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Your search keyword '"Lambrichts, Ivo"' showing total 21 results
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21 results on '"Lambrichts, Ivo"'

1. Extracellular vesicle‐associated cholesterol supports the regenerative functions of macrophages in the brain

Author

Vanherle, Sam, primary, Guns, Jeroen, additional, Loix, Melanie, additional, Mingneau, Fleur, additional, Dierckx, Tess, additional, Wouters, Flore, additional, Kuipers, Koen, additional, Vangansewinkel, Tim, additional, Wolfs, Esther, additional, Lins, Paula Pincela, additional, Bronckaers, Annelies, additional, Lambrichts, Ivo, additional, Dehairs, Jonas, additional, Swinnen, Johannes V., additional, Verberk, Sanne G. S., additional, Haidar, Mansour, additional, Hendriks, Jerome J. A., additional, and Bogie, Jeroen F. J., additional

Published
2023
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3. Volumetry of ovine incisors dental pulp for further regenerative therapy

Author

Ems, Guillaume, Severino, Leandra, Nisolle, Jean-François, Nicaise, Charles, Lambrichts, Ivo, LoMonaco, Melissa, Bronckaers, Annelies, Hontoir, Fanny, Vandeweerd, Jean-Michel, Hontoir, Fanny/0000-0003-0847-8167, Ems, Guillaume, Severino, Leandra, Nisolle, Jean-Francois, Nicaise, Charles, LAMBRICHTS, Ivo, LO MONACO, Melissa, BRONCKAERS, Annelies, Hontoir, Fanny, Vandeweerd, Jean-Michel, UCL - SSS/IREC/MONT - Pôle Mont Godinne, and UCL - (MGD) Service de radiologie - résonance magnétique

Subjects
volumetry, sheep, pulp, stem cells, animal model, teeth
Abstract

Mesenchymal stem cells (MSCs) are used for regenerative therapy. Dental pulp MSCs make extracted wisdom teeth a useful resource in humans. Preclinical validation of regenerative therapies requires large animal models such as the sheep. Since stem cells can be retrieved from the dental pulp of ovine incisors, the best age to extract a maximal volume of dental pulp needs to be defined. The objective of this ex vivo study was to quantify incisors dental pulp volume, in sheep of various age. Three jaws were dedicated to histology (one per age group); the others were imaged with a computed tomography scanner [3 years-old (n = 9), 4 (n = 3) and 6 (n = 5)]. The incisors dental pulp volume was measured after 3D reconstruction. Multiple linear regression showed that dental pulp volume of ovine incisors decreases with age (beta-estimate = -3.3; p < 0.0001) and teeth position from the more central to the more lateral (beta-estimate = -4.9; p = 0.0009). Weight was not a relevant variable in the regression model. The dental pulp volume ranged from 36.7 to 19.6 mm3 in 3-year-old sheep, from 23.6 to 11.3 in 4-year-old sheep, and from 19.4 to 11.5 in 6-year-old sheep. The pulp volume of the most central teeth (first intermediate) was significantly higher than the most lateral teeth (corner). Haematoxylin-Eosin-Safran of the whole incisors, and of isolated dental pulps demonstrated a similar morphology to that in humans. The first intermediate incisor of 3-year-old sheep should be selected preferentially in preclinical research to retrieve the highest volume of dental pulp. This work was supported by the FNRS—Fonds de la Recherche Scientifique (CR40000921, 2020-2023) as Dr. Hontoir Fanny is a FNRS post-doctoral researcher. We acknowledge Lucie Rendez, Florent Houbaille, and Nicolas DeSmet, imaging technicians of the CHU UCL NAMUR—Godinne (Centre Hospitalier UniversitaireUniversité Catholique de Louvain-Namur) for their precious technical help in this project. We acknowledge Narilis Institute for their support.

