alexander M. Ballatori, Shane Shahrestani, Andy Ton, Xiao T. Chen, Tarek Yamout, Brandon S. Gettleman, Nathanael D. Heckmann, Lawrence R. Menendez, and Alexander B. Christ
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Introduction. Surgical excisions of upper and lower extremity malignancies are increasing annually, due in part to the rising incidence of sarcomas. The purpose of this study is to compare readmissions, reoperation rate, and complications following surgical excision of soft/connective tissue vs bone malignancies of the upper and lower extremities. Methods. The Nationwide Readmissions Database (NRD) was queried from 2016-2017 to conduct a retrospective analysis of 16,435 patients diagnosed with malignant neoplasms of the long bone (ULLB, n = 1,433) and soft tissue (ULST, n = 2,049) of the upper limb and malignant neoplasms of the long bone (LLLB, n = 5,422) and soft tissue (LLST, n = 7,531) of the lower limb. Patients who underwent surgical excision of their neoplasms were included. Binomial multivariate logistic regression was used to compare complications, nonelective readmission rates, and reoperation rates between the two groups at 30 and 90 days. Results. Average age of the ULST group was 61.88, with 36% female. Average age of the ULLB group was 44.97, with 41.90% female. Average age of the LLST group was 60.96, with 46.90% female. Average age of the LLLB group was 43.09, with 42.60% female. The ULST group had lower odds of readmission within 30 days p=0.263, which became significant within 90 days of surgery p=0.045. The LLST group had significantly higher odds of infection, reoperation within 30 to 90 days of the index surgery compared to the LLLB group p
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- 2023
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6. Nonstandard Errors
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MENKVELD, ALBERT J., primary, DREBER, ANNA, additional, HOLZMEISTER, FELIX, additional, HUBER, JUERGEN, additional, JOHANNESSON, MAGNUS, additional, KIRCHLER, MICHAEL, additional, NEUSÜß, SEBASTIAN, additional, RAZEN, MICHAEL, additional, WEITZEL, UTZ, additional, ABAD‐DÍAZ, DAVID, additional, ABUDY, MENACHEM (MENI), additional, ADRIAN, TOBIAS, additional, AIT‐SAHALIA, YACINE, additional, AKMANSOY, OLIVIER, additional, ALCOCK, JAMIE T., additional, ALEXEEV, VITALI, additional, ALOOSH, ARASH, additional, AMATO, LIVIA, additional, AMAYA, DIEGO, additional, ANGEL, JAMES J., additional, AVETIKIAN, ALEJANDRO T., additional, BACH, AMADEUS, additional, BAIDOO, EDWIN, additional, BAKALLI, GAETAN, additional, BAO, LI, additional, BARBON, ANDREA, additional, BASHCHENKO, OKSANA, additional, BINDRA, PARAMPREET C., additional, BJØNNES, GEIR H., additional, BLACK, JEFFREY R., additional, BLACK, BERNARD S., additional, BOGOEV, DIMITAR, additional, CORREA, SANTIAGO BOHORQUEZ, additional, BONDARENKO, OLEG, additional, BOS, CHARLES S., additional, BOSCH‐ROSA, CIRIL, additional, BOURI, ELIE, additional, BROWNLEES, CHRISTIAN, additional, CALAMIA, ANNA, additional, CAO, VIET NGA, additional, CAPELLE‐BLANCARD, GUNTHER, additional, ROMERO, LAURA M. CAPERA, additional, CAPORIN, MASSIMILIANO, additional, CARRION, ALLEN, additional, CASKURLU, TOLGA, additional, CHAKRABARTY, BIDISHA, additional, CHEN, JIAN, additional, CHERNOV, MIKHAIL, additional, CHEUNG, WILLIAM, additional, CHINCARINI, LUDWIG B., additional, CHORDIA, TARUN, additional, CHOW, SHEUNG‐CHI, additional, CLAPHAM, BENJAMIN, additional, COLLIARD, JEAN‐EDOUARD, additional, COMERTON‐FORDE, CAROLE, additional, CURRAN, EDWARD, additional, DAO, THONG, additional, DARE, WALE, additional, DAVIES, RYAN J., additional, BLASIS, RICCARDO DE, additional, NARD, GIANLUCA F. DE, additional, DECLERCK, FANY, additional, DEEV, OLEG, additional, DEGRYSE, HANS, additional, DEKU, SOLOMON Y., additional, DESAGRE, CHRISTOPHE, additional, DIJK, MATHIJS A. VAN, additional, DIM, CHUKWUMA, additional, DIMPFL, THOMAS, additional, DONG, YUN JIANG, additional, DRUMMOND, PHILIP A., additional, DUDDA, TOM, additional, DUEVSKI, TEODOR, additional, DUMITRESCU, ARIADNA, additional, DYAKOV, TEODOR, additional, DYHRBERG, ANNE HAUBO, additional, DZIELIŃSKI, MICHAŁ, additional, EKSI, ASLI, additional, KALAK, IZIDIN EL, additional, ELLEN, SASKIA TER, additional, EUGSTER, NICOLAS, additional, EVANS, MARTIN D. D., additional, FARRELL, MICHAEL, additional, FELEZ‐VINAS, ESTER, additional, FERRARA, GERARDO, additional, FERROUHI, EL MEHDI, additional, FLORI, ANDREA, additional, FLUHARTY‐JAIDEE, JONATHAN T., additional, FOLEY, SEAN D. V., additional, FONG, KINGSLEY Y. L., additional, FOUCAULT, THIERRY, additional, FRANUS, TATIANA, additional, FRANZONI, FRANCESCO, additional, FRIJNS, BART, additional, FRÖMMEL, MICHAEL, additional, FU, SERVANNA M., additional, FÜLLBRUNN, SASCHA C., additional, GAN, BAOQING, additional, GAO, GE, additional, GEHRIG, THOMAS P., additional, GEMAYEL, ROLAND, additional, GERRITSEN, DIRK, additional, GIL‐BAZO, JAVIER, additional, GILDER, DUDLEY, additional, GLOSTEN, LAWRENCE R., additional, GOMEZ, THOMAS, additional, GORBENKO, ARSENY, additional, GRAMMIG, JOACHIM, additional, GRÉGOIRE, VINCENT, additional, GÜÇBILMEZ, UFUK, additional, HAGSTRÖMER, BJÖRN, additional, HAMBUCKERS, JULIEN, additional, HAPNES, ERIK, additional, HARRIS, JEFFREY H., additional, HARRIS, LAWRENCE, additional, HARTMANN, SIMON, additional, HASSE, JEAN‐BAPTISTE, additional, HAUTSCH, NIKOLAUS, additional, HE, XUE‐ZHONG (TONY), additional, HEATH, DAVIDSON, additional, HEDIGER, SIMON, additional, HENDERSHOTT, TERRENCE, additional, HIBBERT, ANN MARIE, additional, HJALMARSSON, ERIK, additional, HOELSCHER, SETH A., additional, HOFFMANN, PETER, additional, HOLDEN, CRAIG W., additional, HORENSTEIN, ALEX R., additional, HUANG, WENQIAN, additional, HUANG, DA, additional, HURLIN, CHRISTOPHE, additional, ILCZUK, KONRAD, additional, IVASHCHENKO, ALEXEY, additional, IYER, SUBRAMANIAN R., additional, JAHANSHAHLOO, HOSSEIN, additional, JALKH, NAJI, additional, JONES, CHARLES M., additional, JURKATIS, SIMON, additional, JYLHÄ, PETRI, additional, KAECK, ANDREAS T., additional, KAISER, GABRIEL, additional, KARAM, ARZÉ, additional, KARMAZIENE, EGLE, additional, KASSNER, BERNHARD, additional, KAUSTIA, MARKKU, additional, KAZAK, EKATERINA, additional, KEARNEY, FEARGHAL, additional, KERVEL, VINCENT VAN, additional, KHAN, SAAD A., additional, KHOMYN, MARTA K., additional, KLEIN, TONY, additional, KLEIN, OLGA, additional, KLOS, ALEXANDER, additional, KOETTER, MICHAEL, additional, KOLOKOLOV, ALEKSEY, additional, KORAJCZYK, ROBERT A., additional, KOZHAN, ROMAN, additional, KRAHNEN, JAN P., additional, KUHLE, PAUL, additional, KWAN, AMY, additional, LAJAUNIE, QUENTIN, additional, LAM, F. Y. ERIC C., additional, LAMBERT, MARIE, additional, LANGLOIS, HUGUES, additional, LAUSEN, JENS, additional, LAUTER, TOBIAS, additional, LEIPPOLD, MARKUS, additional, LEVIN, VLADIMIR, additional, LI, YIJIE, additional, LI, HUI, additional, LIEW, CHEE