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32 results on '"Kilpatrick, Trevor"'

1. Patient‐determined disease steps is not interchangeable with the Expanded Disease Status Scale in mild to moderate multiple sclerosis

Author

Foong, Yi Chao, primary, Merlo, Daniel, additional, Gresle, Melissa, additional, Zhu, Chao, additional, Buzzard, Katherine, additional, Lechner‐Scott, Jeannette, additional, Barnett, Michael, additional, Taylor, Bruce, additional, Kalincik, Tomas, additional, Kilpatrick, Trevor, additional, Darby, David, additional, Dobay, Pamela, additional, van Beek, Johan, additional, Hyde, Robert, additional, Butzkueven, Helmut, additional, and van der Walt, Anneke, additional

Published
2023
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2. Functional correlates of motor control impairments in multiple sclerosis: A 7 Tesla task functional MRI study

Author

Strik, Myrte, primary, Shanahan, Camille J., additional, Walt, Anneke, additional, Boonstra, Frederique M. C., additional, Glarin, Rebecca, additional, Galea, Mary P., additional, Kilpatrick, Trevor J., additional, Geurts, Jeroen J. G., additional, Cleary, Jon O., additional, Schoonheim, Menno M., additional, and Kolbe, Scott C., additional

Published
2021
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4. Genome sequencing uncovers phenocopies in primary progressive multiple sclerosis

Author

Jia, Xiaoming, primary, Madireddy, Lohith, additional, Caillier, Stacy, additional, Santaniello, Adam, additional, Esposito, Federica, additional, Comi, Giancarlo, additional, Stuve, Olaf, additional, Zhou, Yuan, additional, Taylor, Bruce, additional, Kilpatrick, Trevor, additional, Martinelli‐Boneschi, Filippo, additional, Cree, Bruce A.C., additional, Oksenberg, Jorge R., additional, Hauser, Stephen L., additional, and Baranzini, Sergio E, additional

Published
2018
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7. Galanin is an autocrine myelin and oligodendrocyte trophic signal induced by leukemia inhibitory factor

Author

Gresle, Melissa M., primary, Butzkueven, Helmut, additional, Perreau, Victoria M., additional, Jonas, Anna, additional, Xiao, Junhua, additional, Thiem, Stefan, additional, Holmes, Fiona E., additional, Doherty, William, additional, Soo, Pik-Ying, additional, Binder, Michele D., additional, Akkermann, Rainer, additional, Jokubaitis, Vilija G., additional, Cate, Holly S., additional, Marriott, Mark P., additional, Gundlach, Andrew L., additional, Wynick, David, additional, and Kilpatrick, Trevor J., additional

Published
2015
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8. Ceruloplasmin gene-deficient mice with experimental autoimmune encephalomyelitis show attenuated early disease evolution

Author

Gresle, Melissa M., primary, Schulz, Katrin, additional, Jonas, Anna, additional, Perreau, Victoria M., additional, Cipriani, Tania, additional, Baxter, Alan G., additional, Miranda-Hernandez, Socorro, additional, Field, Judith, additional, Jokubaitis, Vilija G., additional, Cherny, Robert, additional, Volitakis, Irene, additional, David, Samuel, additional, Kilpatrick, Trevor J., additional, and Butzkueven, Helmut, additional

Published
2014
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13. The role of latitude, ultraviolet radiation exposure and vitamin D in childhood asthma and hayfever: an Australian multicenter study

Author

Hughes, Ann Maree, primary, Lucas, Robyn Marjorie, additional, Ponsonby, Anne-Louise, additional, Chapman, Caron, additional, Coulthard, Alan, additional, Dear, Keith, additional, Dwyer, Terry, additional, Kilpatrick, Trevor J., additional, McMichael, Anthony J., additional, Pender, Michael P., additional, Taylor, Bruce V., additional, Valery, Patricia, additional, van der Mei, Ingrid A. F., additional, and Williams, David, additional

Published
2010
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14. Modulation of bone morphogenic protein signalling alters numbers of astrocytes and oligodendroglia in the subventricular zone during cuprizone‐induced demyelination

Author

Cate, Holly S., primary, Sabo, Jennifer K., additional, Merlo, Daniel, additional, Kemper, Dennis, additional, Aumann, Tim D., additional, Robinson, Julien, additional, Merson, Toby D., additional, Emery, Ben, additional, Perreau, Victoria M., additional, and Kilpatrick, Trevor J., additional

Published
2010
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18. Leukemia inhibitory factor signaling modulates both central nervous system demyelination and myelin repair

