Search

Your search keyword '"Koenig, Steven C."' showing total 13 results
Start Over Author "Koenig, Steven C." Publisher wiley
13 results on '"Koenig, Steven C."'

9. Response to Letter to the Editor: A Novel Subcutaneous Counterpulsation Device: Acute Hemodynamic Efficacy During Pharmacologically Induced Hypertension, Hypotension, and Heart Failure

Author

Bartoli, Carlo R., primary, Dowling, Robert D., additional, Wilson, Gregory C., additional, Giridharan, Guruprasad A., additional, Slaughter, Mark S., additional, Sherwood, Leslie C., additional, Spence, Paul A., additional, Prabhu, Sumanth D., additional, and Koenig, Steven C., additional

Published
2011
Full Text
View/download PDF

13. Flow features and device-induced blood trauma in CF-VADs under a pulsatile blood flow condition: A CFD comparative study.

Author

Chen Z, Jena SK, Giridharan GA, Koenig SC, Slaughter MS, Griffith BP, and Wu ZJ

Subjects
Algorithms, Equipment Design, Heart Failure therapy, Hemolysis, Humans, Shear Strength, Heart-Assist Devices, Pulsatile Flow
Abstract

In this study, the flow features and device-associated blood trauma in 4 clinical ventricular assist devices (VADs; 2 implantable axial VADs, 1 implantable centrifugal VAD, and 1 extracorporeal VAD) were computationally analyzed under clinically relevant pulsatile flow conditions. The 4 VADs were operated at fixed pump speed at a mean rate of 4.5 L/min. Mean pressure difference, wall shear stress, volume distribution of scalar shear stress (SSS), and shear-induced hemolysis index (HI) were derived from the flow field of each VAD and were compared. The computationally predicted mean pressure difference across the 3 implantable VADs was ~70 mmHg, and the extracorporeal VAD was ~345 mmHg, which matched well with their reported pressure-flow curves. The axial VADs had higher mean wall shear stress and SSS compared with the centrifugal VADs. However, the residence time of the centrifugal VADs was much longer compared with the axial VADs because of the large volume of the centrifugal VADs. The highest SSS was observed in one axial VAD, and the longest exposure time was observed in 1 centrifugal VAD. These 2 VADs generated the highest HI. The shear-induced HI varied as a function of flow rate within each cardiac cycle. At fixed pump speed, the HI was greatest at low flow rate due to longer exposure time to shear stress compared with at high flow rate. Subsequently, we hypothesize that to reduce the risk of blood trauma during VAD support, shear stress magnitude and exposure time need to be minimized., (Copyright © 2017 John Wiley & Sons, Ltd.)

Published
2018
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results