YOONG, additional, LINDNER, THOMAS, additional, LINTON, OLIVER, additional, LIU, JIACHENG, additional, LIU, ANQI, additional, LLORENTE, GUILLERMO, additional, LOF, MATTHIJS, additional, LOHR, ARIEL, additional, LONGSTAFF, FRANCIS, additional, LOPEZ‐LIRA, ALEJANDRO, additional, MANKAD, SHAWN, additional, MANO, NICOLA, additional, MARCHAL, ALEXIS, additional, MARTINEAU, CHARLES, additional, MAZZOLA, FRANCESCO, additional, MELOSO, DEBRAH, additional, MI, MICHAEL G., additional, MIHET, ROXANA, additional, MOHAN, VIJAY, additional, MOINAS, SOPHIE, additional, MOORE, DAVID, additional, MU, LIANGYI, additional, MURAVYEV, DMITRIY, additional, MURPHY, DERMOT, additional, NESZVEDA, GABOR, additional, NEUMEIER, CHRISTIAN, additional, NIELSSON, ULF, additional, NIMALENDRAN, MAHENDRARAJAH, additional, NOLTE, SVEN, additional, NORDEN, LARS L., additional, O'NEILL, PETER, additional, OBAID, KHALED, additional, ØDEGAARD, BERNT A., additional, ÖSTBERG, PER, additional, PAGNOTTA, EMILIANO, additional, PAINTER, MARCUS, additional, PALAN, STEFAN, additional, PALIT, IMON J., additional, PARK, ANDREAS, additional, PASCUAL, ROBERTO, additional, PASQUARIELLO, PAOLO, additional, PASTOR, LUBOS, additional, PATEL, VINAY, additional, PATTON, ANDREW J., additional, PEARSON, NEIL D., additional, PELIZZON, LORIANA, additional, PELLI, MICHELE, additional, PELSTER, MATTHIAS, additional, PÉRIGNON, CHRISTOPHE, additional, PFIFFER, CAMERON, additional, PHILIP, RICHARD, additional, PLÍHAL, TOMÁŠ, additional, PRAKASH, PUNEET, additional, PRESS, OLIVER‐ALEXANDER, additional, PRODROMOU, TINA, additional, PROKOPCZUK, MARCEL, additional, PUTNINS, TALIS, additional, QIAN, YA, additional, RAIZADA, GAURAV, additional, RAKOWSKI, DAVID, additional, RANALDO, ANGELO, additional, REGIS, LUCA, additional, REITZ, STEFAN, additional, RENAULT, THOMAS, additional, RENJIE, REX W., additional, RENO, ROBERTO, additional, RIDDIOUGH, STEVEN J., additional, RINNE, KALLE, additional, RINTAMÄKI, PAUL, additional, RIORDAN, RYAN, additional, RITTMANNSBERGER, THOMAS, additional, LONGARELA, IÑAKI RODRÍGUEZ, additional, ROESCH, DOMINIK, additional, ROGNONE, LAVINIA, additional, ROSEMAN, BRIAN, additional, ROŞU, IOANID, additional, ROY, SAURABH, additional, RUDOLF, NICOLAS, additional, RUSH, STEPHEN R., additional, RZAYEV, KHALADDIN, additional, RZEŹNIK, ALEKSANDRA A., additional, SANFORD, ANTHONY, additional, SANKARAN, HARIKUMAR, additional, SARKAR, ASANI, additional, SARNO, LUCIO, additional, SCAILLET, OLIVIER, additional, SCHARNOWSKI, STEFAN, additional, SCHENK‐HOPPÉ, KLAUS R., additional, SCHERTLER, ANDREA, additional, SCHNEIDER, MICHAEL, additional, SCHROEDER, FLORIAN, additional, SCHÜRHOFF, NORMAN, additional, SCHUSTER, PHILIPP, additional, SCHWARZ, MARCO A., additional, SEASHOLES, MARK S., additional, SEEGER, NORMAN J., additional, SHACHAR, OR, additional, SHKILKO, ANDRIY, additional, SHUI, JESSICA, additional, SIKIC, MARIO, additional, SIMION, GIORGIA, additional, SMALES, LEE A., additional, SÖDERLIND, PAUL, additional, SOJLI, ELVIRA, additional, SOKOLOV, KONSTANTIN, additional, SÖNKSEN, JANTJE, additional, SPOKEVICIUTE, LAIMA, additional, STEFANOVA, DENITSA, additional, SUBRAHMANYAM, MARTI G., additional, SZASZI, BARNABAS, additional, TALAVERA, OLEKSANDR, additional, TANG, YUEHUA, additional, TAYLOR, NICK, additional, THAM, WING WAH, additional, THEISSEN, ERIK, additional, THIMME, JULIAN, additional, TONKS, IAN, additional, TRAN, HAI, additional, TRAPIN, LUCA, additional, TROLLE, ANDERS B., additional, VADUVA, M. ANDREEA, additional, VALENTE, GIORGIO, additional, NESS, ROBERT A. VAN, additional, VASQUEZ, AURELIO, additional, VEROUSIS, THANOS, additional, VERWIJMEREN, PATRICK, additional, VILHELMSSON, ANDERS, additional, VILKOV, GRIGORY, additional, VLADIMIROV, VLADIMIR, additional, VOGEL, SEBASTIAN, additional, VOIGT, STEFAN, additional, WAGNER, WOLF, additional, WALTHER, THOMAS, additional, WEISS, PATRICK, additional, WEL, MICHEL VAN DER, additional, WERNER, INGRID M., additional, WESTERHOLM, P. JOAKIM, additional, WESTHEIDE, CHRISTIAN, additional, WIKA, HANS C., additional, WIPPLINGER, EVERT, additional, WOLF, MICHAEL, additional, WOLFF, CHRISTIAN C. P., additional, WOLK, LEONARD, additional, WONG, WING‐KEUNG, additional, WRAMPELMEYER, JAN, additional, WU, ZHEN‐XING, additional, XIA, SHUO, additional, XIU, DACHENG, additional, XU, KE, additional, XU, CAIHONG, additional, YADAV, PRADEEP K., additional, YAGÜE, JOSÉ, additional, YAN, CHENG, additional, YANG, ANTTI, additional, YOO, WOONGSUN, additional, YU, WENJIA, additional, YU, YIHE, additional, YU, SHIHAO, additional, YUESHEN, BART Z., additional, YUFEROVA, DARYA, additional, ZAMOJSKI, MARCIN, additional, ZAREEI, ABALFAZL, additional, ZEISBERGER, STEFAN M., additional, ZHANG, LU, additional, ZHANG, S. SARAH, additional, ZHANG, XIAOYU, additional, ZHAO, LU, additional, ZHONG, ZHUO, additional, ZHOU, Z. IVY, additional, ZHOU, CHEN, additional, ZHU, XINGYU S., additional, ZOICAN, MARIUS, additional, and ZWINKELS, REMCO, additional
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- 2024
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7. Electrodiagnostic reporting preferences of referring physicians: An exploratory survey
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Mun, Kyung Joon, primary, Farag, Jordan, additional, and Robinson, Lawrence R., additional
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- 2024
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8. Systematic and other reviews: Criteria and complexities
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Robert T. Sataloff, Matthew L. Bush, Rakesh Chandra, Douglas Chepeha, Brian Rotenberg, Edward W. Fisher, David Goldenberg, Ehab Y. Hanna, Joseph E. Kerschner, Dennis H. Kraus, John H. Krouse, Daqing Li, Michael Link, Lawrence R. Lustig, Samuel H. Selesnick, Raj Sindwani, Richard J. Smith, James R. Tysome, Peter C. Weber, and D. Bradley Welling
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Otorhinolaryngology ,RF1-547 ,Surgery ,RD1-811 - Published
- 2021
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9. Non-Standard Errors