Published
2023

6. Prevention of acute radiodermatitis by photobiomodulation: A randomized, placebo-controlled trial in breast cancer patients (TRANSDERMIS trial)

Author

Robijns, Jolien, primary, Censabella, Sandrine, additional, Claes, Stefan, additional, Pannekoeke, Luc, additional, Bussé, Lore, additional, Colson, Dora, additional, Kaminski, Iris, additional, Bulens, Paul, additional, Maes, Annelies, additional, Noé, Leen, additional, Brosens, Marc, additional, Timmermans, An, additional, Lambrichts, Ivo, additional, Somers, Veerle, additional, and Mebis, Jeroen, additional

Published
2018
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8. MicroCT assessment of bone microarchitecture in implant sites reconstructed with autogenous and xenogenous grafts: a pilot study

Author

de Faria Vasconcelos, Karla, primary, dos Santos Corpas, Lívia, additional, da Silveira, Bernardo Mattos, additional, Laperre, Kjell, additional, Padovan, Luis Eduardo, additional, Jacobs, Reinhilde, additional, de Freitas, Paulo Henrique Luiz, additional, Lambrichts, Ivo, additional, and Bóscolo, Frab Norberto, additional

Published
2016
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21. Canonical and non-canonical EcfG sigma factors control the general stress response in Rhizobium etli

Author

Ann Jans, Ivo Lambrichts, Jan Michiels, Maarten Fauvart, Kristof Engelen, Shanjun Gao, Maarten Vercruysse, Jans, Ann, Vercruysse, Maarten, Gao, Shanjun, Engelen, Kristof, LAMBRICHTS, Ivo, Fauvart, Maarten, and Michiels, Jan

Subjects
STRUCTURAL BASIS, EXPRESSION, alpha-proteobacteria, Mutant, TcrX, 2-COMPONENT SYSTEM, Sigma Factor, Biology, Models, Biological, Rhizobium etli, Genome, Microbiology, ALARMONE PPGPP, Stress, Physiological, Sigma factor, CAULOBACTER-CRESCENTUS, α-proteobacteria, EcfG, Gene, Original Research, Genetics, Science & Technology, Phylogenetic tree, Gene Expression Regulation, Bacterial, Phenotype, PHYR, PhyR, Response regulator, ESCHERICHIA-COLI, general stress response, Settore AGR/16 - MICROBIOLOGIA AGRARIA, FACTOR MIMICRY, ECF sigma factor, REGULATOR, Life Sciences & Biomedicine
Abstract

A core component of the α-proteobacterial general stress response (GSR) is the extracytoplasmic function (ECF) sigma factor EcfG, exclusively present in this taxonomic class. Half of the completed α-proteobacterial genome sequences contain two or more copies of genes encoding σEcfG-like sigma factors, with the primary copy typically located adjacent to genes coding for a cognate anti-sigma factor (NepR) and two-component response regulator (PhyR). So far, the widespread occurrence of additional, non-canonical σEcfG copies has not satisfactorily been explained. This study explores the hierarchical relation between Rhizobium etli σEcfG1 and σEcfG2, canonical and non-canonical σEcfG proteins, respectively. Contrary to reports in other species, we find that σEcfG1 and σEcfG2 act in parallel, as nodes of a complex regulatory network, rather than in series, as elements of a linear regulatory cascade. We demonstrate that both sigma factors control unique yet also shared target genes, corroborating phenotypic evidence. σEcfG1 drives expression of rpoH2, explaining the increased heat sensitivity of an ecfG1 mutant, while katG is under control of σEcfG2, accounting for reduced oxidative stress resistance of an ecfG2 mutant. We also identify non-coding RNA genes as novel σEcfG targets. We propose a modified model for GSR regulation in R. etli, in which σEcfG1 and σEcfG2 function largely independently. Based on a phylogenetic analysis and considering the prevalence of α-proteobacterial genomes with multiple σEcfG copies, this model may also be applicable to numerous other species. This research has been funded by the Interuniversity Attraction Poles Programme initiated by the Belgian Science Policy Office and was supported by grants from the Research Council of the KU Leuven (GOA/011/2008) and from the Fund for Scientific Research-Flanders (G.0412.10).

Published
2013

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