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Your search keyword '"Kinugawa, T."' showing total 8 results
Start Over Author "Kinugawa, T." Publisher wiley
8 results on '"Kinugawa, T."'

4. Tonic block of the Na+ current in single atrial and ventricular guineapig myocytes, by a new antiarrhythmic drug, Ro 22‐9194

Author

Hiroe, K., primary, Hisatome, I., additional, Tanaka, Y., additional, Ahmmed, GU, additional, Sasaki, N., additional, Shimoyama, M., additional, Tsuboi, M., additional, Inoue, Y., additional, Manabe, I., additional, Yamamoto, Y., additional, Ohtahata, A., additional, Kinugawa, T., additional, Ogino, K., additional, Igawa, O., additional, Yoshida, A., additional, Shigemasa, C., additional, and Sato, R., additional

Published
1997
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8. Inhibitory actions of amoxapine, a tricyclic antidepressant agent, on electrophysiological properties of mammalian isolated cardiac preparations.

Author

Kinugawa T, Kotake H, and Mashiba H

Subjects
Action Potentials drug effects, Animals, Electrophysiology, Guinea Pigs, Heart physiology, In Vitro Techniques, Membrane Potentials drug effects, Papillary Muscles drug effects, Papillary Muscles physiology, Rabbits, Sinoatrial Node drug effects, Amoxapine pharmacology, Dibenzoxazepines pharmacology, Heart drug effects
Abstract

1. The electrophysiological effects of amoxapine were examined in guinea-pig isolated papillary muscles and rabbit sinoatrial nodes using a conventional microelectrode technique. 2. In papillary muscles, amoxapine above 10 microM caused a dose-dependent decrease in the maximum upstroke velocity (Vmax) of the action potential and in the action potential amplitude (APA), whereas the action potential duration at 90% repolarization (APD90) was significantly prolonged. For a decrease in Vmax, amoxapine produced a negative shift of the curve relating Vmax to the resting potential (Em) along the voltage axis to more negative membrane potentials. 3. Amoxapine also decreased Vmax and the overshoot potential of K+-depolarized slow action potentials of papillary muscle preparations. 4. In spontaneously beating sinoatrial node preparations, amoxapine above 3 microM reduced the heart rate, Vmax, APA and the slope of phase 4 depolarization in a dose-dependent manner. 5. It was concluded that amoxapine exerts inhibitory actions on fast- and slow-response fibres of the heart and these actions can be mainly explained by inhibition of both fast Na+ and slow Ca2+ channels.

Published
1988
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