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Leerstoel Stigchel, Helmholtz Institute, Experimental Psychology (onderzoeksprogramma PF), Finance, UU LEG Research UUSE Multidisciplinary Economics, Sub General Pharmaceutics, Menkveld, Albert J., Abudy, Menachem (Meni), Grammig, Joachim, Gregoire, Vincent, Hagströmer, Björn, Hambuckers, Julien, Hapnes, Erik, Harris, Jeffrey H., Harris, Lawrence, Hartmann, Simon, Hasse, Jean-Baptiste, Hautsch, Nikolaus, Adrian, Tobias, He, Xue-Zhong 'Tony', Heath, Davidson, Hediger, Simon, Hendershott, Terrence J., Hibbert, Ann Marie, Hjalmarsson, Erik, Hoelscher, Seth, Hoffmann, Peter, Holden, Craig W., Horenstein, Alex R., Ait-Sahalia, Yacine, Huang, Wenqian, Huang, Da, Hurlin, Christophe, Ivashchenko, Alexey, Iyer, Subramanian R., Jahanshahloo, Hossein, Jalkh, Naji, Jones, Charles M., Jurkatis, Simon, Jylha, Petri, Akmansoy, Olivier, Kaeck, Andreas, Kaiser, Gabriel, Karam, Arzé, Karmaziene, Egle, Kassner, Bernhard, Kaustia, Markku, Kazak, Ekaterina, Kearney, Fearghal, van Kervel, Vincent, Khan, Saad, Alcock, Jamie, Khomyn, Marta, Klein, Tony, Klein, Olga, Klos, Alexander, Koetter, Michael, Krahnen, Jan Pieter, Kolokolov, Aleksey, Korajczyk, Robert A., Kozhan, Roman, Kwan, Amy, Alexeev, Vitali, Lajaunie, Quentin, Lam, Full Yet Eric Campbell, Lambert, Marie, Langlois, Hugues, Lausen, Jens, Lauter, Tobias, Leippold, Markus, Levin, Vladimir, Li, Yijie, Li, (Michael) Hui, Aloosh, Arash, Liew, Chee Yoong, Lindner, Thomas, Linton, Oliver B., Liu, Jiacheng, Liu, Anqi, Llorente-Alvarez, Jesus-Guillermo, Lof, Matthijs, Lohr, Ariel, Longstaff, Francis A., Lopez-Lira, Alejandro, Amato, Livia, Mankad, Shawn, Mano, Nicola, Marchal, Alexis, Martineau, Charles, Mazzola, Francesco, Meloso, Debrah C, Mihet, Roxana, Mohan, Vijay, Moinas, Sophie, Moore, David, Amaya, Diego, Mu, Liangyi, Muravyev, Dmitriy, Murphy, Dermot, Neszveda, Gabor, Neumeier, Christian, Nielsson, Ulf, Nimalendran, Mahendrarajah, Nolte, Sven, Nordén, Lars L., O'Neill, Peter, Angel, James J., Obaid, Khaled, Ødegaard, Bernt Arne, Östberg, Per, Painter, Marcus, Palan, Stefan, Palit, Imon, Park, Andreas, Pascual Gascó, Roberto, Pasquariello, Paolo, Pastor, Lubos, Dreber, Anna, Bach, Amadeus, Patel, Vinay, Patton, Andrew J., Pearson, Neil D., Pelizzon, Loriana, Pelster, Matthias, Pérignon, Christophe, Pfiffer, Cameron, Philip, Richard, Plíhal, Tomáš, Prakash, Puneet, Baidoo, Edwin, Press, Oliver-Alexander, Prodromou, Tina, Putnins, Talis J., Raizada, Gaurav, Rakowski, David A., Ranaldo, Angelo, Regis, Luca, Reitz, Stefan, Renault, Thomas, Wang, Renjie, Bakalli, Gaetan, Renò, Roberto, Riddiough, Steven, Rinne, Kalle, Rintamäki, Paul, Riordan, Ryan, Rittmannsberger, Thomas, Rodríguez Longarela, Iñaki, Rösch, Dominik, Rognone, Lavinia, Roseman, Brian, Barbon, Andrea, Rosu, Ioanid, Roy, Saurabh, Rudolf, Nicolas, Rush, Stephen, Rzayev, Khaladdin, Rzeźnik, Aleksandra, Sanford, Anthony, Sankaran, Harikumar, Sarkar, Asani, Sarno, Lucio, Bashchenko, Oksana, Scaillet, Olivier, Scharnowski, Stefan, Schenk-Hoppé, Klaus Reiner, Schertler, Andrea, Schneider, Michael, Schroeder, Florian, Schürhoff, Norman, Schuster, Philipp, Schwarz, Marco A., Seasholes, Mark S., Bindra, Parampreet Christopher, Seeger, Norman, Shachar, Or, Shkilko, Andriy, Shui, Jessica, Sikic, Mario, Simion, Giorgia, Smales, Lee A., Söderlind, Paul, Sojli, Elvira, Sokolov, Konstantin, Bjonnes, Geir Hoidal, Spokeviciute, Laima, Stefanova, Denitsa, Subrahmanyam, Marti G., Neusüss, Sebastian, Szaszi, Barnabas, Talavera, Oleksandr, Tang, Yuehua, Taylor, Nicholas, Tham, Wing Wah, Theissen, Erik, Black, Jeffrey R., Thimme, Julian, Tonks, Ian, Tran, Hai, Trapin, Luca, Trolle, Anders B., Valente, Giorgio, Van Ness, Robert A., Vasquez, Aurelio, Verousis, Thanos, Verwijmeren, Patrick, Black, Bernard S., Vilhelmsson, Anders, Vilkov, Grigory, Vladimirov, Vladimir, Vogel, Sebastian, Voigt, Stefan, Wagner, Wolf, Walther, Thomas, Weiss, Patrick, van der Wel, Michel, Werner, Ingrid M., Bohorquez, Santiago, Westerholm, P. Joakim, Westheide, Christian, Wipplinger, Evert, Wolf, Michael, Wolff, Christian C. P., Wolk, Leonard, Wong, Wing-Keung, Wrampelmeyer, Jan, Xia, Shuo, Xiu, Dacheng, Holzmeister, Felix, Bondarenko, Oleg, Xu, Ke, Xu, Caihong, Yadav, Pradeep K., Yagüe, José, Yan, Cheng, Yang, Antti, Yoo, Woongsun, Yu, Wenjia, Yu, Shihao, Yueshen, Bart Zhou, Bos, Charles S., Yuferova, Darya, Zamojski, Marcin, Zareei, Abalfazl, Zeisberger, Stefan, Zhang, Lu, Zhang, Xiaoyu, Zhong, Zhuo, Zhou, Z. Ivy, Zhou, Chen, Zhu, Xingyu, Bosch-Rosa, Ciril, Zoican, Marius, Zwinkels, Remco C.J., Chen, Jian, Duevski, Teodor, Gao, Ge, Gemayel, Roland, Gilder, Dudley, Kuhle, Paul, Pagnotta, Emiliano, Pelli, Michele, Bouri, Elie, Sönksen, Jantje, Ilczuk, Konrad, Bogoev, Dimitar, Qian, Ya, Wika, Hans C., Yu, Yihe, Zhao, Lu, Mi, Michael, Bao, Li, Brownlees, Christian T., Vaduva, Andreea, Prokopczuk, Marcel, Avetikian, Alejandro, Wu, Zhen-Xing, Calamia, Anna, Cao, Viet Nga, Capelle-Blancard, Gunther, Capera, Laura, Caporin, Massimiliano, Huber, Juergen, Carrion, Allen, Caskurlu, Tolga, Chakrabarty, Bidisha, Chernov, Mikhail, Cheung, William Ming Yan, Chincarini, Ludwig B., Chordia, Tarun, Chow, Sheung Chi, Clapham, Benjamin, Colliard, Jean-Edouard, Johanneson, Magnus, Comerton-Forde, Carole, Curran, Edward, Dao, Thong, Dare, Wale, Davies, Ryan J., De Blasis, Riccardo, De Nard, Gianluca, Declerck, Fany, Deev, Oleg, Degryse, Hans, Kirchler, Michael, Deku, Solomon, Desagre, Christophe, Dim, Chukwuma, Dimpfl, Thomas, Dong, Yun Jiang, Drummond, Philip, Dudda, Tom, Dumitrescu, Ariadna, Dyakov, Teodor, Razen, Michael, Dyhrberg, Anne Haubo, Dzieliński, Michał, Eksi, Asli, El Kalak, Izidin, ter Ellen, Saskia, Eugster, Nicolas, Evans, Martin D.D., Farrell, Michael, Félez-Viñas, Ester, Ferrara, Gerardo, Weitzel, Utz, FERROUHI, El Mehdi, Flori, Andrea, Fluharty-Jaidee, Jonathan, Foley, Sean, Fong, Kingsley Y. L., Foucault, Thierry, Franus, Tatiana, Franzoni, Francesco A., Frijns, Bart, Frömmel, Michael, Abad, David, Fu, Servanna Mianjun, Füllbrunn, Sascha, Gan, Baoqing, Gehrig, Thomas, Gerritsen, Dirk, Gil-Bazo, Javier, Glosten, Lawrence R., Gomez, Thomas, Gorbenko, Arseny, Güçbilmez, Ufuk, Van Dijk, Matthijs A., Leerstoel Stigchel, Helmholtz Institute, Experimental Psychology (onderzoeksprogramma PF), Finance, UU LEG Research UUSE Multidisciplinary Economics, Sub General Pharmaceutics, Menkveld, Albert J., Abudy, Menachem (Meni), Grammig, Joachim, Gregoire, Vincent, Hagströmer, Björn, Hambuckers, Julien, Hapnes, Erik, Harris, Jeffrey H., Harris, Lawrence, Hartmann, Simon, Hasse, Jean-Baptiste, Hautsch, Nikolaus, Adrian, Tobias, He, Xue-Zhong 'Tony', Heath, Davidson, Hediger, Simon, Hendershott, Terrence J., Hibbert, Ann Marie, Hjalmarsson, Erik, Hoelscher, Seth, Hoffmann, Peter, Holden, Craig W., Horenstein, Alex R., Ait-Sahalia, Yacine, Huang, Wenqian, Huang, Da, Hurlin, Christophe, Ivashchenko, Alexey, Iyer, Subramanian R., Jahanshahloo, Hossein, Jalkh, Naji, Jones, Charles M., Jurkatis, Simon, Jylha, Petri, Akmansoy, Olivier, Kaeck, Andreas, Kaiser, Gabriel, Karam, Arzé, Karmaziene, Egle, Kassner, Bernhard, Kaustia, Markku, Kazak, Ekaterina, Kearney, Fearghal, van Kervel, Vincent, Khan, Saad, Alcock, Jamie, Khomyn, Marta, Klein, Tony, Klein, Olga, Klos, Alexander, Koetter, Michael, Krahnen, Jan Pieter, Kolokolov, Aleksey, Korajczyk, Robert A., Kozhan, Roman, Kwan, Amy, Alexeev, Vitali, Lajaunie, Quentin, Lam, Full Yet Eric Campbell, Lambert, Marie, Langlois, Hugues, Lausen, Jens, Lauter, Tobias, Leippold, Markus, Levin, Vladimir, Li, Yijie, Li, (Michael) Hui, Aloosh, Arash, Liew, Chee