1. Allergic manifestation 15 years after early intervention with hydrolyzed formulas – the<scp>GINI</scp>Study
- Author
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von Berg, A., Filipiak-Pittroff, B., Schulz, H., Hoffmann, U., Link, E., Sußmann, M., Schnappinger, M., Brüske, I., Standl, M., Krämer, U., Hoffmann, B., Heinrich, J., Bauer, C.P., Koletzko, S., Berdel, D., and GINIplus Study Group ()
- Subjects
Male ,Pediatrics ,Allergy ,hydrolyzed infant formulas ,nutritional intervention ,0302 clinical medicine ,Odds Ratio ,Prevalence ,randomized trial ,Immunology and Allergy ,Cumulative incidence ,Child ,Incidence ,Incidence (epidemiology) ,Milk Proteins ,15‐year follow‐up from birth ,Infant Formula ,double‐blind ,Milk ,Experimental Allergy and Immunology ,Child, Preschool ,Female ,Original Article ,medicine.medical_specialty ,Adolescent ,Immunology ,15-year Follow-up From Birth ,Allergy Prevention ,Double-blind ,Hydrolyzed Infant Formulas ,Nutritional Intervention ,Randomized Trial ,03 medical and health sciences ,030225 pediatrics ,Hypersensitivity ,medicine ,Animals ,Humans ,Asthma ,allergy prevention ,business.industry ,Infant, Newborn ,Infant ,Odds ratio ,medicine.disease ,Confidence interval ,Patient Outcome Assessment ,030228 respiratory system ,Infant formula ,Spirometry ,Relative risk ,Cattle ,ORIGINAL ARTICLES ,business ,Follow-Up Studies - Abstract
Background Data on the long-term impact of hydrolyzed formulas on allergies are scarce. Objective To assess the association between early intervention with hydrolyzed formulas in high-risk children and allergic outcomes in adolescence. Methods GINI trial participants (n = 2252) received one of four formulas in the first four months of life as breastmilk substitute if necessary: partial or extensive whey hydrolyzate (pHF-W, eHF-W), extensive casein hydrolyzate (eHF-C) or standard cow′s milk formula (CMF) as reference. Associations between these formulas and the cumulative incidence and prevalence of parent-reported physician-diagnosed asthma, allergic rhinitis (AR) and eczema, as well as spirometric indices and sensitization, were examined using generalized linear models. Results Between 11 and 15 years, the prevalence of asthma was reduced in the eHF-C group compared to CMF (odds ratio (OR) 0.49, 95% confidence interval (CI) 0.26–0.89), which is consistent with the spirometric results. The cumulative incidence of AR was lower in eHF-C (risk ratio (RR) 0.77, 95% CI 0.59–0.99]) and the AR prevalence in pHF-W (OR 0.67, 95% CI 0.47–0.95) and eHF-C (OR 0.59, 95% CI 0.41–0.84). The cumulative incidence of eczema was reduced in pHF-W (RR 0.75, 95% CI 0.59–0.96) and eHF-C (RR 0.60, 95% CI 0.46–0.77), as was the eczema prevalence between 11 and 15 years in eHF-C (OR 0.42, 95% CI 0.23–0.79). No significant effects were found in the eHF-W group on any manifestation,nor was there an effect on sensitization with any formula. Conclusion In high-risk children, early intervention using different hydrolyzed formulas has variable preventative effects on asthma, allergic rhinitis and eczema up to adolescence.
- Published
- 2015