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57 results on '"Konno, K."'

2. Prostaglandin D2increases Cl secretion across canine tracheal epithelium through cyclooxygenase stimulation and cAMP production

Author

K. Isono, Takao Takizawa, Konno K, Noritaka Sakai, T. Kanemura, F. Yamauchi, Jun Tamaoki, and Atsushi Chiyotani

Subjects
Male, medicine.medical_specialty, Physiology, Prostaglandin, In Vitro Techniques, Epithelium, chemistry.chemical_compound, Dogs, Chlorides, Chloride Channels, Internal medicine, Cyclic AMP, Electrochemistry, medicine, Animals, Channel blocker, Transepithelial potential difference, Prostaglandin D2, Membrane Proteins, Transport inhibitor, Adenosine, Amiloride, Trachea, Endocrinology, chemistry, Prostaglandin-Endoperoxide Synthases, Respiratory epithelium, Female, medicine.drug
Abstract

Prostaglandin (PG) D2 is one cyclo-oxygenase product of arachidonic acid metabolites that may play a role in the pathogenesis of asthma. To determine the effect of PGD2 on ion transport by airway epithelium and its mechanism of action, we measured bioelectric properties of canine cultured tracheal epithelium under short-circuit conditions in vitro. PGD2 (10(-7) M) increased short-circuit current (Isc) from 5.5 +/- 1.2 to 14.1 +/- 2.9 microA cm-2 (means +/- SE, P less than 0.01) when added to the mucosal solution, and to 22.2 +/- 3.8 microA cm-2 (P less than 0.001) when added to the submucosal solution, an effect that was accompanied by the corresponding increases in transepithelial potential difference and conductance. These effects were dose-dependent. The PGD2-induced increase in Isc was not altered by preincubation of cells with autonomic antagonists (phentolamine, propranolol, atropine), the lipoxygenase inhibitor AA-861, the protein kinase C inhibitor H-7, or the Na channel blocker amiloride, but it was inhibited by each of indomethacin, piroxicam, the Cl channel blocker diphenylamine-2-carboxylate, the Cl transport inhibitor furosemide, and Cl-free medium. Intracellular adenosine 3',5'-cyclic monophosphate (cAMP) levels were dose-dependently increased by PGD2. These results suggest that PGD2 may selectively stimulate airway epithelial Cl secretion via cyclo-oxygenase- and cAMP-dependent pathway.

Published
1992

3. Neoplastic Alteration of a Membrane-associated Sialidase of Rat Liver

Author

Konno K, Shigeru Tsuiki, Junji Sagawa, and Taeko Miyagi

Subjects
Male, Rat liver, Cancer Research, Immunoprecipitation, Neuraminidase, Membrane sialidase, Biology, Sialidase, Article, Liver Neoplasms, Experimental, Gangliosides, Animals, Antiserum, Hepatoma, Fetus, Ganglioside, Cell Membrane, Liver Neoplasms, Brain, Rats, Inbred Strains, Precipitin, Precipitin Tests, Pathophysiology, Rats, Membrane, Liver, Oncology, Biochemistry
Abstract

Rat liver participate fraction contains two types of membrane‐associated and gangliosides‐hydrolyzing sialidase, which have been shown to be identical to two membrane‐associated sialidases of rat brain (I and II) chromatographically, immunologically and in substrate specificity. Chromatography on AH‐Sepharose 4B of the membrane sialidases of rat primary hepatoma induced by 3′‐methyl‐4‐dimethylaminoazobenzene (MeDAB) further revealed that hepatocarcinogenesis induces a marked decrease in sialidase II but no decrease in sialidase I. Using antisera against sialidases I and II of rat brain, immunoprecipitation studies of the solubilized particulate fractions of rat liver and MeDAB‐hepatoma gave results similar to those obtained chromatographically. Using the same immunological technique, sialidase II but not sialidase I was found to be decreased in AH109 A hepatoma and in regenerating and fetal liver.

Published
1990

10. ChemInform Abstract: Utilization of Wieland Furoxan Synthesis for Preparation of 4-Aryl-1,2, 5-oxadiazole-3-yl Carbamate Derivatives Having Potent Anti-HIV Activity.

Author

TAKAYAMA, H., primary, SHIRAKAWA, S., additional, KITAJIMA, M., additional, AIMI, N., additional, YAMAGUCHI, K., additional, HANASAKI, Y., additional, IDE, T., additional, KATSUURA, K., additional, FUJIWARA, M., additional, IJICHI, K., additional, KONNO, K., additional, SIGETA, S., additional, YOKOTA, T., additional, and BABA, M., additional

Published
2010
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24. Tissue specific metabolism of 1α,25‐dihydroxy‐20‐epi‐vitamin D3 into new metabolites with significant biological activity: Studies in rat osteosarcoma cells (UMR 106 and ROS 17/2.8)

Author

Siu‐Caldera, M‐L., primary, Rao, D. Sunita, additional, Astecker, N., additional, Weiskopf, A., additional, Vouros, P., additional, Konno, K., additional, Fujishima, T., additional, Takayama, H., additional, Peleg, S., additional, and Reddy, G. Satyanarayana, additional

Published
2001
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26. Isolated splenic metastases.

Author

Ishida, H, primary, Konno, K, additional, Ishida, J, additional, Shirayama, K, additional, Naganuma, H, additional, Komatsuda, T, additional, Hamashima, Y, additional, and Masamune, O, additional

Published
1997
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