Yoong, Lindner, Thomas, Linton, Oliver B., Liu, Jiacheng, Liu, Anqi, Llorente-Alvarez, Jesus-Guillermo, Lof, Matthijs, Lohr, Ariel, Longstaff, Francis A., Lopez-Lira, Alejandro, Amato, Livia, Mankad, Shawn, Mano, Nicola, Marchal, Alexis, Martineau, Charles, Mazzola, Francesco, Meloso, Debrah C, Mihet, Roxana, Mohan, Vijay, Moinas, Sophie, Moore, David, Amaya, Diego, Mu, Liangyi, Muravyev, Dmitriy, Murphy, Dermot, Neszveda, Gabor, Neumeier, Christian, Nielsson, Ulf, Nimalendran, Mahendrarajah, Nolte, Sven, Nordén, Lars L., O'Neill, Peter, Angel, James J., Obaid, Khaled, Ødegaard, Bernt Arne, Östberg, Per, Painter, Marcus, Palan, Stefan, Palit, Imon, Park, Andreas, Pascual Gascó, Roberto, Pasquariello, Paolo, Pastor, Lubos, Dreber, Anna, Bach, Amadeus, Patel, Vinay, Patton, Andrew J., Pearson, Neil D., Pelizzon, Loriana, Pelster, Matthias, Pérignon, Christophe, Pfiffer, Cameron, Philip, Richard, Plíhal, Tomáš, Prakash, Puneet, Baidoo, Edwin, Press, Oliver-Alexander, Prodromou, Tina, Putnins, Talis J., Raizada, Gaurav, Rakowski, David A., Ranaldo, Angelo, Regis, Luca, Reitz, Stefan, Renault, Thomas, Wang, Renjie, Bakalli, Gaetan, Renò, Roberto, Riddiough, Steven, Rinne, Kalle, Rintamäki, Paul, Riordan, Ryan, Rittmannsberger, Thomas, Rodríguez Longarela, Iñaki, Rösch, Dominik, Rognone, Lavinia, Roseman, Brian, Barbon, Andrea, Rosu, Ioanid, Roy, Saurabh, Rudolf, Nicolas, Rush, Stephen, Rzayev, Khaladdin, Rzeźnik, Aleksandra, Sanford, Anthony, Sankaran, Harikumar, Sarkar, Asani, Sarno, Lucio, Bashchenko, Oksana, Scaillet, Olivier, Scharnowski, Stefan, Schenk-Hoppé, Klaus Reiner, Schertler, Andrea, Schneider, Michael, Schroeder, Florian, Schürhoff, Norman, Schuster, Philipp, Schwarz, Marco A., Seasholes, Mark S., Bindra, Parampreet Christopher, Seeger, Norman, Shachar, Or, Shkilko, Andriy, Shui, Jessica, Sikic, Mario, Simion, Giorgia, Smales, Lee A., Söderlind, Paul, Sojli, Elvira, Sokolov, Konstantin, Bjonnes, Geir Hoidal, Spokeviciute, Laima, Stefanova, Denitsa, Subrahmanyam, Marti G., Neusüss, Sebastian, Szaszi, Barnabas, Talavera, Oleksandr, Tang, Yuehua, Taylor, Nicholas, Tham, Wing Wah, Theissen, Erik, Black, Jeffrey R., Thimme, Julian, Tonks, Ian, Tran, Hai, Trapin, Luca, Trolle, Anders B., Valente, Giorgio, Van Ness, Robert A., Vasquez, Aurelio, Verousis, Thanos, Verwijmeren, Patrick, Black, Bernard S., Vilhelmsson, Anders, Vilkov, Grigory, Vladimirov, Vladimir, Vogel, Sebastian, Voigt, Stefan, Wagner, Wolf, Walther, Thomas, Weiss, Patrick, van der Wel, Michel, Werner, Ingrid M., Bohorquez, Santiago, Westerholm, P. Joakim, Westheide, Christian, Wipplinger, Evert, Wolf, Michael, Wolff, Christian C. P., Wolk, Leonard, Wong, Wing-Keung, Wrampelmeyer, Jan, Xia, Shuo, Xiu, Dacheng, Holzmeister, Felix, Bondarenko, Oleg, Xu, Ke, Xu, Caihong, Yadav, Pradeep K., Yagüe, José, Yan, Cheng, Yang, Antti, Yoo, Woongsun, Yu, Wenjia, Yu, Shihao, Yueshen, Bart Zhou, Bos, Charles S., Yuferova, Darya, Zamojski, Marcin, Zareei, Abalfazl, Zeisberger, Stefan, Zhang, Lu, Zhang, Xiaoyu, Zhong, Zhuo, Zhou, Z. Ivy, Zhou, Chen, Zhu, Xingyu, Bosch-Rosa, Ciril, Zoican, Marius, Zwinkels, Remco C.J., Chen, Jian, Duevski, Teodor, Gao, Ge, Gemayel, Roland, Gilder, Dudley, Kuhle, Paul, Pagnotta, Emiliano, Pelli, Michele, Bouri, Elie, Sönksen, Jantje, Ilczuk, Konrad, Bogoev, Dimitar, Qian, Ya, Wika, Hans C., Yu, Yihe, Zhao, Lu, Mi, Michael, Bao, Li, Brownlees, Christian T., Vaduva, Andreea, Prokopczuk, Marcel, Avetikian, Alejandro, Wu, Zhen-Xing, Calamia, Anna, Cao, Viet Nga, Capelle-Blancard, Gunther, Capera, Laura, Caporin, Massimiliano, Huber, Juergen, Carrion, Allen, Caskurlu, Tolga, Chakrabarty, Bidisha, Chernov, Mikhail, Cheung, William Ming Yan, Chincarini, Ludwig B., Chordia, Tarun, Chow, Sheung Chi, Clapham, Benjamin, Colliard, Jean-Edouard, Johanneson, Magnus, Comerton-Forde, Carole, Curran, Edward, Dao, Thong, Dare, Wale, Davies, Ryan J., De Blasis, Riccardo, De Nard, Gianluca, Declerck, Fany, Deev, Oleg, Degryse, Hans, Kirchler, Michael, Deku, Solomon, Desagre, Christophe, Dim, Chukwuma, Dimpfl, Thomas, Dong, Yun Jiang, Drummond, Philip, Dudda, Tom, Dumitrescu, Ariadna, Dyakov, Teodor, Razen, Michael, Dyhrberg, Anne Haubo, Dzieliński, Michał, Eksi, Asli, El Kalak, Izidin, ter Ellen, Saskia, Eugster, Nicolas, Evans, Martin D.D., Farrell, Michael, Félez-Viñas, Ester, Ferrara, Gerardo, Weitzel, Utz, FERROUHI, El Mehdi, Flori, Andrea, Fluharty-Jaidee, Jonathan, Foley, Sean, Fong, Kingsley Y. L., Foucault, Thierry, Franus, Tatiana, Franzoni, Francesco A., Frijns, Bart, Frömmel, Michael, Abad, David, Fu, Servanna Mianjun, Füllbrunn, Sascha, Gan, Baoqing, Gehrig, Thomas, Gerritsen, Dirk, Gil-Bazo, Javier, Glosten, Lawrence R., Gomez, Thomas, Gorbenko, Arseny, Güçbilmez, Ufuk, and Van Dijk, Matthijs A.
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- 2024
10. Comparison of electrodiagnostic findings in acute traumatic versus chronic non‐traumatic ulnar neuropathy at the elbow
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Robinson, Lawrence R., primary, Broadhurst, Peter, additional, and Wasserman, Alex, additional
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- 2023
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11. P-004: HEALTH CARE TRANSITION (HCT) FOR SICKLE CELL DISEASE (SCD) CAN BE STANDARDIZED: RESULTS OF IMPLEMENTING A SCD HCT LEARNING COLLABORATIVE.
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OSUNKWO I., CORNETTE J., COURTLANDT C., WHITE P., PATTERSON C., MCMANUS P., NOONAN L., and LAWRENCE R.
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Diseases of the blood and blood-forming organs ,RC633-647.5 - Published
- 2022
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12. Provocative changes in nerve conductions – Fact or fiction?
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Robinson, Lawrence R., primary
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- 2023
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13. Outcomes in elderly patients undergoing hepatic resection compared to liver transplant for hepatocellular carcinoma
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Khan, Sameer A., primary, Ahmed, Fasih A., additional, Hafeez, Muhammad S., additional, Feng, Lawrence R., additional, Seth, Abhinav, additional, Kwon, Yong K., additional, and Aziz, Hassan, additional
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- 2023
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14. Racing performance of Thoroughbred racehorses with suspensory ligament branch desmitis treated with mesenchymal stem cells (2010–2019)
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Hansen, Stefanie H., primary, Bramlage, Lawrence R., additional, and Moore, George E., additional
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- 2023
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15. Are parenchymal cells a source of supplemental diet for aphids?
