1. GADA and anti-ZnT8 complicate the outcome of phenotypic type 2 diabetes of adults
- Author
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Kalle Kisand, Raivo Uibo, V. Nemvalts, Katrin Pruul, Kadri Haller-Kikkatalo, and Koit Reimand
- Subjects
Male ,medicine.medical_specialty ,Clinical Biochemistry ,030209 endocrinology & metabolism ,Zinc Transporter 8 ,Type 2 diabetes ,Logistic regression ,Biochemistry ,Gastroenterology ,Nephropathy ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,Diabetic Nephropathies ,Age of Onset ,Risk factor ,Cation Transport Proteins ,Pancreas ,Adiposity ,Aged ,Autoantibodies ,Retrospective Studies ,030304 developmental biology ,0303 health sciences ,Glutamate Decarboxylase ,business.industry ,Autoantibody ,General Medicine ,Odds ratio ,Middle Aged ,Prognosis ,medicine.disease ,3. Good health ,Phenotype ,Diabetes Mellitus, Type 2 ,Immunoglobulin G ,Immunology ,Disease Progression ,Population study ,Female ,business ,Polyneuropathy ,Biomarkers - Abstract
Background A proportion of phenotypic type 2 diabetes (T2D) patients produce pancreatic autoantibodies and a majority of T2D patients develop serious life-disabling complications over time despite the implementation of adequate clinical interventions. This study determined whether the presence of pancreatic autoantibodies (GADA, IA-2A, anti-ZnT8, or ICA) was associated with serious complications or concomitant diseases of adult patients diagnosed with T2D (N = 305). Main results In the study population, 22·3% (N = 68) of subjects were positive for at least 1 of the 4 of the markers associated with autoimmune diabetes (presence of pancreatic autoantibody โ pAb), followed by GADA (14·1%, N = 43), ICA (8·9%, N = 27), anti-ZnT8 (5·6%, N = 17) and IA-2A (2·0%, N = 6). Logistic regression analysis adjusted for patient's age, gender and duration of T2D revealed that (i) pAb was associated with higher prevalence of adiposity (odds ratio of adjusted regression model (adOR) 2·51, P = 0·032); (ii) pAb, GADA and anti-ZnT8 were associated with autoimmune thyroid disease (adORs 3·07, P = 0·012; 6·29, P
- Published
- 2015