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Your search keyword '"Koboldt, C. M."' showing total 12 results
Start Over Author "Koboldt, C. M." Publisher wiley
12 results on '"Koboldt, C. M."'

2. ChemInform Abstract: 1,2-Diarylcyclopentenes as Selective Cyclooxygenase-2 Inhibitors and Orally Active anti-Inflammatory Agents.

Author

LI, J. L., primary, ANDERSON, G. D., additional, BURTON, E. G., additional, COGBURN, J. N., additional, COLLINS, J. T., additional, GARLAND, D. J., additional, GREGORY, S. A., additional, HUANG, H.-C., additional, ISAKSON, P. C., additional, KOBOLDT, C. M., additional, LOGUSCH, E. W., additional, NORTON, M. B., additional, PERKINS, W. E., additional, REINHARD, E. J., additional, SEIBERT, K., additional, VEENHUIZEN, A. W., additional, ZHANG, Y., additional, and REITZ, D. B., additional

Published
2010
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3. ChemInform Abstract: Novel Terphenyls as Selective Cyclooxygenase-2 Inhibitors and Orally Active anti-Inflammatory Agents.

Author

LI, J. J., primary, NORTON, M. B., additional, REINHARD, E. J., additional, ANDERSON, G. D., additional, GREGORY, S. A., additional, ISAKSON, P. C., additional, KOBOLDT, C. M., additional, MASFERRER, J. L., additional, PERKINS, W. E., additional, SEIBERT, K., additional, ZHANG, Y., additional, ZWEIFEL, B. S., additional, and REITZ, D. B., additional

Published
2010
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7. ChemInform Abstract: 1,2‐Diarylimidazoles as Potent, Cyclooxygenase‐2 Selective, and Orally Active Antiinflammatory Agents.

Author

KHANNA, I. K., primary, WEIER, R. M., additional, YU, Y., additional, XU, X. D., additional, KOSZYK, F. J., additional, COLLINS, P. W., additional, KOBOLDT, C. M., additional, VEENHUIZEN, A. W., additional, PERKINS, W. E., additional, CASLER, J. J., additional, MASFERRER, J. L., additional, ZHANG, Y. Y., additional, GREGORY, S. A., additional, SEIBERT, K., additional, and ISAKSON, P. C., additional

Published
1997
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8. ChemInform Abstract: Diarylspiro(2.4)heptenes as Orally Active, Highly Selective Cyclooxygenase‐2 Inhibitors: Synthesis and Structure‐Activity Relationships.

Author

HUANG, H.‐C., primary, LI, J. J., additional, GARLAND, D. J., additional, CHAMBERLAIN, T. S., additional, REINHARD, E. J., additional, MANNING, R. E., additional, SEIBERT, K., additional, KOBOLDT, C. M., additional, GREGORY, S. A., additional, ANDERSON, G. D., additional, VEENHUIZEN, A. W., additional, ZHANG, Y., additional, PERKINS, W. E., additional, BURTON, E. G., additional, COGBURN, J. N., additional, ISAKSON, P. C., additional, and REITZ, D. B., additional

Published
1996
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10. ChemInform Abstract: Novel 1,2‐Diarylcyclopentenes are Selective, Potent, and Orally Active Cyclooxygenase Inhibitors.

Author

REITZ, D. B., primary, LI, J. J., additional, NORTON, M. B., additional, REINHARD, E. J., additional, HUANG, H.‐C., additional, PENICK, M. A., additional, COLLINS, J. T., additional, GARLAND, D. J., additional, SEIBERT, K., additional, KOBOLDT, C. M., additional, GREGORY, S. A., additional, VEENHUIZEN, A., additional, ZHANG, Y., additional, and ISAKSON, P. C., additional

Published
1995
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11. ChemInform Abstract: Selective Cyclooxygenase Inhibitors: Novel 4‐Spiro 1,2‐ Diarylcyclopentenes are Potent and Orally Active COX‐2 Inhibitors.

Author

REITZ, D. B., primary, HUANG, H.‐C., additional, LI, J. J., additional, GARLAND, D. J., additional, MANNING, R. E., additional, ANDERSON, G. D., additional, GREGORY, S. A., additional, KOBOLDT, C. M., additional, PERKINS, W. E., additional, SEIBERT, K., additional, and ISAKSON, P. C., additional

Published
1995
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12. 4,5-Diaryloxazole inhibitors of cyclooxygenase-2 (COX-2).

Author

Talley JJ, Bertenshaw SR, Brown DL, Carter JS, Graneto MJ, Koboldt CM, Masferrer JL, Norman BH, Rogier DJ Jr, Zwwifel BS, and Seibert K

Subjects
Animals, Cyclooxygenase 2, Cyclooxygenase 2 Inhibitors, Humans, Membrane Proteins, Anti-Inflammatory Agents, Non-Steroidal pharmacology, Cyclooxygenase Inhibitors pharmacology, Isoenzymes drug effects, Oxazoles pharmacology, Prostaglandin-Endoperoxide Synthases drug effects
Abstract

A series of methysulfonyl or sulfonamido substituted 4,5-diaryloxazole were prepared and evaluated for their ability to inhibit the inducible form of cyclooxygenase (COX-2) in vitro and in vivo. Several unique substitution patterns were identified that led to potent and selective inhibitors of COX-2. In general, 2-trifluoromethly-4,5-diaryloxazoles substituted with a methylsulfonyl or sulfonamido group were particularly potent inhibitors. One of the more potent compounds with a selectivity for COX-2 of about 800 fold was 4b (SC-299). SC-299, a highly fluorescent molecule, may be useful for spectroscopic studies on preferential inhibitor binding to COX-2.

Published
1999
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