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Adriana E. Alvarez and Lawrence R. Griffing
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Insect Science ,Ecology, Evolution, Behavior and Systematics - Published
- 2023
16. Multiparametric MRI characterization of level dependent differences in lumbar muscle size, quality, and microstructure
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David B. Berry, Ana E. Rodriguez‐Soto, Erin K. Englund, Bahar Shahidi, Callan Parra, Lawrence R. Frank, Karen R. Kelly, and Samuel R. Ward
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diffusion tensor imaging ,fatty infiltration ,lumbar spine ,MRI ,skeletal muscle ,Orthopedic surgery ,RD701-811 - Abstract
Abstract Magnetic resonance imaging (MRI) is a diagnostic tool that can be used to noninvasively assess lumbar muscle size and fatty infiltration, important biomarkers of muscle health. Diffusion tensor imaging (DTI) is an MRI technique that is sensitive to muscle microstructural features such as fiber size (an important biomarker of muscle health), which is typically only assessed using invasive biopsy techniques. The goal of this study was to establish normative values of level‐dependent lumbar muscle size, fat signal fraction, and restricted diffusion assessed by MRI in a highly active population. Forty‐two active‐duty Marines were imaged using a (a) high‐resolution anatomical, (b) fat‐water separation, and (c) DT‐MRI scan. The multifidus and erector spinae muscles were compared at each level using two‐way repeated measures ANOVA. Secondary analysis included Three dimensional (3D) reconstructions to qualitatively assess lumbar muscle size, fatty infiltration, and fiber orientation via tractography. The erector spinae was found to be larger than the multifidus above L5, with lower fat signal fraction above L3, and a less restricted diffusion profile than the multifidus above L4, with this pattern reversed in the lower lumbar spine. 3D reconstructions demonstrated accumulations of epimuscular fat in the anterior and posterior regions of the lumbar musculature, with minimal intramuscular fatty infiltration. Tractography images demonstrated different orientations of adjacent lumbar musculature, which cannot be visualized with standard MRI pulse sequences. The level dependent differences found in this study provide a normative baseline, for which to better understand whole muscle and microstructural changes associated with aging, low back pain, and pathology.
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- 2020
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17. Versatile Production of Multivariate, Hyperdimensional End Group and Main Chain Functionalized Polyolefins
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Fischbach, Danyon M., primary, Krstic, Katharina A., additional, and Sita, Lawrence R., additional
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- 2023
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18. Rapid Phase Transitions of Thermotropic Glycolipid Quasicrystal and Frank‐Kasper Mesophases: A Mechanistic Rosetta Stone
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Wentz, Charlotte M., primary, Lachmayr, Kätchen K., additional, Tsai, Esther H. R., additional, and Sita, Lawrence R., additional
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- 2023
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19. Traumatic injury to peripheral nerves
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Lawrence R. Robinson
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medicine.medical_specialty ,Time Factors ,Electrodiagnosis ,Physiology ,Central nervous system ,Neural Conduction ,Electromyography ,Models, Biological ,Cellular and Molecular Neuroscience ,Physical medicine and rehabilitation ,Peripheral nerve ,Peripheral Nerve Injuries ,Physiology (medical) ,Animals ,Medicine ,Humans ,Peripheral Nerves ,Muscle, Skeletal ,Nerve Transfer ,Radial nerve ,Needle electromyography ,Plexus ,medicine.diagnostic_test ,business.industry ,Peripheral Nervous System Diseases ,Recovery of Function ,medicine.disease ,Prognosis ,Peripheral ,Electrophysiology ,medicine.anatomical_structure ,Traumatic injury ,Anesthesia ,Peripheral nervous system ,Wounds and Injuries ,Upper limb ,Sciatic nerve ,Neurology (clinical) ,business ,Neuroscience ,Penetrating trauma ,Sensory nerve - Abstract
Publisher Summary This chapter discusses the epidemiology and classification of traumatic peripheral nerve injuries, the effects of these injuries on nerve and muscle, and how electrodiagnosis is used to help classify the injury. Traumatic injury to peripheral nerves results in considerable disability across the world. In peacetime, peripheral nerve injuries result commonly from motor vehicle accident trauma and less commonly from penetrating trauma, such as falls and industrial accidents. If plexus and root injuries are also included, the incidence is about 5%. In the upper limb, the nerve injured most commonly is the radial nerve, followed by the ulnar and median nerves. Lower limb peripheral nerve injuries are less common, and the sciatic nerve is injured most frequently, followed by the peroneal and rarely the tibial or femoral nerves. Peripheral nerve injuries may be seen in isolation, but they also often accompany central nervous system (CNS) trauma. Peripheral nerve injuries have significant impact, as they impede the recovery of function and return to work. There is also a risk of secondary disability from falls, fractures, or other injuries.
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- 2022
20. Novel spinal cord stimulation system with a <scp>Battery‐Free</scp> micro‐implantable pulse generator
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Mark N. Malinowski, Gary Heit, Lawrence R. Poree, James Makous, and Kasra Amirdelfan
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Anesthesiology and Pain Medicine - Published
- 2022
21. Two‐Year Outcomes After Pediatric In‐Office Tympanostomy Using Lidocaine/Epinephrine Iontophoresis and an Automated Tube Delivery System
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Waldman, Erik H., primary, Ingram, Amy, additional, Vidrine, D. Macy, additional, Gould, Andrew R., additional, Zeiders, Jacob W., additional, Ow, Randall A., additional, Thompson, Christopher R., additional, Moss, Jonathan R., additional, Mehta, Ritvik, additional, McClay, John E., additional, Brenski, Amy, additional, Gavin, John, additional, Ansley, John, additional, Yen, David M., additional, Chadha, Neil K., additional, Murray, Michael T., additional, Kozak, Frederick K., additional, York, Christopher, additional, Brown, David M., additional, Grunstein, Eli, additional, Sprecher, Robert C., additional, Sherman, Denise A., additional, Schoem, Scott R., additional, Puchalski, Robert, additional, Hills, Susannah, additional, Harfe, Dan, additional, England, Laura J., additional, Syms, Charles A., additional, and Lustig, Lawrence R., additional
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- 2023
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22. Are parenchymal cells a source of supplemental diet for aphids?
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Alvarez, Adriana E., primary and Griffing, Lawrence R., additional
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- 2023
- Full Text
- View/download PDF
23. Pain versus anxiety during electrodiagnostic studies
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Robinson, Lawrence R., primary
- Published
- 2023
- Full Text
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24. Versatile Production of Multivariate, Hyperdimensional End Group and Main Chain Functionalized Polyolefins
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Fischbach, Danyon M., Fischbach, Danyon M., Krstic, Katharina A., Sita, Lawrence R., Fischbach, Danyon M., Fischbach, Danyon M., Krstic, Katharina A., and Sita, Lawrence R.
- Abstract
The (stereoselective) living coordinative copolymerization of 1-alkenes with 4-aryl-1,6-heptadienes, in both the absence and presence of multiple equivalents of a reversible chain transfer agent, is established as a highly versatile strategy for production of multivariate hyperdimensional functionalized semi-crystalline or amorphous polyolefins that optionally possess either mono- or difunctionalized (telechelic) end-groups in combination with a programmable level of incorporation of orthogonal functional groups within the main-chain. The non-conjugated diene comonomers are readily obtained from a diverse range of aryl carboxaldehyde precursors through a one-step bis-allylation process. These results serve to provide a new platform for exploring the science and technology of a vast new landscape of functionalized classes of polyolefins that are now accessible in practical and scalable quantities.
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- 2023
25. Two‐Year Outcomes After Pediatric In‐Office Tympanostomy Using Lidocaine/Epinephrine Iontophoresis and an Automated Tube Delivery System
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Erik H. Waldman, Amy Ingram, D. Macy Vidrine, Andrew R. Gould, Jacob W. Zeiders, Randall A. Ow, Christopher R. Thompson, Jonathan R. Moss, Ritvik Mehta, John E. McClay, Amy Brenski, John Gavin, John Ansley, David M. Yen, Neil K. Chadha, Michael T. Murray, Frederick K. Kozak, Christopher York, David M. Brown, Eli Grunstein, Robert C. Sprecher, Denise A. Sherman, Scott R. Schoem, Robert Puchalski, Susannah Hills, Dan Harfe, Laura J. England, Charles A. Syms, and Lawrence R. Lustig
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Otorhinolaryngology ,Surgery - Published