Author

Marriott, Mark P., primary, Emery, Ben, additional, Cate, Holly S., additional, Binder, Michele D., additional, Kemper, Dennis, additional, Wu, Qizhu, additional, Kolbe, Scott, additional, Gordon, Ian R., additional, Wang, Hong, additional, Egan, Gary, additional, Murray, Simon, additional, Butzkueven, Helmut, additional, and Kilpatrick, Trevor J., additional

Published
2008
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22. Multiple Sclerosis: A Haplotype Association Study

Author

Foote, Simon J., primary, Rubio, Justin P., additional, Bahlo, Melanie, additional, Kilpatrick, Trevor J., additional, Speed, Terence P., additional, Stankovich, Jim, additional, Burfoot, Rachel, additional, Butzkueven, Helmut, additional, Johnson, Laura, additional, Wilkinson, Chris, additional, Taylor, Bruce, additional, Sale, Michele, additional, van der Mei, Ingrid A. F., additional, Dickinson, Joanne L., additional, and Groom, Patricia, additional

Published
2005
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24. Expression of the low‐affinity neurotrophin receptor, p75NTR, is upregulated by oligodendroglial progenitors adjacent to the subventricular zone in response to demyelination

Author

Petratos, Steven, primary, Gonzales, Michael F., additional, Azari, Michael F., additional, Marriott, Mark, additional, Minichiello, Rebecca A., additional, Shipham, Kylie A, additional, Profyris, Christos, additional, Nicolaou, Antonis, additional, Boyle, Kristy, additional, Cheema, Surindar S., additional, and Kilpatrick, Trevor J., additional

Published
2004
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29. The Patient-Determined Disease Steps scale is not interchangeable with the Expanded Disease Status Scale in mild to moderate multiple sclerosis.

Author

Foong YC, Merlo D, Gresle M, Zhu C, Buzzard K, Lechner-Scott J, Barnett M, Taylor B, Kalincik T, Kilpatrick T, Darby D, Dobay P, van Beek J, Hyde R, Butzkueven H, and van der Walt A

Subjects
Humans, Reproducibility of Results, Disability Evaluation, Outcome Assessment, Health Care, Multiple Sclerosis diagnosis, Multiple Sclerosis, Relapsing-Remitting diagnosis
Abstract

Background and Purpose: The validity, reliability, and longitudinal performance of the Patient-Determined Disease Steps (PDDS) scale is unknown in people with multiple sclerosis (MS) with mild to moderate disability. We aimed to examine the psychometric properties and longitudinal performance of the PDDS., Methods: We included relapsing-remitting MS patients with an Expanded Disability Status Scale (EDSS) score of less than 4. Validity and test-retest reliability was examined. Longitudinal data were analysed with mixed-effect modelling and Cohen's kappa for concordance in confirmed disability progression (CDP)., Results: We recruited a total of 1093 participants, of whom 904 had complete baseline data. The baseline correlation between PDDS and EDSS was weak (ρ = 0.45, p < 0.001). PDDS had stronger correlations with patient-reported outcomes (PROs). Conversely, EDSS had stronger correlations with age, disease duration, Kurtzke's functional systems and processing speed test. PDDS test-retest reliability was good to excellent (concordance correlation coefficient = 0.73-0.89). Longitudinally, PDDS was associated with EDSS, age and depression. A higher EDSS score was associated with greater PDSS progression. The magnitude of these associations was small. There was no concordance in CDP as assessed by PDDS and EDSS., Conclusion: The PDDS has greater correlation with other PROs but less correlation with other MS-related outcome measures compared to the EDSS. There was little correlation between PDDS and EDSS longitudinally. Our findings suggest that the PDDS scale is not interchangeable with the EDSS., (© 2023 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology.)

Published
2024
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30. Inhibitory saccadic dysfunction is associated with cerebellar injury in multiple sclerosis.

Author

Kolbe SC, Kilpatrick TJ, Mitchell PJ, White O, Egan GF, and Fielding J

Subjects
Adult, Brain Mapping, Cognition Disorders etiology, Diffusion Magnetic Resonance Imaging, Disability Evaluation, Female, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Neuropsychological Tests, Brain Injuries etiology, Cerebellum pathology, Multiple Sclerosis complications, Ocular Motility Disorders etiology
Abstract

