Search

Your search keyword '"LIN, B."' showing total 119 results
Start Over Author "LIN, B." Publisher wiley
119 results on '"LIN, B."'

2. The effect of tailing lipidation on the bioactivity of antimicrobial peptides and their aggregation tendency Special Issue: Emerging Investigators

Author

Lin, B, Hung, A, Singleton, W, Darmawan, KK, Moses, R, Yao, B, Wu, H, Barlow, A, Marc-Antoine, S, Sloan, AJ, Hossain, MA, Wade, JD, Hong, Y, O'Brien-Simpson, NM, Li, W, Lin, B, Hung, A, Singleton, W, Darmawan, KK, Moses, R, Yao, B, Wu, H, Barlow, A, Marc-Antoine, S, Sloan, AJ, Hossain, MA, Wade, JD, Hong, Y, O'Brien-Simpson, NM, and Li, W

Abstract

Antimicrobial peptides (AMPs) are potentially powerful alternatives to conventional antibiotics in combating multidrug resistance, given their broad spectrum of activity. They mainly interact with cell membranes through surface electrostatic potentials and the formation of secondary structures, resulting in permeability and destruction of target microorganism membranes. Our earlier work showed that two leading AMPs, MSI‐78 (4–20) and pardaxin (1–22), had potent antimicrobial activity against a range of bacteria. It is known that the attachment of moderate‐length lipid carbon chains to cationic peptides can further improve the functionality of these peptides through enhanced interactions with the membrane lipid bilayer, inducing membrane curvature, destabilization, and potential leakage. Thus, in this work, we aimed to investigate the antimicrobial activity, oligomerization propensity, and lipid‐membrane binding interactions of a range of N‐terminal lipidated analogs of MSI‐78 (4–20) and pardaxin (1–22). Molecular modeling results suggest that aggregation of the N‐lipidated AMPs may impart greater structural stability to the peptides in solution and a greater depth of lipid bilayer insertion for the N‐lipidated AMPs over the parental peptide. Our experimental and computational findings provide insights into how N‐terminal lipidation of AMPs may alter their conformations, with subsequent effects on their functional properties in regard to their self‐aggregation behavior, membrane interactions, and antimicrobial activity.

Published
2023

4. Polygenic liability for schizophrenia and childhood adversity influences daily‐life emotion dysregulation and psychosis proneness

Author

Pries, L.‐K., primary, Klingenberg, B., additional, Menne‐Lothmann, C., additional, Decoster, J., additional, van Winkel, R., additional, Collip, D., additional, Delespaul, P., additional, De Hert, M., additional, Derom, C., additional, Thiery, E., additional, Jacobs, N., additional, Wichers, M., additional, Cinar, O., additional, Lin, B. D., additional, Luykx, J. J., additional, Rutten, B. P. F., additional, van Os, J., additional, and Guloksuz, S., additional

Published
2020
Full Text
View/download PDF

6. Prospective randomized controlled trial comparing treatment efficacy and tolerance of picosecond alexandrite laser with a diffractive lens array and triple combination cream in female asian patients with melasma

Author

Wang, Y.‐J., primary, Lin, E.‐T., additional, Chen, Y.‐T., additional, Chiu, P.‐C., additional, Lin, B.‐S., additional, Chiang, H.‐M., additional, Huang, Y.‐H., additional, Wang, K.‐Y., additional, Lin, H.‐Y., additional, Chang, T.‐M., additional, and Chang, C.‐C., additional

Published
2019
Full Text
View/download PDF

9. Abstracts of the 25th International Isotope Society (UK Group) symposium: Synthesis and applications of labelled compounds 2016