- 2023
26. An enigmatic pelagic fish with internalized red muscle: A future regional endotherm or forever an ectotherm?
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Martin C. Arostegui, Michelle R. Shero, Lawrence R. Frank, Rachel M. Berquist, and Camrin D. Braun
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Aquatic Science ,Ecology, Evolution, Behavior and Systematics - Published
- 2023
27. Imaging Life
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Lawrence R. Griffing
- Published
- 2023
28. Pain versus anxiety during electrodiagnostic studies
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Lawrence R. Robinson
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Cellular and Molecular Neuroscience ,Physiology ,Physiology (medical) ,Neurology (clinical) - Published
- 2023
29. Pharmacokinetics of glaucine after intravenous and oral administrations and detection of systemic aporphine alkaloids after ingestion of tulip poplar shavings in horses
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Joanne E. Haughan, Jaclyn R. Missanelli, Youwen You, Darko Stefanovski, Lawrence R. Soma, and Mary A. Robinson
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Pharmacology ,Eating ,Aporphines ,Cross-Over Studies ,General Veterinary ,Area Under Curve ,Injections, Intravenous ,Anti-Inflammatory Agents ,Administration, Oral ,Animals ,Tulipa ,Horses ,Half-Life - Abstract
Glaucine, an aporphine alkaloid with anti-tussive, anti-inflammatory, and anti-nociceptive properties, has been identified in post-race samples from racehorses. To investigate pharmacokinetics of glaucine in horses, a three-way crossover study of intravenous and oral glaucine (0.1 mg/kg) and orally administered tulip poplar shavings (50 g shavings = 0.001 mg/kg glaucine) was performed in six horses. A two-compartment model best described IV administration with alpha (
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- 2022
30. Current status and trends in subspecialty certification in physical medicine and rehabilitation
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Sunil Sabharwal, Carolyn L. Kinney, Mikaela M. Raddatz, Sherilyn W. Driscoll, Gerard E. Francisco, Lawrence R. Robinson, Carolyn Geis, and William Micheo
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Neurology ,Rehabilitation ,Physical Therapy, Sports Therapy and Rehabilitation ,Neurology (clinical) - Abstract
There is a need to better understand the overall state of sub-specialization in physical medicine and rehabilitation (PMR).To examine the status and trends in subspecialty certification for each of the seven subspecialties approved for American Board of Physical Medicine and Rehabilitation (ABPMR) diplomates.Retrospective analysis of deidentified information from the ABPMR database.Physicians certified by ABPMR through 2019.Not applicable.For each subspecialty, we examined: (1) the number of certificates issued to ABPMR diplomates; (2) the recertification rate; (3) the yearly trends for total active, new, and expired certificates; and (4) for ABPMR-administered subspecialties, recertification rates for those entering the subspecialty through fellowship completion versus a "grandfathered" practice pathway.Of 11,421 ABPMR diplomates in the United States in 2019, a total of 3560 (31.2%) had 3985 active subspecialty certificates. Pain Medicine (PM) was the most common subspecialty certification (15.5% of all ABPMR diplomates) followed by Sports Medicine (SM, 6.6%), Brain Injury Medicine (BIM, 4.8%), Spinal Cord Injury Medicine (SCIM, 4.2%), Pediatric Rehabilitation Medicine (PRM, 2.5%), Neuromuscular Medicine (NMM, 0.7%), and Hospice and Palliative Medicine (HPM, 0.5%). For diplomates with more than one subspecialty certification, PM and SM was the most frequent combination. Both the recertification rate and the end of practice track eligibility influenced certification trends differently for individual subspecialties. The average number of new certificates added annually for every subspecialty was higher before than after the temporary practice track-based eligibility ended; the difference was statistically significant (p .05) for SCIM, PM, SM, and NMM. The recertification rate for all subspecialties combined was 73.4%. For the subspecialties (SCIM, PRM) for which these data were available, fellowship candidates had higher recertification rates than those grandfathered through a practice track.This report informs stakeholders about the state and evolution of subspecialty certification in PMR over time.
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- 2022
31. Comparative results of 3 treatments for medial femoral condyle subchondral cystic lesions in Thoroughbred racehorses
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Chelsea E. Klein, Lawrence R. Bramlage, Darko Stefanovski, Alan J. Ruggles, Rolf M. Embertson, and Scott A. Hopper
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General Veterinary ,Animals ,Bone Cysts ,Humans ,Horse Diseases ,Femur ,Horses ,Epiphyses ,Retrospective Studies - Abstract
To compare 3 different methods for treatment of medial femoral condyle (MFC) subchondral cystic lesions in Thoroughbred horses24 months old based on the criterion of ability to race post-treatment.Retrospective cohort study.Thoroughbreds (n = 107, age 24 months) diagnosed with MFC subchondral cystic lesions.Medical records between January 2004 and December 2017 were reviewed. Three treatment methods were used in these horses during that time frame: arthroscopic debridement, intralesional autologous mesenchymal stem cell (MSC) injection, and intralesional corticosteroid injection. The outcome evaluated was the ability to compete in a pari-mutuel race.Seventy-eight of 107 Thoroughbreds (73%) raced post-treatment; 41/57 (72%) of horses treated by arthroscopic debridement raced; 16/19 (84%) of horses treated with intralesional MSCs raced; 21/31 (68%) of horses treated with intralesional corticosteroids raced. There was no difference between groups in the ability to start a race. Sex, limb affected, and lesion size also had no effect on the ability to start a race. There was a trend for increasing lesion size reducing the probability of racing.Seventy-three percent of the horses raced, but there was no difference in the ability of unraced Thoroughbreds to race after treatment of MFC subchondral cystic lesions with arthroscopic debridement, intralesional mesenchymal stem cells, or intralesional corticosteroids.The 3 reported treatment options may be considered for treatment of MFC subchondral cystic lesions with a good prognosis for racing post-treatment. Owners should be advised that increasing lesion size decreases the probability of racing.
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- 2022
32. Performance on the <scp>American Board of Physical Medicine and Rehabilitation</scp> certifying examinations: Rural and urban physicians
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Lawrence R. Robinson, Mikaela M. Raddatz, and Kevin Murphy
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Medical education ,Neurology ,business.industry ,Rehabilitation ,Medicine ,Physical Therapy, Sports Therapy and Rehabilitation ,Neurology (clinical) ,business - Abstract
Over 60 million people in the United States live in a rural community making up approximately 20% of the population. Data are minimal about the physiatrists who serve this rural population, their performance on certification examinations and how the American Board of Physical Medicine and Rehabilitation (ABPMR) serves their ongoing educational, assessment, and practice needs.To compare the performance of rural and urban physicians on the Part I, Part II, and maintenance of certification (MOC) examinations along with subspecialty preference and continuance of primary certification.Retrospective cross-sectional study.Board-eligible PMR physicians and certified diplomates of the ABPMR.Physicians who participated in an initial certification or maintenance of certification examination with the ABPMR between 2010 and 2019.Comparisons of physician pass rates, mean scaled scores (aggregates), and program pass rates on ABPMR certifying examinations were completed. Cross-reference to national database and ABPMR practice site zip codes provided sociogeographic linkage.Not applicable MAIN OUTCOME MEASURES: Physician mean scaled scores, pass rates, subspecialty preferences, and primary certification status.There were no meaningful differences in performance on the ABPMR Part I, II, and MOC examinations between rural and urban physiatrists. Most common subspecialty is the pain medicine certification whose diplomates most frequently drop their primary certification. Pediatric rehabilitation medicine certification is rare in rural localities and a health care disparity.The study found no meaningful differences in the performance of rural and urban physicians on the ABPMR certifying examinations.
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- 2022
33. <scp>Mouse‐INtraDuctal</scp> ( <scp>MIND</scp> ): an in vivo model for studying the underlying mechanisms of <scp>DCIS</scp> malignancy
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Amanda L. Amin, Mark Redick, E. Shelley Hwang, Mingchu Xu, Jeffrey Thompson, Allison Aripoli, Emily Wedlock, Ashley I. Huppe, Haleigh E. Harper, Fang Fan, Yan Hong, Hana Razek, R Meierotto, Onalisa Winblad, Alastair M. Thompson, Susan G. Hilsenbeck, Ossama Tawfik, Christa R. Balanoff, Michael Ricci, Darlene Limback, Hayley Hansford, Kelsey E. Larson, Jamie L. Wagner, Lisa May, Fariba Behbod, Lawrence R. Ricci, Therese Cusick, Andy Futreal, Hanan S. Elsarraj, Carolyn S Kaufman, Marc Inciardi, Jianhua Zhang, Jason Gatewood, Andrew K. Godwin, Haley Haines, and Rashna Madan
- Subjects
Pathology ,medicine.medical_specialty ,Time Factors ,Receptor expression ,Breast Neoplasms ,Mice, SCID ,Malignancy ,Pathology and Forensic Medicine ,Breast cancer ,Cell Movement ,Mice, Inbred NOD ,In vivo ,Biomarkers, Tumor ,medicine ,Animals ,Humans ,Neoplasm Invasiveness ,skin and connective tissue diseases ,Cell Proliferation ,Comedo ,business.industry ,Cancer ,Epithelial Cells ,Ductal carcinoma ,medicine.disease ,Carcinoma, Intraductal, Noninfiltrating ,Mutation ,Cancer cell ,Disease Progression ,Heterografts ,Female ,medicine.symptom ,Receptors, Progesterone ,business ,Neoplasm Transplantation - Abstract
Due to widespread adoption of screening mammography, there has been a significant increase in new diagnoses of ductal carcinoma in situ (DCIS). However, DCIS prognosis remains unclear. To address this gap, we developed an in vivo model, Mouse-INtraDuctal (MIND), in which patient-derived DCIS epithelial cells are injected intraductally and allowed to progress naturally in mice. Similar to human DCIS, the cancer cells formed in situ lesions inside the mouse mammary ducts and mimicked all histologic subtypes including micropapillary, papillary, cribriform, solid, and comedo. Among 37 patient samples injected into 202 xenografts, at median duration of 9 months, 20 samples (54%) injected into 95 xenografts showed in vivo invasive progression, while 17 (46%) samples injected into 107 xenografts remained non-invasive. Among the 20 samples that showed invasive progression, nine samples injected into 54 xenografts exhibited a mixed pattern in which some xenografts showed invasive progression while others remained non-invasive. Among the clinically relevant biomarkers, only elevated progesterone receptor expression in patient DCIS and the extent of in vivo growth in xenografts predicted an invasive outcome. The Tempus XT assay was used on 16 patient DCIS formalin-fixed, paraffin-embedded sections including eight DCISs that showed invasive progression, five DCISs that remained non-invasive, and three DCISs that showed a mixed pattern in the xenografts. Analysis of the frequency of cancer-related pathogenic mutations among the groups showed no significant differences (KW: p 0.05). There were also no differences in the frequency of high, moderate, or low severity mutations (KW; p 0.05). These results suggest that genetic changes in the DCIS are not the primary driver for the development of invasive disease. © 2021 The Authors. The Journal of Pathology published by John WileySons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
