1. Transient heart rate reduction improves acute decompensated heart failure‐induced left ventricular and coronary dysfunction
- Author
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Nicolas Peschanski, Najah Harouki, Matthieu Soulie, Marianne Lachaux, Lionel Nicol, Isabelle Remy‐Jouet, Jean‐Paul Henry, Anais Dumesnil, Sylvanie Renet, Françoise Fougerousse, Ebba Brakenhielm, Antoine Ouvrard‐Pascaud, Christian Thuillez, Vincent Richard, Jérôme Roussel, and Paul Mulder
- Subjects
Acute decompensation ,Heart failure ,Heart rate reduction ,Coronary endothelium ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Abstract Aims Acute decompensated heart failure (ADHF), a live‐threatening complication of heart failure (HF), associates a further decrease of the already by HF‐impaired cardiac function with an increase in heart rate. We evaluated, using a new model of ADHF, whether heart rate reduction (HRR) opposes the acute decompensation‐related aggravation of cardiovascular dysfunction. Methods and results Cardiac output (echocardiography), cardiac tissue perfusion (magnetic resonance imaging), pulmonary wet weight, and in vitro coronary artery relaxation (Mulvany) were assessed 1 and 14 days after acute decompensation induced by salt‐loading (1.8 g/kg, PO) in rats with well‐established HF due to coronary ligation. HRR was induced by administration of the If current inhibitor S38844, 12 mg/kg PO twice daily for 2.5 days initiated 12 h or 6 days after salt‐loading (early or delayed treatment, respectively). After 24 h, salt‐loading resulted in acute decompensation, characterized by a reduction in cardiac output (HF: 130 ± 5 mL/min, ADHF: 105 ± 8 mL/min; P
- Published
- 2021
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