Cognitive dysfunction is common in patients with multiple sclerosis (MS). Saccadic eye movement paradigms such as antisaccades (AS) can sensitively interrogate cognitive function, in particular, the executive and attentional processes of response selection and inhibition. Although we have previously demonstrated significant deficits in the generation of AS in MS patients, the neuropathological changes underlying these deficits were not elucidated. In this study, 24 patients with relapsing-remitting MS underwent testing using an AS paradigm. Rank correlation and multiple regression analyses were subsequently used to determine whether AS errors in these patients were associated with: (i) neurological and radiological abnormalities, as measured by standard clinical techniques, (ii) cognitive dysfunction, and (iii) regionally specific cerebral white and gray-matter damage. Although AS error rates in MS patients did not correlate with clinical disability (using the Expanded Disability Status Score), T2 lesion load or brain parenchymal fraction, AS error rate did correlate with performance on the Paced Auditory Serial Addition Task and the Symbol Digit Modalities Test, neuropsychological tests commonly used in MS. Further, voxel-wise regression analyses revealed associations between AS errors and reduced fractional anisotropy throughout most of the cerebellum, and increased mean diffusivity in the cerebellar vermis. Region-wise regression analyses confirmed that AS errors also correlated with gray-matter atrophy in the cerebellum right VI subregion. These results support the use of the AS paradigm as a marker for cognitive dysfunction in MS and implicate structural and microstructural changes to the cerebellum as a contributing mechanism for AS deficits in these patients., (Copyright © 2013 Wiley Periodicals, Inc.)

Published
2014
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31. Diffusion tensor imaging of the optic radiations after optic neuritis.

Author

Kolbe S, Bajraszewski C, Chapman C, Nguyen T, Mitchell P, Paine M, Butzkueven H, Johnston L, Kilpatrick T, and Egan G

Subjects
Adult, Aged, Algorithms, Anisotropy, Brain Mapping, Evoked Potentials, Visual physiology, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Optic Nerve Diseases pathology, Optic Nerve Injuries pathology, Probability, Visual Acuity physiology, Young Adult, Diffusion Tensor Imaging methods, Optic Neuritis pathology
Abstract

Trans-synaptic degeneration could exacerbate neurodegeneration in multiple sclerosis (MS). We aimed to assess whether anterograde trans-synaptic degeneration could be identified in the primary visual pathway in vivo. Diffusion tensor imaging (DTI) was used to assess the optic radiations in 15 patients with previous optic nerve inflammation and 9 healthy volunteers. A probabilistic atlas of the optic radiations was created from healthy diffusion tractography data. Lengthwise profiles for DTI parameters (axial [λ(||) ], radial [λ(⟂) ] and mean diffusivity [MD], fractional anisotropy [FA] and the angle of deviation of the principal eigenvector [α]) were analyzed for patients and controls. Patients also underwent multifocal visual evoked potential (mfVEP) assessments to characterize the latency and amplitude of cortical potentials. Correlations were performed between mfVEP latency and amplitude in the left and right visual hemi-fields and DTI parameters in the contra-lateral optic radiations. Patients displayed a significant decrease in λ(||) within the body of both optic radiations, which significantly correlated with loss of mfVEP amplitude. Abnormal λ(⟂) and FA were detected bilaterally throughout the optic radiations in patients but the abnormality was not associated with amplitude reduction or latency prolongation of the mfVEP. An abnormal α value was observed in the left optic radiations of patients, and the α value in the body of the optic radiations also correlated with mfVEP amplitude loss. The assocation between bilateral DTI abnormalities within the optic radiations and loss of afferent electrical activity could indicate anterograde trans-synaptic degeneration occurs following optic neuritis., (Copyright © 2011 Wiley Periodicals, Inc.)

Published
2012
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32. Multiple sclerosis: a haplotype association study.

Author

Foote SJ, Rubio JP, Bahlo M, Kilpatrick TJ, Speed TP, Stankovich J, Burfoot R, Butzkueven H, Johnson L, Wilkinson C, Taylor B, Sale M, van der Mei IA, Dickinson JL, and Groom P

Subjects
Humans, Multiple Sclerosis epidemiology, Tasmania epidemiology, Haplotypes, Multiple Sclerosis genetics
Abstract

Results are presented from a genomewide haplotype association study on multiple sclerosis (MS) cases from Tasmania, an island state of Australia. Cases were ascertained on strict clinical and radiological grounds and on the fact that they had at least one grandparent born in the state. This enriched for early settler chromosomes among present day Tasmanians with MS and increased the chances of finding common haplotype sharing at disease predisposition loci in distant relatives sharing common ancestral haplotypes. Four-to-five close relatives were also collected for each of 170 cases and 105 population-based controls. All were genotyped at a 5cM resolution, haplotypes reconstructed and sharing estimated using an empirical approach based on sorting haplotypes to find the most common at each locus and then generating a test statistic for excess sharing in the cases based on permutation testing. Five initial loci were found where there was an excess sharing in the cases. These were fine-mapped with 10-12 additional markers. Only loci on chromosomes 6 and 10 remained after fine mapping. These loci demonstrate an increase in sharing of multi-marker haplotypes in MS cases compared to both population control transmitted haplotypes and case non-transmitted haplotypes.

Published
2005

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