- Published
- 2021
34. Open Access: Is There a Predator at the Door?
- Author
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Rakesh Chandra MD, Edward W. Fisher MA, DM (Oxon), FRCS, Terry M. Jones BSc(Hons), MBBS, FRCSEd, FRCS(ORL-HNS), MD, David W. Kennedy MD, Dennis H. Kraus MD, FACS, John H. Krouse MD, PhD, MBA, Michael Link MD, Lawrence R. Lustig MD, Bert W. O’Malley MD, Jay F. Piccirillo MD, FACS, Robert Ruben MD, FAAP, FACS, Robert T. Sataloff MD, DMA, FACS, Raj Sindwani MD, Richard J. Smith MD, Michael G. Stewart MD, MPH, FACS, Peter C. Weber MD, D. Bradley Welling M.D., Ph.D., FACS, and Robin Youngs MB BS MD FRCS
- Subjects
Otorhinolaryngology ,RF1-547 ,Surgery ,RD1-811 - Published
- 2018
- Full Text
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35. Impact of <scp>COVID</scp> ‐19 on Otolaryngology Literature
- Author
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Ehab Y. Hanna, Edward W Fisher, John H. Krouse, Eleanor F. Gerhard, Lawrence R. Lustig, Ashkan Monfared, Joseph E. Kerschner, Yeshwant Chillakuru, Timothy Shim, Timothy L. Smith, and Samuel H. Selesnick
- Subjects
medicine.medical_specialty ,2019-20 coronavirus outbreak ,Coronavirus disease 2019 (COVID-19) ,business.industry ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Acceptance rate ,COVID-19 ,Bibliometrics ,Otolaryngology ,Otorhinolaryngology ,COVID‐19 ,Original Reports ,medicine ,Retrospective analysis ,Humans ,scientific publication ,publication trends ,business ,Pandemics ,Retrospective Studies ,Demography ,Publication types - Abstract
OBJECTIVES/HYPOTHESIS: To understand the effect of the COVID-19 pandemic on the volume, quality, and impact of otolaryngology publications. STUDY DESIGN: Retrospective analysis. METHODS: Fifteen of the top peer-reviewed otolaryngology journals were queried on PubMed for COVID and non-COVID-related articles from April 1, 2020 to March 31, 2021 (pandemic period) and pre-COVID articles from the year prior. Information on total number of submissions and rate of acceptance were collected from seven top-ranked journals. RESULTS: Our PubMed query returned 759 COVID articles, 4,885 non-COVID articles, and 4,200 pre-COVID articles, corresponding to a 34% increase in otolaryngology publications during the pandemic period. Meta-analysis/reviews and miscellaneous publication types made up a larger portion of COVID publications than that of non-COVID and pre-COVID publications. Compared to pre-COVID articles, citations per article 120 days after publication and Altmetric Attention Score were higher in both COVID articles (citations/article: 2.75 ± 0.45, P < .001; Altmetric Attention Score: 2.05 ± 0.60, P = .001) and non-COVID articles (citations/article: 0.03 ± 0.01, P = .002; Altmetric Attention Score: 0.67 ± 0.28, P = .016). COVID manuscripts were associated with a 1.65 times higher acceptance rate compared to non-COVID articles (P < .001). CONCLUSIONS: COVID-19 was associated with an increase in volume, citations, and attention for both COVID and non-COVID articles compared to pre-COVID articles. However, COVID articles were associated with lower evidence levels than non-COVID and pre-COVID articles. LEVEL OF EVIDENCE: Level 3 Laryngoscope, 2021.
- Published
- 2021
36. Molecular assessment of dietary niche partitioning in an endemic island radiation of tropical mammals
- Author
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Lawrence R. Heaney, Dakota M. Rowsey, and Anna L. Petrosky
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Mammals ,Phylogenetic tree ,Ecology ,Philippines ,Niche differentiation ,Biology ,Adaptation, Physiological ,Biological Evolution ,Diet ,Ecological relationship ,Adaptive radiation ,Genetics ,Animals ,Evolutionary ecology ,Identification (biology) ,Adaptation ,Clade ,Ecosystem ,Phylogeny ,Ecology, Evolution, Behavior and Systematics - Abstract
Island radiations represent unique evolutionary histories in unique ecological contexts. These radiations provide opportunities to investigate ecological diversification in groups that typically exhibit niche partitioning among their constituents, including partitioning of food resources. DNA metabarcoding produces finer levels of diet identification than traditional methods, allowing us to examine dietary niche partitioning in communities or clades in which species share superficially similar diets. Here, we use DNA metabarcoding to investigate dietary niche partitioning in an endemic radiation of mammals in the Philippines. Our data reveal niche partitioning as well as phylogenetically-uncorrelated adaptive evolution in this small mammal community. Because 70% of the focal species belong to the tribe Chrotomyini, an endemic Philippine radiation of murid rodents that feed extensively on earthworms, this study sheds light on dietary adaptation and its role in the co-occurrence of closely related species. Our results reveal fine-scale resource partitioning within this community; our data provide compelling evidence for niche partitioning of diet that was masked by previous diet categories and will help in further dissecting the model adaptive radiation of endemic small mammals on Luzon. This study reinforces the notion that DNA metabarcoding can be a valuable tool for investigating both ecological relationships and evolutionary ecology at the community and phylogenetic level, respectively.
- Published
- 2021
37. Speleothem‐based chronology and environmental context of deposits from the Mishin Kamik Cave, NW Bulgaria – A contribution to the archaeological study of the Late Pleistocene human occupation in the Balkans
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Elena Marinova, Stefanka Ivanova, Thomas Goovaerts, Lawrence R. Edwards, Maria Gurova, Hai Cheng, Sophie Verheyden, Christian Burlet, Chemistry, and Analytical, Environmental & Geo-Chemistry
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geography ,Neanderthal ,geography.geographical_feature_category ,biology ,Context (archaeology) ,Pleistocene ,Paleontology ,Speleothem ,MIS 6 ,karst ,Karst ,Archaeology ,Arts and Humanities (miscellaneous) ,Cave ,biology.animal ,Earth and Planetary Sciences (miscellaneous) ,Middle Palaeolithic ,Geology ,Chronology - Abstract
The Balkan Peninsula represents one of the most important human pathways into and out of Europe during the Pleistocene. Mishin Kamik cave, located in the karst region of Western Stara Planina, has a rich faunal content and shows promising features indicating a human occupation site with the discovery of potential bone artefacts and an intriguing accumulation of bear skulls and bones. Petrographic study and U-series dating of a stalagmite and other calcite deposits in the cave provide an absolute chronological frame for the detrital infillings and their archaeological content and inform the environmental and climatic context of the cave evolution. Most detrital deposits in the cave were probably deposited before Marine Isotope Stage (MIS) 5 and the cave morphology and sedimentary deposits display current morphologies since ~135 ka. Consequently, the palaeontological and archaeological findings are older than ~135 ka. Calcite dated on and under the accumulation of bear skulls and bones suggests deposition during MIS 7. A first depositional contextualization of the bone accumulation does not allow us to discriminate between a natural or anthropogenic origin. The study emphasizes the added value of speleothem studies in archaeological sites and particularly in bringing a well-constrained chronological and environmental framework.
- Published
- 2021
38. Prediction of Adaptive Self-Regulatory Responses to Arthritis Pain Anxiety in Exercising Adults: Does Pain Acceptance Matter?
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Miranda A Cary, Nancy C Gyurcsik, and Lawrence R Brawley
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Medicine (General) ,R5-920 - Abstract
BACKGROUND: Exercising for ≥150 min/week is a recommended strategy for self-managing arthritis. However, exercise nonadherence is a problem. Arthritis pain anxiety may interfere with regular exercise. According to the fear-avoidance model, individuals may confront their pain anxiety by using adaptive self-regulatory responses (eg, changing exercise type or duration). Furthermore, the anxiety-self-regulatory responses relationship may vary as a function of individuals’ pain acceptance levels.