Author

Aboagye, E., primary, Alger, K., additional, Archibald, S.J., additional, Bakar, N.B.A., additional, Barton, N., additional, Bergare, J., additional, Bloom, J., additional, Bragg, R., additional, Burke, B.P., additional, Burns, M.J., additional, Carroll, L., additional, Calatayud, D.G., additional, Cawthorne, C., additional, Cortezon-Tamarit, F., additional, Crean, C., additional, Crump, M.P., additional, Dilworth, J.R., additional, Domarkas, J., additional, Duckett, S.B., additional, Eggleston, I., additional, Elmore, C.S., additional, van Es, E.M., additional, Fekete, M., additional, Goodwin, M., additional, Green, G.G.R., additional, Grönberg, G., additional, Hayes, C.J., additional, Hayes, M.A., additional, Hollis, S., additional, Hueting, R., additional, Ivanov, P., additional, Johnston, G., additional, Kerr, W.J., additional, Kohler, A., additional, Knox, G., additional, Lawrie, K., additional, Lee, R.E., additional, Lewis, W., additional, Lin, B., additional, Lockley, W.J.S., additional, López-Torres, E., additional, Lv, K., additional, Maddocks, S., additional, Marsh, B.J., additional, Mendiola, A., additional, Mirabello, V., additional, Miranda, C.S., additional, Norcott, P.L., additional, O'Hagan, D., additional, Olaru, A.M., additional, Pascu, S.I., additional, Rayner, P.J., additional, Read, D., additional, Ridge, K., additional, Ritter, T., additional, Roberts, I., additional, Samuri, N., additional, Sarpaki, S., additional, Somers, D., additional, Taylor, R., additional, Tuttle, T., additional, Varcoe, J.R., additional, and Willis, C.L., additional

Published
2017
Full Text
View/download PDF

11. Weight-correction of carbon dioxide diffusion coefficient (DCO2) reduces its inter-individual variability and improves its correlation with blood carbon dioxide levels in neonates receiving high-frequency oscillatory ventilation

Author

Belteki, G, Lin, B, Morley, CJ, Belteki, G, Lin, B, and Morley, CJ

Abstract

BACKGROUND: Carbon-dioxide elimination during high-frequency oscillatory ventilation (HFOV) is thought to be proportional to the carbon dioxide diffusion coefficient (DCO2 ) which is calculated as frequency x (tidal volume)2 . DCO2 can be used to as an indicator of CO2 elimination but values obtained in different patients cannot be directly compared. OBJECTIVES: To analyze the relationship between DCO2 , the weight-corrected DCO2 (DCO2 corr) and blood gas PCO2 values obtained from infants receiving HFOV. METHODS: DCO2 data were obtained from 14 infants at 1/s sampling rate and the mean DCO2 was determined over 10 min periods preceding the time of the blood gas. DCO2 corr was calculated by dividing the DCO2 by the square of the body weight in kg. RESULTS: Weight-correction significantly reduced the inter-individual variability of DCO2 . When data from all the babies were combined, standard DCO2 showed no correlation with PCO2 but DCO2 corr showed a weak but statistically significant inverse correlation. The correlation was better when the endotracheal leak was <10%. There was significant inverse but weaker correlation between the HFOV tidal volume (VThf) and the PCO2 . In any baby, DCO2 corr >50 mL2 /sec/kg2 or VThf > 2.5 mL/kg was rarely needed to avoid hypercapnia. CONCLUSIONS: Weight-correction of DCO2 values improved its comparability between patients. Weight-corrected DCO2 correlated better with PCO2 than uncorrected DCO2 but the correlation was weak.

Published
2017

12. The association between investigative interviewers' knowledge of question type and adherence to best-practice interviewing

Author

Su-Lin B. Yii, Belinda Guadagno, and Martine B. Powell

Subjects
Protocol (science), Closed-ended question, Medical education, Computer-assisted personal interviewing, Interview, Recall, Best practice, Psychology, Association (psychology), Applied Psychology, Pathology and Forensic Medicine, Task (project management), Clinical psychology
Abstract

It is well established that not all investigative interviewers adhere to ‘best-practice’ interview guidelines (i.e., the use of open-ended questions) when interviewing child witnesses about abuse. However, little research has examined the sub skills associated with open question usage. In this article, we examined the association between investigative interviewers' ability to identify various types of questions and adherence to open-ended questions in a standardized mock interview. Study 1, incorporating 27 trainee police interviewers, revealed positive associations between open-ended question usage and two tasks; a recognition task where trainees used a structured protocol to guide their response and a recall task where they generated examples of open-ended questions from memory. In Study 2, incorporating a more heterogeneous sample of 40 professionals and a different training format and range of tests, positive relationships between interviewers' identification of questions and adherence to best-practice interviewing was consistently revealed. A measure of interviewer knowledge about what constitutes best-practice investigative (as opposed to knowledge of question types) showed no association with interviewer performance. The implications of these findings for interviewer training programs are discussed.

Published
2012

Catalog

Books, media, physical & digital resources
See catalog results