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- 2015
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39. Stereomodulation of Poly(4‐methyl‐1‐pentene): Adoption of a Neglected and Misunderstood Commercial Polyolefin
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Charlotte M. Wentz, Danyon M. Fischbach, and Lawrence R. Sita
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General Medicine ,General Chemistry ,Catalysis - Abstract
A toolbox of living coordination polymerization methods based on CPAM group 4 metal initiators has been applied for the stereomodulation of poly(4-methyl-1-pentene) (PMP) tacticity to provide new fundamental forms in which thermal phase transitions, T
- Published
- 2022
40. Preoperative electrodiagnostic planning for upper limb peripheral nerve transfers in cervical spinal cord injury: A narrative review
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Jordan Silverman, Jana Dengler, Cimon Song, and Lawrence R. Robinson
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Neurology ,Rehabilitation ,Physical Therapy, Sports Therapy and Rehabilitation ,Neurology (clinical) - Abstract
Peripheral nerve transfer (PNT) to improve upper limb function following cervical spinal cord injury (SCI) involves the transfer of supralesional donor nerves under voluntary control to intralesional or sublesional lower motor neurons not under voluntary control. Appropriate selection of donor and recipient nerves and surgical timing affect functional outcomes. Although the gold standard of nerve selection is intraoperative nerve stimulation, preoperative electrodiagnostic (EDX) evaluation may help guide surgical planning. Currently there is no standardized preoperative EDX protocol. This study reviews the EDX workup preceding PNT surgery in cervical SCI and proposes an informed EDX protocol to assist with surgical planning. The PICO (Population, Intervention, Comparison, Outcome) framework was used to formulate relevant Medical Subject Headings (MeSH) terms and identify published cases of PNT in cervical SCI in Medline, Embase, CINAHL, and Emcare databases in the last 10 years. The EDX techniques evaluating putative donor nerves, recipient nerve branches, time sensitivity of nerve transfer and other electrophysiological parameters were summarized to guide creation of a preoperative EDX protocol. Needle electromyography (EMG) was the most commonly used EDX technique to identify healthy donor nerves. Although needle EMG has also been used on recipient nerves, compound muscle action potential amplitudes may provide a more accurate determination of recipient nerve health and time sensitivity for nerve transfer. Although there has been progress in presurgical EDX evaluation, EMG and nerve conduction study approaches are variable, and each has limitations in their utility for preoperative planning. There is need for standardization in the EDX evaluation preceding PNT surgery to assist with donor and recipient nerve selection, surgical timing and to optimize outcomes. Based on results of this review, herein we propose the PreSCIse (PRotocol for Electrodiagnosis in SCI Surgery of the upper Extremity) preoperative EDX panel to achieve said goals through an interdisciplinary and patient-centered approach.
- Published
- 2022
41. Stereomodulation of Poly(4‐methyl‐1‐pentene): Adoption of a Neglected and Misunderstood Commercial Polyolefin
- Author
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Wentz, Charlotte M., primary, Fischbach, Danyon M., additional, and Sita, Lawrence R., additional
- Published
- 2022
- Full Text
- View/download PDF
42. Alfred R. Wallace's enduring influence on biogeographical studies of the Indo‐Australian archipelago
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Ali, Jason R., primary and Heaney, Lawrence R., additional
- Published
- 2022
- Full Text
- View/download PDF
43. Implementation considerations for delivering inpatient COVID rehabilitation: A qualitative study
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Sheppard, Christine L., primary, Szigeti, Zara, additional, Simpson, Robert, additional, Minezes, Jacqueline, additional, Hitzig, Sander L., additional, Mayo, Amanda, additional, Robinson, Lawrence R., additional, Lung, Maria, additional, and Wasilewski, Marina B., additional
- Published
- 2022
- Full Text
- View/download PDF
44. Traumatic injury to peripheral nerves
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Robinson, Lawrence R., primary
- Published
- 2022
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45. Preoperative electrodiagnostic planning for upper limb peripheral nerve transfers in cervical spinal cord injury: A narrative review
- Author
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Silverman, Jordan, primary, Dengler, Jana, additional, Song, Cimon, additional, and Robinson, Lawrence R., additional
- Published
- 2022
- Full Text
- View/download PDF
46. Role of electrodiagnosis in nerve transfers for focal neuropathies and brachial plexopathies
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Lawrence R. Robinson and Paul Binhammer
- Subjects
medicine.medical_specialty ,Physiology ,Electromyography ,Cellular and Molecular Neuroscience ,Physical medicine and rehabilitation ,Peripheral Nerve Injuries ,Physiology (medical) ,Humans ,Medicine ,Brachial Plexus ,Axon ,Brachial Plexus Neuropathies ,Nerve Transfer ,medicine.diagnostic_test ,business.industry ,Electrodiagnosis ,Neurapraxia ,Nerve injury ,medicine.disease ,medicine.anatomical_structure ,Peripheral nervous system ,Neurology (clinical) ,medicine.symptom ,business ,Brachial plexus ,Reinnervation - Abstract
Over the past 2 decades, the surgical treatment of brachial plexus and peripheral nerve injuries has advanced considerably. Nerve transfers have become an important surgical tool in addition to nerve repair and grafting. Electrodiagnosis has traditionally played a role in the diagnosis and localization of peripheral nervous system injuries, but a different approach is needed for surgical decision-making and monitoring recovery. When patients have complete or severe injuries they should be referred to surgical colleagues early after injury, as outcomes are best when nerve transfers are performed within the first 3 to 6 mo after onset. Patients with minimal recovery of voluntary activity are particularly challenging, and the presence of a few motor unit action potentials in these individuals should be interpreted on the basis of timing and evidence of ongoing reinnervation. Evaluation of potential recipient and donor muscles, as well as redundant muscles, for nerve transfers requires an individualized approach to optimize the chances of a successful surgical intervention. Anomalous innervation takes on new importance in these patients. Communication between surgeons and electrodiagnostic medicine specialists (EMSs) is best facilitated by a joint collaborative clinic. Ongoing monitoring of recovery post-operatively is critical to allow for decision making for continued surgical and rehabilitation treatments. Different electrodiagnostic findings are expected with resolution of neurapraxia, distal axon sprouting, and axonal regrowth. As new surgical techniques become available, EMSs will play an important role in the assessment and treatment of these patients with severe nerve injuries.
- Published
- 2021
47. Gene transcripts expressed in equine white blood cells are potential biomarkers of extracorporeal shock wave therapy
- Author
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Lawrence R. Soma, Darko Stefanovski, Joanne Haughan, Jinwen Chen, Zibin Jiang, and Mary A Robinson
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Extracorporeal Shockwave Therapy ,Microarray ,medicine.medical_treatment ,Analgesic ,Pharmaceutical Science ,Bioinformatics ,01 natural sciences ,Analytical Chemistry ,Transcriptome ,03 medical and health sciences ,0302 clinical medicine ,Gene expression ,Leukocytes ,Animals ,Humans ,Environmental Chemistry ,Medicine ,Horses ,030216 legal & forensic medicine ,Spectroscopy ,business.industry ,010401 analytical chemistry ,Horse ,BMPR1A ,0104 chemical sciences ,Real-time polymerase chain reaction ,Extracorporeal shockwave therapy ,Inflammation Mediators ,business ,Biomarkers - Abstract
Extracorporeal shockwave therapy (ESWT) is a treatment applied to musculoskeletal injuries in equine athletes to alleviate pain and accelerate healing. ESWT also causes acute tissue damage. Therefore, its ability to act as an analgesic and cause tissue damage potentially increases the risk of a catastrophic event if used shortly before a strenuous competition such as horseracing. While ESWT is prohibited by many racing jurisdictions within 10 days prior to competition, a test to detect whether a horse has received ESWT is needed. ESWT changes the protein levels of inflammatory mediators in blood, and white blood cells (WBC) typically produce these proteins. Changes in gene expression precede changes in protein production; thus, it was hypothesized that WBC gene transcripts might serve as biomarkers of ESWT. To test this hypothesis, six thoroughbred horses received a single administration of ESWT to the distal limb, and WBC RNA was extracted from blood samples collected before (0 h) and after ESWT (2, 4, 6, 24, 48, and 72 h). Targeted and untargeted analyses evaluated the transcriptome using quantitative PCR (qPCR) and microarray. The expression of IL-1α, IL-1β, TNF-α, IL-1Ra1, IL-1Ra2 and TGF-β1, and BMPR1A in circulating WBCs was significantly up-regulated, while IFN-γ, ZNF483, TMEM80, CAH6, ENPP, and S8723 were significantly down-regulated at various time points following ESWT. These data support the hypothesis that changes in WBC gene transcripts could serve as biomarkers for ESWT.
- Published
- 2021
48. Adverse effects of electroconvulsive therapy on cognitive performance
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Sasha S. Getty and Lawrence R. Faziola
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electroconvulsive therapy, cognitive performance ,Psychiatry ,RC435-571 - Abstract
Not available
- Published
- 2017
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49. A case of mania presenting with hypersexual behavior and gender dysphoria that resolved with valproic acid
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Michelle R. Heare, Maria Barsky, and Lawrence R. Faziola
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Psychiatry ,mania ,hypersexual ,gender dysphoria ,RC435-571 - Abstract
Hypersexuality and gender dysphoria have both been described in the literature as symptoms of mania. Hypersexuality is listed in the Diagnostic and Statistical Manual of Mental Disorders 5 as part of the diagnostic criteria for bipolar disorder. Gender dysphoria is less often described and its relation to mania remains unclear. This case report describes a young homosexual man presenting in a manic episode with co-morbid amphetamine abuse whose mania was marked by hypersexuality and the new onset desire to be a woman. Both of these symptoms resolved with the addition of valproic acid to antipsychotics. This case report presents the existing literature on hypersexuality and gender dysphoria in mania and describes a treatment option that has not been previously reported.
- Published
- 2016
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50. The Pathways of Policy Feedback: How Health Reform Influences Political Efficacy and Participation
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Suzanne Mettler, Lawrence R. Jacobs, and Ling Zhu
- Subjects
Public Administration ,Sociology and Political Science ,Political science ,Political efficacy ,Management, Monitoring, Policy and Law ,Public administration ,Health reform - Published
- 2021
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